Recovery of function in dorsal horn following partial deafferentation
L. M. Pubols and M. E. Goldberger 1. Collateral sprouting of L6 dorsal root afferents within the dorsal horn of the L6 spinal cord segment has been shown anatomically to occur following transection of all other lumbosacral dorsal roots in the cat. The present study was performed to examine a possibl...
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| Veröffentlicht in: | Journal of neurophysiology 1980-01, Vol.43 (1), p.102-117 |
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| description | L. M. Pubols and M. E. Goldberger
1. Collateral sprouting of L6 dorsal root afferents within the dorsal horn
of the L6 spinal cord segment has been shown anatomically to occur
following transection of all other lumbosacral dorsal roots in the cat. The
present study was performed to examine a possible physiological correlate
of that sprouting, namely, an altered somatotopic organization of the
dorsal horn at L6. This was evaluated by microelectrode mapping of the L6
dorsal horn in normal cats and in cats with L6 spared, lumbosacral dorsal
rhizotomies performed 2 days (subacute spared root) or more than 8 wk
(chronic spared root), prior to recording. 2. In normal cats the
mediolateral somatotopic sequence of hindlimb representation in the L6
dorsal horn is ventral digits 2 and 3, dorsal digits 2 and 3, dorsal foot,
rostral and lateral ankle, lateral leg, lateral thigh, and back. In both
subacute and chronic spared-root cats the somatotopic sequence is similar
to that of normal cats, but there is a loss of proximal thigh and back
representation. This proximal body region is represented at the lateral
edge of the dorsal horn in normal animals. 3. There was a partial loss of
responsiveness of cells in the dorsal horn in the subacute spared-root
group and a partial recovery of responsiveness in the chronic group. In the
subacute group punctures exhibiting no responses to tactile input tended to
be clustered in the lateral dorsal horn. 4. The lateral one-fourth of the
dorsal horn in each animal was analyzed in terms of the percentage of
recording loci occurring within it. The percentages of recording loci
having receptive fields proximal to, distal to, and spanning the middle of
the thigh (proximal, distal, and intermediate RFs) were tabulated for each
animal. Subacute animals had a significantly lower-than-normal overall
percentage of responsive loci in the lateral dorsal horn, but chronic
animals did not. The percentage of distal fields therein was not different
for the normal versus the subacute group, signifying that the loss of
proximal and intermediate fields was responsible for the difference in
overall percentage. Chronic animals, however, had significantly more distal
fields than did normals. When all fields having any distal component were
compared (i.e., distal and intermediate), the difference between the
chronic and normal groups did not reach significance. One possible
explanation of these findings is that loci having both proximal and distal
RF com |
| doi_str_mv | 10.1152/jn.1980.43.1.102 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_highw</sourceid><recordid>TN_cdi_highwire_physiology_jn_43_1_102</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74965910</sourcerecordid><originalsourceid>FETCH-LOGICAL-c325t-d3a20a1d6730d593998688ec4e902e4646436f05caba7ed0ac1cc2c8496521793</originalsourceid><addsrcrecordid>eNpFkN1LwzAUxYMoc07ffRH65FvrTdK0zaOM-QEDQfQ5ZGm6ZnRJTVpH_3tbNib34V4O5_wuHITuMSQYM_K0swnmBSQpTXCCgVyg-SiTGDNeXKI5wHhTyPNrdBPCDgByBmSGZjllmKXZHK0-tXK_2g-Rq6Kqt6ozzkbGRqXzQTZR7byNKtc07mDsNmql78wol1pWlfbadnIK3KKrSjZB3532An2_rL6Wb_H64_V9-byOFSWsi0sqCUhcZjmFknHKeZEVhVap5kB0mo1DswqYkhuZ6xKkwkoRVaQ8YwTnnC7Q45HbevfT69CJvQlKN4202vVB5JOTYxiNcDQq70LwuhKtN3vpB4FBTM2JnRVTcyKlAo8iGSMPJ3a_2evyHDhV9f-7Ntv6YLwWbT0E4xq3HSbaGfQH-g129g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74965910</pqid></control><display><type>article</type><title>Recovery of function in dorsal horn following partial deafferentation</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Pubols, L. M ; Goldberger, M. E</creator><creatorcontrib>Pubols, L. M ; Goldberger, M. E</creatorcontrib><description>L. M. Pubols and M. E. Goldberger
1. Collateral sprouting of L6 dorsal root afferents within the dorsal horn
of the L6 spinal cord segment has been shown anatomically to occur
following transection of all other lumbosacral dorsal roots in the cat. The
present study was performed to examine a possible physiological correlate
of that sprouting, namely, an altered somatotopic organization of the
dorsal horn at L6. This was evaluated by microelectrode mapping of the L6
dorsal horn in normal cats and in cats with L6 spared, lumbosacral dorsal
rhizotomies performed 2 days (subacute spared root) or more than 8 wk
(chronic spared root), prior to recording. 2. In normal cats the
mediolateral somatotopic sequence of hindlimb representation in the L6
dorsal horn is ventral digits 2 and 3, dorsal digits 2 and 3, dorsal foot,
rostral and lateral ankle, lateral leg, lateral thigh, and back. In both
subacute and chronic spared-root cats the somatotopic sequence is similar
to that of normal cats, but there is a loss of proximal thigh and back
representation. This proximal body region is represented at the lateral
edge of the dorsal horn in normal animals. 3. There was a partial loss of
responsiveness of cells in the dorsal horn in the subacute spared-root
group and a partial recovery of responsiveness in the chronic group. In the
subacute group punctures exhibiting no responses to tactile input tended to
be clustered in the lateral dorsal horn. 4. The lateral one-fourth of the
dorsal horn in each animal was analyzed in terms of the percentage of
recording loci occurring within it. The percentages of recording loci
having receptive fields proximal to, distal to, and spanning the middle of
the thigh (proximal, distal, and intermediate RFs) were tabulated for each
animal. Subacute animals had a significantly lower-than-normal overall
percentage of responsive loci in the lateral dorsal horn, but chronic
animals did not. The percentage of distal fields therein was not different
for the normal versus the subacute group, signifying that the loss of
proximal and intermediate fields was responsible for the difference in
overall percentage. Chronic animals, however, had significantly more distal
fields than did normals. When all fields having any distal component were
compared (i.e., distal and intermediate), the difference between the
chronic and normal groups did not reach significance. One possible
explanation of these findings is that loci having both proximal and distal
RF components are unresponsive 2 days after partial denervation, but
recover responsiveness to their spared distal input over an 8-wk period.
One possible mechanism mediating these changes is localized sprouting of
intact, spared axons. Other mechanisms of functional recovery, such as
interneuronal sprouting, denervation supersensitivity, and unmasking of
latent synapses, are discussed in relation to these and other data.</description><identifier>ISSN: 0022-3077</identifier><identifier>EISSN: 1522-1598</identifier><identifier>DOI: 10.1152/jn.1980.43.1.102</identifier><identifier>PMID: 7351546</identifier><language>eng</language><publisher>United States: Am Phys Soc</publisher><subject>Animals ; Back - innervation ; Cats ; Denervation ; Electrophysiology ; Female ; Hindlimb - innervation ; Locomotion ; Male ; Mechanoreceptors - physiology ; Neurons, Afferent - physiology ; Posture ; Reflex - physiology ; Skin - innervation ; Space life sciences ; Spinal Cord - physiology ; Spinal Nerve Roots - physiology ; Touch - physiology</subject><ispartof>Journal of neurophysiology, 1980-01, Vol.43 (1), p.102-117</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-d3a20a1d6730d593998688ec4e902e4646436f05caba7ed0ac1cc2c8496521793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7351546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pubols, L. M</creatorcontrib><creatorcontrib>Goldberger, M. E</creatorcontrib><title>Recovery of function in dorsal horn following partial deafferentation</title><title>Journal of neurophysiology</title><addtitle>J Neurophysiol</addtitle><description>L. M. Pubols and M. E. Goldberger
1. Collateral sprouting of L6 dorsal root afferents within the dorsal horn
of the L6 spinal cord segment has been shown anatomically to occur
following transection of all other lumbosacral dorsal roots in the cat. The
present study was performed to examine a possible physiological correlate
of that sprouting, namely, an altered somatotopic organization of the
dorsal horn at L6. This was evaluated by microelectrode mapping of the L6
dorsal horn in normal cats and in cats with L6 spared, lumbosacral dorsal
rhizotomies performed 2 days (subacute spared root) or more than 8 wk
(chronic spared root), prior to recording. 2. In normal cats the
mediolateral somatotopic sequence of hindlimb representation in the L6
dorsal horn is ventral digits 2 and 3, dorsal digits 2 and 3, dorsal foot,
rostral and lateral ankle, lateral leg, lateral thigh, and back. In both
subacute and chronic spared-root cats the somatotopic sequence is similar
to that of normal cats, but there is a loss of proximal thigh and back
representation. This proximal body region is represented at the lateral
edge of the dorsal horn in normal animals. 3. There was a partial loss of
responsiveness of cells in the dorsal horn in the subacute spared-root
group and a partial recovery of responsiveness in the chronic group. In the
subacute group punctures exhibiting no responses to tactile input tended to
be clustered in the lateral dorsal horn. 4. The lateral one-fourth of the
dorsal horn in each animal was analyzed in terms of the percentage of
recording loci occurring within it. The percentages of recording loci
having receptive fields proximal to, distal to, and spanning the middle of
the thigh (proximal, distal, and intermediate RFs) were tabulated for each
animal. Subacute animals had a significantly lower-than-normal overall
percentage of responsive loci in the lateral dorsal horn, but chronic
animals did not. The percentage of distal fields therein was not different
for the normal versus the subacute group, signifying that the loss of
proximal and intermediate fields was responsible for the difference in
overall percentage. Chronic animals, however, had significantly more distal
fields than did normals. When all fields having any distal component were
compared (i.e., distal and intermediate), the difference between the
chronic and normal groups did not reach significance. One possible
explanation of these findings is that loci having both proximal and distal
RF components are unresponsive 2 days after partial denervation, but
recover responsiveness to their spared distal input over an 8-wk period.
One possible mechanism mediating these changes is localized sprouting of
intact, spared axons. Other mechanisms of functional recovery, such as
interneuronal sprouting, denervation supersensitivity, and unmasking of
latent synapses, are discussed in relation to these and other data.</description><subject>Animals</subject><subject>Back - innervation</subject><subject>Cats</subject><subject>Denervation</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Hindlimb - innervation</subject><subject>Locomotion</subject><subject>Male</subject><subject>Mechanoreceptors - physiology</subject><subject>Neurons, Afferent - physiology</subject><subject>Posture</subject><subject>Reflex - physiology</subject><subject>Skin - innervation</subject><subject>Space life sciences</subject><subject>Spinal Cord - physiology</subject><subject>Spinal Nerve Roots - physiology</subject><subject>Touch - physiology</subject><issn>0022-3077</issn><issn>1522-1598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkN1LwzAUxYMoc07ffRH65FvrTdK0zaOM-QEDQfQ5ZGm6ZnRJTVpH_3tbNib34V4O5_wuHITuMSQYM_K0swnmBSQpTXCCgVyg-SiTGDNeXKI5wHhTyPNrdBPCDgByBmSGZjllmKXZHK0-tXK_2g-Rq6Kqt6ozzkbGRqXzQTZR7byNKtc07mDsNmql78wol1pWlfbadnIK3KKrSjZB3532An2_rL6Wb_H64_V9-byOFSWsi0sqCUhcZjmFknHKeZEVhVap5kB0mo1DswqYkhuZ6xKkwkoRVaQ8YwTnnC7Q45HbevfT69CJvQlKN4202vVB5JOTYxiNcDQq70LwuhKtN3vpB4FBTM2JnRVTcyKlAo8iGSMPJ3a_2evyHDhV9f-7Ntv6YLwWbT0E4xq3HSbaGfQH-g129g</recordid><startdate>19800101</startdate><enddate>19800101</enddate><creator>Pubols, L. M</creator><creator>Goldberger, M. E</creator><general>Am Phys Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800101</creationdate><title>Recovery of function in dorsal horn following partial deafferentation</title><author>Pubols, L. M ; Goldberger, M. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-d3a20a1d6730d593998688ec4e902e4646436f05caba7ed0ac1cc2c8496521793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Animals</topic><topic>Back - innervation</topic><topic>Cats</topic><topic>Denervation</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Hindlimb - innervation</topic><topic>Locomotion</topic><topic>Male</topic><topic>Mechanoreceptors - physiology</topic><topic>Neurons, Afferent - physiology</topic><topic>Posture</topic><topic>Reflex - physiology</topic><topic>Skin - innervation</topic><topic>Space life sciences</topic><topic>Spinal Cord - physiology</topic><topic>Spinal Nerve Roots - physiology</topic><topic>Touch - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pubols, L. M</creatorcontrib><creatorcontrib>Goldberger, M. E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pubols, L. M</au><au>Goldberger, M. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recovery of function in dorsal horn following partial deafferentation</atitle><jtitle>Journal of neurophysiology</jtitle><addtitle>J Neurophysiol</addtitle><date>1980-01-01</date><risdate>1980</risdate><volume>43</volume><issue>1</issue><spage>102</spage><epage>117</epage><pages>102-117</pages><issn>0022-3077</issn><eissn>1522-1598</eissn><abstract>L. M. Pubols and M. E. Goldberger
1. Collateral sprouting of L6 dorsal root afferents within the dorsal horn
of the L6 spinal cord segment has been shown anatomically to occur
following transection of all other lumbosacral dorsal roots in the cat. The
present study was performed to examine a possible physiological correlate
of that sprouting, namely, an altered somatotopic organization of the
dorsal horn at L6. This was evaluated by microelectrode mapping of the L6
dorsal horn in normal cats and in cats with L6 spared, lumbosacral dorsal
rhizotomies performed 2 days (subacute spared root) or more than 8 wk
(chronic spared root), prior to recording. 2. In normal cats the
mediolateral somatotopic sequence of hindlimb representation in the L6
dorsal horn is ventral digits 2 and 3, dorsal digits 2 and 3, dorsal foot,
rostral and lateral ankle, lateral leg, lateral thigh, and back. In both
subacute and chronic spared-root cats the somatotopic sequence is similar
to that of normal cats, but there is a loss of proximal thigh and back
representation. This proximal body region is represented at the lateral
edge of the dorsal horn in normal animals. 3. There was a partial loss of
responsiveness of cells in the dorsal horn in the subacute spared-root
group and a partial recovery of responsiveness in the chronic group. In the
subacute group punctures exhibiting no responses to tactile input tended to
be clustered in the lateral dorsal horn. 4. The lateral one-fourth of the
dorsal horn in each animal was analyzed in terms of the percentage of
recording loci occurring within it. The percentages of recording loci
having receptive fields proximal to, distal to, and spanning the middle of
the thigh (proximal, distal, and intermediate RFs) were tabulated for each
animal. Subacute animals had a significantly lower-than-normal overall
percentage of responsive loci in the lateral dorsal horn, but chronic
animals did not. The percentage of distal fields therein was not different
for the normal versus the subacute group, signifying that the loss of
proximal and intermediate fields was responsible for the difference in
overall percentage. Chronic animals, however, had significantly more distal
fields than did normals. When all fields having any distal component were
compared (i.e., distal and intermediate), the difference between the
chronic and normal groups did not reach significance. One possible
explanation of these findings is that loci having both proximal and distal
RF components are unresponsive 2 days after partial denervation, but
recover responsiveness to their spared distal input over an 8-wk period.
One possible mechanism mediating these changes is localized sprouting of
intact, spared axons. Other mechanisms of functional recovery, such as
interneuronal sprouting, denervation supersensitivity, and unmasking of
latent synapses, are discussed in relation to these and other data.</abstract><cop>United States</cop><pub>Am Phys Soc</pub><pmid>7351546</pmid><doi>10.1152/jn.1980.43.1.102</doi><tpages>16</tpages></addata></record> |
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| ispartof | Journal of neurophysiology, 1980-01, Vol.43 (1), p.102-117 |
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| language | eng |
| recordid | cdi_highwire_physiology_jn_43_1_102 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Back - innervation Cats Denervation Electrophysiology Female Hindlimb - innervation Locomotion Male Mechanoreceptors - physiology Neurons, Afferent - physiology Posture Reflex - physiology Skin - innervation Space life sciences Spinal Cord - physiology Spinal Nerve Roots - physiology Touch - physiology |
| title | Recovery of function in dorsal horn following partial deafferentation |
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