Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy?1
Purpose: To assess lesion-related and technical factors that affect diagnostic yield in image-guided core-needle biopsy (CNB) of bone and soft-tissue lesions. Materials and Methods: Institutional review board approval and verbal informed consent were obtained for a HIPAA-compliant prospective study...
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| Veröffentlicht in: | Radiology 2008-09, Vol.248 (3), p.962 |
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| creator | Jim S. Wu Jeffrey D. Goldsmith Perry J. Horwich Sanjay K. Shetty Mary G. Hochman |
| description | Purpose: To assess lesion-related and technical factors that affect diagnostic yield in image-guided core-needle biopsy (CNB) of bone
and soft-tissue lesions.
Materials and Methods: Institutional review board approval and verbal informed consent were obtained for a HIPAA-compliant prospective study of
151 consecutive CNBs of bone ( n = 88) and soft-tissue ( n = 63) lesions. Each CNB specimen was reported separately in the final pathology report. Diagnostic yield (total number of
biopsies that yield a diagnosis divided by total number of biopsies) was calculated for all lesions and subgroups on the basis
of lesion composition (lytic, sclerotic, soft tissue), lesion size (â¤2, >2 to 5, or >5 cm), biopsy needle gauge, image guidance
modality, number of specimens obtained, and specimen length (10 mm). The minimum number of specimens required
to obtain a diagnosis was determined on the basis of the specimen number at which the diagnostic yield reached a plateau.
Ï 2 And Wilcoxon rank-sum tests were performed in bivariate analyses to evaluate associations between each factor and diagnostic
yield. Significant factors were evaluated with multivariate logistic regression.
Results: Diagnostic yield was 77% for all lesions. Yield was 87% for lytic bone lesions and 57% for sclerotic bone lesions ( P = .002). Diagnostic yield increased with larger lesions (54% for lesions ⤠2 cm, 75% for lesions > 2 to 5 cm, and 86% for
lesions > 5 cm [ P = .006]). There was no difference in diagnostic yield for bone versus soft-tissue lesions or according to needle gauge or
image guidance modality. Diagnostic yield was 77% for bone lesions and 76% for soft-tissue lesions ( P = .88). Yield was 83%, 72%, 77%, and 83% for biopsies performed with 14-, 15-, 16-, and 18-gauge needles, respectively ( P = .57). Yield was 77% with computed tomographic guidance and 78% with ultrasonographic guidance ( P = .99). Diagnostic yield increased with number of specimens obtained and with longer specimen length; it reached a plateau
at three specimens for bone lesions and four specimens for soft-tissue lesions.
Conclusion: Diagnostic yield is higher in lytic than in sclerotic bone lesions, in larger lesions, and for longer specimens. Obtaining
a minimum of three specimens in bone lesions and four specimens in soft-tissue lesions optimizes diagnostic yield.
© RSNA, 2008 |
| doi_str_mv | 10.1148/radiol.2483071742 |
| format | Article |
| fullrecord | <record><control><sourceid>highwire</sourceid><recordid>TN_cdi_highwire_smallpub3_radiology248_3_962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>radiology248_3_962</sourcerecordid><originalsourceid>FETCH-highwire_smallpub3_radiology248_3_9623</originalsourceid><addsrcrecordid>eNqVz81KxDAUQOEgCtafB3B3H8CMSZPajhtxRgcHBjcOiKsSm5s0kmmG3hSZt1fQF3B1NmfzMXYlxUxK3dyMxoYUZ6VulKhlrcsjVsiqrLlUsjpmhRBK8UbL-Sk7I_oUQuqqqQvmF2lAMIOF1-Qy3waiCWGDFNJAd_DWmwwr0-U0Ejw4h12Gx2D8kCiHDt4DRgvJwXpnPHI_BYsWlmlE_oJoI8IipD0d7uUFO3EmEl7-9Zxdr562y2feB99_hRFb2pkY99OHan8tyR9-NK1q57el-uf-DVtCVTU</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy?1</title><source>Alma/SFX Local Collection</source><creator>Jim S. Wu ; Jeffrey D. Goldsmith ; Perry J. Horwich ; Sanjay K. Shetty ; Mary G. Hochman</creator><creatorcontrib>Jim S. Wu ; Jeffrey D. Goldsmith ; Perry J. Horwich ; Sanjay K. Shetty ; Mary G. Hochman</creatorcontrib><description>Purpose: To assess lesion-related and technical factors that affect diagnostic yield in image-guided core-needle biopsy (CNB) of bone
and soft-tissue lesions.
Materials and Methods: Institutional review board approval and verbal informed consent were obtained for a HIPAA-compliant prospective study of
151 consecutive CNBs of bone ( n = 88) and soft-tissue ( n = 63) lesions. Each CNB specimen was reported separately in the final pathology report. Diagnostic yield (total number of
biopsies that yield a diagnosis divided by total number of biopsies) was calculated for all lesions and subgroups on the basis
of lesion composition (lytic, sclerotic, soft tissue), lesion size (â¤2, >2 to 5, or >5 cm), biopsy needle gauge, image guidance
modality, number of specimens obtained, and specimen length (<5, 5â10, or >10 mm). The minimum number of specimens required
to obtain a diagnosis was determined on the basis of the specimen number at which the diagnostic yield reached a plateau.
Ï 2 And Wilcoxon rank-sum tests were performed in bivariate analyses to evaluate associations between each factor and diagnostic
yield. Significant factors were evaluated with multivariate logistic regression.
Results: Diagnostic yield was 77% for all lesions. Yield was 87% for lytic bone lesions and 57% for sclerotic bone lesions ( P = .002). Diagnostic yield increased with larger lesions (54% for lesions ⤠2 cm, 75% for lesions > 2 to 5 cm, and 86% for
lesions > 5 cm [ P = .006]). There was no difference in diagnostic yield for bone versus soft-tissue lesions or according to needle gauge or
image guidance modality. Diagnostic yield was 77% for bone lesions and 76% for soft-tissue lesions ( P = .88). Yield was 83%, 72%, 77%, and 83% for biopsies performed with 14-, 15-, 16-, and 18-gauge needles, respectively ( P = .57). Yield was 77% with computed tomographic guidance and 78% with ultrasonographic guidance ( P = .99). Diagnostic yield increased with number of specimens obtained and with longer specimen length; it reached a plateau
at three specimens for bone lesions and four specimens for soft-tissue lesions.
Conclusion: Diagnostic yield is higher in lytic than in sclerotic bone lesions, in larger lesions, and for longer specimens. Obtaining
a minimum of three specimens in bone lesions and four specimens in soft-tissue lesions optimizes diagnostic yield.
© RSNA, 2008</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.2483071742</identifier><language>eng</language><publisher>Radiological Society of North America</publisher><ispartof>Radiology, 2008-09, Vol.248 (3), p.962</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Jim S. Wu</creatorcontrib><creatorcontrib>Jeffrey D. Goldsmith</creatorcontrib><creatorcontrib>Perry J. Horwich</creatorcontrib><creatorcontrib>Sanjay K. Shetty</creatorcontrib><creatorcontrib>Mary G. Hochman</creatorcontrib><title>Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy?1</title><title>Radiology</title><description>Purpose: To assess lesion-related and technical factors that affect diagnostic yield in image-guided core-needle biopsy (CNB) of bone
and soft-tissue lesions.
Materials and Methods: Institutional review board approval and verbal informed consent were obtained for a HIPAA-compliant prospective study of
151 consecutive CNBs of bone ( n = 88) and soft-tissue ( n = 63) lesions. Each CNB specimen was reported separately in the final pathology report. Diagnostic yield (total number of
biopsies that yield a diagnosis divided by total number of biopsies) was calculated for all lesions and subgroups on the basis
of lesion composition (lytic, sclerotic, soft tissue), lesion size (â¤2, >2 to 5, or >5 cm), biopsy needle gauge, image guidance
modality, number of specimens obtained, and specimen length (<5, 5â10, or >10 mm). The minimum number of specimens required
to obtain a diagnosis was determined on the basis of the specimen number at which the diagnostic yield reached a plateau.
Ï 2 And Wilcoxon rank-sum tests were performed in bivariate analyses to evaluate associations between each factor and diagnostic
yield. Significant factors were evaluated with multivariate logistic regression.
Results: Diagnostic yield was 77% for all lesions. Yield was 87% for lytic bone lesions and 57% for sclerotic bone lesions ( P = .002). Diagnostic yield increased with larger lesions (54% for lesions ⤠2 cm, 75% for lesions > 2 to 5 cm, and 86% for
lesions > 5 cm [ P = .006]). There was no difference in diagnostic yield for bone versus soft-tissue lesions or according to needle gauge or
image guidance modality. Diagnostic yield was 77% for bone lesions and 76% for soft-tissue lesions ( P = .88). Yield was 83%, 72%, 77%, and 83% for biopsies performed with 14-, 15-, 16-, and 18-gauge needles, respectively ( P = .57). Yield was 77% with computed tomographic guidance and 78% with ultrasonographic guidance ( P = .99). Diagnostic yield increased with number of specimens obtained and with longer specimen length; it reached a plateau
at three specimens for bone lesions and four specimens for soft-tissue lesions.
Conclusion: Diagnostic yield is higher in lytic than in sclerotic bone lesions, in larger lesions, and for longer specimens. Obtaining
a minimum of three specimens in bone lesions and four specimens in soft-tissue lesions optimizes diagnostic yield.
© RSNA, 2008</description><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqVz81KxDAUQOEgCtafB3B3H8CMSZPajhtxRgcHBjcOiKsSm5s0kmmG3hSZt1fQF3B1NmfzMXYlxUxK3dyMxoYUZ6VulKhlrcsjVsiqrLlUsjpmhRBK8UbL-Sk7I_oUQuqqqQvmF2lAMIOF1-Qy3waiCWGDFNJAd_DWmwwr0-U0Ejw4h12Gx2D8kCiHDt4DRgvJwXpnPHI_BYsWlmlE_oJoI8IipD0d7uUFO3EmEl7-9Zxdr562y2feB99_hRFb2pkY99OHan8tyR9-NK1q57el-uf-DVtCVTU</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Jim S. Wu</creator><creator>Jeffrey D. Goldsmith</creator><creator>Perry J. Horwich</creator><creator>Sanjay K. Shetty</creator><creator>Mary G. Hochman</creator><general>Radiological Society of North America</general><scope/></search><sort><creationdate>20080901</creationdate><title>Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy?1</title><author>Jim S. Wu ; Jeffrey D. Goldsmith ; Perry J. Horwich ; Sanjay K. Shetty ; Mary G. Hochman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-highwire_smallpub3_radiology248_3_9623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jim S. Wu</creatorcontrib><creatorcontrib>Jeffrey D. Goldsmith</creatorcontrib><creatorcontrib>Perry J. Horwich</creatorcontrib><creatorcontrib>Sanjay K. Shetty</creatorcontrib><creatorcontrib>Mary G. Hochman</creatorcontrib><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jim S. Wu</au><au>Jeffrey D. Goldsmith</au><au>Perry J. Horwich</au><au>Sanjay K. Shetty</au><au>Mary G. Hochman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy?1</atitle><jtitle>Radiology</jtitle><date>2008-09-01</date><risdate>2008</risdate><volume>248</volume><issue>3</issue><spage>962</spage><pages>962-</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>Purpose: To assess lesion-related and technical factors that affect diagnostic yield in image-guided core-needle biopsy (CNB) of bone
and soft-tissue lesions.
Materials and Methods: Institutional review board approval and verbal informed consent were obtained for a HIPAA-compliant prospective study of
151 consecutive CNBs of bone ( n = 88) and soft-tissue ( n = 63) lesions. Each CNB specimen was reported separately in the final pathology report. Diagnostic yield (total number of
biopsies that yield a diagnosis divided by total number of biopsies) was calculated for all lesions and subgroups on the basis
of lesion composition (lytic, sclerotic, soft tissue), lesion size (â¤2, >2 to 5, or >5 cm), biopsy needle gauge, image guidance
modality, number of specimens obtained, and specimen length (<5, 5â10, or >10 mm). The minimum number of specimens required
to obtain a diagnosis was determined on the basis of the specimen number at which the diagnostic yield reached a plateau.
Ï 2 And Wilcoxon rank-sum tests were performed in bivariate analyses to evaluate associations between each factor and diagnostic
yield. Significant factors were evaluated with multivariate logistic regression.
Results: Diagnostic yield was 77% for all lesions. Yield was 87% for lytic bone lesions and 57% for sclerotic bone lesions ( P = .002). Diagnostic yield increased with larger lesions (54% for lesions ⤠2 cm, 75% for lesions > 2 to 5 cm, and 86% for
lesions > 5 cm [ P = .006]). There was no difference in diagnostic yield for bone versus soft-tissue lesions or according to needle gauge or
image guidance modality. Diagnostic yield was 77% for bone lesions and 76% for soft-tissue lesions ( P = .88). Yield was 83%, 72%, 77%, and 83% for biopsies performed with 14-, 15-, 16-, and 18-gauge needles, respectively ( P = .57). Yield was 77% with computed tomographic guidance and 78% with ultrasonographic guidance ( P = .99). Diagnostic yield increased with number of specimens obtained and with longer specimen length; it reached a plateau
at three specimens for bone lesions and four specimens for soft-tissue lesions.
Conclusion: Diagnostic yield is higher in lytic than in sclerotic bone lesions, in larger lesions, and for longer specimens. Obtaining
a minimum of three specimens in bone lesions and four specimens in soft-tissue lesions optimizes diagnostic yield.
© RSNA, 2008</abstract><pub>Radiological Society of North America</pub><doi>10.1148/radiol.2483071742</doi></addata></record> |
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| title | Bone and Soft-Tissue Lesions: What Factors Affect Diagnostic Yield of Image-guided Core-Needle Biopsy?1 |
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