Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition

Division of Therapeutics, University Hospital, Nottingham NG7 2UH, United Kingdom Elevation in cell cAMP content can inhibit mitogenic signaling in cultured human airway smooth muscle (HASM) cells. We studied the effects of the type 3-selective phosphodiesterase inhibitor siguazodan, the type 4-sele...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 1999-03, Vol.276 (3), p.412-L419
Hauptverfasser:	Billington, Charlotte K, Joseph, Sunil K, Swan, Caroline, Scott, Mark G. H, Jobson, Timothy M, Hall, Ian P
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Becaplermin Cell Division - drug effects Cell Division - physiology Cells, Cultured Cyclic AMP - physiology Guanidines - pharmacology Humans Isoenzymes - metabolism Luciferases - metabolism Muscle, Smooth - cytology Muscle, Smooth - enzymology Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - metabolism Platelet-Derived Growth Factor - pharmacology Proto-Oncogene Proteins c-sis Pyridazines - pharmacology Thymidine - metabolism Trachea - cytology Trachea - enzymology
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