Effect of chronic ANG I-converting enzyme inhibition on aging processes. IV. Cerebral blood flow regulation
I. Lartaud, T. Makki, L. Bray-des-Boscs, N. Niederhoffer, J. Atkinson, B. Corman and C. Capdeville-Atkinson Laboratoire de Pharmacologie Cardio-vasculaire, Faculte de Pharmacie de l'Universite de Nancy I, France. Age-related changes in systemic arterial blood pressure, basal cerebral blood flow...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1994-09, Vol.267 (3), p.687-R694 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 267 |
| creator | Lartaud, I Makki, T Bray-des-Boscs, L Niederhoffer, N Atkinson, J Corman, B Capdeville-Atkinson, C |
| description | I. Lartaud, T. Makki, L. Bray-des-Boscs, N. Niederhoffer, J. Atkinson, B. Corman and C. Capdeville-Atkinson
Laboratoire de Pharmacologie Cardio-vasculaire, Faculte de Pharmacie de l'Universite de Nancy I, France.
Age-related changes in systemic arterial blood pressure, basal cerebral
blood flow (CBF), and CBF regulatory capacity were investigated in awake
6-, 12-, 24-, and 30-mo-old male Wistar (WAG/Rij) rats, one-half of which
received the angiotensin I-converting enzyme inhibitor (ACEI) perindopril
from 6 mo onward. There was no age-dependent change in mean arterial blood
pressure, basal CBF, or cerebrovascular reactivity to hypercapnia, but the
lower limit of CBF autoregulation rose from 70 mmHg at 6 and 12 mo to 90
mmHg in 24- and 30-mo-old animals. ACEI lowered mean arterial blood
pressure but had no effect on basal CBF or on cerebrovascular reactivity to
hypercapnia. ACEI shifted the lower limit of CBF autoregulation to a
20-mmHg-lower level in 12- and 24-mo animals but not in rats treated for 2
yr, i.e., from the ages of 6 to 30 mo. In conclusion, the main age-related
change in CBF regulation was an increase in the lower limit of CBF
autoregulation to a higher blood pressure level. Treatment with ACEI
partially restored the lower limit of CBF autoregulation. |
| doi_str_mv | 10.1152/ajpregu.1994.267.3.r687 |
| format | Article |
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Laboratoire de Pharmacologie Cardio-vasculaire, Faculte de Pharmacie de l'Universite de Nancy I, France.
Age-related changes in systemic arterial blood pressure, basal cerebral
blood flow (CBF), and CBF regulatory capacity were investigated in awake
6-, 12-, 24-, and 30-mo-old male Wistar (WAG/Rij) rats, one-half of which
received the angiotensin I-converting enzyme inhibitor (ACEI) perindopril
from 6 mo onward. There was no age-dependent change in mean arterial blood
pressure, basal CBF, or cerebrovascular reactivity to hypercapnia, but the
lower limit of CBF autoregulation rose from 70 mmHg at 6 and 12 mo to 90
mmHg in 24- and 30-mo-old animals. ACEI lowered mean arterial blood
pressure but had no effect on basal CBF or on cerebrovascular reactivity to
hypercapnia. ACEI shifted the lower limit of CBF autoregulation to a
20-mmHg-lower level in 12- and 24-mo animals but not in rats treated for 2
yr, i.e., from the ages of 6 to 30 mo. In conclusion, the main age-related
change in CBF regulation was an increase in the lower limit of CBF
autoregulation to a higher blood pressure level. Treatment with ACEI
partially restored the lower limit of CBF autoregulation.</description><identifier>ISSN: 0363-6119</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1994.267.3.r687</identifier><identifier>PMID: 8092312</identifier><language>eng</language><publisher>United States</publisher><subject>Aging - physiology ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Animals ; Blood Pressure - drug effects ; Cerebrovascular Circulation - drug effects ; Cerebrovascular Circulation - physiology ; Heart Rate - drug effects ; Homeostasis - drug effects ; Hypercapnia - physiopathology ; Male ; Rats ; Rats, Wistar ; Time Factors ; Vascular Resistance - drug effects</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 1994-09, Vol.267 (3), p.687-R694</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-2f6e1db8b1775c7f7843c44ae5b96730691f6ec0e9caac88b2d6da32187769123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8092312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lartaud, I</creatorcontrib><creatorcontrib>Makki, T</creatorcontrib><creatorcontrib>Bray-des-Boscs, L</creatorcontrib><creatorcontrib>Niederhoffer, N</creatorcontrib><creatorcontrib>Atkinson, J</creatorcontrib><creatorcontrib>Corman, B</creatorcontrib><creatorcontrib>Capdeville-Atkinson, C</creatorcontrib><title>Effect of chronic ANG I-converting enzyme inhibition on aging processes. IV. Cerebral blood flow regulation</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol</addtitle><description>I. Lartaud, T. Makki, L. Bray-des-Boscs, N. Niederhoffer, J. Atkinson, B. Corman and C. Capdeville-Atkinson
Laboratoire de Pharmacologie Cardio-vasculaire, Faculte de Pharmacie de l'Universite de Nancy I, France.
Age-related changes in systemic arterial blood pressure, basal cerebral
blood flow (CBF), and CBF regulatory capacity were investigated in awake
6-, 12-, 24-, and 30-mo-old male Wistar (WAG/Rij) rats, one-half of which
received the angiotensin I-converting enzyme inhibitor (ACEI) perindopril
from 6 mo onward. There was no age-dependent change in mean arterial blood
pressure, basal CBF, or cerebrovascular reactivity to hypercapnia, but the
lower limit of CBF autoregulation rose from 70 mmHg at 6 and 12 mo to 90
mmHg in 24- and 30-mo-old animals. ACEI lowered mean arterial blood
pressure but had no effect on basal CBF or on cerebrovascular reactivity to
hypercapnia. ACEI shifted the lower limit of CBF autoregulation to a
20-mmHg-lower level in 12- and 24-mo animals but not in rats treated for 2
yr, i.e., from the ages of 6 to 30 mo. In conclusion, the main age-related
change in CBF regulation was an increase in the lower limit of CBF
autoregulation to a higher blood pressure level. Treatment with ACEI
partially restored the lower limit of CBF autoregulation.</description><subject>Aging - physiology</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Heart Rate - drug effects</subject><subject>Homeostasis - drug effects</subject><subject>Hypercapnia - physiopathology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Vascular Resistance - drug effects</subject><issn>0363-6119</issn><issn>0002-9513</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1r2zAUhkXpyLKsP2FMV72zpw9Hsi5L6LJA2GC0uxWyfGwrc6xUchqyXz-ZhFI4cC7ej3N4EPpKSU7pkn0zu0OA9phTpYqcCZnzPIhS3qB5UllGC0Vu0ZxwwTNBqfqIPsW4I4QUvOAzNCuJYpyyOfr72DRgR-wbbLvgB2fxw8813mTWD68QRje0GIZ_5z1gN3SucqPzA05j2kk6BG8hRog53vzJ8QoCVMH0uOq9r3HT-xOe3uzNFPuMPjSmj3B33Qv0_P3xafUj2_5ab1YP28xypsaMNQJoXZUVlXJpZSPLgtuiMLCslJCcCEWTwxJQ1hhblhWrRW04o6WUSWN8ge4vvem7lyPEUe9dtND3ZgB_jFoKSQsieTLKi9EGH2OARh-C25tw1pToCbO-YtYTZp0wa65_J8wp-eV64ljtoX7LXbkmPbvonWu7kwugD905Ot_79vxW-q7vP-chjDs</recordid><startdate>199409</startdate><enddate>199409</enddate><creator>Lartaud, I</creator><creator>Makki, T</creator><creator>Bray-des-Boscs, L</creator><creator>Niederhoffer, N</creator><creator>Atkinson, J</creator><creator>Corman, B</creator><creator>Capdeville-Atkinson, C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199409</creationdate><title>Effect of chronic ANG I-converting enzyme inhibition on aging processes. IV. Cerebral blood flow regulation</title><author>Lartaud, I ; Makki, T ; Bray-des-Boscs, L ; Niederhoffer, N ; Atkinson, J ; Corman, B ; Capdeville-Atkinson, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-2f6e1db8b1775c7f7843c44ae5b96730691f6ec0e9caac88b2d6da32187769123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aging - physiology</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Heart Rate - drug effects</topic><topic>Homeostasis - drug effects</topic><topic>Hypercapnia - physiopathology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lartaud, I</creatorcontrib><creatorcontrib>Makki, T</creatorcontrib><creatorcontrib>Bray-des-Boscs, L</creatorcontrib><creatorcontrib>Niederhoffer, N</creatorcontrib><creatorcontrib>Atkinson, J</creatorcontrib><creatorcontrib>Corman, B</creatorcontrib><creatorcontrib>Capdeville-Atkinson, C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lartaud, I</au><au>Makki, T</au><au>Bray-des-Boscs, L</au><au>Niederhoffer, N</au><au>Atkinson, J</au><au>Corman, B</au><au>Capdeville-Atkinson, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chronic ANG I-converting enzyme inhibition on aging processes. IV. Cerebral blood flow regulation</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1994-09</date><risdate>1994</risdate><volume>267</volume><issue>3</issue><spage>687</spage><epage>R694</epage><pages>687-R694</pages><issn>0363-6119</issn><issn>0002-9513</issn><eissn>1522-1490</eissn><abstract>I. Lartaud, T. Makki, L. Bray-des-Boscs, N. Niederhoffer, J. Atkinson, B. Corman and C. Capdeville-Atkinson
Laboratoire de Pharmacologie Cardio-vasculaire, Faculte de Pharmacie de l'Universite de Nancy I, France.
Age-related changes in systemic arterial blood pressure, basal cerebral
blood flow (CBF), and CBF regulatory capacity were investigated in awake
6-, 12-, 24-, and 30-mo-old male Wistar (WAG/Rij) rats, one-half of which
received the angiotensin I-converting enzyme inhibitor (ACEI) perindopril
from 6 mo onward. There was no age-dependent change in mean arterial blood
pressure, basal CBF, or cerebrovascular reactivity to hypercapnia, but the
lower limit of CBF autoregulation rose from 70 mmHg at 6 and 12 mo to 90
mmHg in 24- and 30-mo-old animals. ACEI lowered mean arterial blood
pressure but had no effect on basal CBF or on cerebrovascular reactivity to
hypercapnia. ACEI shifted the lower limit of CBF autoregulation to a
20-mmHg-lower level in 12- and 24-mo animals but not in rats treated for 2
yr, i.e., from the ages of 6 to 30 mo. In conclusion, the main age-related
change in CBF regulation was an increase in the lower limit of CBF
autoregulation to a higher blood pressure level. Treatment with ACEI
partially restored the lower limit of CBF autoregulation.</abstract><cop>United States</cop><pmid>8092312</pmid><doi>10.1152/ajpregu.1994.267.3.r687</doi></addata></record> |
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| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 1994-09, Vol.267 (3), p.687-R694 |
| issn | 0363-6119 0002-9513 1522-1490 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aging - physiology Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Blood Pressure - drug effects Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Heart Rate - drug effects Homeostasis - drug effects Hypercapnia - physiopathology Male Rats Rats, Wistar Time Factors Vascular Resistance - drug effects |
| title | Effect of chronic ANG I-converting enzyme inhibition on aging processes. IV. Cerebral blood flow regulation |
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