Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb
Previous studies in the fetal lamb have demonstrated that hyperglycemia stimulates the fetal metabolic rate. The present study examined the effects of chronic fetal hyperglycemia on fetal cerebral metabolic rate and electrocortical activity. Nine chronically instrumented fetal lambs had measurements...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1993-12, Vol.265 (6), p.1262-R1269 |
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| container_end_page | R1269 |
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| container_issue | 6 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 265 |
| creator | Rosenkrantz, T.S Knox, I Zalneraitis, E.L Raye, J.R Porte, P.J Cramer, R Smoloski, R Philipps, A.F |
| description | Previous studies in the fetal lamb have demonstrated that hyperglycemia stimulates the fetal metabolic rate. The present study examined the effects of chronic fetal hyperglycemia on fetal cerebral metabolic rate and electrocortical activity. Nine chronically instrumented fetal lambs had measurements of cerebral blood flow and cerebral uptake/excretion of oxygen, glucose, lactate, and beta-hydroxybutyrate taken before and during a 48-h fetal glucose infusion. Electrocortical activity was also recorded. The fetal arterial glucose concentration was 19.8 +/- 2.0 mg/dl before glucose infusion and 48 +/- 4.5 to 54.6 +/- 6.6 mg/dl during the infusion period. Cerebral blood flow and cerebral glucose and oxygen uptake increased by 219, 209, and 171%, respectively, by the end of the infusion period. There was a linear relationship between the fetal arterial glucose concentration and cerebral blood flow and cerebral glucose and oxygen uptakes. The electroencephalogram showed significant slowing with increases in the cerebral metabolic rate. These findings suggest that fetal hyperglycemia is associated with significant metabolic stimulation of the brain |
| doi_str_mv | 10.1152/ajpregu.1993.265.6.r1262 |
| format | Article |
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The present study examined the effects of chronic fetal hyperglycemia on fetal cerebral metabolic rate and electrocortical activity. Nine chronically instrumented fetal lambs had measurements of cerebral blood flow and cerebral uptake/excretion of oxygen, glucose, lactate, and beta-hydroxybutyrate taken before and during a 48-h fetal glucose infusion. Electrocortical activity was also recorded. The fetal arterial glucose concentration was 19.8 +/- 2.0 mg/dl before glucose infusion and 48 +/- 4.5 to 54.6 +/- 6.6 mg/dl during the infusion period. Cerebral blood flow and cerebral glucose and oxygen uptake increased by 219, 209, and 171%, respectively, by the end of the infusion period. There was a linear relationship between the fetal arterial glucose concentration and cerebral blood flow and cerebral glucose and oxygen uptakes. The electroencephalogram showed significant slowing with increases in the cerebral metabolic rate. These findings suggest that fetal hyperglycemia is associated with significant metabolic stimulation of the brain</description><identifier>ISSN: 0002-9513</identifier><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 2163-5773</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1993.265.6.r1262</identifier><identifier>PMID: 8285266</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arteries - embryology ; AZUCAR EN SANGRE ; Blood Glucose - metabolism ; Brain - metabolism ; Cerebral Cortex - physiopathology ; Chronic Disease ; CIRCULACION SANGUINEA ; CIRCULATION SANGUINE ; DIABETE ; DIABETES ; Electroencephalography ; Fetal Blood ; Fetus - physiology ; Glucose - metabolism ; HIPERGLICEMIA ; Hyperglycemia - metabolism ; Hyperglycemia - physiopathology ; HYPERGLYCEMIE ; INSULINA ; INSULINE ; Lactates - blood ; Lactic Acid ; METABOLISME ; METABOLISMO ; NUTRIENTES ; OVIN ; OVINOS ; Oxygen - blood ; Oxygen Consumption ; Sheep ; SUBSTANCE NUTRITIVE ; SUCRE DU SANG</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 1993-12, Vol.265 (6), p.1262-R1269</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8285266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosenkrantz, T.S</creatorcontrib><creatorcontrib>Knox, I</creatorcontrib><creatorcontrib>Zalneraitis, E.L</creatorcontrib><creatorcontrib>Raye, J.R</creatorcontrib><creatorcontrib>Porte, P.J</creatorcontrib><creatorcontrib>Cramer, R</creatorcontrib><creatorcontrib>Smoloski, R</creatorcontrib><creatorcontrib>Philipps, A.F</creatorcontrib><title>Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol</addtitle><description>Previous studies in the fetal lamb have demonstrated that hyperglycemia stimulates the fetal metabolic rate. The present study examined the effects of chronic fetal hyperglycemia on fetal cerebral metabolic rate and electrocortical activity. Nine chronically instrumented fetal lambs had measurements of cerebral blood flow and cerebral uptake/excretion of oxygen, glucose, lactate, and beta-hydroxybutyrate taken before and during a 48-h fetal glucose infusion. Electrocortical activity was also recorded. The fetal arterial glucose concentration was 19.8 +/- 2.0 mg/dl before glucose infusion and 48 +/- 4.5 to 54.6 +/- 6.6 mg/dl during the infusion period. Cerebral blood flow and cerebral glucose and oxygen uptake increased by 219, 209, and 171%, respectively, by the end of the infusion period. There was a linear relationship between the fetal arterial glucose concentration and cerebral blood flow and cerebral glucose and oxygen uptakes. The electroencephalogram showed significant slowing with increases in the cerebral metabolic rate. These findings suggest that fetal hyperglycemia is associated with significant metabolic stimulation of the brain</description><subject>Animals</subject><subject>Arteries - embryology</subject><subject>AZUCAR EN SANGRE</subject><subject>Blood Glucose - metabolism</subject><subject>Brain - metabolism</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Chronic Disease</subject><subject>CIRCULACION SANGUINEA</subject><subject>CIRCULATION SANGUINE</subject><subject>DIABETE</subject><subject>DIABETES</subject><subject>Electroencephalography</subject><subject>Fetal Blood</subject><subject>Fetus - physiology</subject><subject>Glucose - metabolism</subject><subject>HIPERGLICEMIA</subject><subject>Hyperglycemia - metabolism</subject><subject>Hyperglycemia - physiopathology</subject><subject>HYPERGLYCEMIE</subject><subject>INSULINA</subject><subject>INSULINE</subject><subject>Lactates - blood</subject><subject>Lactic Acid</subject><subject>METABOLISME</subject><subject>METABOLISMO</subject><subject>NUTRIENTES</subject><subject>OVIN</subject><subject>OVINOS</subject><subject>Oxygen - blood</subject><subject>Oxygen Consumption</subject><subject>Sheep</subject><subject>SUBSTANCE NUTRITIVE</subject><subject>SUCRE DU SANG</subject><issn>0002-9513</issn><issn>0363-6119</issn><issn>2163-5773</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkF1r2zAUhkVZybK2f2Aw0NXu7FmSJdmXI6xrIVBom7uCkOUjW0GOPMnp8L-fQ0JhV4dz3o8DD0KYFDkhnP7Q-zFCd8xJXbOcCp6LPBIq6BVaUyJYxqVkn9C6KAqa1Zywz-hLSvtlJZyVK7SqaMWpEGv0toEITdQeDzDpJniXBqwPLQYPZorBhDg5s8jaTO7dTTN2Bzz1gE0fw-Gk-Bn38wix87OBwRlslyKPvR6aW3RttU9wd5k3aHf_63XzkG2ffj9ufm4zwyoyZbxthYWitlQaaNqKlsxyY4kWAJLWpGJWWlq2suUNW67aloRpI0ndskJawW7Q93PvGMOfI6RJDS4Z8F4fIByTkoJwKQRZjNXZaGJIKYJVY3SDjrMihTqBVRew6gRWLWCVUM8nsEv02-XHsRmg_QheSC56ftZ71_V_XQQ19nNywYdu_mj9v_DrOWB1ULqLLqndS12Wpawk-wcc6ZHZ</recordid><startdate>19931201</startdate><enddate>19931201</enddate><creator>Rosenkrantz, T.S</creator><creator>Knox, I</creator><creator>Zalneraitis, E.L</creator><creator>Raye, J.R</creator><creator>Porte, P.J</creator><creator>Cramer, R</creator><creator>Smoloski, R</creator><creator>Philipps, A.F</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931201</creationdate><title>Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb</title><author>Rosenkrantz, T.S ; Knox, I ; Zalneraitis, E.L ; Raye, J.R ; Porte, P.J ; Cramer, R ; Smoloski, R ; Philipps, A.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-5dd6fe09f27cebd8243f5cf1a6ee729183f7f24d7d5b31a6af413ac719d307f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Arteries - embryology</topic><topic>AZUCAR EN SANGRE</topic><topic>Blood Glucose - metabolism</topic><topic>Brain - metabolism</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Chronic Disease</topic><topic>CIRCULACION SANGUINEA</topic><topic>CIRCULATION SANGUINE</topic><topic>DIABETE</topic><topic>DIABETES</topic><topic>Electroencephalography</topic><topic>Fetal Blood</topic><topic>Fetus - physiology</topic><topic>Glucose - metabolism</topic><topic>HIPERGLICEMIA</topic><topic>Hyperglycemia - metabolism</topic><topic>Hyperglycemia - physiopathology</topic><topic>HYPERGLYCEMIE</topic><topic>INSULINA</topic><topic>INSULINE</topic><topic>Lactates - blood</topic><topic>Lactic Acid</topic><topic>METABOLISME</topic><topic>METABOLISMO</topic><topic>NUTRIENTES</topic><topic>OVIN</topic><topic>OVINOS</topic><topic>Oxygen - blood</topic><topic>Oxygen Consumption</topic><topic>Sheep</topic><topic>SUBSTANCE NUTRITIVE</topic><topic>SUCRE DU SANG</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosenkrantz, T.S</creatorcontrib><creatorcontrib>Knox, I</creatorcontrib><creatorcontrib>Zalneraitis, E.L</creatorcontrib><creatorcontrib>Raye, J.R</creatorcontrib><creatorcontrib>Porte, P.J</creatorcontrib><creatorcontrib>Cramer, R</creatorcontrib><creatorcontrib>Smoloski, R</creatorcontrib><creatorcontrib>Philipps, A.F</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. 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Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1993-12-01</date><risdate>1993</risdate><volume>265</volume><issue>6</issue><spage>1262</spage><epage>R1269</epage><pages>1262-R1269</pages><issn>0002-9513</issn><issn>0363-6119</issn><eissn>2163-5773</eissn><eissn>1522-1490</eissn><abstract>Previous studies in the fetal lamb have demonstrated that hyperglycemia stimulates the fetal metabolic rate. The present study examined the effects of chronic fetal hyperglycemia on fetal cerebral metabolic rate and electrocortical activity. Nine chronically instrumented fetal lambs had measurements of cerebral blood flow and cerebral uptake/excretion of oxygen, glucose, lactate, and beta-hydroxybutyrate taken before and during a 48-h fetal glucose infusion. Electrocortical activity was also recorded. The fetal arterial glucose concentration was 19.8 +/- 2.0 mg/dl before glucose infusion and 48 +/- 4.5 to 54.6 +/- 6.6 mg/dl during the infusion period. Cerebral blood flow and cerebral glucose and oxygen uptake increased by 219, 209, and 171%, respectively, by the end of the infusion period. There was a linear relationship between the fetal arterial glucose concentration and cerebral blood flow and cerebral glucose and oxygen uptakes. The electroencephalogram showed significant slowing with increases in the cerebral metabolic rate. These findings suggest that fetal hyperglycemia is associated with significant metabolic stimulation of the brain</abstract><cop>United States</cop><pmid>8285266</pmid><doi>10.1152/ajpregu.1993.265.6.r1262</doi></addata></record> |
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| subjects | Animals Arteries - embryology AZUCAR EN SANGRE Blood Glucose - metabolism Brain - metabolism Cerebral Cortex - physiopathology Chronic Disease CIRCULACION SANGUINEA CIRCULATION SANGUINE DIABETE DIABETES Electroencephalography Fetal Blood Fetus - physiology Glucose - metabolism HIPERGLICEMIA Hyperglycemia - metabolism Hyperglycemia - physiopathology HYPERGLYCEMIE INSULINA INSULINE Lactates - blood Lactic Acid METABOLISME METABOLISMO NUTRIENTES OVIN OVINOS Oxygen - blood Oxygen Consumption Sheep SUBSTANCE NUTRITIVE SUCRE DU SANG |
| title | Cerebral metabolism and electrocortical activity in the chronically hyperglycemic fetal lamb |
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