17beta-Estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney

1 Department of Medicine, Georgetown University Medical Center, Washington, DC; and 2 Center for the Study of Sex Differences: in Health, Aging and Disease, Georgetown University Medical Center, Washington, DC Submitted 31 May 2006 ; accepted in final form 15 August 2006 We previously reported that...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2007-02, Vol.292 (2), p.R769-R777
Hauptverfasser:	Mankhey, Richard W, Wells, Corinne C, Bhatti, Faizah, Maric, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - metabolism Albuminuria - prevention & control Animals Blotting, Western Collagen Type I - metabolism Collagen Type IV - metabolism Creatinine - urine Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - enzymology Diabetic Nephropathies - pathology Estradiol - therapeutic use Extracellular Matrix Proteins - biosynthesis Female Fibronectins - metabolism Fibrosis - pathology Fibrosis - prevention & control Immunohistochemistry Kidney - metabolism Kidney - pathology Matrix Metalloproteinases - metabolism Nephritis, Interstitial - pathology Nephritis, Interstitial - prevention & control Rats Rats, Sprague-Dawley
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