Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs
W. C. Engeland, D. F. Bereiter and D. S. Gann Adrenomedullary secretion of methionine (Met)-enkephalin and of leucine (Leu)-enkephalin was measured in awake trained dogs subjected to 10 or 20% hemorrhage. Enkephalin secretory rates increased in proportion to the magnitude of hemorrhage with the rati...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1986-08, Vol.251 (2), p.341-R348 |
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| container_end_page | R348 |
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| container_issue | 2 |
| container_start_page | 341 |
| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 251 |
| creator | Engeland, W. C Bereiter, D. F Gann, D. S |
| description | W. C. Engeland, D. F. Bereiter and D. S. Gann
Adrenomedullary secretion of methionine (Met)-enkephalin and of leucine
(Leu)-enkephalin was measured in awake trained dogs subjected to 10 or 20%
hemorrhage. Enkephalin secretory rates increased in proportion to the
magnitude of hemorrhage with the ratio of Met-enkephalin to Leu-enkephalin
being approximately 4:1. Arterial concentrations of enkephalins reflected
adrenal secretion only in dogs exhibiting the largest secretory responses
to hemorrhage. Cross-correlation analysis of 12 individual experiments
showed that Met-enkephalin and epinephrine secretory rates were maximally
correlated at 0-min delay, suggesting that enkephalins are cosecreted with
catecholamines. The molar ratio in adrenal venous blood of epinephrine to
Met-enkephalin ranges from 480 +/- 50 to 570 +/- 60. Chronic denervation of
the adrenal by removing thoracic and lumbar splanchnic nerves prevented the
Met-enkephalin and catecholamine secretory responses to hemorrhage. These
data show that the adrenal medulla secretes enkephalins in response to
stimuli activated by hemorrhage. These findings suggest that secretion of
opiate-like peptides into the peripheral circulation may be a component of
the sympathetic response to trauma. |
| doi_str_mv | 10.1152/ajpregu.1986.251.2.R341 |
| format | Article |
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Adrenomedullary secretion of methionine (Met)-enkephalin and of leucine
(Leu)-enkephalin was measured in awake trained dogs subjected to 10 or 20%
hemorrhage. Enkephalin secretory rates increased in proportion to the
magnitude of hemorrhage with the ratio of Met-enkephalin to Leu-enkephalin
being approximately 4:1. Arterial concentrations of enkephalins reflected
adrenal secretion only in dogs exhibiting the largest secretory responses
to hemorrhage. Cross-correlation analysis of 12 individual experiments
showed that Met-enkephalin and epinephrine secretory rates were maximally
correlated at 0-min delay, suggesting that enkephalins are cosecreted with
catecholamines. The molar ratio in adrenal venous blood of epinephrine to
Met-enkephalin ranges from 480 +/- 50 to 570 +/- 60. Chronic denervation of
the adrenal by removing thoracic and lumbar splanchnic nerves prevented the
Met-enkephalin and catecholamine secretory responses to hemorrhage. These
data show that the adrenal medulla secretes enkephalins in response to
stimuli activated by hemorrhage. These findings suggest that secretion of
opiate-like peptides into the peripheral circulation may be a component of
the sympathetic response to trauma.</description><identifier>ISSN: 0363-6119</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1986.251.2.R341</identifier><identifier>PMID: 3740317</identifier><language>eng</language><publisher>United States</publisher><subject>Adrenal Glands - innervation ; Adrenal Glands - secretion ; Animals ; Arteries ; Denervation ; Dogs ; Enkephalin, Leucine - secretion ; Enkephalin, Methionine - blood ; Enkephalin, Methionine - secretion ; Epinephrine - secretion ; Female ; Hemodynamics ; Hemorrhage - blood ; Hemorrhage - metabolism ; Hemorrhage - physiopathology ; Male ; Norepinephrine - secretion ; Sympathetic Nervous System - physiology ; Wakefulness</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 1986-08, Vol.251 (2), p.341-R348</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3740317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Engeland, W. C</creatorcontrib><creatorcontrib>Bereiter, D. F</creatorcontrib><creatorcontrib>Gann, D. S</creatorcontrib><title>Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol</addtitle><description>W. C. Engeland, D. F. Bereiter and D. S. Gann
Adrenomedullary secretion of methionine (Met)-enkephalin and of leucine
(Leu)-enkephalin was measured in awake trained dogs subjected to 10 or 20%
hemorrhage. Enkephalin secretory rates increased in proportion to the
magnitude of hemorrhage with the ratio of Met-enkephalin to Leu-enkephalin
being approximately 4:1. Arterial concentrations of enkephalins reflected
adrenal secretion only in dogs exhibiting the largest secretory responses
to hemorrhage. Cross-correlation analysis of 12 individual experiments
showed that Met-enkephalin and epinephrine secretory rates were maximally
correlated at 0-min delay, suggesting that enkephalins are cosecreted with
catecholamines. The molar ratio in adrenal venous blood of epinephrine to
Met-enkephalin ranges from 480 +/- 50 to 570 +/- 60. Chronic denervation of
the adrenal by removing thoracic and lumbar splanchnic nerves prevented the
Met-enkephalin and catecholamine secretory responses to hemorrhage. These
data show that the adrenal medulla secretes enkephalins in response to
stimuli activated by hemorrhage. These findings suggest that secretion of
opiate-like peptides into the peripheral circulation may be a component of
the sympathetic response to trauma.</description><subject>Adrenal Glands - innervation</subject><subject>Adrenal Glands - secretion</subject><subject>Animals</subject><subject>Arteries</subject><subject>Denervation</subject><subject>Dogs</subject><subject>Enkephalin, Leucine - secretion</subject><subject>Enkephalin, Methionine - blood</subject><subject>Enkephalin, Methionine - secretion</subject><subject>Epinephrine - secretion</subject><subject>Female</subject><subject>Hemodynamics</subject><subject>Hemorrhage - blood</subject><subject>Hemorrhage - metabolism</subject><subject>Hemorrhage - physiopathology</subject><subject>Male</subject><subject>Norepinephrine - secretion</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Wakefulness</subject><issn>0363-6119</issn><issn>0002-9513</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkFtr3DAQRkVoSbdpfkKpnvpmVyPJujyW0CaFQKC3VyHL40tiW67kJey_r5ddQp4G5nzzDRxCPgErASr-xT8uCbt9CdaokldQ8vKnkHBBdhvlBUjL3pAdE0oUCsC-I-9zfmSMSSHFJbkUWjIBekf-_jpMi197XIdAQ5zXFEcaW-qbhLMfacaQNhbn4xLnJ1x6Pw5zpr5dMdEep5hS7zukw0z9s39C2sQufyBvWz9mvD7PK_Ln-7ffN3fF_cPtj5uv90Xglq-FUbqRNlQSFFd13VRta4VRWIGWpq5tkIFLMFpY4CJApRVnnhuOxvDQsEZckc-n3iXFf3vMq5uGHHAc_Yxxn51W1nCQegvqUzCkmHPC1i1pmHw6OGDuaNSdjbqjUbcZddwdjW6XH88v9vWEzcvdWeHGixPvh65_HhK6pT_kIY6xO7yUvur7D7CuhHw</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>Engeland, W. C</creator><creator>Bereiter, D. F</creator><creator>Gann, D. S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860801</creationdate><title>Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs</title><author>Engeland, W. C ; Bereiter, D. F ; Gann, D. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-867d49c541626bbd5ff9386e51748bb9c4c2418739123c157620a282e882cd0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adrenal Glands - innervation</topic><topic>Adrenal Glands - secretion</topic><topic>Animals</topic><topic>Arteries</topic><topic>Denervation</topic><topic>Dogs</topic><topic>Enkephalin, Leucine - secretion</topic><topic>Enkephalin, Methionine - blood</topic><topic>Enkephalin, Methionine - secretion</topic><topic>Epinephrine - secretion</topic><topic>Female</topic><topic>Hemodynamics</topic><topic>Hemorrhage - blood</topic><topic>Hemorrhage - metabolism</topic><topic>Hemorrhage - physiopathology</topic><topic>Male</topic><topic>Norepinephrine - secretion</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Wakefulness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Engeland, W. C</creatorcontrib><creatorcontrib>Bereiter, D. F</creatorcontrib><creatorcontrib>Gann, D. S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Engeland, W. C</au><au>Bereiter, D. F</au><au>Gann, D. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>251</volume><issue>2</issue><spage>341</spage><epage>R348</epage><pages>341-R348</pages><issn>0363-6119</issn><issn>0002-9513</issn><eissn>1522-1490</eissn><abstract>W. C. Engeland, D. F. Bereiter and D. S. Gann
Adrenomedullary secretion of methionine (Met)-enkephalin and of leucine
(Leu)-enkephalin was measured in awake trained dogs subjected to 10 or 20%
hemorrhage. Enkephalin secretory rates increased in proportion to the
magnitude of hemorrhage with the ratio of Met-enkephalin to Leu-enkephalin
being approximately 4:1. Arterial concentrations of enkephalins reflected
adrenal secretion only in dogs exhibiting the largest secretory responses
to hemorrhage. Cross-correlation analysis of 12 individual experiments
showed that Met-enkephalin and epinephrine secretory rates were maximally
correlated at 0-min delay, suggesting that enkephalins are cosecreted with
catecholamines. The molar ratio in adrenal venous blood of epinephrine to
Met-enkephalin ranges from 480 +/- 50 to 570 +/- 60. Chronic denervation of
the adrenal by removing thoracic and lumbar splanchnic nerves prevented the
Met-enkephalin and catecholamine secretory responses to hemorrhage. These
data show that the adrenal medulla secretes enkephalins in response to
stimuli activated by hemorrhage. These findings suggest that secretion of
opiate-like peptides into the peripheral circulation may be a component of
the sympathetic response to trauma.</abstract><cop>United States</cop><pmid>3740317</pmid><doi>10.1152/ajpregu.1986.251.2.R341</doi></addata></record> |
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| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 1986-08, Vol.251 (2), p.341-R348 |
| issn | 0363-6119 0002-9513 1522-1490 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpregu_251_2_R341 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adrenal Glands - innervation Adrenal Glands - secretion Animals Arteries Denervation Dogs Enkephalin, Leucine - secretion Enkephalin, Methionine - blood Enkephalin, Methionine - secretion Epinephrine - secretion Female Hemodynamics Hemorrhage - blood Hemorrhage - metabolism Hemorrhage - physiopathology Male Norepinephrine - secretion Sympathetic Nervous System - physiology Wakefulness |
| title | Sympathetic control of adrenal secretion of enkephalins after hemorrhage in awake dogs |
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