Acute unilateral renal denervation in rats with extracellular volume expansion
E. Bello-Reuss, E. Pastoriza-Munoz and R. E. Colindres Sodium reabsorption along the nephron was studied before and after acute unilateral denervation of the left kidney in anesthetized rats with extracellular volume expansion. Studies were also performed before and after sham denervation. Denervati...
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| Veröffentlicht in: | American journal of physiology. Renal physiology 1977-01, Vol.232 (1), p.26-F32 |
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| container_title | American journal of physiology. Renal physiology |
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| creator | Bello-Reuss, E Pastoriza-Munoz, E Colindres, R. E |
| description | E. Bello-Reuss, E. Pastoriza-Munoz and R. E. Colindres
Sodium reabsorption along the nephron was studied before and after acute
unilateral denervation of the left kidney in anesthetized rats with
extracellular volume expansion. Studies were also performed before and
after sham denervation. Denervation increased urine volume (V) from the
left kidney from 35.2 to 59.2 mul min-1 (P less than 0.001) and urinary
sodium excretion (UNaV) from 6.9 to 11.8 mueq min-1 (P less than 0.001).
The control right kidney showed a simultaneous 45% decrease in V and UNaV.
Inulin clearance (GFR) and renal plasma flow (RPF) remained unchanged after
denervation in both kidneys. Left kidney late proximal (F/P)m decreased
from 1.50 to 1.24 (P less than 0.01); single-nephron GFR (SNGFR) remained
unchanged. (F/P)m ratios were also decreased in early distal (3.87-2.65, P
less than 0.005) and late distal (5.48-3.83, P less than 0.02)
convolutions. Fractional and absolute Na reabsorption in the distal
convolution did not decrease. GFR, RPF, V, UNa, late proximal (F/P)m, and
SNGFR were unchanged in sham-denervated rats. The increases in V and UNa V
produced by acute renal denervation in the volume-expanded anesthetized
animal are thus caused by further depression of proximal tubular salt and
water reabsorption. |
| doi_str_mv | 10.1152/ajprenal.1977.232.1.f26 |
| format | Article |
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Sodium reabsorption along the nephron was studied before and after acute
unilateral denervation of the left kidney in anesthetized rats with
extracellular volume expansion. Studies were also performed before and
after sham denervation. Denervation increased urine volume (V) from the
left kidney from 35.2 to 59.2 mul min-1 (P less than 0.001) and urinary
sodium excretion (UNaV) from 6.9 to 11.8 mueq min-1 (P less than 0.001).
The control right kidney showed a simultaneous 45% decrease in V and UNaV.
Inulin clearance (GFR) and renal plasma flow (RPF) remained unchanged after
denervation in both kidneys. Left kidney late proximal (F/P)m decreased
from 1.50 to 1.24 (P less than 0.01); single-nephron GFR (SNGFR) remained
unchanged. (F/P)m ratios were also decreased in early distal (3.87-2.65, P
less than 0.005) and late distal (5.48-3.83, P less than 0.02)
convolutions. Fractional and absolute Na reabsorption in the distal
convolution did not decrease. GFR, RPF, V, UNa, late proximal (F/P)m, and
SNGFR were unchanged in sham-denervated rats. The increases in V and UNa V
produced by acute renal denervation in the volume-expanded anesthetized
animal are thus caused by further depression of proximal tubular salt and
water reabsorption.</description><identifier>ISSN: 0363-6127</identifier><identifier>ISSN: 0002-9513</identifier><identifier>ISSN: 1931-857X</identifier><identifier>EISSN: 2161-1157</identifier><identifier>EISSN: 1522-1466</identifier><identifier>DOI: 10.1152/ajprenal.1977.232.1.f26</identifier><identifier>PMID: 835710</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Denervation ; Inulin ; Kidney - blood supply ; Kidney - innervation ; Kidney Tubules, Distal - physiology ; Kidney Tubules, Proximal - physiology ; Male ; Natriuresis ; Nephrons - physiology ; Rats ; Regional Blood Flow ; Sodium - metabolism ; Water</subject><ispartof>American journal of physiology. Renal physiology, 1977-01, Vol.232 (1), p.26-F32</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-5cb2fb33c3ba399def6fbd8f2136485b0d95baf45faf6f659f946fff9e65844c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/835710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bello-Reuss, E</creatorcontrib><creatorcontrib>Pastoriza-Munoz, E</creatorcontrib><creatorcontrib>Colindres, R. E</creatorcontrib><title>Acute unilateral renal denervation in rats with extracellular volume expansion</title><title>American journal of physiology. Renal physiology</title><addtitle>Am J Physiol</addtitle><description>E. Bello-Reuss, E. Pastoriza-Munoz and R. E. Colindres
Sodium reabsorption along the nephron was studied before and after acute
unilateral denervation of the left kidney in anesthetized rats with
extracellular volume expansion. Studies were also performed before and
after sham denervation. Denervation increased urine volume (V) from the
left kidney from 35.2 to 59.2 mul min-1 (P less than 0.001) and urinary
sodium excretion (UNaV) from 6.9 to 11.8 mueq min-1 (P less than 0.001).
The control right kidney showed a simultaneous 45% decrease in V and UNaV.
Inulin clearance (GFR) and renal plasma flow (RPF) remained unchanged after
denervation in both kidneys. Left kidney late proximal (F/P)m decreased
from 1.50 to 1.24 (P less than 0.01); single-nephron GFR (SNGFR) remained
unchanged. (F/P)m ratios were also decreased in early distal (3.87-2.65, P
less than 0.005) and late distal (5.48-3.83, P less than 0.02)
convolutions. Fractional and absolute Na reabsorption in the distal
convolution did not decrease. GFR, RPF, V, UNa, late proximal (F/P)m, and
SNGFR were unchanged in sham-denervated rats. The increases in V and UNa V
produced by acute renal denervation in the volume-expanded anesthetized
animal are thus caused by further depression of proximal tubular salt and
water reabsorption.</description><subject>Animals</subject><subject>Denervation</subject><subject>Inulin</subject><subject>Kidney - blood supply</subject><subject>Kidney - innervation</subject><subject>Kidney Tubules, Distal - physiology</subject><subject>Kidney Tubules, Proximal - physiology</subject><subject>Male</subject><subject>Natriuresis</subject><subject>Nephrons - physiology</subject><subject>Rats</subject><subject>Regional Blood Flow</subject><subject>Sodium - metabolism</subject><subject>Water</subject><issn>0363-6127</issn><issn>0002-9513</issn><issn>1931-857X</issn><issn>2161-1157</issn><issn>1522-1466</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwyAcxonxbU6_gYk9eWstUKAcF-PUZNHLPBPawtqFtRXazX17mZ315Ink_7zw5AfAHYwjCAl6kOvWqlqaCHLGIoRRBCON6AmYIEhh6D3sFExiTHFIIWKX4Mq5dRwjRFN6Ac5TTBiMJ-BtlvedCvq6MrJTVprgpzUoVK3sVnZVUwdVHVjZuWBXdWWgvjorc2VMb6QNto3pN8ofW1k7770GZ1oap26O7xR8zJ-Wjy_h4v359XG2CHPMSReSPEM6wzjHmcScF0pTnRWpRhDTJCVZXHCSSZ0QLb1CCdc8oVprrihJkyTHU3A_9La2-eyV68SmcodVslZN70SKGUeccW9kgzG3jXNWadHaaiPtXsBYHECKX5DiAFJ4kAKKOaI-eXv8os82qhhzAzkv80Euq1W5q6wSbbn3CEyz2ot5b8zSkxrLx1rRFtpnw_-z456_Kd-3L5mV</recordid><startdate>19770101</startdate><enddate>19770101</enddate><creator>Bello-Reuss, E</creator><creator>Pastoriza-Munoz, E</creator><creator>Colindres, R. E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19770101</creationdate><title>Acute unilateral renal denervation in rats with extracellular volume expansion</title><author>Bello-Reuss, E ; Pastoriza-Munoz, E ; Colindres, R. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-5cb2fb33c3ba399def6fbd8f2136485b0d95baf45faf6f659f946fff9e65844c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Denervation</topic><topic>Inulin</topic><topic>Kidney - blood supply</topic><topic>Kidney - innervation</topic><topic>Kidney Tubules, Distal - physiology</topic><topic>Kidney Tubules, Proximal - physiology</topic><topic>Male</topic><topic>Natriuresis</topic><topic>Nephrons - physiology</topic><topic>Rats</topic><topic>Regional Blood Flow</topic><topic>Sodium - metabolism</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bello-Reuss, E</creatorcontrib><creatorcontrib>Pastoriza-Munoz, E</creatorcontrib><creatorcontrib>Colindres, R. E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Renal physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bello-Reuss, E</au><au>Pastoriza-Munoz, E</au><au>Colindres, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute unilateral renal denervation in rats with extracellular volume expansion</atitle><jtitle>American journal of physiology. Renal physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1977-01-01</date><risdate>1977</risdate><volume>232</volume><issue>1</issue><spage>26</spage><epage>F32</epage><pages>26-F32</pages><issn>0363-6127</issn><issn>0002-9513</issn><issn>1931-857X</issn><eissn>2161-1157</eissn><eissn>1522-1466</eissn><abstract>E. Bello-Reuss, E. Pastoriza-Munoz and R. E. Colindres
Sodium reabsorption along the nephron was studied before and after acute
unilateral denervation of the left kidney in anesthetized rats with
extracellular volume expansion. Studies were also performed before and
after sham denervation. Denervation increased urine volume (V) from the
left kidney from 35.2 to 59.2 mul min-1 (P less than 0.001) and urinary
sodium excretion (UNaV) from 6.9 to 11.8 mueq min-1 (P less than 0.001).
The control right kidney showed a simultaneous 45% decrease in V and UNaV.
Inulin clearance (GFR) and renal plasma flow (RPF) remained unchanged after
denervation in both kidneys. Left kidney late proximal (F/P)m decreased
from 1.50 to 1.24 (P less than 0.01); single-nephron GFR (SNGFR) remained
unchanged. (F/P)m ratios were also decreased in early distal (3.87-2.65, P
less than 0.005) and late distal (5.48-3.83, P less than 0.02)
convolutions. Fractional and absolute Na reabsorption in the distal
convolution did not decrease. GFR, RPF, V, UNa, late proximal (F/P)m, and
SNGFR were unchanged in sham-denervated rats. The increases in V and UNa V
produced by acute renal denervation in the volume-expanded anesthetized
animal are thus caused by further depression of proximal tubular salt and
water reabsorption.</abstract><cop>United States</cop><pmid>835710</pmid><doi>10.1152/ajprenal.1977.232.1.f26</doi></addata></record> |
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| identifier | ISSN: 0363-6127 |
| ispartof | American journal of physiology. Renal physiology, 1977-01, Vol.232 (1), p.26-F32 |
| issn | 0363-6127 0002-9513 1931-857X 2161-1157 1522-1466 |
| language | eng |
| recordid | cdi_highwire_physiology_ajprenal_232_1_F26 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Denervation Inulin Kidney - blood supply Kidney - innervation Kidney Tubules, Distal - physiology Kidney Tubules, Proximal - physiology Male Natriuresis Nephrons - physiology Rats Regional Blood Flow Sodium - metabolism Water |
| title | Acute unilateral renal denervation in rats with extracellular volume expansion |
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