Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior
Department of Psychiatry, University of Wisconsin-Madison Medical School, Madison, Wisconsin 53719 Amylin, a calcitonin gene-related peptide-like peptide coreleased with insulin, exerts anorexic effects on central administration. Because previous studies revealed dense amylin binding in the nucleus...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2001-10, Vol.281 (4), p.1232-R1242 |
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| container_end_page | R1242 |
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| container_issue | 4 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 281 |
| creator | Baldo, Brian A Kelley, Ann E |
| description | Department of Psychiatry, University of
Wisconsin-Madison Medical School, Madison, Wisconsin 53719
Amylin, a calcitonin
gene-related peptide-like peptide coreleased with insulin, exerts
anorexic effects on central administration. Because previous studies
revealed dense amylin binding in the nucleus accumbens (Acb),
we investigated the behavioral effects of amylin infusions (10, 30, and
100 ng/side) into Acb subregions. Intra-Acb shell amylin infusions
decreased ambulation, rearing, feeding, and drinking in either
food-deprived rats or water-deprived rats; motor activity was affected
more potently than ingestive behavior. Moreover, intra-Acb shell amylin
reduced motor activity in nondeprived rats tested in the absence of
food or water, indicating that the expression of amylin's effects is
independent of drive or proximal incentives. Intra-Acb core amylin
infusions in water-deprived rats also decreased ambulation and water
intake, although anterior Acb placements were associated with smaller
motor effects, regardless of Acb subregion. In contrast to amylin's
effects, intra-Acb shell infusions of orexin-A (50, 100, and 500 ng/side) had no effects on motor activity, feeding, or drinking. Hence
the Acb may be a target for behavioral regulation by satiety-related
peptides like amylin.
hypocretin/orexin; feeding; drinking; locomotor activity; satiety |
| doi_str_mv | 10.1152/ajpregu.2001.281.4.r1232 |
| format | Article |
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Wisconsin-Madison Medical School, Madison, Wisconsin 53719
Amylin, a calcitonin
gene-related peptide-like peptide coreleased with insulin, exerts
anorexic effects on central administration. Because previous studies
revealed dense amylin binding in the nucleus accumbens (Acb),
we investigated the behavioral effects of amylin infusions (10, 30, and
100 ng/side) into Acb subregions. Intra-Acb shell amylin infusions
decreased ambulation, rearing, feeding, and drinking in either
food-deprived rats or water-deprived rats; motor activity was affected
more potently than ingestive behavior. Moreover, intra-Acb shell amylin
reduced motor activity in nondeprived rats tested in the absence of
food or water, indicating that the expression of amylin's effects is
independent of drive or proximal incentives. Intra-Acb core amylin
infusions in water-deprived rats also decreased ambulation and water
intake, although anterior Acb placements were associated with smaller
motor effects, regardless of Acb subregion. In contrast to amylin's
effects, intra-Acb shell infusions of orexin-A (50, 100, and 500 ng/side) had no effects on motor activity, feeding, or drinking. Hence
the Acb may be a target for behavioral regulation by satiety-related
peptides like amylin.
hypocretin/orexin; feeding; drinking; locomotor activity; satiety</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.2001.281.4.r1232</identifier><identifier>PMID: 11557632</identifier><language>eng</language><publisher>United States</publisher><subject>Amyloid - administration & dosage ; Animals ; Behavior, Animal - drug effects ; Carrier Proteins - administration & dosage ; Dose-Response Relationship, Drug ; Drinking Behavior - drug effects ; Eating - drug effects ; Feeding Behavior - drug effects ; Food Deprivation ; Infusions, Parenteral ; Intracellular Signaling Peptides and Proteins ; Islet Amyloid Polypeptide ; Male ; Microinjections ; Motor Activity - drug effects ; Neuropeptides - administration & dosage ; Nucleus Accumbens - anatomy & histology ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - physiology ; Orexins ; Rats ; Rats, Sprague-Dawley ; Water Deprivation</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2001-10, Vol.281 (4), p.1232-R1242</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-e3cdc7937701d2b8f9f8d6adce6354defa54e826c0bc193ada46709edec32c2b3</citedby><cites>FETCH-LOGICAL-c401t-e3cdc7937701d2b8f9f8d6adce6354defa54e826c0bc193ada46709edec32c2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11557632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baldo, Brian A</creatorcontrib><creatorcontrib>Kelley, Ann E</creatorcontrib><title>Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>Department of Psychiatry, University of
Wisconsin-Madison Medical School, Madison, Wisconsin 53719
Amylin, a calcitonin
gene-related peptide-like peptide coreleased with insulin, exerts
anorexic effects on central administration. Because previous studies
revealed dense amylin binding in the nucleus accumbens (Acb),
we investigated the behavioral effects of amylin infusions (10, 30, and
100 ng/side) into Acb subregions. Intra-Acb shell amylin infusions
decreased ambulation, rearing, feeding, and drinking in either
food-deprived rats or water-deprived rats; motor activity was affected
more potently than ingestive behavior. Moreover, intra-Acb shell amylin
reduced motor activity in nondeprived rats tested in the absence of
food or water, indicating that the expression of amylin's effects is
independent of drive or proximal incentives. Intra-Acb core amylin
infusions in water-deprived rats also decreased ambulation and water
intake, although anterior Acb placements were associated with smaller
motor effects, regardless of Acb subregion. In contrast to amylin's
effects, intra-Acb shell infusions of orexin-A (50, 100, and 500 ng/side) had no effects on motor activity, feeding, or drinking. Hence
the Acb may be a target for behavioral regulation by satiety-related
peptides like amylin.
hypocretin/orexin; feeding; drinking; locomotor activity; satiety</description><subject>Amyloid - administration & dosage</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Carrier Proteins - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking Behavior - drug effects</subject><subject>Eating - drug effects</subject><subject>Feeding Behavior - drug effects</subject><subject>Food Deprivation</subject><subject>Infusions, Parenteral</subject><subject>Intracellular Signaling Peptides and Proteins</subject><subject>Islet Amyloid Polypeptide</subject><subject>Male</subject><subject>Microinjections</subject><subject>Motor Activity - drug effects</subject><subject>Neuropeptides - administration & dosage</subject><subject>Nucleus Accumbens - anatomy & histology</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - physiology</subject><subject>Orexins</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Water Deprivation</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtv1DAUhS0EokPhLyCv2CX1Ky92VUWhUiUkVNaWY9_MuHLi4Ech_x6PZoBuWF1f-Zxzjz6EMCU1pQ27Uo9rgH2uGSG0Zj2tRR0o4-wF2pVvVlExkJdoR3jLq5bS4QK9ifGRECK44K_RRQlpupazHdLX8-bsgu0y5Wj98ZE8DirhJWsHOWKldZ5HWCJefYIluQ0bKOdjhIhnn3wokmSfbNqwWkwJ2EMsO-ARDurJ-vAWvZqUi_DuPC_R99tPDzdfqvuvn-9uru8rLQhNFXBtdDfwriPUsLGfhqk3rTIaWt4IA5NqBPSs1WTUdODKKNF2ZAADmjPNRn6JPpxy1-B_5FJCzjZqcE4t4HOUHaVt0_d9EfYnoQ4-xgCTXIOdVdgkJfIIWJ4ByyNgWQBLIb8dARfr-_ONPM5g_hnPRIvg40lwsPvDTxtAroetkHV-v8nb7NwD_Ep_8p8ly9VMxVz_3_y307M6vwFec6Kt</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Baldo, Brian A</creator><creator>Kelley, Ann E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20011001</creationdate><title>Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior</title><author>Baldo, Brian A ; Kelley, Ann E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-e3cdc7937701d2b8f9f8d6adce6354defa54e826c0bc193ada46709edec32c2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amyloid - administration & dosage</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Carrier Proteins - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drinking Behavior - drug effects</topic><topic>Eating - drug effects</topic><topic>Feeding Behavior - drug effects</topic><topic>Food Deprivation</topic><topic>Infusions, Parenteral</topic><topic>Intracellular Signaling Peptides and Proteins</topic><topic>Islet Amyloid Polypeptide</topic><topic>Male</topic><topic>Microinjections</topic><topic>Motor Activity - drug effects</topic><topic>Neuropeptides - administration & dosage</topic><topic>Nucleus Accumbens - anatomy & histology</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - physiology</topic><topic>Orexins</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Water Deprivation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baldo, Brian A</creatorcontrib><creatorcontrib>Kelley, Ann E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baldo, Brian A</au><au>Kelley, Ann E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2001-10-01</date><risdate>2001</risdate><volume>281</volume><issue>4</issue><spage>1232</spage><epage>R1242</epage><pages>1232-R1242</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract>Department of Psychiatry, University of
Wisconsin-Madison Medical School, Madison, Wisconsin 53719
Amylin, a calcitonin
gene-related peptide-like peptide coreleased with insulin, exerts
anorexic effects on central administration. Because previous studies
revealed dense amylin binding in the nucleus accumbens (Acb),
we investigated the behavioral effects of amylin infusions (10, 30, and
100 ng/side) into Acb subregions. Intra-Acb shell amylin infusions
decreased ambulation, rearing, feeding, and drinking in either
food-deprived rats or water-deprived rats; motor activity was affected
more potently than ingestive behavior. Moreover, intra-Acb shell amylin
reduced motor activity in nondeprived rats tested in the absence of
food or water, indicating that the expression of amylin's effects is
independent of drive or proximal incentives. Intra-Acb core amylin
infusions in water-deprived rats also decreased ambulation and water
intake, although anterior Acb placements were associated with smaller
motor effects, regardless of Acb subregion. In contrast to amylin's
effects, intra-Acb shell infusions of orexin-A (50, 100, and 500 ng/side) had no effects on motor activity, feeding, or drinking. Hence
the Acb may be a target for behavioral regulation by satiety-related
peptides like amylin.
hypocretin/orexin; feeding; drinking; locomotor activity; satiety</abstract><cop>United States</cop><pmid>11557632</pmid><doi>10.1152/ajpregu.2001.281.4.r1232</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2001-10, Vol.281 (4), p.1232-R1242 |
| issn | 0363-6119 1522-1490 |
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| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Amyloid - administration & dosage Animals Behavior, Animal - drug effects Carrier Proteins - administration & dosage Dose-Response Relationship, Drug Drinking Behavior - drug effects Eating - drug effects Feeding Behavior - drug effects Food Deprivation Infusions, Parenteral Intracellular Signaling Peptides and Proteins Islet Amyloid Polypeptide Male Microinjections Motor Activity - drug effects Neuropeptides - administration & dosage Nucleus Accumbens - anatomy & histology Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Orexins Rats Rats, Sprague-Dawley Water Deprivation |
| title | Amylin infusion into rat nucleus accumbens potently depresses motor activity and ingestive behavior |
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