Response of arterial smooth muscle to length perturbation
Department of Anatomy and Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3 The ability of arterial smooth muscle to generate tension is influenced by muscle length. An unsettled question is whether the length-tension relationshi...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2000-11, Vol.89 (5), p.2065-2072 |
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| container_title | Journal of applied physiology (1985) |
| container_volume | 89 |
| creator | Seow, Chun Y |
| description | Department of Anatomy and Department of Pharmacology and
Therapeutics, University of British Columbia, Vancouver, British
Columbia, Canada V6T 1Z3
The ability of arterial smooth muscle to generate tension is
influenced by muscle length. An unsettled question is whether the
length-tension relationship is a simple reflection of the contractile
filament overlap, as it is in skeletal muscle. There are several
factors that could potentially affect tension generation in arterial
smooth muscle; these include stretch-induced myogenic response and
length-oscillation-induced disruption of the contractile filament
organization. In this study, in which rabbit carotid arterial
preparations were used, we found that different length-tension curves
could be obtained at different times after a length change. In
addition, length oscillation at a frequency of normal pulse rate and
with small to moderate oscillation amplitude was found to potentiate
tension generation but reduced tension at large amplitudes. The
observed response could be attributed to adaptation of the muscle to
length change over time and to myogenic potentiation associated with
stretching of the muscle.
carotid artery; length oscillation; tension recovery; plasticity |
| doi_str_mv | 10.1152/jappl.2000.89.5.2065 |
| format | Article |
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Therapeutics, University of British Columbia, Vancouver, British
Columbia, Canada V6T 1Z3
The ability of arterial smooth muscle to generate tension is
influenced by muscle length. An unsettled question is whether the
length-tension relationship is a simple reflection of the contractile
filament overlap, as it is in skeletal muscle. There are several
factors that could potentially affect tension generation in arterial
smooth muscle; these include stretch-induced myogenic response and
length-oscillation-induced disruption of the contractile filament
organization. In this study, in which rabbit carotid arterial
preparations were used, we found that different length-tension curves
could be obtained at different times after a length change. In
addition, length oscillation at a frequency of normal pulse rate and
with small to moderate oscillation amplitude was found to potentiate
tension generation but reduced tension at large amplitudes. The
observed response could be attributed to adaptation of the muscle to
length change over time and to myogenic potentiation associated with
stretching of the muscle.
carotid artery; length oscillation; tension recovery; plasticity</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2000.89.5.2065</identifier><identifier>PMID: 11053363</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adaptation, Physiological - physiology ; Animals ; Biological and medical sciences ; Blood Pressure - physiology ; Blood vessels ; Blood vessels and receptors ; Carotid Arteries - physiology ; Fundamental and applied biological sciences. Psychology ; Muscle Contraction - physiology ; Muscle, Smooth, Vascular - physiology ; Muscular system ; Periodicity ; Pulsatile Flow - physiology ; Rabbits ; Tension ; Vasoconstriction - physiology ; Vertebrates: cardiovascular system</subject><ispartof>Journal of applied physiology (1985), 2000-11, Vol.89 (5), p.2065-2072</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-15c7e838ad03706e75cfb36deef9354c4c5bde85c8b9e820fbde61c640e5cb6c3</citedby><cites>FETCH-LOGICAL-c436t-15c7e838ad03706e75cfb36deef9354c4c5bde85c8b9e820fbde61c640e5cb6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3025,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=821420$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11053363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seow, Chun Y</creatorcontrib><title>Response of arterial smooth muscle to length perturbation</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Department of Anatomy and Department of Pharmacology and
Therapeutics, University of British Columbia, Vancouver, British
Columbia, Canada V6T 1Z3
The ability of arterial smooth muscle to generate tension is
influenced by muscle length. An unsettled question is whether the
length-tension relationship is a simple reflection of the contractile
filament overlap, as it is in skeletal muscle. There are several
factors that could potentially affect tension generation in arterial
smooth muscle; these include stretch-induced myogenic response and
length-oscillation-induced disruption of the contractile filament
organization. In this study, in which rabbit carotid arterial
preparations were used, we found that different length-tension curves
could be obtained at different times after a length change. In
addition, length oscillation at a frequency of normal pulse rate and
with small to moderate oscillation amplitude was found to potentiate
tension generation but reduced tension at large amplitudes. The
observed response could be attributed to adaptation of the muscle to
length change over time and to myogenic potentiation associated with
stretching of the muscle.
carotid artery; length oscillation; tension recovery; plasticity</description><subject>Adaptation, Physiological - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - physiology</subject><subject>Blood vessels</subject><subject>Blood vessels and receptors</subject><subject>Carotid Arteries - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Muscular system</subject><subject>Periodicity</subject><subject>Pulsatile Flow - physiology</subject><subject>Rabbits</subject><subject>Tension</subject><subject>Vasoconstriction - physiology</subject><subject>Vertebrates: cardiovascular system</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1L5DAUhoO4rKPuP1ikKIg3HfPd9HIRPxaEhcW9Dml6OtMhbWrS4s6_N3UGZYXNTXKS5z0nPAh9J3hJiKDXGzMMbkkxxktVLkU6SXGAFumJ5kRicogWqhA4L4QqjtBxjBuMCeeCfEVHhGDBmGQLVP6GOPg-QuabzIQRQmtcFjvvx3XWTdE6yEafOehX6WKAME6hMmPr-1P0pTEuwrf9foL-3N0-3Tzkj7_uf978eMwtZ3LMibAFKKZMjVmBJRTCNhWTNUBTMsEtt6KqQQmrqhIUxU2qJLGSYxC2kpadoMtd3yH45wniqLs2WnDO9OCnqAvKJMWUJvD8E7jxU-jT3zRNi6iyUAniO8gGH2OARg-h7UzYaoL17FW_edWzV61KLfTsNcXO9r2nqoP6I7QXmYCLPWCiNa4JprdtfOcUJZziRF3tqHW7Wr-0AfSw3sbWO7_azoP_mcj_j95Nzj3B33HOvEf0UDfsFef6oq0</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Seow, Chun Y</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>Response of arterial smooth muscle to length perturbation</title><author>Seow, Chun Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-15c7e838ad03706e75cfb36deef9354c4c5bde85c8b9e820fbde61c640e5cb6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adaptation, Physiological - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - physiology</topic><topic>Blood vessels</topic><topic>Blood vessels and receptors</topic><topic>Carotid Arteries - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>Muscular system</topic><topic>Periodicity</topic><topic>Pulsatile Flow - physiology</topic><topic>Rabbits</topic><topic>Tension</topic><topic>Vasoconstriction - physiology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seow, Chun Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seow, Chun Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of arterial smooth muscle to length perturbation</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>89</volume><issue>5</issue><spage>2065</spage><epage>2072</epage><pages>2065-2072</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Department of Anatomy and Department of Pharmacology and
Therapeutics, University of British Columbia, Vancouver, British
Columbia, Canada V6T 1Z3
The ability of arterial smooth muscle to generate tension is
influenced by muscle length. An unsettled question is whether the
length-tension relationship is a simple reflection of the contractile
filament overlap, as it is in skeletal muscle. There are several
factors that could potentially affect tension generation in arterial
smooth muscle; these include stretch-induced myogenic response and
length-oscillation-induced disruption of the contractile filament
organization. In this study, in which rabbit carotid arterial
preparations were used, we found that different length-tension curves
could be obtained at different times after a length change. In
addition, length oscillation at a frequency of normal pulse rate and
with small to moderate oscillation amplitude was found to potentiate
tension generation but reduced tension at large amplitudes. The
observed response could be attributed to adaptation of the muscle to
length change over time and to myogenic potentiation associated with
stretching of the muscle.
carotid artery; length oscillation; tension recovery; plasticity</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11053363</pmid><doi>10.1152/jappl.2000.89.5.2065</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2000-11, Vol.89 (5), p.2065-2072 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_highwire_physiology_jap_89_5_2065 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adaptation, Physiological - physiology Animals Biological and medical sciences Blood Pressure - physiology Blood vessels Blood vessels and receptors Carotid Arteries - physiology Fundamental and applied biological sciences. Psychology Muscle Contraction - physiology Muscle, Smooth, Vascular - physiology Muscular system Periodicity Pulsatile Flow - physiology Rabbits Tension Vasoconstriction - physiology Vertebrates: cardiovascular system |
| title | Response of arterial smooth muscle to length perturbation |
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