Conformational Coupling in DNA Polymerase Information Transfer [and Discussion]

The extraordinary fidelity of DNA replication during forward polymerization and exonuclease error correction is largely a function of a conformational change that occurs in response to a correct dNTP binding to properly base-paired duplex DNA. The conformational change serves as a kinetic barrier to...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 1992-04, Vol.336 (1276), p.107-112
Hauptverfasser:	Johnson, Kenneth A., Thorneley, R. N. F., Gutfreund, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Base Sequence Biochemistry Catalysis Chemical reactions DNA DNA Replication DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism Enzymes Exonucleases - metabolism Kinetics Molecular Sequence Data Nucleotides Polydeoxyribonucleotides - chemistry Polymerization Protein Conformation Sulfur Thermodynamics
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