Interferon-gamma regulation of interleukin 6 in monocytic cells
D. E. Biondillo, S. A. Konicek and G. K. Iwamoto Department of Medicine, Indiana University School of Medicine, Indianapolis 46202. The regulation of interleukin 6 (IL-6) is dependent on many factors that include numerous stimuli such as lipopolysaccharide (LPS), viruses, and other cytokines. These...
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| Veröffentlicht in: | American journal of physiology. Lung cellular and molecular physiology 1994-11, Vol.267 (5), p.564-L568 |
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| container_end_page | L568 |
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| container_issue | 5 |
| container_start_page | 564 |
| container_title | American journal of physiology. Lung cellular and molecular physiology |
| container_volume | 267 |
| creator | Biondillo, D. E Konicek, S. A Iwamoto, G. K |
| description | D. E. Biondillo, S. A. Konicek and G. K. Iwamoto
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
The regulation of interleukin 6 (IL-6) is dependent on many factors that
include numerous stimuli such as lipopolysaccharide (LPS), viruses, and
other cytokines. These studies demonstrate the ability of interferon-gamma
(IFN-gamma) to significantly enhance IL-6 mRNA and protein production in
LPS-stimulated monocytes and THP-1 cells. IL-6 protein production was
increased sevenfold in LPS-stimulated cells with the addition of IFN-gamma.
IL-6 mRNA production was increased in a dose-dependent fashion up to
15-fold in LPS-stimulated cells with the addition of IFN-gamma. The
enhanced production of IL-6 mRNA that occurs with the addition of IFN-gamma
to LPS-stimulated monocytic cells was due to increased transcription of
IL-6 mRNA. The ability of IFN-gamma to enhance IL-6 production may play an
important role in many inflammatory processes. |
| doi_str_mv | 10.1152/ajplung.1994.267.5.l564 |
| format | Article |
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Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
The regulation of interleukin 6 (IL-6) is dependent on many factors that
include numerous stimuli such as lipopolysaccharide (LPS), viruses, and
other cytokines. These studies demonstrate the ability of interferon-gamma
(IFN-gamma) to significantly enhance IL-6 mRNA and protein production in
LPS-stimulated monocytes and THP-1 cells. IL-6 protein production was
increased sevenfold in LPS-stimulated cells with the addition of IFN-gamma.
IL-6 mRNA production was increased in a dose-dependent fashion up to
15-fold in LPS-stimulated cells with the addition of IFN-gamma. The
enhanced production of IL-6 mRNA that occurs with the addition of IFN-gamma
to LPS-stimulated monocytic cells was due to increased transcription of
IL-6 mRNA. The ability of IFN-gamma to enhance IL-6 production may play an
important role in many inflammatory processes.</description><identifier>ISSN: 1040-0605</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1504</identifier><identifier>DOI: 10.1152/ajplung.1994.267.5.l564</identifier><identifier>PMID: 7526705</identifier><language>eng</language><publisher>United States</publisher><subject>Antigens, CD - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Half-Life ; Humans ; Interferon-gamma - pharmacology ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Lipopolysaccharide Receptors ; Lipopolysaccharides - pharmacology ; Monocytes - metabolism ; RNA, Messenger - chemistry ; RNA, Messenger - metabolism ; Transcription, Genetic - drug effects ; Tumor Cells, Cultured</subject><ispartof>American journal of physiology. Lung cellular and molecular physiology, 1994-11, Vol.267 (5), p.564-L568</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-8f2bf57209d6e68f824bd89e080e8c51fe919bba0f339230314bd507c23ecba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7526705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biondillo, D. E</creatorcontrib><creatorcontrib>Konicek, S. A</creatorcontrib><creatorcontrib>Iwamoto, G. K</creatorcontrib><title>Interferon-gamma regulation of interleukin 6 in monocytic cells</title><title>American journal of physiology. Lung cellular and molecular physiology</title><addtitle>Am J Physiol</addtitle><description>D. E. Biondillo, S. A. Konicek and G. K. Iwamoto
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
The regulation of interleukin 6 (IL-6) is dependent on many factors that
include numerous stimuli such as lipopolysaccharide (LPS), viruses, and
other cytokines. These studies demonstrate the ability of interferon-gamma
(IFN-gamma) to significantly enhance IL-6 mRNA and protein production in
LPS-stimulated monocytes and THP-1 cells. IL-6 protein production was
increased sevenfold in LPS-stimulated cells with the addition of IFN-gamma.
IL-6 mRNA production was increased in a dose-dependent fashion up to
15-fold in LPS-stimulated cells with the addition of IFN-gamma. The
enhanced production of IL-6 mRNA that occurs with the addition of IFN-gamma
to LPS-stimulated monocytic cells was due to increased transcription of
IL-6 mRNA. The ability of IFN-gamma to enhance IL-6 production may play an
important role in many inflammatory processes.</description><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation, Myelomonocytic - metabolism</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Interferon-gamma - pharmacology</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - metabolism</subject><subject>Lipopolysaccharide Receptors</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Monocytes - metabolism</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription, Genetic - drug effects</subject><subject>Tumor Cells, Cultured</subject><issn>1040-0605</issn><issn>0002-9513</issn><issn>1522-1504</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1LwzAUhoMoU6c_QewfaD1JmrS9Ehl-DAbe7D6kWdJlpk1JW6T_3oyN4dU5h4f3hfMg9Iwhw5iRF3no3dQ1Ga6qPCO8yFjmGM-v0F2kJMUM8uu4Qw4pcGC36H4YDgDAAPgCLQoWM8Du0Ou6G3UwOvgubWTbyiToZnJytL5LvEnsETs9_dgu4fFKWt95NY9WJUo7NzygGyPdoB_Pc4m2H-_b1Ve6-f5cr942qaJ5MaalIbVhBYFqxzUvTUnyeldWGkrQpWLY6ApXdS3BUFoRChRHzqBQhGpVS7pExalWBT8MQRvRB9vKMAsM4ihEnIWIoxARnxNMbKKQmHw6JfupbvXukjsbiDw98b1t9r82aNHv58F655v5Uvqv7w-D1G91</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>Biondillo, D. E</creator><creator>Konicek, S. A</creator><creator>Iwamoto, G. K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19941101</creationdate><title>Interferon-gamma regulation of interleukin 6 in monocytic cells</title><author>Biondillo, D. E ; Konicek, S. A ; Iwamoto, G. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-8f2bf57209d6e68f824bd89e080e8c51fe919bba0f339230314bd507c23ecba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation, Myelomonocytic - metabolism</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Interferon-gamma - pharmacology</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukin-6 - metabolism</topic><topic>Lipopolysaccharide Receptors</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Monocytes - metabolism</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription, Genetic - drug effects</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biondillo, D. E</creatorcontrib><creatorcontrib>Konicek, S. A</creatorcontrib><creatorcontrib>Iwamoto, G. K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biondillo, D. E</au><au>Konicek, S. A</au><au>Iwamoto, G. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interferon-gamma regulation of interleukin 6 in monocytic cells</atitle><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>267</volume><issue>5</issue><spage>564</spage><epage>L568</epage><pages>564-L568</pages><issn>1040-0605</issn><issn>0002-9513</issn><eissn>1522-1504</eissn><abstract>D. E. Biondillo, S. A. Konicek and G. K. Iwamoto
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
The regulation of interleukin 6 (IL-6) is dependent on many factors that
include numerous stimuli such as lipopolysaccharide (LPS), viruses, and
other cytokines. These studies demonstrate the ability of interferon-gamma
(IFN-gamma) to significantly enhance IL-6 mRNA and protein production in
LPS-stimulated monocytes and THP-1 cells. IL-6 protein production was
increased sevenfold in LPS-stimulated cells with the addition of IFN-gamma.
IL-6 mRNA production was increased in a dose-dependent fashion up to
15-fold in LPS-stimulated cells with the addition of IFN-gamma. The
enhanced production of IL-6 mRNA that occurs with the addition of IFN-gamma
to LPS-stimulated monocytic cells was due to increased transcription of
IL-6 mRNA. The ability of IFN-gamma to enhance IL-6 production may play an
important role in many inflammatory processes.</abstract><cop>United States</cop><pmid>7526705</pmid><doi>10.1152/ajplung.1994.267.5.l564</doi></addata></record> |
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| identifier | ISSN: 1040-0605 |
| ispartof | American journal of physiology. Lung cellular and molecular physiology, 1994-11, Vol.267 (5), p.564-L568 |
| issn | 1040-0605 0002-9513 1522-1504 |
| language | eng |
| recordid | cdi_highwire_physiology_ajplung_267_5_L564 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Half-Life Humans Interferon-gamma - pharmacology Interleukin-6 - genetics Interleukin-6 - metabolism Lipopolysaccharide Receptors Lipopolysaccharides - pharmacology Monocytes - metabolism RNA, Messenger - chemistry RNA, Messenger - metabolism Transcription, Genetic - drug effects Tumor Cells, Cultured |
| title | Interferon-gamma regulation of interleukin 6 in monocytic cells |
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