The Glutamate-Receptor Linked cGMP Cascade of Retinal On-Bipolar Cells is Pertussis and Cholera Toxin-Sensitive

Whole-cell patch-clamp recordings were obtained from light-responsive on-bipolar cells in retinal slices of the dogfish. Inclusion of the A-subunit of pertussis toxin in the patch-pipette solution resulted in an increase in inward current and membrane conductance, and a block of light-evoked current...

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Veröffentlicht in:	Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1992-01, Vol.247 (1318), p.17-20
Hauptverfasser:	Shiells, R. A., Falk, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Acinar cells Adenylate Cyclase Toxin Animals Cholera Cholera Toxin - pharmacology Chromaffin cells Cyclic GMP - metabolism Darkness Dogfish In Vitro Techniques Isoquinolines - pharmacology Macromolecular Substances Membrane Potentials - drug effects Models, Neurological NAD - pharmacology Neurons Pertussis Toxin Photoreceptors Piperazines - pharmacology Pipettes Protein Kinase Inhibitors Retina - cytology Retina - drug effects Retina - physiology Retinal bipolar cells Retinal rods Synapses - drug effects Synapses - physiology Toxins Virulence Factors, Bordetella - pharmacology Whooping cough
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