Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats
Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences, University of California, Davis, California 95616-8519 Male Zucker rats were exposed to 2 G for 8 wk to test the hypothesis that the leptin regulatory pathway contributes to recovery from effects of 2 G on feeding, g...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2001-02, Vol.90 (2), p.606-614 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Warren, L. Elisabeth Horwitz, Barbara A Hamilton, Jock S Fuller, Charles A |
| description | Section of Neurobiology, Physiology, and Behavior, Division of
Biological Sciences, University of California, Davis, California
95616-8519
Male Zucker rats were
exposed to 2 G for 8 wk to test the hypothesis that the leptin
regulatory pathway contributes to recovery from effects of 2 G on
feeding, growth, and nutrient partitioning. After initial hypophagia,
body mass-independent food intake of the lean rats exposed to 2 G
surpassed that of the lean rats maintained at 1 G, but food intake of
the obese rats exposed to 2 G remained low. After 8 wk at 2 G, body
mass and carcass fat were less in both genotypes. Leptin and percent
fat were lower in lean rats exposed to 2 G vs. 1 G but did not differ
in obese rats exposed to 2 G vs. 1 G. Although exposure to 2 G did not
alter uncoupling protein-1 levels, it did elicit white fat pad-specific
changes in lipoprotein lipase activity in obese but not lean rats. We conclude that 2 G affects both genotypes but that the lean Zucker rats
recover their food intake and growth rate and retain "normal" lipoprotein lipase activity to a greater degree than do the obese rats,
emphasizing the importance of a functional leptin regulatory pathway in
this acclimation.
centrifugation; body mass; food intake; fat metabolism; gravity |
| doi_str_mv | 10.1152/jappl.2001.90.2.606 |
| format | Article |
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Biological Sciences, University of California, Davis, California
95616-8519
Male Zucker rats were
exposed to 2 G for 8 wk to test the hypothesis that the leptin
regulatory pathway contributes to recovery from effects of 2 G on
feeding, growth, and nutrient partitioning. After initial hypophagia,
body mass-independent food intake of the lean rats exposed to 2 G
surpassed that of the lean rats maintained at 1 G, but food intake of
the obese rats exposed to 2 G remained low. After 8 wk at 2 G, body
mass and carcass fat were less in both genotypes. Leptin and percent
fat were lower in lean rats exposed to 2 G vs. 1 G but did not differ
in obese rats exposed to 2 G vs. 1 G. Although exposure to 2 G did not
alter uncoupling protein-1 levels, it did elicit white fat pad-specific
changes in lipoprotein lipase activity in obese but not lean rats. We conclude that 2 G affects both genotypes but that the lean Zucker rats
recover their food intake and growth rate and retain "normal" lipoprotein lipase activity to a greater degree than do the obese rats,
emphasizing the importance of a functional leptin regulatory pathway in
this acclimation.
centrifugation; body mass; food intake; fat metabolism; gravity</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2001.90.2.606</identifier><identifier>PMID: 11160060</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Legacy CDMS: Am Physiological Soc</publisher><subject>Adipose Tissue, Brown - metabolism ; Animals ; Biological and medical sciences ; Body fat ; Body Weight ; Carrier Proteins - metabolism ; Centrifugation ; Eating ; Gravitation ; Gravity ; Ion Channels ; Leptin - blood ; Life Sciences (General) ; Lipoprotein Lipase - metabolism ; Male ; Medical sciences ; Membrane Proteins - metabolism ; Metabolic diseases ; Metabolism ; Mitochondrial Proteins ; Obesity ; Obesity - metabolism ; Proteins ; Rats ; Rats, Zucker ; Rodents ; Space life sciences ; Thinness - metabolism ; Uncoupling Protein 1</subject><ispartof>Journal of applied physiology (1985), 2001-02, Vol.90 (2), p.606-614</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Feb 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-f434027c8614abc56fbbe57ad932ef751d08cea5c660b46456ff466ef0491a433</citedby><cites>FETCH-LOGICAL-c498t-f434027c8614abc56fbbe57ad932ef751d08cea5c660b46456ff466ef0491a433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3037,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=980464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11160060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warren, L. Elisabeth</creatorcontrib><creatorcontrib>Horwitz, Barbara A</creatorcontrib><creatorcontrib>Hamilton, Jock S</creatorcontrib><creatorcontrib>Fuller, Charles A</creatorcontrib><title>Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Section of Neurobiology, Physiology, and Behavior, Division of
Biological Sciences, University of California, Davis, California
95616-8519
Male Zucker rats were
exposed to 2 G for 8 wk to test the hypothesis that the leptin
regulatory pathway contributes to recovery from effects of 2 G on
feeding, growth, and nutrient partitioning. After initial hypophagia,
body mass-independent food intake of the lean rats exposed to 2 G
surpassed that of the lean rats maintained at 1 G, but food intake of
the obese rats exposed to 2 G remained low. After 8 wk at 2 G, body
mass and carcass fat were less in both genotypes. Leptin and percent
fat were lower in lean rats exposed to 2 G vs. 1 G but did not differ
in obese rats exposed to 2 G vs. 1 G. Although exposure to 2 G did not
alter uncoupling protein-1 levels, it did elicit white fat pad-specific
changes in lipoprotein lipase activity in obese but not lean rats. We conclude that 2 G affects both genotypes but that the lean Zucker rats
recover their food intake and growth rate and retain "normal" lipoprotein lipase activity to a greater degree than do the obese rats,
emphasizing the importance of a functional leptin regulatory pathway in
this acclimation.
centrifugation; body mass; food intake; fat metabolism; gravity</description><subject>Adipose Tissue, Brown - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Body Weight</subject><subject>Carrier Proteins - metabolism</subject><subject>Centrifugation</subject><subject>Eating</subject><subject>Gravitation</subject><subject>Gravity</subject><subject>Ion Channels</subject><subject>Leptin - blood</subject><subject>Life Sciences (General)</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - metabolism</subject><subject>Metabolic diseases</subject><subject>Metabolism</subject><subject>Mitochondrial Proteins</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Rodents</subject><subject>Space life sciences</subject><subject>Thinness - metabolism</subject><subject>Uncoupling Protein 1</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>CYI</sourceid><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAUhSMEokPhF4CQBRJsmsGvOMkSVW1BqsSmbNhYjnM948FjBzsRzL_HacJDSHhjy_c79x77FMVzgreEVPTdQQ2D21KMybbFW7oVWDwoNrlCSyIweVhsmrrCZV019VnxJKVDJjmvyOPijJBMYIE3RbgyBvSYUDCIohsUPFK9HUKy4-kCORhG6_Oeb4YYRrB-PqsEF0j5Hk1eh2lw1u_QWi4JmhlQ_h4IHSRAXyb9FSKKakxPi0dGuQTP1v28-Hx9dXf5obz9dPPx8v1tqXnbjKXhjGNa60YQrjpdCdN1UNWqbxkFU1ekx40GVWkhcMcFz4DhQoDBvCWKM3ZevFn6Zl_fJkijPNqkwTnlIUxJ1lgwQlidwVf_gIcwRZ-9STovVlORIbZAOoaUIhg5RHtU8SQJlnMY8j4MOYchWyypzGFk1cu19dQdof-jWX8_A69XQCWtnInKa5t-c22D89My9WKhvEpK-jGmeQ7HhNBlytulvLe7_XcbQQ77U7LBhd1ptvW3H_Z_8npy7g5-jLPkl0IOvWE_AYHUuxQ</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Warren, L. 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Elisabeth ; Horwitz, Barbara A ; Hamilton, Jock S ; Fuller, Charles A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-f434027c8614abc56fbbe57ad932ef751d08cea5c660b46456ff466ef0491a433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adipose Tissue, Brown - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Body Weight</topic><topic>Carrier Proteins - metabolism</topic><topic>Centrifugation</topic><topic>Eating</topic><topic>Gravitation</topic><topic>Gravity</topic><topic>Ion Channels</topic><topic>Leptin - blood</topic><topic>Life Sciences (General)</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - metabolism</topic><topic>Metabolic diseases</topic><topic>Metabolism</topic><topic>Mitochondrial Proteins</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Rodents</topic><topic>Space life sciences</topic><topic>Thinness - metabolism</topic><topic>Uncoupling Protein 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warren, L. 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Elisabeth</au><au>Horwitz, Barbara A</au><au>Hamilton, Jock S</au><au>Fuller, Charles A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>90</volume><issue>2</issue><spage>606</spage><epage>614</epage><pages>606-614</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Section of Neurobiology, Physiology, and Behavior, Division of
Biological Sciences, University of California, Davis, California
95616-8519
Male Zucker rats were
exposed to 2 G for 8 wk to test the hypothesis that the leptin
regulatory pathway contributes to recovery from effects of 2 G on
feeding, growth, and nutrient partitioning. After initial hypophagia,
body mass-independent food intake of the lean rats exposed to 2 G
surpassed that of the lean rats maintained at 1 G, but food intake of
the obese rats exposed to 2 G remained low. After 8 wk at 2 G, body
mass and carcass fat were less in both genotypes. Leptin and percent
fat were lower in lean rats exposed to 2 G vs. 1 G but did not differ
in obese rats exposed to 2 G vs. 1 G. Although exposure to 2 G did not
alter uncoupling protein-1 levels, it did elicit white fat pad-specific
changes in lipoprotein lipase activity in obese but not lean rats. We conclude that 2 G affects both genotypes but that the lean Zucker rats
recover their food intake and growth rate and retain "normal" lipoprotein lipase activity to a greater degree than do the obese rats,
emphasizing the importance of a functional leptin regulatory pathway in
this acclimation.
centrifugation; body mass; food intake; fat metabolism; gravity</abstract><cop>Legacy CDMS</cop><pub>Am Physiological Soc</pub><pmid>11160060</pmid><doi>10.1152/jappl.2001.90.2.606</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2001-02, Vol.90 (2), p.606-614 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_highwire_physiology_jap_90_2_606 |
| source | MEDLINE; American Physiological Society; NASA Technical Reports Server; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adipose Tissue, Brown - metabolism Animals Biological and medical sciences Body fat Body Weight Carrier Proteins - metabolism Centrifugation Eating Gravitation Gravity Ion Channels Leptin - blood Life Sciences (General) Lipoprotein Lipase - metabolism Male Medical sciences Membrane Proteins - metabolism Metabolic diseases Metabolism Mitochondrial Proteins Obesity Obesity - metabolism Proteins Rats Rats, Zucker Rodents Space life sciences Thinness - metabolism Uncoupling Protein 1 |
| title | Effects of 2 G on adiposity, leptin, lipoprotein lipase, and uncoupling protein-1 in lean and obese Zucker rats |
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