Forebrain control of fluid and electrolyte homeostasis and angiotensin sensitivity in rabbit
G. D. Fink and W. J. Bryan A small discrete area near the optic recess of the anterior ventral third ventricle (AV3V) in the rat brain has been shown to be an important mediator of cardiovascular and dipsogenic response to angiotensin II and osmotic stimuli and to be involved in normal day-to-day re...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 1980-11, Vol.239 (5), p.372-R376 |
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| container_end_page | R376 |
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| container_issue | 5 |
| container_start_page | 372 |
| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 239 |
| creator | Fink, G. D Bryan, W. J |
| description | G. D. Fink and W. J. Bryan
A small discrete area near the optic recess of the anterior ventral third
ventricle (AV3V) in the rat brain has been shown to be an important
mediator of cardiovascular and dipsogenic response to angiotensin II and
osmotic stimuli and to be involved in normal day-to-day regulation of water
and electrolyte balance. However, no attempt has been made until now to
explore the function of the AV3V in species other than the rat. In the
present study, rabbits subjected to electrolytic lesion of the AV3V
exhibited expanded plasma volume and plasma sodium concentration, and
significantly attenuated pressor responses to angiotensin II and hypertonic
sodium chloride solutions injected via the lateral ventricles. Resting
arterial pressure, plasma potassium concentration, extracellular fluid
volume, and pressor responses to intravenous angiotensin II were not
changed by lesioning. Thus, the effects of AV3V lesions in rabbits are
similar, but not identical, to those previously observed in rats. Rabbits
should be a suitable species in which to carry out studies aimed at
distinguishing central and peripheral cardiovascular effects of angiotensin
II. |
| doi_str_mv | 10.1152/ajpregu.1980.239.5.R372 |
| format | Article |
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A small discrete area near the optic recess of the anterior ventral third
ventricle (AV3V) in the rat brain has been shown to be an important
mediator of cardiovascular and dipsogenic response to angiotensin II and
osmotic stimuli and to be involved in normal day-to-day regulation of water
and electrolyte balance. However, no attempt has been made until now to
explore the function of the AV3V in species other than the rat. In the
present study, rabbits subjected to electrolytic lesion of the AV3V
exhibited expanded plasma volume and plasma sodium concentration, and
significantly attenuated pressor responses to angiotensin II and hypertonic
sodium chloride solutions injected via the lateral ventricles. Resting
arterial pressure, plasma potassium concentration, extracellular fluid
volume, and pressor responses to intravenous angiotensin II were not
changed by lesioning. Thus, the effects of AV3V lesions in rabbits are
similar, but not identical, to those previously observed in rats. Rabbits
should be a suitable species in which to carry out studies aimed at
distinguishing central and peripheral cardiovascular effects of angiotensin
II.</description><identifier>ISSN: 0363-6119</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.1980.239.5.R372</identifier><identifier>PMID: 7435649</identifier><language>eng</language><publisher>United States</publisher><subject>Angiotensin II - physiology ; Animals ; Blood Pressure ; Brain - physiology ; Cerebral Ventricles ; Drinking Behavior - physiology ; Heart Rate ; Homeostasis ; Male ; Rabbits ; Water-Electrolyte Balance</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 1980-11, Vol.239 (5), p.372-R376</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-90cea884d1beb0aa092183319ab3fd772a005121f3034582feaa23fe8014c4b43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7435649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fink, G. D</creatorcontrib><creatorcontrib>Bryan, W. J</creatorcontrib><title>Forebrain control of fluid and electrolyte homeostasis and angiotensin sensitivity in rabbit</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol</addtitle><description>G. D. Fink and W. J. Bryan
A small discrete area near the optic recess of the anterior ventral third
ventricle (AV3V) in the rat brain has been shown to be an important
mediator of cardiovascular and dipsogenic response to angiotensin II and
osmotic stimuli and to be involved in normal day-to-day regulation of water
and electrolyte balance. However, no attempt has been made until now to
explore the function of the AV3V in species other than the rat. In the
present study, rabbits subjected to electrolytic lesion of the AV3V
exhibited expanded plasma volume and plasma sodium concentration, and
significantly attenuated pressor responses to angiotensin II and hypertonic
sodium chloride solutions injected via the lateral ventricles. Resting
arterial pressure, plasma potassium concentration, extracellular fluid
volume, and pressor responses to intravenous angiotensin II were not
changed by lesioning. Thus, the effects of AV3V lesions in rabbits are
similar, but not identical, to those previously observed in rats. Rabbits
should be a suitable species in which to carry out studies aimed at
distinguishing central and peripheral cardiovascular effects of angiotensin
II.</description><subject>Angiotensin II - physiology</subject><subject>Animals</subject><subject>Blood Pressure</subject><subject>Brain - physiology</subject><subject>Cerebral Ventricles</subject><subject>Drinking Behavior - physiology</subject><subject>Heart Rate</subject><subject>Homeostasis</subject><subject>Male</subject><subject>Rabbits</subject><subject>Water-Electrolyte Balance</subject><issn>0363-6119</issn><issn>0002-9513</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1Lw0AQhhdRaq3-BDEnb4n72SRHKVYFQRC9CcsmmSRbkmzd3Sj59yY2FE_DzPsx8CB0Q3BEiKB3are3UPURSRMcUZZGInpjMT1By1GlIeEpPkVLzNYsXBOSnqML53YYY844W6BFzJlY83SJPrfGQmaV7oLcdN6aJjBlUDa9LgLVFQE0kE_XwUNQmxaM88pp96eprtLGQ-fGsJuG19_aD8G4WpVl2l-is1I1Dq7muUIf24f3zVP48vr4vLl_CXNOuA9TnINKEl6QDDKsFE4pSRgjqcpYWcQxVRgLQknJMOMioSUoRVkJCSY85xlnK3R76N1b89WD87LVLoemUR2Y3slYMMFiEY_G-GDMrXHOQin3VrfKDpJgOXGVM1c5cZUjVynkxHVMXs8v-qyF4pibQY56eNBrXdU_2oLc14PTpjHVcCz91_cLszKILw</recordid><startdate>198011</startdate><enddate>198011</enddate><creator>Fink, G. D</creator><creator>Bryan, W. J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198011</creationdate><title>Forebrain control of fluid and electrolyte homeostasis and angiotensin sensitivity in rabbit</title><author>Fink, G. D ; Bryan, W. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-90cea884d1beb0aa092183319ab3fd772a005121f3034582feaa23fe8014c4b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Angiotensin II - physiology</topic><topic>Animals</topic><topic>Blood Pressure</topic><topic>Brain - physiology</topic><topic>Cerebral Ventricles</topic><topic>Drinking Behavior - physiology</topic><topic>Heart Rate</topic><topic>Homeostasis</topic><topic>Male</topic><topic>Rabbits</topic><topic>Water-Electrolyte Balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fink, G. D</creatorcontrib><creatorcontrib>Bryan, W. J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fink, G. D</au><au>Bryan, W. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Forebrain control of fluid and electrolyte homeostasis and angiotensin sensitivity in rabbit</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1980-11</date><risdate>1980</risdate><volume>239</volume><issue>5</issue><spage>372</spage><epage>R376</epage><pages>372-R376</pages><issn>0363-6119</issn><issn>0002-9513</issn><eissn>1522-1490</eissn><abstract>G. D. Fink and W. J. Bryan
A small discrete area near the optic recess of the anterior ventral third
ventricle (AV3V) in the rat brain has been shown to be an important
mediator of cardiovascular and dipsogenic response to angiotensin II and
osmotic stimuli and to be involved in normal day-to-day regulation of water
and electrolyte balance. However, no attempt has been made until now to
explore the function of the AV3V in species other than the rat. In the
present study, rabbits subjected to electrolytic lesion of the AV3V
exhibited expanded plasma volume and plasma sodium concentration, and
significantly attenuated pressor responses to angiotensin II and hypertonic
sodium chloride solutions injected via the lateral ventricles. Resting
arterial pressure, plasma potassium concentration, extracellular fluid
volume, and pressor responses to intravenous angiotensin II were not
changed by lesioning. Thus, the effects of AV3V lesions in rabbits are
similar, but not identical, to those previously observed in rats. Rabbits
should be a suitable species in which to carry out studies aimed at
distinguishing central and peripheral cardiovascular effects of angiotensin
II.</abstract><cop>United States</cop><pmid>7435649</pmid><doi>10.1152/ajpregu.1980.239.5.R372</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 1980-11, Vol.239 (5), p.372-R376 |
| issn | 0363-6119 0002-9513 1522-1490 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpregu_239_5_R372 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Angiotensin II - physiology Animals Blood Pressure Brain - physiology Cerebral Ventricles Drinking Behavior - physiology Heart Rate Homeostasis Male Rabbits Water-Electrolyte Balance |
| title | Forebrain control of fluid and electrolyte homeostasis and angiotensin sensitivity in rabbit |
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