Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats
F. Carey, R. Forder, M. D. Edge, A. R. Greene, M. A. Horan, P. J. Strijbos and N. J. Rothwell Bioscience Department II, ICI Pharmaceuticals, Macclesfield, United Kingdom. Lipocortins form a group of proteins that have been proposed as mediators of the anti-inflammatory actions of glucocorticoids. In...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1990-08, Vol.259 (2), p.266-R269 |
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| container_end_page | R269 |
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| container_issue | 2 |
| container_start_page | 266 |
| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 259 |
| creator | Carey, F Forder, R Edge, M. D Greene, A. R Horan, M. A Strijbos, P. J Rothwell, N. J |
| description | F. Carey, R. Forder, M. D. Edge, A. R. Greene, M. A. Horan, P. J. Strijbos and N. J. Rothwell
Bioscience Department II, ICI Pharmaceuticals, Macclesfield, United Kingdom.
Lipocortins form a group of proteins that have been proposed as mediators
of the anti-inflammatory actions of glucocorticoids.
Intracerebroventricular injection of a recombinant fragment of lipocortin 1
(NH2-terminal 1-188) caused dose-dependent (0.4-1.2 micrograms) reductions
in the acute increases in colonic temperature and oxygen consumption, which
occurred in response to central injections of recombinant interleukin 1
beta and gamma-interferon in conscious rats. In contrast the lipocortin
fragment did not affect the response to prostaglandin E2, and its activity
was prevented by heat treatment or by pretreatment of animals with
polyclonal antiserum raised to the fragment. Central injection of antiserum
significantly enhanced the thermogenic responses to interleukin 1 beta in
rats treated with dexamethasone without affecting the responses in normal
animals. These results support a physiological role for lipocortin in the
central effects of glucocorticoids. |
| doi_str_mv | 10.1152/ajpregu.1990.259.2.r266 |
| format | Article |
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Bioscience Department II, ICI Pharmaceuticals, Macclesfield, United Kingdom.
Lipocortins form a group of proteins that have been proposed as mediators
of the anti-inflammatory actions of glucocorticoids.
Intracerebroventricular injection of a recombinant fragment of lipocortin 1
(NH2-terminal 1-188) caused dose-dependent (0.4-1.2 micrograms) reductions
in the acute increases in colonic temperature and oxygen consumption, which
occurred in response to central injections of recombinant interleukin 1
beta and gamma-interferon in conscious rats. In contrast the lipocortin
fragment did not affect the response to prostaglandin E2, and its activity
was prevented by heat treatment or by pretreatment of animals with
polyclonal antiserum raised to the fragment. Central injection of antiserum
significantly enhanced the thermogenic responses to interleukin 1 beta in
rats treated with dexamethasone without affecting the responses in normal
animals. These results support a physiological role for lipocortin in the
central effects of glucocorticoids.</description><identifier>ISSN: 0363-6119</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1990.259.2.r266</identifier><identifier>PMID: 2143636</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Annexins ; Biological Factors - pharmacology ; Body Temperature - drug effects ; Calcium-Binding Proteins - pharmacology ; Cytokines ; Dexamethasone - pharmacology ; Drug Synergism ; Interleukin-1 - pharmacology ; Male ; Oxygen Consumption - drug effects ; Peptide Fragments - pharmacology ; Phospholipases - antagonists & inhibitors ; Pyrogens - pharmacology ; Rats ; Rats, Inbred Strains ; Recombinant Proteins</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 1990-08, Vol.259 (2), p.266-R269</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-1016bc8c249f196d423241ef51398c6ee639c28ff6bf058c6d22bc027e775753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2143636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carey, F</creatorcontrib><creatorcontrib>Forder, R</creatorcontrib><creatorcontrib>Edge, M. D</creatorcontrib><creatorcontrib>Greene, A. R</creatorcontrib><creatorcontrib>Horan, M. A</creatorcontrib><creatorcontrib>Strijbos, P. J</creatorcontrib><creatorcontrib>Rothwell, N. J</creatorcontrib><title>Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol</addtitle><description>F. Carey, R. Forder, M. D. Edge, A. R. Greene, M. A. Horan, P. J. Strijbos and N. J. Rothwell
Bioscience Department II, ICI Pharmaceuticals, Macclesfield, United Kingdom.
Lipocortins form a group of proteins that have been proposed as mediators
of the anti-inflammatory actions of glucocorticoids.
Intracerebroventricular injection of a recombinant fragment of lipocortin 1
(NH2-terminal 1-188) caused dose-dependent (0.4-1.2 micrograms) reductions
in the acute increases in colonic temperature and oxygen consumption, which
occurred in response to central injections of recombinant interleukin 1
beta and gamma-interferon in conscious rats. In contrast the lipocortin
fragment did not affect the response to prostaglandin E2, and its activity
was prevented by heat treatment or by pretreatment of animals with
polyclonal antiserum raised to the fragment. Central injection of antiserum
significantly enhanced the thermogenic responses to interleukin 1 beta in
rats treated with dexamethasone without affecting the responses in normal
animals. These results support a physiological role for lipocortin in the
central effects of glucocorticoids.</description><subject>Animals</subject><subject>Annexins</subject><subject>Biological Factors - pharmacology</subject><subject>Body Temperature - drug effects</subject><subject>Calcium-Binding Proteins - pharmacology</subject><subject>Cytokines</subject><subject>Dexamethasone - pharmacology</subject><subject>Drug Synergism</subject><subject>Interleukin-1 - pharmacology</subject><subject>Male</subject><subject>Oxygen Consumption - drug effects</subject><subject>Peptide Fragments - pharmacology</subject><subject>Phospholipases - antagonists & inhibitors</subject><subject>Pyrogens - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Recombinant Proteins</subject><issn>0363-6119</issn><issn>0002-9513</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF9LwzAUR4Moc04_gpgv0JqbpOnyKGP-gYEgew9tmnSZa1OSDum3N7IxfLpwD-f3cBB6ApIDFPS52g_BtMccpCQ5LWRO80CFuELzRGkGXJJrNCdMsEwAyFt0F-OeEMIZZzM0o8ATEnO03rjBax9G12PANlRtZ_oRd75x1pmIhyn41vRO40qPzvcRe4v1NPpv1yecrFCN8R7d2OoQzcP5LtD2db1dvWebz7eP1csm04yLMQMCotZLTbm0IEXDKaMcjC2AyaUWxggmNV1aK2pLivRpKK01oaUpy6Is2AKVp1kdfIzBWDUE11VhUkDUXxZ1zqL-sqiURVH1lbIk8_FkDse6M83FO3dIPDvxnWt3Py4YNeym6PzBt9Nl9N_eLyWRcQQ</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>Carey, F</creator><creator>Forder, R</creator><creator>Edge, M. D</creator><creator>Greene, A. R</creator><creator>Horan, M. A</creator><creator>Strijbos, P. J</creator><creator>Rothwell, N. J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19900801</creationdate><title>Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats</title><author>Carey, F ; Forder, R ; Edge, M. D ; Greene, A. R ; Horan, M. A ; Strijbos, P. J ; Rothwell, N. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-1016bc8c249f196d423241ef51398c6ee639c28ff6bf058c6d22bc027e775753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Annexins</topic><topic>Biological Factors - pharmacology</topic><topic>Body Temperature - drug effects</topic><topic>Calcium-Binding Proteins - pharmacology</topic><topic>Cytokines</topic><topic>Dexamethasone - pharmacology</topic><topic>Drug Synergism</topic><topic>Interleukin-1 - pharmacology</topic><topic>Male</topic><topic>Oxygen Consumption - drug effects</topic><topic>Peptide Fragments - pharmacology</topic><topic>Phospholipases - antagonists & inhibitors</topic><topic>Pyrogens - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Recombinant Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carey, F</creatorcontrib><creatorcontrib>Forder, R</creatorcontrib><creatorcontrib>Edge, M. D</creatorcontrib><creatorcontrib>Greene, A. R</creatorcontrib><creatorcontrib>Horan, M. A</creatorcontrib><creatorcontrib>Strijbos, P. J</creatorcontrib><creatorcontrib>Rothwell, N. J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carey, F</au><au>Forder, R</au><au>Edge, M. D</au><au>Greene, A. R</au><au>Horan, M. A</au><au>Strijbos, P. J</au><au>Rothwell, N. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>259</volume><issue>2</issue><spage>266</spage><epage>R269</epage><pages>266-R269</pages><issn>0363-6119</issn><issn>0002-9513</issn><eissn>1522-1490</eissn><abstract>F. Carey, R. Forder, M. D. Edge, A. R. Greene, M. A. Horan, P. J. Strijbos and N. J. Rothwell
Bioscience Department II, ICI Pharmaceuticals, Macclesfield, United Kingdom.
Lipocortins form a group of proteins that have been proposed as mediators
of the anti-inflammatory actions of glucocorticoids.
Intracerebroventricular injection of a recombinant fragment of lipocortin 1
(NH2-terminal 1-188) caused dose-dependent (0.4-1.2 micrograms) reductions
in the acute increases in colonic temperature and oxygen consumption, which
occurred in response to central injections of recombinant interleukin 1
beta and gamma-interferon in conscious rats. In contrast the lipocortin
fragment did not affect the response to prostaglandin E2, and its activity
was prevented by heat treatment or by pretreatment of animals with
polyclonal antiserum raised to the fragment. Central injection of antiserum
significantly enhanced the thermogenic responses to interleukin 1 beta in
rats treated with dexamethasone without affecting the responses in normal
animals. These results support a physiological role for lipocortin in the
central effects of glucocorticoids.</abstract><cop>United States</cop><pmid>2143636</pmid><doi>10.1152/ajpregu.1990.259.2.r266</doi></addata></record> |
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| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 1990-08, Vol.259 (2), p.266-R269 |
| issn | 0363-6119 0002-9513 1522-1490 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Annexins Biological Factors - pharmacology Body Temperature - drug effects Calcium-Binding Proteins - pharmacology Cytokines Dexamethasone - pharmacology Drug Synergism Interleukin-1 - pharmacology Male Oxygen Consumption - drug effects Peptide Fragments - pharmacology Phospholipases - antagonists & inhibitors Pyrogens - pharmacology Rats Rats, Inbred Strains Recombinant Proteins |
| title | Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats |
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