In vitro cellular effects of perfluorochemicals correlate with their lipid solubility
Department of Biological Research, Alliance Pharmaceutical Corporation, San Diego, California 92121 Preclinical studies comparing perflubron partial liquid ventilation with conventional mechanical ventilation have indicated that perflubron partial liquid ventilation may exert some anti-inflammatory...
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| Veröffentlicht in: | American journal of physiology. Lung cellular and molecular physiology 2000-05, Vol.278 (5), p.1018-L1024 |
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| container_title | American journal of physiology. Lung cellular and molecular physiology |
| container_volume | 278 |
| creator | Obraztsov, Viktor V Neslund, Gerald G Kornbrust, Elisabeth S Flaim, Stephen F Woods, Catherine M |
| description | Department of Biological Research, Alliance Pharmaceutical
Corporation, San Diego, California 92121
Preclinical
studies comparing perflubron partial liquid ventilation with
conventional mechanical ventilation have indicated that perflubron
partial liquid ventilation may exert some anti-inflammatory effects. To
assess whether these effects were related to the lipid solubility
properties of perflubron rather than to nonspecific biophysical
properties of the perfluorocarbon (PFC) liquid phase, we studied the
effects of PFCs with varying lipid solubilities on the platelet
aggregation response to various procoagulants and the erythrocyte
hemolytic response to osmotic stress. In both cases, the degree of the
response was directly related to the lipid solubility of the PFC. All
the perflubron content of erythrocytes was found to be associated with
the membrane compartment. The time to reach a maximum effect on
hemolysis with perflubron was relatively slow (2-4 h), which
paralleled the time for perflubron to accumulate in erythrocyte
membranes. The rate and extent of perflubron partitioning into lecithin
liposomes were similar to those of erythrocyte membranes, supporting
the hypothesis that perflubron was partitioning into the lipid
component of the membranes. Thus some of the potential modulatory
effects of perflubron on excessive inflammatory responses that occur
during acute lung injury and acute respiratory distress syndrome may be
influenced in part by the extent of PFC partitioning into the lipid
bilayers of cellular membranes.
perfluorocarbon; perflubron; membrane partitioning |
| doi_str_mv | 10.1152/ajplung.2000.278.5.l1018 |
| format | Article |
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Corporation, San Diego, California 92121
Preclinical
studies comparing perflubron partial liquid ventilation with
conventional mechanical ventilation have indicated that perflubron
partial liquid ventilation may exert some anti-inflammatory effects. To
assess whether these effects were related to the lipid solubility
properties of perflubron rather than to nonspecific biophysical
properties of the perfluorocarbon (PFC) liquid phase, we studied the
effects of PFCs with varying lipid solubilities on the platelet
aggregation response to various procoagulants and the erythrocyte
hemolytic response to osmotic stress. In both cases, the degree of the
response was directly related to the lipid solubility of the PFC. All
the perflubron content of erythrocytes was found to be associated with
the membrane compartment. The time to reach a maximum effect on
hemolysis with perflubron was relatively slow (2-4 h), which
paralleled the time for perflubron to accumulate in erythrocyte
membranes. The rate and extent of perflubron partitioning into lecithin
liposomes were similar to those of erythrocyte membranes, supporting
the hypothesis that perflubron was partitioning into the lipid
component of the membranes. Thus some of the potential modulatory
effects of perflubron on excessive inflammatory responses that occur
during acute lung injury and acute respiratory distress syndrome may be
influenced in part by the extent of PFC partitioning into the lipid
bilayers of cellular membranes.
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Corporation, San Diego, California 92121
Preclinical
studies comparing perflubron partial liquid ventilation with
conventional mechanical ventilation have indicated that perflubron
partial liquid ventilation may exert some anti-inflammatory effects. To
assess whether these effects were related to the lipid solubility
properties of perflubron rather than to nonspecific biophysical
properties of the perfluorocarbon (PFC) liquid phase, we studied the
effects of PFCs with varying lipid solubilities on the platelet
aggregation response to various procoagulants and the erythrocyte
hemolytic response to osmotic stress. In both cases, the degree of the
response was directly related to the lipid solubility of the PFC. All
the perflubron content of erythrocytes was found to be associated with
the membrane compartment. The time to reach a maximum effect on
hemolysis with perflubron was relatively slow (2-4 h), which
paralleled the time for perflubron to accumulate in erythrocyte
membranes. The rate and extent of perflubron partitioning into lecithin
liposomes were similar to those of erythrocyte membranes, supporting
the hypothesis that perflubron was partitioning into the lipid
component of the membranes. Thus some of the potential modulatory
effects of perflubron on excessive inflammatory responses that occur
during acute lung injury and acute respiratory distress syndrome may be
influenced in part by the extent of PFC partitioning into the lipid
bilayers of cellular membranes.
perfluorocarbon; perflubron; membrane partitioning</description><subject>Animals</subject><subject>Blood Substitutes - pharmacokinetics</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Fluorocarbons - pharmacokinetics</subject><subject>Hemolysis</subject><subject>Humans</subject><subject>Hypotonic Solutions - pharmacology</subject><subject>Lipid Metabolism</subject><subject>Liposomes - metabolism</subject><subject>Olive Oil</subject><subject>Phosphatidylcholines</subject><subject>Plant Oils</subject><subject>Platelet Aggregation - drug effects</subject><subject>Regression Analysis</subject><subject>Solubility</subject><subject>Swine</subject><issn>1040-0605</issn><issn>1522-1504</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u3CAUhVHUKH_tK1SsurN7weCf7KqoaSONlE2yRhhfj4mYwQXcdN4-jGZSzSYrkO53DpePEMqgZEzy7_pldst2XXIAKHnTlrJ0DFh7Rq7ymBdMgviU7yCggBrkJbmO8SXDEqC-IJcMmpaJqroizw9b-tem4KlB5xanA8VxRJMi9SOdMYxu8cGbCTfWaBep8SGg0wnpq00TTRPaQJ2d7UCjd0tvnU27z-R8zDB-OZ435Pn-59Pd72L1-Ovh7seqMEKyVJiu15UALVvAjouKj0JzU8s8bGXH0VQ9g7o3gx4q3VWdGDTret70bcOZbvrqhnw79M7B_1kwJrWxcf8RvUW_RNXkeM1Fm8H2AJrgYww4qjnYjQ47xUDtlaqjUrVXqrJSJdVqrzRHvx7fWPoNDifBg8MM3B6Aya6nVxtQzdMuWu_8eqfuF-ee8F967z9pVvMw5nD5cfj_TifrvAEvAJuh</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>Obraztsov, Viktor V</creator><creator>Neslund, Gerald G</creator><creator>Kornbrust, Elisabeth S</creator><creator>Flaim, Stephen F</creator><creator>Woods, Catherine M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000501</creationdate><title>In vitro cellular effects of perfluorochemicals correlate with their lipid solubility</title><author>Obraztsov, Viktor V ; Neslund, Gerald G ; Kornbrust, Elisabeth S ; Flaim, Stephen F ; Woods, Catherine M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-c9ba340a580e92432f4a2c654518592ec3b106bcdad3a9394da19b27b8721a7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Blood Substitutes - pharmacokinetics</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Fluorocarbons - pharmacokinetics</topic><topic>Hemolysis</topic><topic>Humans</topic><topic>Hypotonic Solutions - pharmacology</topic><topic>Lipid Metabolism</topic><topic>Liposomes - metabolism</topic><topic>Olive Oil</topic><topic>Phosphatidylcholines</topic><topic>Plant Oils</topic><topic>Platelet Aggregation - drug effects</topic><topic>Regression Analysis</topic><topic>Solubility</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obraztsov, Viktor V</creatorcontrib><creatorcontrib>Neslund, Gerald G</creatorcontrib><creatorcontrib>Kornbrust, Elisabeth S</creatorcontrib><creatorcontrib>Flaim, Stephen F</creatorcontrib><creatorcontrib>Woods, Catherine M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obraztsov, Viktor V</au><au>Neslund, Gerald G</au><au>Kornbrust, Elisabeth S</au><au>Flaim, Stephen F</au><au>Woods, Catherine M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro cellular effects of perfluorochemicals correlate with their lipid solubility</atitle><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle><addtitle>Am J Physiol Lung Cell Mol Physiol</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>278</volume><issue>5</issue><spage>1018</spage><epage>L1024</epage><pages>1018-L1024</pages><issn>1040-0605</issn><eissn>1522-1504</eissn><abstract>Department of Biological Research, Alliance Pharmaceutical
Corporation, San Diego, California 92121
Preclinical
studies comparing perflubron partial liquid ventilation with
conventional mechanical ventilation have indicated that perflubron
partial liquid ventilation may exert some anti-inflammatory effects. To
assess whether these effects were related to the lipid solubility
properties of perflubron rather than to nonspecific biophysical
properties of the perfluorocarbon (PFC) liquid phase, we studied the
effects of PFCs with varying lipid solubilities on the platelet
aggregation response to various procoagulants and the erythrocyte
hemolytic response to osmotic stress. In both cases, the degree of the
response was directly related to the lipid solubility of the PFC. All
the perflubron content of erythrocytes was found to be associated with
the membrane compartment. The time to reach a maximum effect on
hemolysis with perflubron was relatively slow (2-4 h), which
paralleled the time for perflubron to accumulate in erythrocyte
membranes. The rate and extent of perflubron partitioning into lecithin
liposomes were similar to those of erythrocyte membranes, supporting
the hypothesis that perflubron was partitioning into the lipid
component of the membranes. Thus some of the potential modulatory
effects of perflubron on excessive inflammatory responses that occur
during acute lung injury and acute respiratory distress syndrome may be
influenced in part by the extent of PFC partitioning into the lipid
bilayers of cellular membranes.
perfluorocarbon; perflubron; membrane partitioning</abstract><cop>United States</cop><pmid>10781433</pmid><doi>10.1152/ajplung.2000.278.5.l1018</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Blood Substitutes - pharmacokinetics Erythrocyte Membrane - metabolism Fluorocarbons - pharmacokinetics Hemolysis Humans Hypotonic Solutions - pharmacology Lipid Metabolism Liposomes - metabolism Olive Oil Phosphatidylcholines Plant Oils Platelet Aggregation - drug effects Regression Analysis Solubility Swine |
| title | In vitro cellular effects of perfluorochemicals correlate with their lipid solubility |
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