Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise
1 Department of Physiology, Monash University, Clayton, Victoria 3168; and 2 School of Health Sciences, Deakin University, Burwood, Victoria 3125, Australia There has been recent interest in the potential performance and metabolic effects of carbohydrate ingestion during exercise lasting ~1 h. In...
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| Veröffentlicht in: | Journal of applied physiology (1985) 2000-11, Vol.89 (5), p.1690-1698 |
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| container_title | Journal of applied physiology (1985) |
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| creator | McConell, Glenn K Canny, Benedict J Daddo, Marcus C Nance, Marcus J Snow, Rodney J |
| description | 1 Department of Physiology, Monash University, Clayton,
Victoria 3168; and 2 School of Health Sciences, Deakin
University, Burwood, Victoria 3125, Australia
There has been
recent interest in the potential performance and metabolic effects of
carbohydrate ingestion during exercise lasting ~1 h. In this study,
13 well-trained men ingested in randomized order either a 6% glucose
solution (CHO trial) or a placebo (Con trial) during exercise to
exhaustion at 83 ± 1% peak oxygen uptake. In six subjects,
vastus lateralis muscle was sampled at rest, at 32 min, and at
exhaustion, and in six subjects, glucose kinetics was determined by
infusion of [6,6- 2 H]glucose in both trials and ingestion
of [6- 3 H]glucose in the CHO trial. Of the 84 g of
glucose ingested during exercise in the CHO trial, only 22 g
appeared in the peripheral circulation. This resulted in a small (12 g)
but significant ( P |
| doi_str_mv | 10.1152/jappl.2000.89.5.1690 |
| format | Article |
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Victoria 3168; and 2 School of Health Sciences, Deakin
University, Burwood, Victoria 3125, Australia
There has been
recent interest in the potential performance and metabolic effects of
carbohydrate ingestion during exercise lasting ~1 h. In this study,
13 well-trained men ingested in randomized order either a 6% glucose
solution (CHO trial) or a placebo (Con trial) during exercise to
exhaustion at 83 ± 1% peak oxygen uptake. In six subjects,
vastus lateralis muscle was sampled at rest, at 32 min, and at
exhaustion, and in six subjects, glucose kinetics was determined by
infusion of [6,6- 2 H]glucose in both trials and ingestion
of [6- 3 H]glucose in the CHO trial. Of the 84 g of
glucose ingested during exercise in the CHO trial, only 22 g
appeared in the peripheral circulation. This resulted in a small (12 g)
but significant ( P < 0.05) increase in glucose uptake
without influencing carbohydrate oxidation, muscle glycogen use, or
time to exhaustion (CHO: 68.1 ± 4.1 min; Con: 69.6 ± 5.5 min). Decreases in muscle phosphocreatine content and increases in
muscle inosine monophosphate and lactate content during exercise were
similar in the two trials. Although endogenous glucose production
during exercise was partially suppressed in the CHO trial, it remained
significantly above preexercise levels throughout exercise. In
conclusion, only 26% of the ingested glucose appeared in the
peripheral circulation. Glucose ingestion increased glucose uptake and
partially reduced endogenous glucose production but had no effect on
carbohydrate oxidation, muscle metabolism, or time to exhaustion during
exercise at 83% peak oxygen uptake.
endogenous glucose production; glucose absorption; insulin; carbohydrate oxidation; muscle inosine monophosphate; humans</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2000.89.5.1690</identifier><identifier>PMID: 11053315</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adenosine Diphosphate - metabolism ; Adenosine Monophosphate - metabolism ; Adenosine Triphosphate - metabolism ; Adult ; Biological and medical sciences ; Carbohydrates ; Exercise ; Fundamental and applied biological sciences. Psychology ; Glucose ; Glucose - biosynthesis ; Glucose - metabolism ; Glucose - pharmacokinetics ; Heart Rate - physiology ; Hemoglobins ; Humans ; Inosine Monophosphate - metabolism ; Insulin ; Insulin - metabolism ; Lactic Acid - metabolism ; Metabolism ; Metabolisms and neurohumoral controls ; Muscle, Skeletal - metabolism ; Muscular system ; Oxidation-Reduction ; Oxygen Consumption - physiology ; Phosphocreatine - metabolism ; Physical Endurance - drug effects ; Physical Endurance - physiology ; Plasma Volume - physiology ; Tritium ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of applied physiology (1985), 2000-11, Vol.89 (5), p.1690-1698</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-8225a0b0e1a6f40d81a31b89cc897fdcd34595f8bafd5f875eedadb6b53e0c233</citedby><cites>FETCH-LOGICAL-c467t-8225a0b0e1a6f40d81a31b89cc897fdcd34595f8bafd5f875eedadb6b53e0c233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=816184$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11053315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McConell, Glenn K</creatorcontrib><creatorcontrib>Canny, Benedict J</creatorcontrib><creatorcontrib>Daddo, Marcus C</creatorcontrib><creatorcontrib>Nance, Marcus J</creatorcontrib><creatorcontrib>Snow, Rodney J</creatorcontrib><title>Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Department of Physiology, Monash University, Clayton,
Victoria 3168; and 2 School of Health Sciences, Deakin
University, Burwood, Victoria 3125, Australia
There has been
recent interest in the potential performance and metabolic effects of
carbohydrate ingestion during exercise lasting ~1 h. In this study,
13 well-trained men ingested in randomized order either a 6% glucose
solution (CHO trial) or a placebo (Con trial) during exercise to
exhaustion at 83 ± 1% peak oxygen uptake. In six subjects,
vastus lateralis muscle was sampled at rest, at 32 min, and at
exhaustion, and in six subjects, glucose kinetics was determined by
infusion of [6,6- 2 H]glucose in both trials and ingestion
of [6- 3 H]glucose in the CHO trial. Of the 84 g of
glucose ingested during exercise in the CHO trial, only 22 g
appeared in the peripheral circulation. This resulted in a small (12 g)
but significant ( P < 0.05) increase in glucose uptake
without influencing carbohydrate oxidation, muscle glycogen use, or
time to exhaustion (CHO: 68.1 ± 4.1 min; Con: 69.6 ± 5.5 min). Decreases in muscle phosphocreatine content and increases in
muscle inosine monophosphate and lactate content during exercise were
similar in the two trials. Although endogenous glucose production
during exercise was partially suppressed in the CHO trial, it remained
significantly above preexercise levels throughout exercise. In
conclusion, only 26% of the ingested glucose appeared in the
peripheral circulation. Glucose ingestion increased glucose uptake and
partially reduced endogenous glucose production but had no effect on
carbohydrate oxidation, muscle metabolism, or time to exhaustion during
exercise at 83% peak oxygen uptake.
endogenous glucose production; glucose absorption; insulin; carbohydrate oxidation; muscle inosine monophosphate; humans</description><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine Monophosphate - metabolism</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates</subject><subject>Exercise</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Glucose - biosynthesis</subject><subject>Glucose - metabolism</subject><subject>Glucose - pharmacokinetics</subject><subject>Heart Rate - physiology</subject><subject>Hemoglobins</subject><subject>Humans</subject><subject>Inosine Monophosphate - metabolism</subject><subject>Insulin</subject><subject>Insulin - metabolism</subject><subject>Lactic Acid - metabolism</subject><subject>Metabolism</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscular system</subject><subject>Oxidation-Reduction</subject><subject>Oxygen Consumption - physiology</subject><subject>Phosphocreatine - metabolism</subject><subject>Physical Endurance - drug effects</subject><subject>Physical Endurance - physiology</subject><subject>Plasma Volume - physiology</subject><subject>Tritium</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGL1DAQx4Mo3t7pNxApCuJLa5Imbfoox90pHPhyPoc0mexmTZuatNzttze9XU4URBiYIfn9Z5j5I_SG4IoQTj_t1TT5imKMK9FVvCJNh5-hTf6iJWkweY42ouW4bLloz9B5SnuMCWOcvERnhGBe14RvkL-yFvRcBFtoFfuwO5ioZijcuIU0uzAWObZ-0SFB8cONMDudCjWaYliS9lAMMKs-eJeGwiwxy7J0hjHTMOYHNepcPUDULsEr9MIqn-D1KV-g79dXd5dfyttvN18vP9-WmjXtXApKucI9BqIay7ARRNWkF53Womut0aZmvONW9MqanFoOYJTpm57XgDWt6wv04dh3iuHnkveQg0savFcjhCXJltYN7hj9L0jE48V4Bt_9Be7DEse8hKSUEta2BGeIHSEdQ0oRrJyiG1Q8SILl6pl89EyunknRSS5Xz7Ls7an30g9gfotOJmXg_QlQSStv16O69MQJ0hDBMvXxSO3cdnfvIshpd0gu-LA9rIP_mMj-jV4v3t_Bw7xqniRyMrb-BUDVw1Y</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>McConell, Glenn K</creator><creator>Canny, Benedict J</creator><creator>Daddo, Marcus C</creator><creator>Nance, Marcus J</creator><creator>Snow, Rodney J</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise</title><author>McConell, Glenn K ; Canny, Benedict J ; Daddo, Marcus C ; Nance, Marcus J ; Snow, Rodney J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-8225a0b0e1a6f40d81a31b89cc897fdcd34595f8bafd5f875eedadb6b53e0c233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adenosine Diphosphate - metabolism</topic><topic>Adenosine Monophosphate - metabolism</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates</topic><topic>Exercise</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>Glucose - biosynthesis</topic><topic>Glucose - metabolism</topic><topic>Glucose - pharmacokinetics</topic><topic>Heart Rate - physiology</topic><topic>Hemoglobins</topic><topic>Humans</topic><topic>Inosine Monophosphate - metabolism</topic><topic>Insulin</topic><topic>Insulin - metabolism</topic><topic>Lactic Acid - metabolism</topic><topic>Metabolism</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscular system</topic><topic>Oxidation-Reduction</topic><topic>Oxygen Consumption - physiology</topic><topic>Phosphocreatine - metabolism</topic><topic>Physical Endurance - drug effects</topic><topic>Physical Endurance - physiology</topic><topic>Plasma Volume - physiology</topic><topic>Tritium</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McConell, Glenn K</creatorcontrib><creatorcontrib>Canny, Benedict J</creatorcontrib><creatorcontrib>Daddo, Marcus C</creatorcontrib><creatorcontrib>Nance, Marcus J</creatorcontrib><creatorcontrib>Snow, Rodney J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McConell, Glenn K</au><au>Canny, Benedict J</au><au>Daddo, Marcus C</au><au>Nance, Marcus J</au><au>Snow, Rodney J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>89</volume><issue>5</issue><spage>1690</spage><epage>1698</epage><pages>1690-1698</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Department of Physiology, Monash University, Clayton,
Victoria 3168; and 2 School of Health Sciences, Deakin
University, Burwood, Victoria 3125, Australia
There has been
recent interest in the potential performance and metabolic effects of
carbohydrate ingestion during exercise lasting ~1 h. In this study,
13 well-trained men ingested in randomized order either a 6% glucose
solution (CHO trial) or a placebo (Con trial) during exercise to
exhaustion at 83 ± 1% peak oxygen uptake. In six subjects,
vastus lateralis muscle was sampled at rest, at 32 min, and at
exhaustion, and in six subjects, glucose kinetics was determined by
infusion of [6,6- 2 H]glucose in both trials and ingestion
of [6- 3 H]glucose in the CHO trial. Of the 84 g of
glucose ingested during exercise in the CHO trial, only 22 g
appeared in the peripheral circulation. This resulted in a small (12 g)
but significant ( P < 0.05) increase in glucose uptake
without influencing carbohydrate oxidation, muscle glycogen use, or
time to exhaustion (CHO: 68.1 ± 4.1 min; Con: 69.6 ± 5.5 min). Decreases in muscle phosphocreatine content and increases in
muscle inosine monophosphate and lactate content during exercise were
similar in the two trials. Although endogenous glucose production
during exercise was partially suppressed in the CHO trial, it remained
significantly above preexercise levels throughout exercise. In
conclusion, only 26% of the ingested glucose appeared in the
peripheral circulation. Glucose ingestion increased glucose uptake and
partially reduced endogenous glucose production but had no effect on
carbohydrate oxidation, muscle metabolism, or time to exhaustion during
exercise at 83% peak oxygen uptake.
endogenous glucose production; glucose absorption; insulin; carbohydrate oxidation; muscle inosine monophosphate; humans</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11053315</pmid><doi>10.1152/jappl.2000.89.5.1690</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of applied physiology (1985), 2000-11, Vol.89 (5), p.1690-1698 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_highwire_physiology_jap_89_5_1690 |
| source | MEDLINE; American Physiological Society Paid; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adenosine Diphosphate - metabolism Adenosine Monophosphate - metabolism Adenosine Triphosphate - metabolism Adult Biological and medical sciences Carbohydrates Exercise Fundamental and applied biological sciences. Psychology Glucose Glucose - biosynthesis Glucose - metabolism Glucose - pharmacokinetics Heart Rate - physiology Hemoglobins Humans Inosine Monophosphate - metabolism Insulin Insulin - metabolism Lactic Acid - metabolism Metabolism Metabolisms and neurohumoral controls Muscle, Skeletal - metabolism Muscular system Oxidation-Reduction Oxygen Consumption - physiology Phosphocreatine - metabolism Physical Endurance - drug effects Physical Endurance - physiology Plasma Volume - physiology Tritium Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effect of carbohydrate ingestion on glucose kinetics and muscle metabolism during intense endurance exercise |
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