Lactate and epinephrine during exercise in altitude natives
Bengt Kayser, Roland Favier, Guido Ferretti, Dominique Desplanches, Hilde Spielvogel, Harry Koubi, Brigitte Sempore, and Hans Hoppeler Département de Physiologie, Centre Médical Universitaire, 1211 Geneva 4; Anatomisches Institut, Universität Bern, 1000 Berne, Switzerland; Unité de Recherche Associé...
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| creator | Kayser, Bengt Favier, Roland Ferretti, Guido Desplanches, Dominique Spielvogel, Hilde Koubi, Harry Sempore, Brigitte Hoppeler, Hans |
| description | Bengt
Kayser,
Roland
Favier,
Guido
Ferretti,
Dominique
Desplanches,
Hilde
Spielvogel,
Harry
Koubi,
Brigitte
Sempore, and
Hans
Hoppeler
Département de Physiologie, Centre Médical
Universitaire, 1211 Geneva 4; Anatomisches Institut, Universität
Bern, 1000 Berne, Switzerland; Unité de Recherche Associé
1341, Centre National de la Recherche Scientifique, Laboratoire de
Physiologie, Université Claude Bernard, 69373 Lyon Cedex 08, France; and Instituto Boliviano de Biología de Altura,
Universidad Mayor de San Andrés, Casilla 717, La Paz, Bolivia
Received 12 March 1996; accepted in final form 23 July 1996.
Kayser, Bengt, Roland Favier, Guido Ferretti, Dominique
Desplanches, Hilde Spielvogel, Harry Koubi, Brigitte Sempore, and Hans
Hoppeler. Lactate and epinephrine during exercise in altitude
natives. J. Appl. Physiol. 81(6):
2488-2494, 1996. We tested the hypothesis that the reported low
blood lactate accumulation ([La]) during exercise in
altitude-native humans is refractory to hypoxia-normoxia transitions by
investigating whether acute changes in inspired
O 2 fraction
(F I O 2 ) affect the
[La] vs. power output ( )
relationship or, alternatively, as reported for lowlanders, whether
changes in [La] vs. on changes in
F I O 2 are related to
changes in blood epinephrine concentration ([Epi]). Altitude natives [ n = 8, age 24 ± 1 (SE) yr, body mass 62 ± 3 kg, height 167 ± 2 cm]
in La Paz, Bolivia (3,600 m) performed incremental exercise with two
legs and one leg in chronic hypoxia and acute normoxia (AN). Submaximal
one- and two-leg O 2 uptake ( O 2 ) vs.
relationships were not altered by
F I O 2 . AN increased two-leg
peak O 2 by 10% and peak
by 7%. AN paradoxically decreased
one-leg peak O 2 by 7%,
whereas peak remained the same. The
[La] vs. relationships were similar to
those reported in unacclimatized lowlanders. There was a shift to the
right on AN, and maximum [La] was reduced by 7 and 8% for
one- and two-leg exercises, respectively. [Epi] and
[La] were tightly related (mean r = 0.81) independently of
F I O 2 . Thus normoxia
attenuated the increment in both [La] and [Epi]
as a function of , whereas the correlation between
[La] and [Epi] was unaffected. These data suggest loose linkage of glycolysis to oxidative phosphorylation under influence from [Epi]. In conclusion, high-altitude
natives appear to be not fundamentally different from lowlanders with regard to the effect of acute changes in
F I O 2 on [La] during exercise.
lactate paradox; energetics
0161- |
| doi_str_mv | 10.1152/jappl.1996.81.6.2488 |
| format | Article |
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Kayser,
Roland
Favier,
Guido
Ferretti,
Dominique
Desplanches,
Hilde
Spielvogel,
Harry
Koubi,
Brigitte
Sempore, and
Hans
Hoppeler
Département de Physiologie, Centre Médical
Universitaire, 1211 Geneva 4; Anatomisches Institut, Universität
Bern, 1000 Berne, Switzerland; Unité de Recherche Associé
1341, Centre National de la Recherche Scientifique, Laboratoire de
Physiologie, Université Claude Bernard, 69373 Lyon Cedex 08, France; and Instituto Boliviano de Biología de Altura,
Universidad Mayor de San Andrés, Casilla 717, La Paz, Bolivia
Received 12 March 1996; accepted in final form 23 July 1996.
Kayser, Bengt, Roland Favier, Guido Ferretti, Dominique
Desplanches, Hilde Spielvogel, Harry Koubi, Brigitte Sempore, and Hans
Hoppeler. Lactate and epinephrine during exercise in altitude
natives. J. Appl. Physiol. 81(6):
2488-2494, 1996. We tested the hypothesis that the reported low
blood lactate accumulation ([La]) during exercise in
altitude-native humans is refractory to hypoxia-normoxia transitions by
investigating whether acute changes in inspired
O 2 fraction
(F I O 2 ) affect the
[La] vs. power output ( )
relationship or, alternatively, as reported for lowlanders, whether
changes in [La] vs. on changes in
F I O 2 are related to
changes in blood epinephrine concentration ([Epi]). Altitude natives [ n = 8, age 24 ± 1 (SE) yr, body mass 62 ± 3 kg, height 167 ± 2 cm]
in La Paz, Bolivia (3,600 m) performed incremental exercise with two
legs and one leg in chronic hypoxia and acute normoxia (AN). Submaximal
one- and two-leg O 2 uptake ( O 2 ) vs.
relationships were not altered by
F I O 2 . AN increased two-leg
peak O 2 by 10% and peak
by 7%. AN paradoxically decreased
one-leg peak O 2 by 7%,
whereas peak remained the same. The
[La] vs. relationships were similar to
those reported in unacclimatized lowlanders. There was a shift to the
right on AN, and maximum [La] was reduced by 7 and 8% for
one- and two-leg exercises, respectively. [Epi] and
[La] were tightly related (mean r = 0.81) independently of
F I O 2 . Thus normoxia
attenuated the increment in both [La] and [Epi]
as a function of , whereas the correlation between
[La] and [Epi] was unaffected. These data suggest loose linkage of glycolysis to oxidative phosphorylation under influence from [Epi]. In conclusion, high-altitude
natives appear to be not fundamentally different from lowlanders with regard to the effect of acute changes in
F I O 2 on [La] during exercise.
lactate paradox; energetics
0161-7567/96 $5.00
Copyright © 1996 the American Physiological Society</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1996.81.6.2488</identifier><identifier>PMID: 9018496</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adult ; Altitude ; Biological and medical sciences ; Epinephrine - metabolism ; Exercise - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Lactates - metabolism ; Male ; Space life sciences ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Journal of applied physiology (1985), 1996-12, Vol.81 (6), p.2488-2494</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-7621f65e2a8a87399c947bba52b95b6875e4671066aa048222b1cde529f52d63</citedby><cites>FETCH-LOGICAL-c517t-7621f65e2a8a87399c947bba52b95b6875e4671066aa048222b1cde529f52d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2530442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9018496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kayser, Bengt</creatorcontrib><creatorcontrib>Favier, Roland</creatorcontrib><creatorcontrib>Ferretti, Guido</creatorcontrib><creatorcontrib>Desplanches, Dominique</creatorcontrib><creatorcontrib>Spielvogel, Hilde</creatorcontrib><creatorcontrib>Koubi, Harry</creatorcontrib><creatorcontrib>Sempore, Brigitte</creatorcontrib><creatorcontrib>Hoppeler, Hans</creatorcontrib><title>Lactate and epinephrine during exercise in altitude natives</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Bengt
Kayser,
Roland
Favier,
Guido
Ferretti,
Dominique
Desplanches,
Hilde
Spielvogel,
Harry
Koubi,
Brigitte
Sempore, and
Hans
Hoppeler
Département de Physiologie, Centre Médical
Universitaire, 1211 Geneva 4; Anatomisches Institut, Universität
Bern, 1000 Berne, Switzerland; Unité de Recherche Associé
1341, Centre National de la Recherche Scientifique, Laboratoire de
Physiologie, Université Claude Bernard, 69373 Lyon Cedex 08, France; and Instituto Boliviano de Biología de Altura,
Universidad Mayor de San Andrés, Casilla 717, La Paz, Bolivia
Received 12 March 1996; accepted in final form 23 July 1996.
Kayser, Bengt, Roland Favier, Guido Ferretti, Dominique
Desplanches, Hilde Spielvogel, Harry Koubi, Brigitte Sempore, and Hans
Hoppeler. Lactate and epinephrine during exercise in altitude
natives. J. Appl. Physiol. 81(6):
2488-2494, 1996. We tested the hypothesis that the reported low
blood lactate accumulation ([La]) during exercise in
altitude-native humans is refractory to hypoxia-normoxia transitions by
investigating whether acute changes in inspired
O 2 fraction
(F I O 2 ) affect the
[La] vs. power output ( )
relationship or, alternatively, as reported for lowlanders, whether
changes in [La] vs. on changes in
F I O 2 are related to
changes in blood epinephrine concentration ([Epi]). Altitude natives [ n = 8, age 24 ± 1 (SE) yr, body mass 62 ± 3 kg, height 167 ± 2 cm]
in La Paz, Bolivia (3,600 m) performed incremental exercise with two
legs and one leg in chronic hypoxia and acute normoxia (AN). Submaximal
one- and two-leg O 2 uptake ( O 2 ) vs.
relationships were not altered by
F I O 2 . AN increased two-leg
peak O 2 by 10% and peak
by 7%. AN paradoxically decreased
one-leg peak O 2 by 7%,
whereas peak remained the same. The
[La] vs. relationships were similar to
those reported in unacclimatized lowlanders. There was a shift to the
right on AN, and maximum [La] was reduced by 7 and 8% for
one- and two-leg exercises, respectively. [Epi] and
[La] were tightly related (mean r = 0.81) independently of
F I O 2 . Thus normoxia
attenuated the increment in both [La] and [Epi]
as a function of , whereas the correlation between
[La] and [Epi] was unaffected. These data suggest loose linkage of glycolysis to oxidative phosphorylation under influence from [Epi]. In conclusion, high-altitude
natives appear to be not fundamentally different from lowlanders with regard to the effect of acute changes in
F I O 2 on [La] during exercise.
lactate paradox; energetics
0161-7567/96 $5.00
Copyright © 1996 the American Physiological Society</description><subject>Adult</subject><subject>Altitude</subject><subject>Biological and medical sciences</subject><subject>Epinephrine - metabolism</subject><subject>Exercise - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lactates - metabolism</subject><subject>Male</subject><subject>Space life sciences</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVoSLdpv0EKPpSSi12NrL_0VELTBhZ62buQ7fGugtd2JbvJfvvK2WWhh5LLzOH93swwj5AboAWAYF8e3Th2BRgjCw2FLBjX-oKsksRykBTekJVWguZKaPWWvIvxkVLgXMAVuTIUNDdyRb6uXT25CTPXNxmOvsdxF1LNmjm1bYbPGGofMfN95rrJT3ODWe8m_wfje3LZui7ih1O_Jpv775u7n_n614-Hu2_rvBagplxJBq0UyJx2WpXG1IarqnKCVUZUMt2IXCqgUjpHuWaMVVA3KJhpBWtkeU0-H8eOYfg9Y5zs3scau871OMzRKi21oPR1kElQUvPyVRC05kIbnkB-BOswxBiwtWPwexcOFqhdQrAvIdglBKvBSruEkGwfT_Pnao_N2XT6etI_nXQXa9e1wfXpx2eMiZJyzhJ2e8R2frt78gHtuDtEP3TD9rAs_mcj_z96P3fdBp-nxXO22LFpy7974rB-</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Kayser, Bengt</creator><creator>Favier, Roland</creator><creator>Ferretti, Guido</creator><creator>Desplanches, Dominique</creator><creator>Spielvogel, Hilde</creator><creator>Koubi, Harry</creator><creator>Sempore, Brigitte</creator><creator>Hoppeler, Hans</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Lactate and epinephrine during exercise in altitude natives</title><author>Kayser, Bengt ; Favier, Roland ; Ferretti, Guido ; Desplanches, Dominique ; Spielvogel, Hilde ; Koubi, Harry ; Sempore, Brigitte ; Hoppeler, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-7621f65e2a8a87399c947bba52b95b6875e4671066aa048222b1cde529f52d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Altitude</topic><topic>Biological and medical sciences</topic><topic>Epinephrine - metabolism</topic><topic>Exercise - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lactates - metabolism</topic><topic>Male</topic><topic>Space life sciences</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kayser, Bengt</creatorcontrib><creatorcontrib>Favier, Roland</creatorcontrib><creatorcontrib>Ferretti, Guido</creatorcontrib><creatorcontrib>Desplanches, Dominique</creatorcontrib><creatorcontrib>Spielvogel, Hilde</creatorcontrib><creatorcontrib>Koubi, Harry</creatorcontrib><creatorcontrib>Sempore, Brigitte</creatorcontrib><creatorcontrib>Hoppeler, Hans</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kayser, Bengt</au><au>Favier, Roland</au><au>Ferretti, Guido</au><au>Desplanches, Dominique</au><au>Spielvogel, Hilde</au><au>Koubi, Harry</au><au>Sempore, Brigitte</au><au>Hoppeler, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactate and epinephrine during exercise in altitude natives</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>81</volume><issue>6</issue><spage>2488</spage><epage>2494</epage><pages>2488-2494</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Bengt
Kayser,
Roland
Favier,
Guido
Ferretti,
Dominique
Desplanches,
Hilde
Spielvogel,
Harry
Koubi,
Brigitte
Sempore, and
Hans
Hoppeler
Département de Physiologie, Centre Médical
Universitaire, 1211 Geneva 4; Anatomisches Institut, Universität
Bern, 1000 Berne, Switzerland; Unité de Recherche Associé
1341, Centre National de la Recherche Scientifique, Laboratoire de
Physiologie, Université Claude Bernard, 69373 Lyon Cedex 08, France; and Instituto Boliviano de Biología de Altura,
Universidad Mayor de San Andrés, Casilla 717, La Paz, Bolivia
Received 12 March 1996; accepted in final form 23 July 1996.
Kayser, Bengt, Roland Favier, Guido Ferretti, Dominique
Desplanches, Hilde Spielvogel, Harry Koubi, Brigitte Sempore, and Hans
Hoppeler. Lactate and epinephrine during exercise in altitude
natives. J. Appl. Physiol. 81(6):
2488-2494, 1996. We tested the hypothesis that the reported low
blood lactate accumulation ([La]) during exercise in
altitude-native humans is refractory to hypoxia-normoxia transitions by
investigating whether acute changes in inspired
O 2 fraction
(F I O 2 ) affect the
[La] vs. power output ( )
relationship or, alternatively, as reported for lowlanders, whether
changes in [La] vs. on changes in
F I O 2 are related to
changes in blood epinephrine concentration ([Epi]). Altitude natives [ n = 8, age 24 ± 1 (SE) yr, body mass 62 ± 3 kg, height 167 ± 2 cm]
in La Paz, Bolivia (3,600 m) performed incremental exercise with two
legs and one leg in chronic hypoxia and acute normoxia (AN). Submaximal
one- and two-leg O 2 uptake ( O 2 ) vs.
relationships were not altered by
F I O 2 . AN increased two-leg
peak O 2 by 10% and peak
by 7%. AN paradoxically decreased
one-leg peak O 2 by 7%,
whereas peak remained the same. The
[La] vs. relationships were similar to
those reported in unacclimatized lowlanders. There was a shift to the
right on AN, and maximum [La] was reduced by 7 and 8% for
one- and two-leg exercises, respectively. [Epi] and
[La] were tightly related (mean r = 0.81) independently of
F I O 2 . Thus normoxia
attenuated the increment in both [La] and [Epi]
as a function of , whereas the correlation between
[La] and [Epi] was unaffected. These data suggest loose linkage of glycolysis to oxidative phosphorylation under influence from [Epi]. In conclusion, high-altitude
natives appear to be not fundamentally different from lowlanders with regard to the effect of acute changes in
F I O 2 on [La] during exercise.
lactate paradox; energetics
0161-7567/96 $5.00
Copyright © 1996 the American Physiological Society</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9018496</pmid><doi>10.1152/jappl.1996.81.6.2488</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of applied physiology (1985), 1996-12, Vol.81 (6), p.2488-2494 |
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| language | eng |
| recordid | cdi_highwire_physiology_jap_81_6_2488 |
| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Altitude Biological and medical sciences Epinephrine - metabolism Exercise - physiology Fundamental and applied biological sciences. Psychology Humans Lactates - metabolism Male Space life sciences Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Lactate and epinephrine during exercise in altitude natives |
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