Expression of peroxidase activity in rat tracheal epithelial cells associated with Mycoplasma pulmonis
M. Kinbara, T. Ueda and K. Hirai Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan. Endogenous peroxidase activity has not been localized in the tracheal mucosal epithelial cells of specific pathogen-free (SPF) rats. After natural infection with Mycoplasma pulmonis in SPF rats, per...
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| Veröffentlicht in: | American journal of physiology. Lung cellular and molecular physiology 1992-01, Vol.262 (1), p.92-L99 |
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| container_end_page | L99 |
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| container_issue | 1 |
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| container_title | American journal of physiology. Lung cellular and molecular physiology |
| container_volume | 262 |
| creator | Kinbara, M Ueda, T Hirai, K |
| description | M. Kinbara, T. Ueda and K. Hirai
Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan.
Endogenous peroxidase activity has not been localized in the tracheal
mucosal epithelial cells of specific pathogen-free (SPF) rats. After
natural infection with Mycoplasma pulmonis in SPF rats, peroxidase activity
became localized to the endoplasmic reticulum, nuclear envelope, and Golgi
apparatus of tracheal ciliated or mucous secretory cells. Some secretory
cells occasionally had peroxidase-positive secretory granules. At 1 wk M.
pulmonis was found to attach to these epithelial cells, which then showed
positive peroxidase activity at 2 wk. Serum antibody titers against M.
pulmonis were positive at 5 wk. These results suggest that virulent
mycoplasma infection and interaction with the tracheal epithelial cells
trigger the de novo expression of peroxidase activity, which seems to play
a role in mucosal anti-microbial defense mechanisms. |
| doi_str_mv | 10.1152/ajplung.1992.262.1.l92 |
| format | Article |
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Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan.
Endogenous peroxidase activity has not been localized in the tracheal
mucosal epithelial cells of specific pathogen-free (SPF) rats. After
natural infection with Mycoplasma pulmonis in SPF rats, peroxidase activity
became localized to the endoplasmic reticulum, nuclear envelope, and Golgi
apparatus of tracheal ciliated or mucous secretory cells. Some secretory
cells occasionally had peroxidase-positive secretory granules. At 1 wk M.
pulmonis was found to attach to these epithelial cells, which then showed
positive peroxidase activity at 2 wk. Serum antibody titers against M.
pulmonis were positive at 5 wk. These results suggest that virulent
mycoplasma infection and interaction with the tracheal epithelial cells
trigger the de novo expression of peroxidase activity, which seems to play
a role in mucosal anti-microbial defense mechanisms.</description><identifier>ISSN: 1040-0605</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1504</identifier><identifier>DOI: 10.1152/ajplung.1992.262.1.l92</identifier><identifier>PMID: 1310227</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Antigens, Bacterial - analysis ; DNA, Bacterial - analysis ; Epithelium - enzymology ; Epithelium - pathology ; Germ-Free Life ; Histocytochemistry ; Male ; Microscopy, Electron ; Peroxidase - metabolism ; Pneumonia, Mycoplasma - enzymology ; Pneumonia, Mycoplasma - microbiology ; Pneumonia, Mycoplasma - pathology ; Rats ; Trachea - enzymology ; Trachea - pathology</subject><ispartof>American journal of physiology. Lung cellular and molecular physiology, 1992-01, Vol.262 (1), p.92-L99</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-fa9ad70cf92e921ff105834bd3498d5e4d111e2f9e7c95608cb5efa7876ab2793</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1310227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinbara, M</creatorcontrib><creatorcontrib>Ueda, T</creatorcontrib><creatorcontrib>Hirai, K</creatorcontrib><title>Expression of peroxidase activity in rat tracheal epithelial cells associated with Mycoplasma pulmonis</title><title>American journal of physiology. Lung cellular and molecular physiology</title><addtitle>Am J Physiol</addtitle><description>M. Kinbara, T. Ueda and K. Hirai
Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan.
Endogenous peroxidase activity has not been localized in the tracheal
mucosal epithelial cells of specific pathogen-free (SPF) rats. After
natural infection with Mycoplasma pulmonis in SPF rats, peroxidase activity
became localized to the endoplasmic reticulum, nuclear envelope, and Golgi
apparatus of tracheal ciliated or mucous secretory cells. Some secretory
cells occasionally had peroxidase-positive secretory granules. At 1 wk M.
pulmonis was found to attach to these epithelial cells, which then showed
positive peroxidase activity at 2 wk. Serum antibody titers against M.
pulmonis were positive at 5 wk. These results suggest that virulent
mycoplasma infection and interaction with the tracheal epithelial cells
trigger the de novo expression of peroxidase activity, which seems to play
a role in mucosal anti-microbial defense mechanisms.</description><subject>Animals</subject><subject>Antigens, Bacterial - analysis</subject><subject>DNA, Bacterial - analysis</subject><subject>Epithelium - enzymology</subject><subject>Epithelium - pathology</subject><subject>Germ-Free Life</subject><subject>Histocytochemistry</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Peroxidase - metabolism</subject><subject>Pneumonia, Mycoplasma - enzymology</subject><subject>Pneumonia, Mycoplasma - microbiology</subject><subject>Pneumonia, Mycoplasma - pathology</subject><subject>Rats</subject><subject>Trachea - enzymology</subject><subject>Trachea - pathology</subject><issn>1040-0605</issn><issn>0002-9513</issn><issn>1522-1504</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtv2zAQhImiQZqk_QkteOopUkjqZR6DII8CLnppz8SaWloMKJElpST696VhozntADM7u_gI-cZZyXkjbuA5uGXal1xKUYpWlLx0UnwgF9kUBW9Y_TFrVrOCtaz5RC5TemaMNYy15-ScV5wJ0V0Qc_8WIqZk_US9oQGjf7M9JKSgZ_ti55XaiUaY6RxBDwiOYrDzgM5mqdG5RCElry3M2NPXbNGfq_bBQRqBhsWNfrLpMzkz4BJ-Oc0r8ufh_vfdU7H99fjj7nZb6Kqu5sKAhL5j2kiBUnBjOGs2Vb3rq1pu-gbrnnOOwkjstGxattG7Bg10m66FnehkdUW-H3tD9H8XTLMabTp8CRP6JakuhwTnbQ62x6COPqWIRoVoR4ir4kwdAKsTYHUArDJgxdVWirz49XRh2Y3Yv68diWb_-ugPdj-82ogqDGvG6_x-_d_5XvcPDw6L1g</recordid><startdate>19920101</startdate><enddate>19920101</enddate><creator>Kinbara, M</creator><creator>Ueda, T</creator><creator>Hirai, K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920101</creationdate><title>Expression of peroxidase activity in rat tracheal epithelial cells associated with Mycoplasma pulmonis</title><author>Kinbara, M ; Ueda, T ; Hirai, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-fa9ad70cf92e921ff105834bd3498d5e4d111e2f9e7c95608cb5efa7876ab2793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antigens, Bacterial - analysis</topic><topic>DNA, Bacterial - analysis</topic><topic>Epithelium - enzymology</topic><topic>Epithelium - pathology</topic><topic>Germ-Free Life</topic><topic>Histocytochemistry</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Peroxidase - metabolism</topic><topic>Pneumonia, Mycoplasma - enzymology</topic><topic>Pneumonia, Mycoplasma - microbiology</topic><topic>Pneumonia, Mycoplasma - pathology</topic><topic>Rats</topic><topic>Trachea - enzymology</topic><topic>Trachea - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinbara, M</creatorcontrib><creatorcontrib>Ueda, T</creatorcontrib><creatorcontrib>Hirai, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinbara, M</au><au>Ueda, T</au><au>Hirai, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of peroxidase activity in rat tracheal epithelial cells associated with Mycoplasma pulmonis</atitle><jtitle>American journal of physiology. Lung cellular and molecular physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1992-01-01</date><risdate>1992</risdate><volume>262</volume><issue>1</issue><spage>92</spage><epage>L99</epage><pages>92-L99</pages><issn>1040-0605</issn><issn>0002-9513</issn><eissn>1522-1504</eissn><abstract>M. Kinbara, T. Ueda and K. Hirai
Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan.
Endogenous peroxidase activity has not been localized in the tracheal
mucosal epithelial cells of specific pathogen-free (SPF) rats. After
natural infection with Mycoplasma pulmonis in SPF rats, peroxidase activity
became localized to the endoplasmic reticulum, nuclear envelope, and Golgi
apparatus of tracheal ciliated or mucous secretory cells. Some secretory
cells occasionally had peroxidase-positive secretory granules. At 1 wk M.
pulmonis was found to attach to these epithelial cells, which then showed
positive peroxidase activity at 2 wk. Serum antibody titers against M.
pulmonis were positive at 5 wk. These results suggest that virulent
mycoplasma infection and interaction with the tracheal epithelial cells
trigger the de novo expression of peroxidase activity, which seems to play
a role in mucosal anti-microbial defense mechanisms.</abstract><cop>United States</cop><pmid>1310227</pmid><doi>10.1152/ajplung.1992.262.1.l92</doi></addata></record> |
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| ispartof | American journal of physiology. Lung cellular and molecular physiology, 1992-01, Vol.262 (1), p.92-L99 |
| issn | 1040-0605 0002-9513 1522-1504 |
| language | eng |
| recordid | cdi_highwire_physiology_ajplung_262_1_L92 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antigens, Bacterial - analysis DNA, Bacterial - analysis Epithelium - enzymology Epithelium - pathology Germ-Free Life Histocytochemistry Male Microscopy, Electron Peroxidase - metabolism Pneumonia, Mycoplasma - enzymology Pneumonia, Mycoplasma - microbiology Pneumonia, Mycoplasma - pathology Rats Trachea - enzymology Trachea - pathology |
| title | Expression of peroxidase activity in rat tracheal epithelial cells associated with Mycoplasma pulmonis |
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