Circulating osteocalcin in rats is inversely responsive to changes in corticosterone
P. E. Patterson-Buckendahl, R. E. Grindeland, D. C. Shakes, E. R. Morey-Holton and C. E. Cann Department of Radiology, University of California, San Francisco 94143. Decreased bone formation in rats during spaceflight may be attributable to corticosteroid excess induced by environmental factors othe...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1988-05, Vol.254 (5), p.828-R833 |
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| container_end_page | R833 |
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| container_issue | 5 |
| container_start_page | 828 |
| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 254 |
| creator | Patterson-Buckendahl, P. E Grindeland, R. E Shakes, D. C Morey-Holton, E. R Cann, C. E |
| description | P. E. Patterson-Buckendahl, R. E. Grindeland, D. C. Shakes, E. R. Morey-Holton and C. E. Cann
Department of Radiology, University of California, San Francisco 94143.
Decreased bone formation in rats during spaceflight may be attributable to
corticosteroid excess induced by environmental factors other than
weightlessness that are associated with spaceflight experiments. To
determine whether decreased osteocalcin, which may reflect altered bone
formation rate, could be associated with corticosteroid excess, we measured
serum osteocalcin in rats after injection of corticosterone or in response
to various environmental stimuli. Exogenous steroid elicited a time- and
dose-related decrease in serum osteocalcin, which was significant within 1
h of administration and maximally 25% below controls 1.5 h after injection
of 3.3 mg corticosterone/kg body wt, the highest dose we tested.
Adrenalectomy resulted in a 38% increase in osteocalcin. Exposure to
environmental stressors lasting from 1.5 h to 3 wk also resulted in
decreased osteocalcin levels, which showed a strong negative correlation (P
less than 0.001) with serum corticosterone levels and adrenal mass after
1-3 wk of chronic cold exposure. Changes in serum osteocalcin were
maximally about +/- 40% after 3 wk of chronic exposure to steroid excess or
depletion. The response of osteocalcin to the well-defined adrenal hormone
system implies an important role for corticosteroids in the control of
serum osteocalcin. |
| doi_str_mv | 10.1152/ajpregu.1988.254.5.R828 |
| format | Article |
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Department of Radiology, University of California, San Francisco 94143.
Decreased bone formation in rats during spaceflight may be attributable to
corticosteroid excess induced by environmental factors other than
weightlessness that are associated with spaceflight experiments. To
determine whether decreased osteocalcin, which may reflect altered bone
formation rate, could be associated with corticosteroid excess, we measured
serum osteocalcin in rats after injection of corticosterone or in response
to various environmental stimuli. Exogenous steroid elicited a time- and
dose-related decrease in serum osteocalcin, which was significant within 1
h of administration and maximally 25% below controls 1.5 h after injection
of 3.3 mg corticosterone/kg body wt, the highest dose we tested.
Adrenalectomy resulted in a 38% increase in osteocalcin. Exposure to
environmental stressors lasting from 1.5 h to 3 wk also resulted in
decreased osteocalcin levels, which showed a strong negative correlation (P
less than 0.001) with serum corticosterone levels and adrenal mass after
1-3 wk of chronic cold exposure. Changes in serum osteocalcin were
maximally about +/- 40% after 3 wk of chronic exposure to steroid excess or
depletion. The response of osteocalcin to the well-defined adrenal hormone
system implies an important role for corticosteroids in the control of
serum osteocalcin.</description><identifier>ISSN: 0363-6119</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1988.254.5.R828</identifier><identifier>PMID: 3259079</identifier><language>eng</language><publisher>United States</publisher><subject>Adrenal Glands - pathology ; Animals ; Calcium-Binding Proteins - blood ; Cold Temperature ; Corticosterone - pharmacology ; Dose-Response Relationship, Drug ; Organ Size ; Osteocalcin ; Osteogenesis ; Rats ; Space Flight ; Space life sciences ; Stress, Physiological - blood ; Thymus Gland - pathology ; Time Factors</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 1988-05, Vol.254 (5), p.828-R833</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c278t-2bd406f2f1d307f51b8f4f988ec92b36977bc6dd09031ca8b998849a64cef1973</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3259079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patterson-Buckendahl, P. E</creatorcontrib><creatorcontrib>Grindeland, R. E</creatorcontrib><creatorcontrib>Shakes, D. C</creatorcontrib><creatorcontrib>Morey-Holton, E. R</creatorcontrib><creatorcontrib>Cann, C. E</creatorcontrib><title>Circulating osteocalcin in rats is inversely responsive to changes in corticosterone</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol</addtitle><description>P. E. Patterson-Buckendahl, R. E. Grindeland, D. C. Shakes, E. R. Morey-Holton and C. E. Cann
Department of Radiology, University of California, San Francisco 94143.
Decreased bone formation in rats during spaceflight may be attributable to
corticosteroid excess induced by environmental factors other than
weightlessness that are associated with spaceflight experiments. To
determine whether decreased osteocalcin, which may reflect altered bone
formation rate, could be associated with corticosteroid excess, we measured
serum osteocalcin in rats after injection of corticosterone or in response
to various environmental stimuli. Exogenous steroid elicited a time- and
dose-related decrease in serum osteocalcin, which was significant within 1
h of administration and maximally 25% below controls 1.5 h after injection
of 3.3 mg corticosterone/kg body wt, the highest dose we tested.
Adrenalectomy resulted in a 38% increase in osteocalcin. Exposure to
environmental stressors lasting from 1.5 h to 3 wk also resulted in
decreased osteocalcin levels, which showed a strong negative correlation (P
less than 0.001) with serum corticosterone levels and adrenal mass after
1-3 wk of chronic cold exposure. Changes in serum osteocalcin were
maximally about +/- 40% after 3 wk of chronic exposure to steroid excess or
depletion. The response of osteocalcin to the well-defined adrenal hormone
system implies an important role for corticosteroids in the control of
serum osteocalcin.</description><subject>Adrenal Glands - pathology</subject><subject>Animals</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Cold Temperature</subject><subject>Corticosterone - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Organ Size</subject><subject>Osteocalcin</subject><subject>Osteogenesis</subject><subject>Rats</subject><subject>Space Flight</subject><subject>Space life sciences</subject><subject>Stress, Physiological - blood</subject><subject>Thymus Gland - pathology</subject><subject>Time Factors</subject><issn>0363-6119</issn><issn>0002-9513</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1LwzAUhoMoc05_gtgr71rz0Y_kUoZfMBBkXoc0Pe0yuqYm7WT_3pSNIRzIxXPeN5wHoQeCE0Iy-qS2vYNmTIjgPKFZmmTJF6f8As0DpTFJBb5Ec8xyFueEiGt04_0WY5yylM3QjNFM4ELM0XppnB5bNZiuiawfwGrVatNFYZwafGTCdHtwHtpD5MD3tvNmD9FgI71RXQMTj7R1g9FT3tkObtFVrVoPd6d3gb5fX9bL93j1-faxfF7FmhZ8iGlZpTivaU0qhos6IyWv0zocBFrQkuWiKEqdVxUWmBGteCkCS4XKUw01EQVboMdjb-_szwh-kDvjNbSt6sCOXhaciJxnNCwWx0XtrPcOatk7s1PuIAmWk0958iknnzL4lJmcfIbk_emLsdxBdc6dBAYeH_nGNJtf40D2m4M3trXN4Vz6r-8PPheFqQ</recordid><startdate>19880501</startdate><enddate>19880501</enddate><creator>Patterson-Buckendahl, P. E</creator><creator>Grindeland, R. E</creator><creator>Shakes, D. C</creator><creator>Morey-Holton, E. R</creator><creator>Cann, C. E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880501</creationdate><title>Circulating osteocalcin in rats is inversely responsive to changes in corticosterone</title><author>Patterson-Buckendahl, P. E ; Grindeland, R. E ; Shakes, D. C ; Morey-Holton, E. R ; Cann, C. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-2bd406f2f1d307f51b8f4f988ec92b36977bc6dd09031ca8b998849a64cef1973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adrenal Glands - pathology</topic><topic>Animals</topic><topic>Calcium-Binding Proteins - blood</topic><topic>Cold Temperature</topic><topic>Corticosterone - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Organ Size</topic><topic>Osteocalcin</topic><topic>Osteogenesis</topic><topic>Rats</topic><topic>Space Flight</topic><topic>Space life sciences</topic><topic>Stress, Physiological - blood</topic><topic>Thymus Gland - pathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patterson-Buckendahl, P. E</creatorcontrib><creatorcontrib>Grindeland, R. E</creatorcontrib><creatorcontrib>Shakes, D. C</creatorcontrib><creatorcontrib>Morey-Holton, E. R</creatorcontrib><creatorcontrib>Cann, C. E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patterson-Buckendahl, P. E</au><au>Grindeland, R. E</au><au>Shakes, D. C</au><au>Morey-Holton, E. R</au><au>Cann, C. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating osteocalcin in rats is inversely responsive to changes in corticosterone</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1988-05-01</date><risdate>1988</risdate><volume>254</volume><issue>5</issue><spage>828</spage><epage>R833</epage><pages>828-R833</pages><issn>0363-6119</issn><issn>0002-9513</issn><eissn>1522-1490</eissn><abstract>P. E. Patterson-Buckendahl, R. E. Grindeland, D. C. Shakes, E. R. Morey-Holton and C. E. Cann
Department of Radiology, University of California, San Francisco 94143.
Decreased bone formation in rats during spaceflight may be attributable to
corticosteroid excess induced by environmental factors other than
weightlessness that are associated with spaceflight experiments. To
determine whether decreased osteocalcin, which may reflect altered bone
formation rate, could be associated with corticosteroid excess, we measured
serum osteocalcin in rats after injection of corticosterone or in response
to various environmental stimuli. Exogenous steroid elicited a time- and
dose-related decrease in serum osteocalcin, which was significant within 1
h of administration and maximally 25% below controls 1.5 h after injection
of 3.3 mg corticosterone/kg body wt, the highest dose we tested.
Adrenalectomy resulted in a 38% increase in osteocalcin. Exposure to
environmental stressors lasting from 1.5 h to 3 wk also resulted in
decreased osteocalcin levels, which showed a strong negative correlation (P
less than 0.001) with serum corticosterone levels and adrenal mass after
1-3 wk of chronic cold exposure. Changes in serum osteocalcin were
maximally about +/- 40% after 3 wk of chronic exposure to steroid excess or
depletion. The response of osteocalcin to the well-defined adrenal hormone
system implies an important role for corticosteroids in the control of
serum osteocalcin.</abstract><cop>United States</cop><pmid>3259079</pmid><doi>10.1152/ajpregu.1988.254.5.R828</doi></addata></record> |
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| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 1988-05, Vol.254 (5), p.828-R833 |
| issn | 0363-6119 0002-9513 1522-1490 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpregu_254_5_R828 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenal Glands - pathology Animals Calcium-Binding Proteins - blood Cold Temperature Corticosterone - pharmacology Dose-Response Relationship, Drug Organ Size Osteocalcin Osteogenesis Rats Space Flight Space life sciences Stress, Physiological - blood Thymus Gland - pathology Time Factors |
| title | Circulating osteocalcin in rats is inversely responsive to changes in corticosterone |
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