Cytotoxic T–cell abundance and virus load in human immunodeficiency virus type 1 and human T–cell leukaemia virus type 1
The correlation between virus load and specific cytotoxic T-lymphocyte (CTL) frequency during the chronic phase in human immunodeficiency virus type 1 (HIV-1) infection has been found to be negative in cross-sectional studies. We report here that, in infection with the related retrovirus human T-cel...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2001-06, Vol.268 (1473), p.1215-1221 |
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| container_title | Proceedings of the Royal Society. B, Biological sciences |
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| creator | Wodarz, Dominik Hall, Sarah E. Usuku, Koichiro Osame, Mitsuhiro Ogg, Graham S. McMichael, Andrew J. Nowak, Martin A. Bangham, Charles R. M. |
| description | The correlation between virus load and specific cytotoxic T-lymphocyte (CTL) frequency during the chronic phase in human immunodeficiency virus type 1 (HIV-1) infection has been found to be negative in cross-sectional studies. We report here that, in infection with the related retrovirus human T-cell leukaemia virus type 1 (HTLV-1), the correlation is positive in asymptomatic carriers and zero in patients with the associated inflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We demonstrate that the direction of the correlation may depend on the efficacy of the CTL response using mathematical models. We conclude that the CTL response is effective in asymptomatic carriers of HTLV-1, but ineffective in patients with HAM/TSP. Virus-mediated impairment of specific CTL production in HIV-1 infection can account for the negative correlation observed. |
| doi_str_mv | 10.1098/rspb.2001.1608 |
| format | Article |
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Virus-mediated impairment of specific CTL production in HIV-1 infection can account for the negative correlation observed.</description><identifier>ISSN: 0962-8452</identifier><identifier>EISSN: 1471-2954</identifier><identifier>DOI: 10.1098/rspb.2001.1608</identifier><identifier>PMID: 11410146</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>AIDS ; Antivirals ; Carrier State - immunology ; Carrier State - virology ; Correlation ; Cytotoxic T Lymphocyte ; HIV ; HIV 1 ; HIV Infections - immunology ; HIV Infections - virology ; HIV-1 - isolation & purification ; HTLV-I Infections - immunology ; HTLV-I Infections - virology ; Human immunodeficiency virus 1 ; Human Immunodeficiency Virus Type L ; Human T lymphotropic virus 1 ; Human T-Cell Leukaemia Virus Type L ; Human T-lymphotropic virus 1 - isolation & purification ; Humans ; Immune response ; Infections ; Mathematical Models ; Mathematics ; Models, Biological ; Paraparesis, Tropical Spastic - immunology ; Paraparesis, Tropical Spastic - virology ; T lymphocytes ; T-Lymphocytes, Cytotoxic - immunology ; Viral load ; Virus Load ; Viruses</subject><ispartof>Proceedings of the Royal Society. 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M.</creatorcontrib><title>Cytotoxic T–cell abundance and virus load in human immunodeficiency virus type 1 and human T–cell leukaemia virus type 1</title><title>Proceedings of the Royal Society. B, Biological sciences</title><addtitle>Proc Biol Sci</addtitle><description>The correlation between virus load and specific cytotoxic T-lymphocyte (CTL) frequency during the chronic phase in human immunodeficiency virus type 1 (HIV-1) infection has been found to be negative in cross-sectional studies. We report here that, in infection with the related retrovirus human T-cell leukaemia virus type 1 (HTLV-1), the correlation is positive in asymptomatic carriers and zero in patients with the associated inflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We demonstrate that the direction of the correlation may depend on the efficacy of the CTL response using mathematical models. We conclude that the CTL response is effective in asymptomatic carriers of HTLV-1, but ineffective in patients with HAM/TSP. Virus-mediated impairment of specific CTL production in HIV-1 infection can account for the negative correlation observed.</description><subject>AIDS</subject><subject>Antivirals</subject><subject>Carrier State - immunology</subject><subject>Carrier State - virology</subject><subject>Correlation</subject><subject>Cytotoxic T Lymphocyte</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - isolation & purification</subject><subject>HTLV-I Infections - immunology</subject><subject>HTLV-I Infections - virology</subject><subject>Human immunodeficiency virus 1</subject><subject>Human Immunodeficiency Virus Type L</subject><subject>Human T lymphotropic virus 1</subject><subject>Human T-Cell Leukaemia Virus Type L</subject><subject>Human T-lymphotropic virus 1 - isolation & purification</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infections</subject><subject>Mathematical Models</subject><subject>Mathematics</subject><subject>Models, Biological</subject><subject>Paraparesis, Tropical Spastic - immunology</subject><subject>Paraparesis, Tropical Spastic - virology</subject><subject>T lymphocytes</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Viral load</subject><subject>Virus Load</subject><subject>Viruses</subject><issn>0962-8452</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhiMEotvClRNCOXHL4nEc27kgwYoCUiWkaunVcmKn621iL3ZSGqkH3oE35ElwmtXCHhAnazTf_J7fv5PkBaAloJK_8WFXLTFCsASK-KNkAYRBhsuCPE4WqKQ446TAJ8lpCFuEUFnw4mlyAkAAAaGL5H419q53d6ZO179-_Kx126ayGqySttaptCq9NX4IaeukSo1NN0MnbWq6brBO6cbURtt63EP9uNMpPEzN3EGy1cON1J2RR-Sz5Ekj26Cf78-z5Ov5h_XqU3bx5ePn1buLrC5o3mc5quPqVZNrSTmR0DRAOC8qghUpFcZMKQUNZY1UeUGZ5MAUAUmiwaJiCPKz5O2suxuqTqta297LVuy86aQfhZNGHHes2YhrdysAcc5wGQVe7wW8-zbo0IvOhMmYtNoNQTBU5ogW_L8gcMA5xyiCyxmsvQvB6-awDSAxJSumZMWUrJiSjQOv_vbwB99HGYF8Brwb42O6mEw_iq0bvI3lv2VfzlPb0Dt_UI1uWPngJ5vbJvT67tCW_kZQlrNCXHEiLtfn7_nlFRUTj2d-Y643343X4mibWOx8iPdTLuJHzQVgKPLfsiXeyw</recordid><startdate>20010622</startdate><enddate>20010622</enddate><creator>Wodarz, Dominik</creator><creator>Hall, Sarah E.</creator><creator>Usuku, Koichiro</creator><creator>Osame, Mitsuhiro</creator><creator>Ogg, Graham S.</creator><creator>McMichael, Andrew J.</creator><creator>Nowak, Martin A.</creator><creator>Bangham, Charles R. M.</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010622</creationdate><title>Cytotoxic T–cell abundance and virus load in human immunodeficiency virus type 1 and human T–cell leukaemia virus type 1</title><author>Wodarz, Dominik ; Hall, Sarah E. ; Usuku, Koichiro ; Osame, Mitsuhiro ; Ogg, Graham S. ; McMichael, Andrew J. ; Nowak, Martin A. ; Bangham, Charles R. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic T–cell abundance and virus load in human immunodeficiency virus type 1 and human T–cell leukaemia virus type 1</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><addtitle>Proc Biol Sci</addtitle><date>2001-06-22</date><risdate>2001</risdate><volume>268</volume><issue>1473</issue><spage>1215</spage><epage>1221</epage><pages>1215-1221</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>The correlation between virus load and specific cytotoxic T-lymphocyte (CTL) frequency during the chronic phase in human immunodeficiency virus type 1 (HIV-1) infection has been found to be negative in cross-sectional studies. 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| identifier | ISSN: 0962-8452 |
| ispartof | Proceedings of the Royal Society. B, Biological sciences, 2001-06, Vol.268 (1473), p.1215-1221 |
| issn | 0962-8452 1471-2954 |
| language | eng |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central |
| subjects | AIDS Antivirals Carrier State - immunology Carrier State - virology Correlation Cytotoxic T Lymphocyte HIV HIV 1 HIV Infections - immunology HIV Infections - virology HIV-1 - isolation & purification HTLV-I Infections - immunology HTLV-I Infections - virology Human immunodeficiency virus 1 Human Immunodeficiency Virus Type L Human T lymphotropic virus 1 Human T-Cell Leukaemia Virus Type L Human T-lymphotropic virus 1 - isolation & purification Humans Immune response Infections Mathematical Models Mathematics Models, Biological Paraparesis, Tropical Spastic - immunology Paraparesis, Tropical Spastic - virology T lymphocytes T-Lymphocytes, Cytotoxic - immunology Viral load Virus Load Viruses |
| title | Cytotoxic T–cell abundance and virus load in human immunodeficiency virus type 1 and human T–cell leukaemia virus type 1 |
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