Intravertebral ANG II effects on plasma renin and Na excretion in dogs at constant renal artery pressure
E. W. Quillen Jr and I. A. Reid Department of Physiology, University of California at San Francisco 94143. Studies were performed to determine whether intravertebral angiotensin II infusion (iva ANG II) decreases renin release by increasing renal perfusion pressure (RPP) and to investigate possible...
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Veröffentlicht in: | American journal of physiology. Renal physiology 1995-02, Vol.268 (2), p.296-F301 |
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container_title | American journal of physiology. Renal physiology |
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creator | Quillen, E. W., Jr Reid, I. A |
description | E. W. Quillen Jr and I. A. Reid
Department of Physiology, University of California at San Francisco 94143.
Studies were performed to determine whether intravertebral angiotensin II
infusion (iva ANG II) decreases renin release by increasing renal perfusion
pressure (RPP) and to investigate possible effects of iva ANG II on renal
function. RPP was electronically servocontrolled in 12 conscious dogs
equipped with chronic vascular catheters and a suprarenal aortic balloon
constrictor while iva ANG II was infused bilaterally for 60 min at 0.33
ng.kg-1.min-1. Without servocontrol, iva ANG II increased mean arterial
pressure (MAP) from 101 +/- 4 to 106 +/- 5 mmHg, urine flow (V) from 0.36
+/- 0.03 to 0.45 +/- 0.04 ml/min, and sodium excretion (UNaV) from 36.2 +/-
7.0 to 62.7 +/- 6.6 mumol/min. Plasma renin activity (PRA) decreased from
6.9 +/- 0.7 to 5.0 +/- 0.6 ng ANG I.ml-1.3 h-1. With servocontrol, iva ANG
II increased MAP from 102 +/- 4 to 109 +/- 5 mmHg while RPP remained
constant with a variation of less than +/- 1 mmHg. PRA did not change
significantly (5.9 +/- 0.3 to 7.0 +/- 0.7 ng ANG I.ml-1.3 h-1). V decreased
from 0.33 +/- 0.02 to 0.26 +/- 0.01 ml/min, and UNaV decreased from 49.0
+/- 5.7 to 29.7 +/- 4.4 mumol/min. The data provide evidence that iva ANG
II decreases renin release by increasing RPP and stimulating the renal
baroreceptor and/or the macula densa mechanisms. In addition, at constant
RPP, ANG II exerts a central action to decrease UNaV. |
doi_str_mv | 10.1152/ajprenal.1995.268.2.F296 |
format | Article |
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Department of Physiology, University of California at San Francisco 94143.
Studies were performed to determine whether intravertebral angiotensin II
infusion (iva ANG II) decreases renin release by increasing renal perfusion
pressure (RPP) and to investigate possible effects of iva ANG II on renal
function. RPP was electronically servocontrolled in 12 conscious dogs
equipped with chronic vascular catheters and a suprarenal aortic balloon
constrictor while iva ANG II was infused bilaterally for 60 min at 0.33
ng.kg-1.min-1. Without servocontrol, iva ANG II increased mean arterial
pressure (MAP) from 101 +/- 4 to 106 +/- 5 mmHg, urine flow (V) from 0.36
+/- 0.03 to 0.45 +/- 0.04 ml/min, and sodium excretion (UNaV) from 36.2 +/-
7.0 to 62.7 +/- 6.6 mumol/min. Plasma renin activity (PRA) decreased from
6.9 +/- 0.7 to 5.0 +/- 0.6 ng ANG I.ml-1.3 h-1. With servocontrol, iva ANG
II increased MAP from 102 +/- 4 to 109 +/- 5 mmHg while RPP remained
constant with a variation of less than +/- 1 mmHg. PRA did not change
significantly (5.9 +/- 0.3 to 7.0 +/- 0.7 ng ANG I.ml-1.3 h-1). V decreased
from 0.33 +/- 0.02 to 0.26 +/- 0.01 ml/min, and UNaV decreased from 49.0
+/- 5.7 to 29.7 +/- 4.4 mumol/min. The data provide evidence that iva ANG
II decreases renin release by increasing RPP and stimulating the renal
baroreceptor and/or the macula densa mechanisms. In addition, at constant
RPP, ANG II exerts a central action to decrease UNaV.</description><identifier>ISSN: 0363-6127</identifier><identifier>ISSN: 0002-9513</identifier><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 2161-1157</identifier><identifier>EISSN: 1522-1466</identifier><identifier>DOI: 10.1152/ajprenal.1995.268.2.F296</identifier><identifier>PMID: 7864169</identifier><language>eng</language><publisher>United States</publisher><subject>Angiotensin II - administration & dosage ; Angiotensin II - pharmacology ; Animals ; Blood Pressure ; Dogs ; Injections, Intravenous ; Injections, Spinal ; Natriuresis - drug effects ; Renal Artery - physiology ; Renin - blood ; Time Factors</subject><ispartof>American journal of physiology. Renal physiology, 1995-02, Vol.268 (2), p.296-F301</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7864169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quillen, E. W., Jr</creatorcontrib><creatorcontrib>Reid, I. A</creatorcontrib><title>Intravertebral ANG II effects on plasma renin and Na excretion in dogs at constant renal artery pressure</title><title>American journal of physiology. Renal physiology</title><addtitle>Am J Physiol</addtitle><description>E. W. Quillen Jr and I. A. Reid
Department of Physiology, University of California at San Francisco 94143.
Studies were performed to determine whether intravertebral angiotensin II
infusion (iva ANG II) decreases renin release by increasing renal perfusion
pressure (RPP) and to investigate possible effects of iva ANG II on renal
function. RPP was electronically servocontrolled in 12 conscious dogs
equipped with chronic vascular catheters and a suprarenal aortic balloon
constrictor while iva ANG II was infused bilaterally for 60 min at 0.33
ng.kg-1.min-1. Without servocontrol, iva ANG II increased mean arterial
pressure (MAP) from 101 +/- 4 to 106 +/- 5 mmHg, urine flow (V) from 0.36
+/- 0.03 to 0.45 +/- 0.04 ml/min, and sodium excretion (UNaV) from 36.2 +/-
7.0 to 62.7 +/- 6.6 mumol/min. Plasma renin activity (PRA) decreased from
6.9 +/- 0.7 to 5.0 +/- 0.6 ng ANG I.ml-1.3 h-1. With servocontrol, iva ANG
II increased MAP from 102 +/- 4 to 109 +/- 5 mmHg while RPP remained
constant with a variation of less than +/- 1 mmHg. PRA did not change
significantly (5.9 +/- 0.3 to 7.0 +/- 0.7 ng ANG I.ml-1.3 h-1). V decreased
from 0.33 +/- 0.02 to 0.26 +/- 0.01 ml/min, and UNaV decreased from 49.0
+/- 5.7 to 29.7 +/- 4.4 mumol/min. The data provide evidence that iva ANG
II decreases renin release by increasing RPP and stimulating the renal
baroreceptor and/or the macula densa mechanisms. In addition, at constant
RPP, ANG II exerts a central action to decrease UNaV.</description><subject>Angiotensin II - administration & dosage</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Blood Pressure</subject><subject>Dogs</subject><subject>Injections, Intravenous</subject><subject>Injections, Spinal</subject><subject>Natriuresis - drug effects</subject><subject>Renal Artery - physiology</subject><subject>Renin - blood</subject><subject>Time Factors</subject><issn>0363-6127</issn><issn>0002-9513</issn><issn>1931-857X</issn><issn>2161-1157</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE9v2zAMxYViQ5Zm_QgDdNrNniXb-nMsgjULUKSX9izQMpU4cGxPUrbl21dZsrUnAnyPj-SPEMqKnLGaf4P95HGAPmda1zkXKuf5A9fihsw5EyxLJvmBzItSlJlgXH4ityHsi4Inq5iRmVSiYkLPyW49RA-_0EdsPPT0frOi6zVF59DGQMeBTj2EA9C0rhsoDC3dAMU_1mPskpp67bgNFCK14xAiDJH-vYxCivQnmu4M4ejxM_nooA94d60L8vLw_Xn5I3t8Wq2X94-Z5bqKmdRlU9daq8bxWrpaaOdaVUhXKWllxdEqKEVbAEpshVW6tiWmX6pGcqgdLxfk6yV38uPPI4ZoDl2w2Pcw4HgMRkpWKaFFMqqL0foxBI_OTL47gD8ZVpgzZPMPsjlDNomc4eYMOY1-ue44Ngds_w9eqSY9v-i7brv73Xk00-4UurEft6e31HeBrwrzjIs</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>Quillen, E. W., Jr</creator><creator>Reid, I. A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950201</creationdate><title>Intravertebral ANG II effects on plasma renin and Na excretion in dogs at constant renal artery pressure</title><author>Quillen, E. W., Jr ; Reid, I. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c294t-793b55998bf257f569ffd807f487c742ec8a36d0ae7ed6c895c3e6414b72a5f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Angiotensin II - administration & dosage</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Blood Pressure</topic><topic>Dogs</topic><topic>Injections, Intravenous</topic><topic>Injections, Spinal</topic><topic>Natriuresis - drug effects</topic><topic>Renal Artery - physiology</topic><topic>Renin - blood</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quillen, E. W., Jr</creatorcontrib><creatorcontrib>Reid, I. A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Renal physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quillen, E. W., Jr</au><au>Reid, I. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravertebral ANG II effects on plasma renin and Na excretion in dogs at constant renal artery pressure</atitle><jtitle>American journal of physiology. Renal physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>268</volume><issue>2</issue><spage>296</spage><epage>F301</epage><pages>296-F301</pages><issn>0363-6127</issn><issn>0002-9513</issn><issn>1931-857X</issn><eissn>2161-1157</eissn><eissn>1522-1466</eissn><abstract>E. W. Quillen Jr and I. A. Reid
Department of Physiology, University of California at San Francisco 94143.
Studies were performed to determine whether intravertebral angiotensin II
infusion (iva ANG II) decreases renin release by increasing renal perfusion
pressure (RPP) and to investigate possible effects of iva ANG II on renal
function. RPP was electronically servocontrolled in 12 conscious dogs
equipped with chronic vascular catheters and a suprarenal aortic balloon
constrictor while iva ANG II was infused bilaterally for 60 min at 0.33
ng.kg-1.min-1. Without servocontrol, iva ANG II increased mean arterial
pressure (MAP) from 101 +/- 4 to 106 +/- 5 mmHg, urine flow (V) from 0.36
+/- 0.03 to 0.45 +/- 0.04 ml/min, and sodium excretion (UNaV) from 36.2 +/-
7.0 to 62.7 +/- 6.6 mumol/min. Plasma renin activity (PRA) decreased from
6.9 +/- 0.7 to 5.0 +/- 0.6 ng ANG I.ml-1.3 h-1. With servocontrol, iva ANG
II increased MAP from 102 +/- 4 to 109 +/- 5 mmHg while RPP remained
constant with a variation of less than +/- 1 mmHg. PRA did not change
significantly (5.9 +/- 0.3 to 7.0 +/- 0.7 ng ANG I.ml-1.3 h-1). V decreased
from 0.33 +/- 0.02 to 0.26 +/- 0.01 ml/min, and UNaV decreased from 49.0
+/- 5.7 to 29.7 +/- 4.4 mumol/min. The data provide evidence that iva ANG
II decreases renin release by increasing RPP and stimulating the renal
baroreceptor and/or the macula densa mechanisms. In addition, at constant
RPP, ANG II exerts a central action to decrease UNaV.</abstract><cop>United States</cop><pmid>7864169</pmid><doi>10.1152/ajprenal.1995.268.2.F296</doi></addata></record> |
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source | MEDLINE; Alma/SFX Local Collection |
subjects | Angiotensin II - administration & dosage Angiotensin II - pharmacology Animals Blood Pressure Dogs Injections, Intravenous Injections, Spinal Natriuresis - drug effects Renal Artery - physiology Renin - blood Time Factors |
title | Intravertebral ANG II effects on plasma renin and Na excretion in dogs at constant renal artery pressure |
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