Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea
Sophia Zinkovska and Debra A. Kirby Children's Hospital, Harvard Medical School, Boston 02115; and Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132 Received 19 July 1995; accepted in final form 19 November 1996. Zinkovska, Sophia, and Debra A. Kirby. Intracerebroventricular pr...
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| creator | Zinkovska, Sophia Kirby, Debra A |
| description | Sophia
Zinkovska and
Debra A.
Kirby
Children's Hospital, Harvard Medical School, Boston 02115; and
Veterans Affairs Medical Center, West Roxbury, Massachusetts
02132
Received 19 July 1995; accepted in final form 19 November 1996.
Zinkovska, Sophia, and Debra A. Kirby.
Intracerebroventricular propranolol prevented vascular resistance
increases on arousal from sleep apnea. J. Appl.
Physiol. 82(5): 1637-1643, 1997. Despite the
increased risk of sudden cardiac death associated with sleep apnea,
little is known about mechanisms controlling cardiovascular responses
to sleep apnea and arousal. Chronically instrumented pigs were used to
investigate the effects of airway obstruction (AO) during
rapid-eye-movement (REM) and non-REM (NREM) sleep and arousal on mean
arterial pressure (MAP), heart rate (HR), cardiac output (CO), and
total peripheral resistance (TPR). A stainless steel
cannula was implanted in the lateral cerebral ventricle. During REM
sleep, HR was 133 ± 10 beats/min, MAP was 65 ± 3 mmHg, CO was
1,435 ± 69 ml/min, and TPR was 0.046 ± 0.004 mmHg · ml 1 · min.
During AO, CO decreased by 90 ± 17 ml/min
( P |
| doi_str_mv | 10.1152/jappl.1997.82.5.1637 |
| format | Article |
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Zinkovska and
Debra A.
Kirby
Children's Hospital, Harvard Medical School, Boston 02115; and
Veterans Affairs Medical Center, West Roxbury, Massachusetts
02132
Received 19 July 1995; accepted in final form 19 November 1996.
Zinkovska, Sophia, and Debra A. Kirby.
Intracerebroventricular propranolol prevented vascular resistance
increases on arousal from sleep apnea. J. Appl.
Physiol. 82(5): 1637-1643, 1997. Despite the
increased risk of sudden cardiac death associated with sleep apnea,
little is known about mechanisms controlling cardiovascular responses
to sleep apnea and arousal. Chronically instrumented pigs were used to
investigate the effects of airway obstruction (AO) during
rapid-eye-movement (REM) and non-REM (NREM) sleep and arousal on mean
arterial pressure (MAP), heart rate (HR), cardiac output (CO), and
total peripheral resistance (TPR). A stainless steel
cannula was implanted in the lateral cerebral ventricle. During REM
sleep, HR was 133 ± 10 beats/min, MAP was 65 ± 3 mmHg, CO was
1,435 ± 69 ml/min, and TPR was 0.046 ± 0.004 mmHg · ml 1 · min.
During AO, CO decreased by 90 ± 17 ml/min
( P < 0.05). On arousal from AO, MAP
increased by 15 ± 3 mmHg, HR increased by 10 ± 3 beats/min, and
TPR increased by 0.008 ± 0.001 mmHg · ml 1 · min
(all P < 0.05). Changes during NREM
were similar but were more modest during AO. After the
intracerebroventricular administration of propranolol (50 µg/kg; a
-adrenoreceptor blocking agent), decreases in CO during AO and
increases in HR during arousal were intact, but increases in MAP and
TPR were no longer significant. These data suggest that
vascular responses to AO during sleep may be regulated in part by
-adrenergic receptors in the central nervous system.
brain; -adrenoreceptor; pig
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1997.82.5.1637</identifier><identifier>PMID: 9134914</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Airway Obstruction - physiopathology ; Animals ; Arousal - physiology ; Biological and medical sciences ; Endothelium, Vascular - chemistry ; Endothelium, Vascular - physiology ; Hemodynamics - physiology ; Injections, Intraventricular ; Medical sciences ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Propranolol - pharmacology ; Receptors, Adrenergic, beta - physiology ; Sleep Apnea Syndromes - physiopathology ; Sleep, REM - physiology ; Swine ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Vascular Resistance - drug effects ; Vasodilator Agents - pharmacology</subject><ispartof>Journal of applied physiology (1985), 1997-05, Vol.82 (5), p.1637-1643</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-e558db165de3c692a49814d1effc758bcd0ad86034ba52a74de97e48dddd9e0f3</citedby><cites>FETCH-LOGICAL-c455t-e558db165de3c692a49814d1effc758bcd0ad86034ba52a74de97e48dddd9e0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2670079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9134914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zinkovska, Sophia</creatorcontrib><creatorcontrib>Kirby, Debra A</creatorcontrib><title>Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Sophia
Zinkovska and
Debra A.
Kirby
Children's Hospital, Harvard Medical School, Boston 02115; and
Veterans Affairs Medical Center, West Roxbury, Massachusetts
02132
Received 19 July 1995; accepted in final form 19 November 1996.
Zinkovska, Sophia, and Debra A. Kirby.
Intracerebroventricular propranolol prevented vascular resistance
increases on arousal from sleep apnea. J. Appl.
Physiol. 82(5): 1637-1643, 1997. Despite the
increased risk of sudden cardiac death associated with sleep apnea,
little is known about mechanisms controlling cardiovascular responses
to sleep apnea and arousal. Chronically instrumented pigs were used to
investigate the effects of airway obstruction (AO) during
rapid-eye-movement (REM) and non-REM (NREM) sleep and arousal on mean
arterial pressure (MAP), heart rate (HR), cardiac output (CO), and
total peripheral resistance (TPR). A stainless steel
cannula was implanted in the lateral cerebral ventricle. During REM
sleep, HR was 133 ± 10 beats/min, MAP was 65 ± 3 mmHg, CO was
1,435 ± 69 ml/min, and TPR was 0.046 ± 0.004 mmHg · ml 1 · min.
During AO, CO decreased by 90 ± 17 ml/min
( P < 0.05). On arousal from AO, MAP
increased by 15 ± 3 mmHg, HR increased by 10 ± 3 beats/min, and
TPR increased by 0.008 ± 0.001 mmHg · ml 1 · min
(all P < 0.05). Changes during NREM
were similar but were more modest during AO. After the
intracerebroventricular administration of propranolol (50 µg/kg; a
-adrenoreceptor blocking agent), decreases in CO during AO and
increases in HR during arousal were intact, but increases in MAP and
TPR were no longer significant. These data suggest that
vascular responses to AO during sleep may be regulated in part by
-adrenergic receptors in the central nervous system.
brain; -adrenoreceptor; pig
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Airway Obstruction - physiopathology</subject><subject>Animals</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Endothelium, Vascular - chemistry</subject><subject>Endothelium, Vascular - physiology</subject><subject>Hemodynamics - physiology</subject><subject>Injections, Intraventricular</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Propranolol - pharmacology</subject><subject>Receptors, Adrenergic, beta - physiology</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sleep, REM - physiology</subject><subject>Swine</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Vascular Resistance - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv1DAQhS1EVZbCPwApB4S4JLUTO7aPqKJQqRKX9mxN7MluKm9i7KSw_x6nu1qJA77Yo_fezPgj5AOjFWOivn6CEHzFtJaVqitRsbaRr8gmS3XJWspek42SgpZSKPmGvE3piVLGuWCX5FKzhmvGN2R7N84RLEbs4vSMuRjs4iEWIU4hwjj5yec3rhK64hnSUY6YhjTDaLEYRhsREqZiGguI05LAF32c9kXyiKGAMCK8Ixc9-ITvT_cVebz99nDzo7z_-f3u5ut9abkQc4lCKNexVjhsbKtr4Fox7hj2vc3_6Kyj4FRLG96BqEFyh1oiVy4fjbRvrsjnY9-8_68F02z2Q7LoPYyYNzNSUyUEF9nIj0Ybp5Qi9ibEYQ_xYBg1K1_zwtesfI2qjTAr3xz7eOq_dHt059AJaNY_nfRMCnyfEdohnW11KymVOtu-HG27Ybv7PUQ0YXdIQ6a9PayD_5nI_2-9Xbx_wD_zmjlHTHB98xfiJ6nR</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>Zinkovska, Sophia</creator><creator>Kirby, Debra A</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970501</creationdate><title>Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea</title><author>Zinkovska, Sophia ; Kirby, Debra A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-e558db165de3c692a49814d1effc758bcd0ad86034ba52a74de97e48dddd9e0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Airway Obstruction - physiopathology</topic><topic>Animals</topic><topic>Arousal - physiology</topic><topic>Biological and medical sciences</topic><topic>Endothelium, Vascular - chemistry</topic><topic>Endothelium, Vascular - physiology</topic><topic>Hemodynamics - physiology</topic><topic>Injections, Intraventricular</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Propranolol - pharmacology</topic><topic>Receptors, Adrenergic, beta - physiology</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><topic>Sleep, REM - physiology</topic><topic>Swine</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zinkovska, Sophia</creatorcontrib><creatorcontrib>Kirby, Debra A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zinkovska, Sophia</au><au>Kirby, Debra A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>82</volume><issue>5</issue><spage>1637</spage><epage>1643</epage><pages>1637-1643</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Sophia
Zinkovska and
Debra A.
Kirby
Children's Hospital, Harvard Medical School, Boston 02115; and
Veterans Affairs Medical Center, West Roxbury, Massachusetts
02132
Received 19 July 1995; accepted in final form 19 November 1996.
Zinkovska, Sophia, and Debra A. Kirby.
Intracerebroventricular propranolol prevented vascular resistance
increases on arousal from sleep apnea. J. Appl.
Physiol. 82(5): 1637-1643, 1997. Despite the
increased risk of sudden cardiac death associated with sleep apnea,
little is known about mechanisms controlling cardiovascular responses
to sleep apnea and arousal. Chronically instrumented pigs were used to
investigate the effects of airway obstruction (AO) during
rapid-eye-movement (REM) and non-REM (NREM) sleep and arousal on mean
arterial pressure (MAP), heart rate (HR), cardiac output (CO), and
total peripheral resistance (TPR). A stainless steel
cannula was implanted in the lateral cerebral ventricle. During REM
sleep, HR was 133 ± 10 beats/min, MAP was 65 ± 3 mmHg, CO was
1,435 ± 69 ml/min, and TPR was 0.046 ± 0.004 mmHg · ml 1 · min.
During AO, CO decreased by 90 ± 17 ml/min
( P < 0.05). On arousal from AO, MAP
increased by 15 ± 3 mmHg, HR increased by 10 ± 3 beats/min, and
TPR increased by 0.008 ± 0.001 mmHg · ml 1 · min
(all P < 0.05). Changes during NREM
were similar but were more modest during AO. After the
intracerebroventricular administration of propranolol (50 µg/kg; a
-adrenoreceptor blocking agent), decreases in CO during AO and
increases in HR during arousal were intact, but increases in MAP and
TPR were no longer significant. These data suggest that
vascular responses to AO during sleep may be regulated in part by
-adrenergic receptors in the central nervous system.
brain; -adrenoreceptor; pig
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9134914</pmid><doi>10.1152/jappl.1997.82.5.1637</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of applied physiology (1985), 1997-05, Vol.82 (5), p.1637-1643 |
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| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adrenergic beta-Antagonists - pharmacology Airway Obstruction - physiopathology Animals Arousal - physiology Biological and medical sciences Endothelium, Vascular - chemistry Endothelium, Vascular - physiology Hemodynamics - physiology Injections, Intraventricular Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology Propranolol - pharmacology Receptors, Adrenergic, beta - physiology Sleep Apnea Syndromes - physiopathology Sleep, REM - physiology Swine Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Vascular Resistance - drug effects Vasodilator Agents - pharmacology |
| title | Intracerebroventricular propranolol prevented vascular resistance increases on arousal from sleep apnea |
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