Relationship between mineralocorticoids and renal Na+-K+-ATPase: sodium reabsorption
C. Westenfelder, G. J. Arevalo, R. L. Baranowski, N. A. Kurtzman and A. I. Katz To evaluate the mechanism responsible for the effect of deoxycorticosterone acetate (DOCA) on renal Na+-K+-ATPase, we compared the relative contribution of this hormone and of increased absolute sodium reabsorption (TNa)...
Gespeichert in:
| Veröffentlicht in: | American journal of physiology. Renal physiology 1977-12, Vol.233 (6), p.593-F599 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | F599 |
|---|---|
| container_issue | 6 |
| container_start_page | 593 |
| container_title | American journal of physiology. Renal physiology |
| container_volume | 233 |
| creator | Westenfelder, C Arevalo, G. J Baranowski, R. L Kurtzman, N. A Katz, A. I |
| description | C. Westenfelder, G. J. Arevalo, R. L. Baranowski, N. A. Kurtzman and A. I. Katz
To evaluate the mechanism responsible for the effect of deoxycorticosterone
acetate (DOCA) on renal Na+-K+-ATPase, we compared the relative
contribution of this hormone and of increased absolute sodium reabsorption
(TNa) to the restoration of the enzyme in kidneys of adrenalectomized rats.
In study A, adrenalectomized animals maintained on a salt-free diet
received 5 mg/kg per day DOCA i.m., while sham-operated and untreated
adrenalectomized rats receiving the same diet served as controls. Absolute
TNa and Na+-K+-ATPase specific activity in the cortex and outer medulla of
DOCA-treated rats were similar to those measured in untreated
adrenalectomized animals, but were significantly lower than in
sham-operated controls. In study B, the adrenalectomized rats did not
receive DOCA but were fed a high salt diet and received isotonic saline, 50
ml/kg per day s.c. Absolute TNa and cortical and medullary Na+-K+-ATPase
specific activity were significantly higher in the salt-loaded group than
in both adrenalectomized and sham-operated rats deprived of salt. These
results suggest that absolute sodium reabsorption is a major determinant of
renal Na+-K+-ATPase activity, and that the effect of DOCA on this enzyme is
secondary to its stimulation of absolute tubular sodium transport. |
| doi_str_mv | 10.1152/ajprenal.1977.233.6.F593 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_highw</sourceid><recordid>TN_cdi_highwire_physiology_ajprenal_233_6_F593</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73721502</sourcerecordid><originalsourceid>FETCH-LOGICAL-c225t-8e8438063d0b859aca50c9bc688dd829d1141f754b4248f11142657f641748453</originalsourceid><addsrcrecordid>eNpNkFtLwzAYhoN4mtN_4EWvvBmtOSf1bgyn4lCReR3SNt0y2qYmHWP_3u4gevXx8Z7gASBCMEGI4Xu9ar1pdJWgVIgEE5LwZMpScgIGGHEU9yZxCgaQcBJzhMUluAphBSHGXPILcI4ok1AOwPzTVLqzrglL20aZ6TbGNFFtG-N15XLnO5s7W4RIN0W0X4ze9Ch-HcXj-YcO5iEKrrDrutd0Fpxvd13X4KzUVTA3xzsEX9PH-eQ5nr0_vUzGszjHmHWxNJISCTkpYCZZqnPNYJ5mOZeyKCROC4QoKgWjGcVUlqh_MWei5BQJKikjQ3B36G29-16b0KnahtxUlW6MWwcliMCIQdwb5cGYexeCN6Vqva213yoE1Y6n-uWpdjxVz1NxtePZR2-PG-usNsVfcA-wl5ODvLSL5cZ6o9rlNlhXucX2r_Rf3w9o0YN7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73721502</pqid></control><display><type>article</type><title>Relationship between mineralocorticoids and renal Na+-K+-ATPase: sodium reabsorption</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Westenfelder, C ; Arevalo, G. J ; Baranowski, R. L ; Kurtzman, N. A ; Katz, A. I</creator><creatorcontrib>Westenfelder, C ; Arevalo, G. J ; Baranowski, R. L ; Kurtzman, N. A ; Katz, A. I</creatorcontrib><description>C. Westenfelder, G. J. Arevalo, R. L. Baranowski, N. A. Kurtzman and A. I. Katz
To evaluate the mechanism responsible for the effect of deoxycorticosterone
acetate (DOCA) on renal Na+-K+-ATPase, we compared the relative
contribution of this hormone and of increased absolute sodium reabsorption
(TNa) to the restoration of the enzyme in kidneys of adrenalectomized rats.
In study A, adrenalectomized animals maintained on a salt-free diet
received 5 mg/kg per day DOCA i.m., while sham-operated and untreated
adrenalectomized rats receiving the same diet served as controls. Absolute
TNa and Na+-K+-ATPase specific activity in the cortex and outer medulla of
DOCA-treated rats were similar to those measured in untreated
adrenalectomized animals, but were significantly lower than in
sham-operated controls. In study B, the adrenalectomized rats did not
receive DOCA but were fed a high salt diet and received isotonic saline, 50
ml/kg per day s.c. Absolute TNa and cortical and medullary Na+-K+-ATPase
specific activity were significantly higher in the salt-loaded group than
in both adrenalectomized and sham-operated rats deprived of salt. These
results suggest that absolute sodium reabsorption is a major determinant of
renal Na+-K+-ATPase activity, and that the effect of DOCA on this enzyme is
secondary to its stimulation of absolute tubular sodium transport.</description><identifier>ISSN: 0363-6127</identifier><identifier>ISSN: 0002-9513</identifier><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 2161-1157</identifier><identifier>EISSN: 1522-1466</identifier><identifier>DOI: 10.1152/ajprenal.1977.233.6.F593</identifier><identifier>PMID: 145808</identifier><language>eng</language><publisher>United States</publisher><subject>Adenosine Triphosphatases - metabolism ; Adrenal Glands - physiology ; Adrenalectomy ; Animals ; Desoxycorticosterone - pharmacology ; Glomerular Filtration Rate - drug effects ; Kidney - drug effects ; Kidney - enzymology ; Kidney - physiology ; Male ; Mineralocorticoids - physiology ; Potassium - metabolism ; Rats ; Sodium - metabolism ; Sodium Chloride - pharmacology</subject><ispartof>American journal of physiology. Renal physiology, 1977-12, Vol.233 (6), p.593-F599</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/145808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westenfelder, C</creatorcontrib><creatorcontrib>Arevalo, G. J</creatorcontrib><creatorcontrib>Baranowski, R. L</creatorcontrib><creatorcontrib>Kurtzman, N. A</creatorcontrib><creatorcontrib>Katz, A. I</creatorcontrib><title>Relationship between mineralocorticoids and renal Na+-K+-ATPase: sodium reabsorption</title><title>American journal of physiology. Renal physiology</title><addtitle>Am J Physiol</addtitle><description>C. Westenfelder, G. J. Arevalo, R. L. Baranowski, N. A. Kurtzman and A. I. Katz
To evaluate the mechanism responsible for the effect of deoxycorticosterone
acetate (DOCA) on renal Na+-K+-ATPase, we compared the relative
contribution of this hormone and of increased absolute sodium reabsorption
(TNa) to the restoration of the enzyme in kidneys of adrenalectomized rats.
In study A, adrenalectomized animals maintained on a salt-free diet
received 5 mg/kg per day DOCA i.m., while sham-operated and untreated
adrenalectomized rats receiving the same diet served as controls. Absolute
TNa and Na+-K+-ATPase specific activity in the cortex and outer medulla of
DOCA-treated rats were similar to those measured in untreated
adrenalectomized animals, but were significantly lower than in
sham-operated controls. In study B, the adrenalectomized rats did not
receive DOCA but were fed a high salt diet and received isotonic saline, 50
ml/kg per day s.c. Absolute TNa and cortical and medullary Na+-K+-ATPase
specific activity were significantly higher in the salt-loaded group than
in both adrenalectomized and sham-operated rats deprived of salt. These
results suggest that absolute sodium reabsorption is a major determinant of
renal Na+-K+-ATPase activity, and that the effect of DOCA on this enzyme is
secondary to its stimulation of absolute tubular sodium transport.</description><subject>Adenosine Triphosphatases - metabolism</subject><subject>Adrenal Glands - physiology</subject><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Desoxycorticosterone - pharmacology</subject><subject>Glomerular Filtration Rate - drug effects</subject><subject>Kidney - drug effects</subject><subject>Kidney - enzymology</subject><subject>Kidney - physiology</subject><subject>Male</subject><subject>Mineralocorticoids - physiology</subject><subject>Potassium - metabolism</subject><subject>Rats</subject><subject>Sodium - metabolism</subject><subject>Sodium Chloride - pharmacology</subject><issn>0363-6127</issn><issn>0002-9513</issn><issn>1931-857X</issn><issn>2161-1157</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkFtLwzAYhoN4mtN_4EWvvBmtOSf1bgyn4lCReR3SNt0y2qYmHWP_3u4gevXx8Z7gASBCMEGI4Xu9ar1pdJWgVIgEE5LwZMpScgIGGHEU9yZxCgaQcBJzhMUluAphBSHGXPILcI4ok1AOwPzTVLqzrglL20aZ6TbGNFFtG-N15XLnO5s7W4RIN0W0X4ze9Ch-HcXj-YcO5iEKrrDrutd0Fpxvd13X4KzUVTA3xzsEX9PH-eQ5nr0_vUzGszjHmHWxNJISCTkpYCZZqnPNYJ5mOZeyKCROC4QoKgWjGcVUlqh_MWei5BQJKikjQ3B36G29-16b0KnahtxUlW6MWwcliMCIQdwb5cGYexeCN6Vqva213yoE1Y6n-uWpdjxVz1NxtePZR2-PG-usNsVfcA-wl5ODvLSL5cZ6o9rlNlhXucX2r_Rf3w9o0YN7</recordid><startdate>197712</startdate><enddate>197712</enddate><creator>Westenfelder, C</creator><creator>Arevalo, G. J</creator><creator>Baranowski, R. L</creator><creator>Kurtzman, N. A</creator><creator>Katz, A. I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197712</creationdate><title>Relationship between mineralocorticoids and renal Na+-K+-ATPase: sodium reabsorption</title><author>Westenfelder, C ; Arevalo, G. J ; Baranowski, R. L ; Kurtzman, N. A ; Katz, A. I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c225t-8e8438063d0b859aca50c9bc688dd829d1141f754b4248f11142657f641748453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adenosine Triphosphatases - metabolism</topic><topic>Adrenal Glands - physiology</topic><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Desoxycorticosterone - pharmacology</topic><topic>Glomerular Filtration Rate - drug effects</topic><topic>Kidney - drug effects</topic><topic>Kidney - enzymology</topic><topic>Kidney - physiology</topic><topic>Male</topic><topic>Mineralocorticoids - physiology</topic><topic>Potassium - metabolism</topic><topic>Rats</topic><topic>Sodium - metabolism</topic><topic>Sodium Chloride - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westenfelder, C</creatorcontrib><creatorcontrib>Arevalo, G. J</creatorcontrib><creatorcontrib>Baranowski, R. L</creatorcontrib><creatorcontrib>Kurtzman, N. A</creatorcontrib><creatorcontrib>Katz, A. I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Renal physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westenfelder, C</au><au>Arevalo, G. J</au><au>Baranowski, R. L</au><au>Kurtzman, N. A</au><au>Katz, A. I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between mineralocorticoids and renal Na+-K+-ATPase: sodium reabsorption</atitle><jtitle>American journal of physiology. Renal physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1977-12</date><risdate>1977</risdate><volume>233</volume><issue>6</issue><spage>593</spage><epage>F599</epage><pages>593-F599</pages><issn>0363-6127</issn><issn>0002-9513</issn><issn>1931-857X</issn><eissn>2161-1157</eissn><eissn>1522-1466</eissn><abstract>C. Westenfelder, G. J. Arevalo, R. L. Baranowski, N. A. Kurtzman and A. I. Katz
To evaluate the mechanism responsible for the effect of deoxycorticosterone
acetate (DOCA) on renal Na+-K+-ATPase, we compared the relative
contribution of this hormone and of increased absolute sodium reabsorption
(TNa) to the restoration of the enzyme in kidneys of adrenalectomized rats.
In study A, adrenalectomized animals maintained on a salt-free diet
received 5 mg/kg per day DOCA i.m., while sham-operated and untreated
adrenalectomized rats receiving the same diet served as controls. Absolute
TNa and Na+-K+-ATPase specific activity in the cortex and outer medulla of
DOCA-treated rats were similar to those measured in untreated
adrenalectomized animals, but were significantly lower than in
sham-operated controls. In study B, the adrenalectomized rats did not
receive DOCA but were fed a high salt diet and received isotonic saline, 50
ml/kg per day s.c. Absolute TNa and cortical and medullary Na+-K+-ATPase
specific activity were significantly higher in the salt-loaded group than
in both adrenalectomized and sham-operated rats deprived of salt. These
results suggest that absolute sodium reabsorption is a major determinant of
renal Na+-K+-ATPase activity, and that the effect of DOCA on this enzyme is
secondary to its stimulation of absolute tubular sodium transport.</abstract><cop>United States</cop><pmid>145808</pmid><doi>10.1152/ajprenal.1977.233.6.F593</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6127 |
| ispartof | American journal of physiology. Renal physiology, 1977-12, Vol.233 (6), p.593-F599 |
| issn | 0363-6127 0002-9513 1931-857X 2161-1157 1522-1466 |
| language | eng |
| recordid | cdi_highwire_physiology_ajprenal_233_6_F593 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphatases - metabolism Adrenal Glands - physiology Adrenalectomy Animals Desoxycorticosterone - pharmacology Glomerular Filtration Rate - drug effects Kidney - drug effects Kidney - enzymology Kidney - physiology Male Mineralocorticoids - physiology Potassium - metabolism Rats Sodium - metabolism Sodium Chloride - pharmacology |
| title | Relationship between mineralocorticoids and renal Na+-K+-ATPase: sodium reabsorption |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T09%3A06%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_highw&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20mineralocorticoids%20and%20renal%20Na+-K+-ATPase:%20sodium%20reabsorption&rft.jtitle=American%20journal%20of%20physiology.%20Renal%20physiology&rft.au=Westenfelder,%20C&rft.date=1977-12&rft.volume=233&rft.issue=6&rft.spage=593&rft.epage=F599&rft.pages=593-F599&rft.issn=0363-6127&rft.eissn=2161-1157&rft_id=info:doi/10.1152/ajprenal.1977.233.6.F593&rft_dat=%3Cproquest_highw%3E73721502%3C/proquest_highw%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=73721502&rft_id=info:pmid/145808&rfr_iscdi=true |