Differential expression of putative transbilayer amphipath transporters
1 Department of Biochemistry and Molecular Biology 4 Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802 2 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 3 Department of Pharmaceutical Science, Graduate Scho...
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| Veröffentlicht in: | Physiological genomics 1999-11, Vol.1 (3), p.139-150 |
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| creator | HALLECK, MARGARET S LAWLER, JOSEPH F., JR BLACKSHAW, SETH GAO, LING NAGARAJAN, PRIYA HACKER, COLEEN PYLE, SCOTT NEWMAN, JASON T NAKANISHI, YOSHINOBU ANDO, HIROSHI WEINSTOCK, DANIEL WILLIAMSON, PATRICK SCHLEGEL, ROBERT A |
| description | 1 Department of Biochemistry and Molecular Biology
4 Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802
2 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3 Department of Pharmaceutical Science, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 9200934, Japan
5 Department of Biology, Amherst College, Amherst, Massachusetts 01002
Halleck, Margaret S., Joseph F. Lawler, Jr., Seth Blackshaw, Ling Gao, Priya Nagarajan, Coleen Hacker, Scott Pyle, Jason T. Newman, Yoshinobu Nakanishi, Hiroshi Ando, Daniel Weinstock, Patrick Williamson, and Robert A. Schlegel. Differential expression of putative transbilayer amphipath transporters. Physiol. Genomics 1: 139150, 1999.The aminophospholipid translocase transports phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Cloning of the gene encoding the enzyme identified a new subfamily of P-type ATPases, proposed to be amphipath transporters. As reported here, mammals express as many as 17 different genes from this subfamily. Phylogenetic analysis reveals the genes to be grouped into several distinct classes and subclasses. To gain information on the functions represented by these groups, Northern analysis and in situ hybridization were used to examine the pattern of expression of a panel of subfamily members in the mouse. The genes are differentially expressed in the respiratory, digestive, and urogenital systems, endocrine organs, the eye, teeth, and thymus. With one exception, all of the genes are highly expressed in the central nervous system (CNS); however, the pattern of expression within the CNS differs substantially from gene to gene. These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths.
in situ hybridization; P-type ATPase; aminophospholipid translocase; cholestasis; central nervous system |
| doi_str_mv | 10.1152/physiolgenomics.1999.1.3.139 |
| format | Article |
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4 Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802
2 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3 Department of Pharmaceutical Science, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 9200934, Japan
5 Department of Biology, Amherst College, Amherst, Massachusetts 01002
Halleck, Margaret S., Joseph F. Lawler, Jr., Seth Blackshaw, Ling Gao, Priya Nagarajan, Coleen Hacker, Scott Pyle, Jason T. Newman, Yoshinobu Nakanishi, Hiroshi Ando, Daniel Weinstock, Patrick Williamson, and Robert A. Schlegel. Differential expression of putative transbilayer amphipath transporters. Physiol. Genomics 1: 139150, 1999.The aminophospholipid translocase transports phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Cloning of the gene encoding the enzyme identified a new subfamily of P-type ATPases, proposed to be amphipath transporters. As reported here, mammals express as many as 17 different genes from this subfamily. Phylogenetic analysis reveals the genes to be grouped into several distinct classes and subclasses. To gain information on the functions represented by these groups, Northern analysis and in situ hybridization were used to examine the pattern of expression of a panel of subfamily members in the mouse. The genes are differentially expressed in the respiratory, digestive, and urogenital systems, endocrine organs, the eye, teeth, and thymus. With one exception, all of the genes are highly expressed in the central nervous system (CNS); however, the pattern of expression within the CNS differs substantially from gene to gene. These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths.
in situ hybridization; P-type ATPase; aminophospholipid translocase; cholestasis; central nervous system</description><identifier>ISSN: 1094-8341</identifier><identifier>EISSN: 1531-2267</identifier><identifier>DOI: 10.1152/physiolgenomics.1999.1.3.139</identifier><identifier>PMID: 11015572</identifier><language>eng</language><publisher>United States: Am Physiological Soc</publisher><subject>Adenosine Triphosphatases - genetics ; Amino Acid Sequence ; Animals ; Blotting, Northern ; Chromosome Mapping ; Cloning, Molecular ; DNA, Complementary - chemistry ; DNA, Complementary - genetics ; Gene Expression Regulation, Enzymologic ; Humans ; In Situ Hybridization ; Isoenzymes - genetics ; Male ; Mice ; Molecular Sequence Data ; Phylogeny ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Alignment ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Tissue Distribution</subject><ispartof>Physiological genomics, 1999-11, Vol.1 (3), p.139-150</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-609f4eb4a456d7c28639c43df20c588c0e2e8c04492c2b61a886dc154f379bab3</citedby><cites>FETCH-LOGICAL-c551t-609f4eb4a456d7c28639c43df20c588c0e2e8c04492c2b61a886dc154f379bab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11015572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HALLECK, MARGARET S</creatorcontrib><creatorcontrib>LAWLER, JOSEPH F., JR</creatorcontrib><creatorcontrib>BLACKSHAW, SETH</creatorcontrib><creatorcontrib>GAO, LING</creatorcontrib><creatorcontrib>NAGARAJAN, PRIYA</creatorcontrib><creatorcontrib>HACKER, COLEEN</creatorcontrib><creatorcontrib>PYLE, SCOTT</creatorcontrib><creatorcontrib>NEWMAN, JASON T</creatorcontrib><creatorcontrib>NAKANISHI, YOSHINOBU</creatorcontrib><creatorcontrib>ANDO, HIROSHI</creatorcontrib><creatorcontrib>WEINSTOCK, DANIEL</creatorcontrib><creatorcontrib>WILLIAMSON, PATRICK</creatorcontrib><creatorcontrib>SCHLEGEL, ROBERT A</creatorcontrib><title>Differential expression of putative transbilayer amphipath transporters</title><title>Physiological genomics</title><addtitle>Physiol Genomics</addtitle><description>1 Department of Biochemistry and Molecular Biology
4 Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802
2 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3 Department of Pharmaceutical Science, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 9200934, Japan
5 Department of Biology, Amherst College, Amherst, Massachusetts 01002
Halleck, Margaret S., Joseph F. Lawler, Jr., Seth Blackshaw, Ling Gao, Priya Nagarajan, Coleen Hacker, Scott Pyle, Jason T. Newman, Yoshinobu Nakanishi, Hiroshi Ando, Daniel Weinstock, Patrick Williamson, and Robert A. Schlegel. Differential expression of putative transbilayer amphipath transporters. Physiol. Genomics 1: 139150, 1999.The aminophospholipid translocase transports phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Cloning of the gene encoding the enzyme identified a new subfamily of P-type ATPases, proposed to be amphipath transporters. As reported here, mammals express as many as 17 different genes from this subfamily. Phylogenetic analysis reveals the genes to be grouped into several distinct classes and subclasses. To gain information on the functions represented by these groups, Northern analysis and in situ hybridization were used to examine the pattern of expression of a panel of subfamily members in the mouse. The genes are differentially expressed in the respiratory, digestive, and urogenital systems, endocrine organs, the eye, teeth, and thymus. With one exception, all of the genes are highly expressed in the central nervous system (CNS); however, the pattern of expression within the CNS differs substantially from gene to gene. These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths.
in situ hybridization; P-type ATPase; aminophospholipid translocase; cholestasis; central nervous system</description><subject>Adenosine Triphosphatases - genetics</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Blotting, Northern</subject><subject>Chromosome Mapping</subject><subject>Cloning, Molecular</subject><subject>DNA, Complementary - chemistry</subject><subject>DNA, Complementary - genetics</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Isoenzymes - genetics</subject><subject>Male</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Tissue Distribution</subject><issn>1094-8341</issn><issn>1531-2267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF2L1TAQhoMo7rr6F6QX4l1rJh9tAyLI6q7CgjfrdUjTyWmkHzFJ1z3_3i6nIqx4MxnCO88MDyFvgFYAkr0LwzH5ZTzgvEzepgqUUhVUvAKunpBzkBxKxurm6dZTJcqWCzgjL1L6QSmIppXPyRkABSkbdk6uP3nnMOKcvRkLvA8R04afi8UVYc0m-zsscjRz6vxojhgLM4XBB5OH03dYYsaYXpJnzowJX-3vBfl-9fn28kt58-366-XHm9JKCbmsqXICO2GErPvGsrbmygreO0atbFtLkeFWhVDMsq4G07Z1b0EKxxvVmY5fkLcnbojLzxVT1pNPFsfRzLisSddKUkZFuwXfn4I2LilFdDpEP5l41ED1g0j9SKR-EKlBc72J3MZf73vWbsL-7_Bubgt8OAUGfxh--Yh_eMvhqK_WcbzF-_x4x07XoXcbgP0f8M9t-1m_AT_6oWI</recordid><startdate>19991111</startdate><enddate>19991111</enddate><creator>HALLECK, MARGARET S</creator><creator>LAWLER, JOSEPH F., JR</creator><creator>BLACKSHAW, SETH</creator><creator>GAO, LING</creator><creator>NAGARAJAN, PRIYA</creator><creator>HACKER, COLEEN</creator><creator>PYLE, SCOTT</creator><creator>NEWMAN, JASON T</creator><creator>NAKANISHI, YOSHINOBU</creator><creator>ANDO, HIROSHI</creator><creator>WEINSTOCK, DANIEL</creator><creator>WILLIAMSON, PATRICK</creator><creator>SCHLEGEL, ROBERT A</creator><general>Am Physiological Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991111</creationdate><title>Differential expression of putative transbilayer amphipath transporters</title><author>HALLECK, MARGARET S ; LAWLER, JOSEPH F., JR ; BLACKSHAW, SETH ; GAO, LING ; NAGARAJAN, PRIYA ; HACKER, COLEEN ; PYLE, SCOTT ; NEWMAN, JASON T ; NAKANISHI, YOSHINOBU ; ANDO, HIROSHI ; WEINSTOCK, DANIEL ; WILLIAMSON, PATRICK ; SCHLEGEL, ROBERT A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-609f4eb4a456d7c28639c43df20c588c0e2e8c04492c2b61a886dc154f379bab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenosine Triphosphatases - genetics</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Blotting, Northern</topic><topic>Chromosome Mapping</topic><topic>Cloning, Molecular</topic><topic>DNA, Complementary - chemistry</topic><topic>DNA, Complementary - genetics</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Isoenzymes - genetics</topic><topic>Male</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Alignment</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HALLECK, MARGARET S</creatorcontrib><creatorcontrib>LAWLER, JOSEPH F., JR</creatorcontrib><creatorcontrib>BLACKSHAW, SETH</creatorcontrib><creatorcontrib>GAO, LING</creatorcontrib><creatorcontrib>NAGARAJAN, PRIYA</creatorcontrib><creatorcontrib>HACKER, COLEEN</creatorcontrib><creatorcontrib>PYLE, SCOTT</creatorcontrib><creatorcontrib>NEWMAN, JASON T</creatorcontrib><creatorcontrib>NAKANISHI, YOSHINOBU</creatorcontrib><creatorcontrib>ANDO, HIROSHI</creatorcontrib><creatorcontrib>WEINSTOCK, DANIEL</creatorcontrib><creatorcontrib>WILLIAMSON, PATRICK</creatorcontrib><creatorcontrib>SCHLEGEL, ROBERT A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HALLECK, MARGARET S</au><au>LAWLER, JOSEPH F., JR</au><au>BLACKSHAW, SETH</au><au>GAO, LING</au><au>NAGARAJAN, PRIYA</au><au>HACKER, COLEEN</au><au>PYLE, SCOTT</au><au>NEWMAN, JASON T</au><au>NAKANISHI, YOSHINOBU</au><au>ANDO, HIROSHI</au><au>WEINSTOCK, DANIEL</au><au>WILLIAMSON, PATRICK</au><au>SCHLEGEL, ROBERT A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of putative transbilayer amphipath transporters</atitle><jtitle>Physiological genomics</jtitle><addtitle>Physiol Genomics</addtitle><date>1999-11-11</date><risdate>1999</risdate><volume>1</volume><issue>3</issue><spage>139</spage><epage>150</epage><pages>139-150</pages><issn>1094-8341</issn><eissn>1531-2267</eissn><abstract>1 Department of Biochemistry and Molecular Biology
4 Department of Veterinary Science, Penn State University, University Park, Pennsylvania 16802
2 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
3 Department of Pharmaceutical Science, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Ishikawa 9200934, Japan
5 Department of Biology, Amherst College, Amherst, Massachusetts 01002
Halleck, Margaret S., Joseph F. Lawler, Jr., Seth Blackshaw, Ling Gao, Priya Nagarajan, Coleen Hacker, Scott Pyle, Jason T. Newman, Yoshinobu Nakanishi, Hiroshi Ando, Daniel Weinstock, Patrick Williamson, and Robert A. Schlegel. Differential expression of putative transbilayer amphipath transporters. Physiol. Genomics 1: 139150, 1999.The aminophospholipid translocase transports phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Cloning of the gene encoding the enzyme identified a new subfamily of P-type ATPases, proposed to be amphipath transporters. As reported here, mammals express as many as 17 different genes from this subfamily. Phylogenetic analysis reveals the genes to be grouped into several distinct classes and subclasses. To gain information on the functions represented by these groups, Northern analysis and in situ hybridization were used to examine the pattern of expression of a panel of subfamily members in the mouse. The genes are differentially expressed in the respiratory, digestive, and urogenital systems, endocrine organs, the eye, teeth, and thymus. With one exception, all of the genes are highly expressed in the central nervous system (CNS); however, the pattern of expression within the CNS differs substantially from gene to gene. These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths.
in situ hybridization; P-type ATPase; aminophospholipid translocase; cholestasis; central nervous system</abstract><cop>United States</cop><pub>Am Physiological Soc</pub><pmid>11015572</pmid><doi>10.1152/physiolgenomics.1999.1.3.139</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Physiological genomics, 1999-11, Vol.1 (3), p.139-150 |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenosine Triphosphatases - genetics Amino Acid Sequence Animals Blotting, Northern Chromosome Mapping Cloning, Molecular DNA, Complementary - chemistry DNA, Complementary - genetics Gene Expression Regulation, Enzymologic Humans In Situ Hybridization Isoenzymes - genetics Male Mice Molecular Sequence Data Phylogeny RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Tissue Distribution |
| title | Differential expression of putative transbilayer amphipath transporters |
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