Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats
Departments of 1 Physiology, 2 Pharmacology and Toxicology, and 3 Medicine, Dartmouth Medical School, Lebanon, New Hampshire 03756-001 In a rat model of chronic mountain sickness, the excessive polycythemic response to hypoxic exposure is associated with profound splenic erythropoiesis. We studie...
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| Veröffentlicht in: | Journal of applied physiology (1985) 1999-11, Vol.87 (5), p.1901-1908 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Kam, H. Y Ou, L. C Thron, C. D Smith, R. P Leiter, J. C |
| description | Departments of 1 Physiology,
2 Pharmacology and Toxicology, and
3 Medicine, Dartmouth Medical
School, Lebanon, New Hampshire 03756-001
In a rat model of chronic mountain sickness, the
excessive polycythemic response to hypoxic exposure is associated with
profound splenic erythropoiesis. We studied the uptake and distribution of radioactive iron and red blood cell (RBC) morphology in intact and
splenectomized rats over a 30-day hypoxic exposure.
Retention of 59 Fe in the plasma
was correlated with 59 Fe uptake by
both spleen and marrow and the appearance of
59 Fe-labeled RBCs in the
blood. 59 Fe uptake in
both the spleen and the marrow paralleled the production of nucleated
RBCs. Splenic 59 Fe uptake was
~10% of the total marrow uptake under normoxic conditions but
increased to 60% of the total marrow uptake during hypoxic exposure.
Peak splenic 59 Fe uptake and
splenomegaly occurred at the most intense phase of erythropoiesis and
coincided with the rapid appearance of
59 Fe-labeled RBCs in the blood.
The bone marrow remains the most important erythropoietic organ under
both resting and stimulated states, but inordinate splenic
erythropoiesis in this rat strain accounts in large measure for the
excessive polycythemia during the development of chronic mountain
sickness in chronic hypoxia.
interaction of splenic and medullary erythropoiesis; high altitude; splenomegaly; splenectomy; leukocytosis; thrombocytosis; thrombocytopenia |
| doi_str_mv | 10.1152/jappl.1999.87.5.1901 |
| format | Article |
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2 Pharmacology and Toxicology, and
3 Medicine, Dartmouth Medical
School, Lebanon, New Hampshire 03756-001
In a rat model of chronic mountain sickness, the
excessive polycythemic response to hypoxic exposure is associated with
profound splenic erythropoiesis. We studied the uptake and distribution of radioactive iron and red blood cell (RBC) morphology in intact and
splenectomized rats over a 30-day hypoxic exposure.
Retention of 59 Fe in the plasma
was correlated with 59 Fe uptake by
both spleen and marrow and the appearance of
59 Fe-labeled RBCs in the
blood. 59 Fe uptake in
both the spleen and the marrow paralleled the production of nucleated
RBCs. Splenic 59 Fe uptake was
~10% of the total marrow uptake under normoxic conditions but
increased to 60% of the total marrow uptake during hypoxic exposure.
Peak splenic 59 Fe uptake and
splenomegaly occurred at the most intense phase of erythropoiesis and
coincided with the rapid appearance of
59 Fe-labeled RBCs in the blood.
The bone marrow remains the most important erythropoietic organ under
both resting and stimulated states, but inordinate splenic
erythropoiesis in this rat strain accounts in large measure for the
excessive polycythemia during the development of chronic mountain
sickness in chronic hypoxia.
interaction of splenic and medullary erythropoiesis; high altitude; splenomegaly; splenectomy; leukocytosis; thrombocytosis; thrombocytopenia</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1999.87.5.1901</identifier><identifier>PMID: 10562635</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Altitude Sickness - metabolism ; Anatomy & physiology ; Animals ; Biological and medical sciences ; Body Weight - physiology ; Chronic Disease ; Disease ; Erythropoiesis - physiology ; Femur - metabolism ; Hemoglobins - metabolism ; Hypoxia - metabolism ; Iron - metabolism ; Iron - pharmacokinetics ; Iron Radioisotopes - pharmacokinetics ; Male ; Medical sciences ; Polycythemia - metabolism ; Rats ; Rats, Sprague-Dawley ; Rodents ; Space life sciences ; Spleen ; Spleen - physiology ; Transport. Aerospace. Diving. Altitude ; Traumas. Diseases due to physical agents</subject><ispartof>Journal of applied physiology (1985), 1999-11, Vol.87 (5), p.1901-1908</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-3115ffb665fe0df3cd6146e8dff2962f1340cf0273def4d834199ad7a7083c13</citedby><cites>FETCH-LOGICAL-c534t-3115ffb665fe0df3cd6146e8dff2962f1340cf0273def4d834199ad7a7083c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3025,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1215900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10562635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kam, H. Y</creatorcontrib><creatorcontrib>Ou, L. C</creatorcontrib><creatorcontrib>Thron, C. D</creatorcontrib><creatorcontrib>Smith, R. P</creatorcontrib><creatorcontrib>Leiter, J. C</creatorcontrib><title>Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Departments of 1 Physiology,
2 Pharmacology and Toxicology, and
3 Medicine, Dartmouth Medical
School, Lebanon, New Hampshire 03756-001
In a rat model of chronic mountain sickness, the
excessive polycythemic response to hypoxic exposure is associated with
profound splenic erythropoiesis. We studied the uptake and distribution of radioactive iron and red blood cell (RBC) morphology in intact and
splenectomized rats over a 30-day hypoxic exposure.
Retention of 59 Fe in the plasma
was correlated with 59 Fe uptake by
both spleen and marrow and the appearance of
59 Fe-labeled RBCs in the
blood. 59 Fe uptake in
both the spleen and the marrow paralleled the production of nucleated
RBCs. Splenic 59 Fe uptake was
~10% of the total marrow uptake under normoxic conditions but
increased to 60% of the total marrow uptake during hypoxic exposure.
Peak splenic 59 Fe uptake and
splenomegaly occurred at the most intense phase of erythropoiesis and
coincided with the rapid appearance of
59 Fe-labeled RBCs in the blood.
The bone marrow remains the most important erythropoietic organ under
both resting and stimulated states, but inordinate splenic
erythropoiesis in this rat strain accounts in large measure for the
excessive polycythemia during the development of chronic mountain
sickness in chronic hypoxia.
interaction of splenic and medullary erythropoiesis; high altitude; splenomegaly; splenectomy; leukocytosis; thrombocytosis; thrombocytopenia</description><subject>Altitude Sickness - metabolism</subject><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - physiology</subject><subject>Chronic Disease</subject><subject>Disease</subject><subject>Erythropoiesis - physiology</subject><subject>Femur - metabolism</subject><subject>Hemoglobins - metabolism</subject><subject>Hypoxia - metabolism</subject><subject>Iron - metabolism</subject><subject>Iron - pharmacokinetics</subject><subject>Iron Radioisotopes - pharmacokinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polycythemia - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Space life sciences</subject><subject>Spleen</subject><subject>Spleen - physiology</subject><subject>Transport. Aerospace. Diving. Altitude</subject><subject>Traumas. Diseases due to physical agents</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkW2L1DAQx4so3nr6DUSKiPima57TvpTDU-FAkH0fculk2720iUnLbb-96e3iE4ivMpn5_WeY-RfFS4y2GHPy_qBDcFvcNM22llueI4QfFZtcIhUWCD8uNrXkqJK8lhfFs5QOCGHGOH5aXGDEBRGUb4q7b95B6W05dVCm4ADGsh8ffnDU-z1EPUFbBu8Ws-Ts0JsyQgp-TFBOvuyW4I-9XjWmi37M5cHP46RzIvXmboSU1mJuk54XT6x2CV6c38tid_1xd_W5uvn66cvVh5vKcMqmiub1rL0VgltAraWmFZgJqFtrSSOIxZQhYxGRtAXL2pqyfATdSi1RTQ2ml8XbU9sQ_fcZ0qSGPhlwTo_g56REQ2opGP8vSCTOR6Ukg6__Ag9-jmPeQRFCcC0xpxliJ8hEn1IEq0LsBx0XhZFaHVMPjqnVMVVLxdXqWJa9OveebwdofxOdLMrAmzOgk9HORj2aPv3iCOYNQhl7d8K6ft_d9xFU6JbUe-f3yzr5j5Hs3-j17NwOjtOq-SlRIfvwA6pmwbw</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Kam, H. Y</creator><creator>Ou, L. C</creator><creator>Thron, C. D</creator><creator>Smith, R. P</creator><creator>Leiter, J. C</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>H8D</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats</title><author>Kam, H. Y ; Ou, L. C ; Thron, C. D ; Smith, R. P ; Leiter, J. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-3115ffb665fe0df3cd6146e8dff2962f1340cf0273def4d834199ad7a7083c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Altitude Sickness - metabolism</topic><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - physiology</topic><topic>Chronic Disease</topic><topic>Disease</topic><topic>Erythropoiesis - physiology</topic><topic>Femur - metabolism</topic><topic>Hemoglobins - metabolism</topic><topic>Hypoxia - metabolism</topic><topic>Iron - metabolism</topic><topic>Iron - pharmacokinetics</topic><topic>Iron Radioisotopes - pharmacokinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polycythemia - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Space life sciences</topic><topic>Spleen</topic><topic>Spleen - physiology</topic><topic>Transport. Aerospace. Diving. Altitude</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kam, H. Y</creatorcontrib><creatorcontrib>Ou, L. C</creatorcontrib><creatorcontrib>Thron, C. D</creatorcontrib><creatorcontrib>Smith, R. P</creatorcontrib><creatorcontrib>Leiter, J. 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Y</au><au>Ou, L. C</au><au>Thron, C. D</au><au>Smith, R. P</au><au>Leiter, J. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>87</volume><issue>5</issue><spage>1901</spage><epage>1908</epage><pages>1901-1908</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Departments of 1 Physiology,
2 Pharmacology and Toxicology, and
3 Medicine, Dartmouth Medical
School, Lebanon, New Hampshire 03756-001
In a rat model of chronic mountain sickness, the
excessive polycythemic response to hypoxic exposure is associated with
profound splenic erythropoiesis. We studied the uptake and distribution of radioactive iron and red blood cell (RBC) morphology in intact and
splenectomized rats over a 30-day hypoxic exposure.
Retention of 59 Fe in the plasma
was correlated with 59 Fe uptake by
both spleen and marrow and the appearance of
59 Fe-labeled RBCs in the
blood. 59 Fe uptake in
both the spleen and the marrow paralleled the production of nucleated
RBCs. Splenic 59 Fe uptake was
~10% of the total marrow uptake under normoxic conditions but
increased to 60% of the total marrow uptake during hypoxic exposure.
Peak splenic 59 Fe uptake and
splenomegaly occurred at the most intense phase of erythropoiesis and
coincided with the rapid appearance of
59 Fe-labeled RBCs in the blood.
The bone marrow remains the most important erythropoietic organ under
both resting and stimulated states, but inordinate splenic
erythropoiesis in this rat strain accounts in large measure for the
excessive polycythemia during the development of chronic mountain
sickness in chronic hypoxia.
interaction of splenic and medullary erythropoiesis; high altitude; splenomegaly; splenectomy; leukocytosis; thrombocytosis; thrombocytopenia</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>10562635</pmid><doi>10.1152/jappl.1999.87.5.1901</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1999-11, Vol.87 (5), p.1901-1908 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_highwire_physiology_jap_87_5_1901 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Altitude Sickness - metabolism Anatomy & physiology Animals Biological and medical sciences Body Weight - physiology Chronic Disease Disease Erythropoiesis - physiology Femur - metabolism Hemoglobins - metabolism Hypoxia - metabolism Iron - metabolism Iron - pharmacokinetics Iron Radioisotopes - pharmacokinetics Male Medical sciences Polycythemia - metabolism Rats Rats, Sprague-Dawley Rodents Space life sciences Spleen Spleen - physiology Transport. Aerospace. Diving. Altitude Traumas. Diseases due to physical agents |
| title | Role of the spleen in the exaggerated polycythemic response to hypoxia in chronic mountain sickness in rats |
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