Antisense to NPY-Y1 Demonstrates that Y1 Receptors in the Hypothalamus Underlie NPY Hypothermia and Feeding in Rats

Neuropeptide Y (NPY) is a highly potent endogenous peptide which when injected into the medial hypothalamus causes spontaneous eating behaviour and an intense fall in body temperature (Tb). This study used antisense oligodeoxynucleotides (ODNs) to determine whether the Y1 subtype of NPY receptor cou...

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Veröffentlicht in:	Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1996-07, Vol.263 (1372), p.881-886
Hauptverfasser:	Lopez-Valpuesta, F. J., Nyce, J. W., Griffin-Biggs, T. A., Ice, J. C., Myers, R. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal feeding behavior Animals Base Sequence Body Temperature - drug effects Body weight Body Weight - drug effects Feeding Behavior - drug effects Feeding Behavior - physiology Fever Food intake Hypothalamus Hypothermia Male Microinjections Molecular Sequence Data Motor Activity - drug effects Neurons Neuropeptide Y - biosynthesis Neuropeptide Y - genetics Neuropeptides Oligonucleotides Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - pharmacology Rats Rats, Sprague-Dawley Receptors Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - physiology Thionucleotides Time Factors Transcription, Genetic - drug effects Ventromedial Hypothalamic Nucleus - drug effects Ventromedial Hypothalamic Nucleus - physiology
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