Age is independently related to muscle metabolic capacity in premenopausal women
Departments of 1 Human Studies, 2 Nutrition Sciences, 3 Diagnostic and Therapeutic Sciences, and 7 Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294; 4 Physical Therapy Program, The University of Findlay, Findlay, Ohio 45840; 5 Pennington Biomedical Rese...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2002-07, Vol.93 (1), p.70-76 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Hunter, Gary R Newcomer, Bradley R Weinsier, Roland L Karapondo, Daniel L Larson-Meyer, D. Enette Joanisse, Denis R Bamman, Marcas M |
| description | Departments of 1 Human Studies,
2 Nutrition Sciences, 3 Diagnostic and
Therapeutic Sciences, and 7 Physiology and Biophysics,
University of Alabama at Birmingham, Birmingham, Alabama 35294;
4 Physical Therapy Program, The University of Findlay,
Findlay, Ohio 45840; 5 Pennington Biomedical Research
Center, Louisiana State University, Baton Rouge, Louisiana 70803;
and 6 Division of Kinesiology, Laval University and
Laval Hospital Research Center, Sainte-Foy, Quebec City, Quebec,
Canada G1K 7P4
The purpose of this study was to
determine whether muscle metabolic capacity was inversely related to
age after adjusting for physical activity in sedentary premenopausal
women. Eighty-three women (ages 23-47 yr) had their
free-living, activity-related energy expenditure evaluated with doubly
labeled water procedures, and room calorimeter determined sleeping
energy expenditure. Maximum O 2 uptake and strength were
evaluated in all subjects, whereas 31 P-magnetic resonance
spectroscopy determined metabolic economy during maximal exercise, and
muscle biopsy maximal enzyme activity was evaluated in subsets of the
sample (48 and 18 subjects, respectively). Age was significantly
related to whole body treadmill endurance time ( r = 0.32), plantar flexion strength ( r = 0.29), maximum O 2 uptake ( r = 0.27),
31 P-magnetic resonance spectroscopy ADP recovery rate
( r = 0.44), and anaerobic glycolytic capacity
( r = 0.37), and muscle biopsy citrate synthase
activity ( r = 0.48), glyceraldehyde-3-phosphate dehydrogenase ( r = 0.54), phosphofructokinase
( r = 0.62), and phosphorylase ( r = 0.58) activity even after adjusting for activity-related energy
expenditure. These data suggest that, in sedentary premenopausal women,
both oxidative and glycolytic muscle capacity decrease with age even
when physical activity is taken into account.
energy expenditure; aerobic capacity; anaerobic capacity |
| doi_str_mv | 10.1152/japplphysiol.01239.2001 |
| format | Article |
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2 Nutrition Sciences, 3 Diagnostic and
Therapeutic Sciences, and 7 Physiology and Biophysics,
University of Alabama at Birmingham, Birmingham, Alabama 35294;
4 Physical Therapy Program, The University of Findlay,
Findlay, Ohio 45840; 5 Pennington Biomedical Research
Center, Louisiana State University, Baton Rouge, Louisiana 70803;
and 6 Division of Kinesiology, Laval University and
Laval Hospital Research Center, Sainte-Foy, Quebec City, Quebec,
Canada G1K 7P4
The purpose of this study was to
determine whether muscle metabolic capacity was inversely related to
age after adjusting for physical activity in sedentary premenopausal
women. Eighty-three women (ages 23-47 yr) had their
free-living, activity-related energy expenditure evaluated with doubly
labeled water procedures, and room calorimeter determined sleeping
energy expenditure. Maximum O 2 uptake and strength were
evaluated in all subjects, whereas 31 P-magnetic resonance
spectroscopy determined metabolic economy during maximal exercise, and
muscle biopsy maximal enzyme activity was evaluated in subsets of the
sample (48 and 18 subjects, respectively). Age was significantly
related to whole body treadmill endurance time ( r = 0.32), plantar flexion strength ( r = 0.29), maximum O 2 uptake ( r = 0.27),
31 P-magnetic resonance spectroscopy ADP recovery rate
( r = 0.44), and anaerobic glycolytic capacity
( r = 0.37), and muscle biopsy citrate synthase
activity ( r = 0.48), glyceraldehyde-3-phosphate dehydrogenase ( r = 0.54), phosphofructokinase
( r = 0.62), and phosphorylase ( r = 0.58) activity even after adjusting for activity-related energy
expenditure. These data suggest that, in sedentary premenopausal women,
both oxidative and glycolytic muscle capacity decrease with age even
when physical activity is taken into account.
energy expenditure; aerobic capacity; anaerobic capacity</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/japplphysiol.01239.2001</identifier><identifier>PMID: 12070188</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Absorptiometry, Photon ; Adult ; Age ; Aging - physiology ; Anaerobic Threshold - physiology ; Biological and medical sciences ; Energy Metabolism - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Menopause ; Metabolism ; Middle Aged ; Muscle Fibers, Skeletal - physiology ; Muscle, Skeletal - anatomy & histology ; Muscle, Skeletal - enzymology ; Muscle, Skeletal - metabolism ; Muscular system ; Oxidation-Reduction ; Oxygen Consumption - physiology ; Physical Endurance - physiology ; Premenopause - physiology ; Sleep - physiology ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system ; Women</subject><ispartof>Journal of applied physiology (1985), 2002-07, Vol.93 (1), p.70-76</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Physiological Society Jul 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-341c57cd0e66f71db4bcb0da4890e622932eb4e6e360bf9b2efe52108fcb902c3</citedby><cites>FETCH-LOGICAL-c440t-341c57cd0e66f71db4bcb0da4890e622932eb4e6e360bf9b2efe52108fcb902c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13763383$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12070188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hunter, Gary R</creatorcontrib><creatorcontrib>Newcomer, Bradley R</creatorcontrib><creatorcontrib>Weinsier, Roland L</creatorcontrib><creatorcontrib>Karapondo, Daniel L</creatorcontrib><creatorcontrib>Larson-Meyer, D. Enette</creatorcontrib><creatorcontrib>Joanisse, Denis R</creatorcontrib><creatorcontrib>Bamman, Marcas M</creatorcontrib><title>Age is independently related to muscle metabolic capacity in premenopausal women</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Departments of 1 Human Studies,
2 Nutrition Sciences, 3 Diagnostic and
Therapeutic Sciences, and 7 Physiology and Biophysics,
University of Alabama at Birmingham, Birmingham, Alabama 35294;
4 Physical Therapy Program, The University of Findlay,
Findlay, Ohio 45840; 5 Pennington Biomedical Research
Center, Louisiana State University, Baton Rouge, Louisiana 70803;
and 6 Division of Kinesiology, Laval University and
Laval Hospital Research Center, Sainte-Foy, Quebec City, Quebec,
Canada G1K 7P4
The purpose of this study was to
determine whether muscle metabolic capacity was inversely related to
age after adjusting for physical activity in sedentary premenopausal
women. Eighty-three women (ages 23-47 yr) had their
free-living, activity-related energy expenditure evaluated with doubly
labeled water procedures, and room calorimeter determined sleeping
energy expenditure. Maximum O 2 uptake and strength were
evaluated in all subjects, whereas 31 P-magnetic resonance
spectroscopy determined metabolic economy during maximal exercise, and
muscle biopsy maximal enzyme activity was evaluated in subsets of the
sample (48 and 18 subjects, respectively). Age was significantly
related to whole body treadmill endurance time ( r = 0.32), plantar flexion strength ( r = 0.29), maximum O 2 uptake ( r = 0.27),
31 P-magnetic resonance spectroscopy ADP recovery rate
( r = 0.44), and anaerobic glycolytic capacity
( r = 0.37), and muscle biopsy citrate synthase
activity ( r = 0.48), glyceraldehyde-3-phosphate dehydrogenase ( r = 0.54), phosphofructokinase
( r = 0.62), and phosphorylase ( r = 0.58) activity even after adjusting for activity-related energy
expenditure. These data suggest that, in sedentary premenopausal women,
both oxidative and glycolytic muscle capacity decrease with age even
when physical activity is taken into account.
energy expenditure; aerobic capacity; anaerobic capacity</description><subject>Absorptiometry, Photon</subject><subject>Adult</subject><subject>Age</subject><subject>Aging - physiology</subject><subject>Anaerobic Threshold - physiology</subject><subject>Biological and medical sciences</subject><subject>Energy Metabolism - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Menopause</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Muscle Fibers, Skeletal - physiology</subject><subject>Muscle, Skeletal - anatomy & histology</subject><subject>Muscle, Skeletal - enzymology</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscular system</subject><subject>Oxidation-Reduction</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical Endurance - physiology</subject><subject>Premenopause - physiology</subject><subject>Sleep - physiology</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><subject>Women</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EokvhL0CEBLcsYzuJk2NVUUCqBIdythxnsuuVExs7UZt_X4dGWlQJH2yN53nn4yXkA4U9pSX7clLeW39conF2D5TxZs8A6AuyS1mW0wroS7KrRQm5KGtxQd7EeEpAUZT0NbmgDATQut6RX1cHzEzMzNihx3SNk12ygFZN2GWTy4Y5aovZgJNqnTU608orbaYlSTIfcMDReTVHZbN7l4K35FWvbMR323tJft98vbv-nt_-_Pbj-uo210UBU84LqkuhO8Cq6gXt2qLVLXSqqJv0xVjDGbYFVsgraPumZdhjySjUvW4bYJpfks9PdX1wf2aMkxxM1GitGtHNUQpacwYNJPDjM_Dk5jCm2SRbTwmwQuIJ0sHFGLCXPphBhUVSkKvj8l_H5V_H5ep4Ur7fys_tgN1Zt1mcgE8boKJWtg9q1CaeOS4qzmt-XuhoDsd7E1Bu3dxhWbvLhksqxTor-z94M1t7hw_TqtgE0nc9fwR_ka5A</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Hunter, Gary R</creator><creator>Newcomer, Bradley R</creator><creator>Weinsier, Roland L</creator><creator>Karapondo, Daniel L</creator><creator>Larson-Meyer, D. Enette</creator><creator>Joanisse, Denis R</creator><creator>Bamman, Marcas M</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Age is independently related to muscle metabolic capacity in premenopausal women</title><author>Hunter, Gary R ; Newcomer, Bradley R ; Weinsier, Roland L ; Karapondo, Daniel L ; Larson-Meyer, D. Enette ; Joanisse, Denis R ; Bamman, Marcas M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-341c57cd0e66f71db4bcb0da4890e622932eb4e6e360bf9b2efe52108fcb902c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Absorptiometry, Photon</topic><topic>Adult</topic><topic>Age</topic><topic>Aging - physiology</topic><topic>Anaerobic Threshold - physiology</topic><topic>Biological and medical sciences</topic><topic>Energy Metabolism - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Menopause</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Muscle Fibers, Skeletal - physiology</topic><topic>Muscle, Skeletal - anatomy & histology</topic><topic>Muscle, Skeletal - enzymology</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscular system</topic><topic>Oxidation-Reduction</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical Endurance - physiology</topic><topic>Premenopause - physiology</topic><topic>Sleep - physiology</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunter, Gary R</creatorcontrib><creatorcontrib>Newcomer, Bradley R</creatorcontrib><creatorcontrib>Weinsier, Roland L</creatorcontrib><creatorcontrib>Karapondo, Daniel L</creatorcontrib><creatorcontrib>Larson-Meyer, D. 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Enette</au><au>Joanisse, Denis R</au><au>Bamman, Marcas M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age is independently related to muscle metabolic capacity in premenopausal women</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>93</volume><issue>1</issue><spage>70</spage><epage>76</epage><pages>70-76</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Departments of 1 Human Studies,
2 Nutrition Sciences, 3 Diagnostic and
Therapeutic Sciences, and 7 Physiology and Biophysics,
University of Alabama at Birmingham, Birmingham, Alabama 35294;
4 Physical Therapy Program, The University of Findlay,
Findlay, Ohio 45840; 5 Pennington Biomedical Research
Center, Louisiana State University, Baton Rouge, Louisiana 70803;
and 6 Division of Kinesiology, Laval University and
Laval Hospital Research Center, Sainte-Foy, Quebec City, Quebec,
Canada G1K 7P4
The purpose of this study was to
determine whether muscle metabolic capacity was inversely related to
age after adjusting for physical activity in sedentary premenopausal
women. Eighty-three women (ages 23-47 yr) had their
free-living, activity-related energy expenditure evaluated with doubly
labeled water procedures, and room calorimeter determined sleeping
energy expenditure. Maximum O 2 uptake and strength were
evaluated in all subjects, whereas 31 P-magnetic resonance
spectroscopy determined metabolic economy during maximal exercise, and
muscle biopsy maximal enzyme activity was evaluated in subsets of the
sample (48 and 18 subjects, respectively). Age was significantly
related to whole body treadmill endurance time ( r = 0.32), plantar flexion strength ( r = 0.29), maximum O 2 uptake ( r = 0.27),
31 P-magnetic resonance spectroscopy ADP recovery rate
( r = 0.44), and anaerobic glycolytic capacity
( r = 0.37), and muscle biopsy citrate synthase
activity ( r = 0.48), glyceraldehyde-3-phosphate dehydrogenase ( r = 0.54), phosphofructokinase
( r = 0.62), and phosphorylase ( r = 0.58) activity even after adjusting for activity-related energy
expenditure. These data suggest that, in sedentary premenopausal women,
both oxidative and glycolytic muscle capacity decrease with age even
when physical activity is taken into account.
energy expenditure; aerobic capacity; anaerobic capacity</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>12070188</pmid><doi>10.1152/japplphysiol.01239.2001</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2002-07, Vol.93 (1), p.70-76 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_highwire_physiology_jap_93_1_70 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Absorptiometry, Photon Adult Age Aging - physiology Anaerobic Threshold - physiology Biological and medical sciences Energy Metabolism - physiology Female Fundamental and applied biological sciences. Psychology Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Menopause Metabolism Middle Aged Muscle Fibers, Skeletal - physiology Muscle, Skeletal - anatomy & histology Muscle, Skeletal - enzymology Muscle, Skeletal - metabolism Muscular system Oxidation-Reduction Oxygen Consumption - physiology Physical Endurance - physiology Premenopause - physiology Sleep - physiology Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system Women |
| title | Age is independently related to muscle metabolic capacity in premenopausal women |
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