Cardiac contractility modulation by electric currents applied during the refractory period
1 Departments of Medicine and 2 Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032; 3 IMPULSE Dynamics, Tirat Hacarmel, 39120; and 4 Department of Physiology And Biophysics, Technion-Israel Institute of Technology, Haifa 31096, Israel Inotropic effe...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 2002-05, Vol.282 (5), p.H1642-H1647 |
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| container_issue | 5 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 282 |
| creator | Mohri, Satoshi He, Kun-Lun Dickstein, Marc Mika, Yuval Shimizu, Juichiro Shemer, Itzhak Yi, Geng-Hua Wang, Jie Ben-Haim, Shlomo Burkhoff, Daniel |
| description | 1 Departments of Medicine and
2 Anesthesiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032;
3 IMPULSE Dynamics, Tirat Hacarmel, 39120; and
4 Department of Physiology And Biophysics,
Technion-Israel Institute of Technology, Haifa 31096, Israel
Inotropic effects of electric currents
applied during the refractory period have been reported in cardiac
muscle in vitro using voltage-clamp techniques. We investigated how
electric currents modulate cardiac contractility in normal canine
hearts in vivo. Six dogs were instrumented to measure regional segment
length, ventricular volume (sonomicrometry), and ventricular pressure. Cardiac contractility modulating (CCM) electric currents (biphasic square pulses, amplitude ±20 mA, total duration 30 ms) were
delivered during the refractory period between pairs of electrodes
placed on anterior and posterior walls. CCM significantly increased
index of global contractility ( E es ) from
5.9 ± 2.9 to 8.3 ± 4.6 mmHg/ml with anterior CCM, from
5.3 ± 1.8 to 8.9 ± 4.0 mmHg/ml with posterior CCM, and from
6.1 ± 2.6 to 11.0 ± 7.0 mmHg/ml with combined CCM ( P |
| doi_str_mv | 10.1152/ajpheart.00959.2001 |
| format | Article |
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2 Anesthesiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032;
3 IMPULSE Dynamics, Tirat Hacarmel, 39120; and
4 Department of Physiology And Biophysics,
Technion-Israel Institute of Technology, Haifa 31096, Israel
Inotropic effects of electric currents
applied during the refractory period have been reported in cardiac
muscle in vitro using voltage-clamp techniques. We investigated how
electric currents modulate cardiac contractility in normal canine
hearts in vivo. Six dogs were instrumented to measure regional segment
length, ventricular volume (sonomicrometry), and ventricular pressure. Cardiac contractility modulating (CCM) electric currents (biphasic square pulses, amplitude ±20 mA, total duration 30 ms) were
delivered during the refractory period between pairs of electrodes
placed on anterior and posterior walls. CCM significantly increased
index of global contractility ( E es ) from
5.9 ± 2.9 to 8.3 ± 4.6 mmHg/ml with anterior CCM, from
5.3 ± 1.8 to 8.9 ± 4.0 mmHg/ml with posterior CCM, and from
6.1 ± 2.6 to 11.0 ± 7.0 mmHg/ml with combined CCM ( P < 0.01, no significant change in volume axis
intercept). End-systolic pressure-segment length relations showed
contractility enhancement near CCM delivery sites, but not remotely.
Relaxation was not influenced. CCM increased mean aortic pressure, but
did not change peripheral resistance. Locally applied
electrical currents enhanced global cardiac contractility via regional
changes in myocardial contractility without impairing relaxation in situ.
canine heart; calcium; in situ heart failure; voltage
clamping</description><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.00959.2001</identifier><identifier>PMID: 11959626</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Aorta - physiology ; Blood Pressure ; Dogs ; Electric Conductivity ; Electric Stimulation ; Electrodes ; Female ; Heart Ventricles - anatomy & histology ; Male ; Myocardial Contraction ; Patch-Clamp Techniques ; Pressure ; Systole ; Vascular Resistance ; Ventricular Function ; Ventricular Function, Left</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 2002-05, Vol.282 (5), p.H1642-H1647</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-18e0de4c006c7420478ba9e49207aa009697dca38f45dc8586b510c8b594966e3</citedby><cites>FETCH-LOGICAL-c428t-18e0de4c006c7420478ba9e49207aa009697dca38f45dc8586b510c8b594966e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11959626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohri, Satoshi</creatorcontrib><creatorcontrib>He, Kun-Lun</creatorcontrib><creatorcontrib>Dickstein, Marc</creatorcontrib><creatorcontrib>Mika, Yuval</creatorcontrib><creatorcontrib>Shimizu, Juichiro</creatorcontrib><creatorcontrib>Shemer, Itzhak</creatorcontrib><creatorcontrib>Yi, Geng-Hua</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Ben-Haim, Shlomo</creatorcontrib><creatorcontrib>Burkhoff, Daniel</creatorcontrib><title>Cardiac contractility modulation by electric currents applied during the refractory period</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol Heart Circ Physiol</addtitle><description>1 Departments of Medicine and
2 Anesthesiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032;
3 IMPULSE Dynamics, Tirat Hacarmel, 39120; and
4 Department of Physiology And Biophysics,
Technion-Israel Institute of Technology, Haifa 31096, Israel
Inotropic effects of electric currents
applied during the refractory period have been reported in cardiac
muscle in vitro using voltage-clamp techniques. We investigated how
electric currents modulate cardiac contractility in normal canine
hearts in vivo. Six dogs were instrumented to measure regional segment
length, ventricular volume (sonomicrometry), and ventricular pressure. Cardiac contractility modulating (CCM) electric currents (biphasic square pulses, amplitude ±20 mA, total duration 30 ms) were
delivered during the refractory period between pairs of electrodes
placed on anterior and posterior walls. CCM significantly increased
index of global contractility ( E es ) from
5.9 ± 2.9 to 8.3 ± 4.6 mmHg/ml with anterior CCM, from
5.3 ± 1.8 to 8.9 ± 4.0 mmHg/ml with posterior CCM, and from
6.1 ± 2.6 to 11.0 ± 7.0 mmHg/ml with combined CCM ( P < 0.01, no significant change in volume axis
intercept). End-systolic pressure-segment length relations showed
contractility enhancement near CCM delivery sites, but not remotely.
Relaxation was not influenced. CCM increased mean aortic pressure, but
did not change peripheral resistance. Locally applied
electrical currents enhanced global cardiac contractility via regional
changes in myocardial contractility without impairing relaxation in situ.
canine heart; calcium; in situ heart failure; voltage
clamping</description><subject>Animals</subject><subject>Aorta - physiology</subject><subject>Blood Pressure</subject><subject>Dogs</subject><subject>Electric Conductivity</subject><subject>Electric Stimulation</subject><subject>Electrodes</subject><subject>Female</subject><subject>Heart Ventricles - anatomy & histology</subject><subject>Male</subject><subject>Myocardial Contraction</subject><subject>Patch-Clamp Techniques</subject><subject>Pressure</subject><subject>Systole</subject><subject>Vascular Resistance</subject><subject>Ventricular Function</subject><subject>Ventricular Function, Left</subject><issn>0363-6135</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EoqXwBUjIP5DWj9iJxQpVlCIhsSkbNpZjO42rtIkcR5C_x6WlsGE1i7nnauYAcIvRFGNGZmrTVlb5MEVIMDElCOEzMI4bkmBGxTkYI8ppwjFlI3DVdRuEEMs4vQQjjCPBCR-D97nyxikNdbMLXungahcGuG1MX6vgmh0sBmhrq4N3MdR7b3ehg6pta2cNNL13uzUMlYXelnu-8QNsrXeNuQYXpao7e3OcE_C2eFzNl8nL69Pz_OEl0SnJQ4Jzi4xNNUJcZylBaZYXSthUEJQpFX_jIjNa0bxMmdE5y3nBMNJ5wUQqOLd0AuihV_um6-IZsvVuq_wgMZJ7U_LHlPw2JfemInV3oNq-2FrzyxzVxMD9IVC5dfXhvJVtNXSuqZv1IBd9Xa_sZzhVk5xIJpeYp0S2poz07H_6dM8fin4BUo6OgQ</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Mohri, Satoshi</creator><creator>He, Kun-Lun</creator><creator>Dickstein, Marc</creator><creator>Mika, Yuval</creator><creator>Shimizu, Juichiro</creator><creator>Shemer, Itzhak</creator><creator>Yi, Geng-Hua</creator><creator>Wang, Jie</creator><creator>Ben-Haim, Shlomo</creator><creator>Burkhoff, Daniel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20020501</creationdate><title>Cardiac contractility modulation by electric currents applied during the refractory period</title><author>Mohri, Satoshi ; He, Kun-Lun ; Dickstein, Marc ; Mika, Yuval ; Shimizu, Juichiro ; Shemer, Itzhak ; Yi, Geng-Hua ; Wang, Jie ; Ben-Haim, Shlomo ; Burkhoff, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-18e0de4c006c7420478ba9e49207aa009697dca38f45dc8586b510c8b594966e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Aorta - physiology</topic><topic>Blood Pressure</topic><topic>Dogs</topic><topic>Electric Conductivity</topic><topic>Electric Stimulation</topic><topic>Electrodes</topic><topic>Female</topic><topic>Heart Ventricles - anatomy & histology</topic><topic>Male</topic><topic>Myocardial Contraction</topic><topic>Patch-Clamp Techniques</topic><topic>Pressure</topic><topic>Systole</topic><topic>Vascular Resistance</topic><topic>Ventricular Function</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohri, Satoshi</creatorcontrib><creatorcontrib>He, Kun-Lun</creatorcontrib><creatorcontrib>Dickstein, Marc</creatorcontrib><creatorcontrib>Mika, Yuval</creatorcontrib><creatorcontrib>Shimizu, Juichiro</creatorcontrib><creatorcontrib>Shemer, Itzhak</creatorcontrib><creatorcontrib>Yi, Geng-Hua</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Ben-Haim, Shlomo</creatorcontrib><creatorcontrib>Burkhoff, Daniel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohri, Satoshi</au><au>He, Kun-Lun</au><au>Dickstein, Marc</au><au>Mika, Yuval</au><au>Shimizu, Juichiro</au><au>Shemer, Itzhak</au><au>Yi, Geng-Hua</au><au>Wang, Jie</au><au>Ben-Haim, Shlomo</au><au>Burkhoff, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac contractility modulation by electric currents applied during the refractory period</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol Heart Circ Physiol</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>282</volume><issue>5</issue><spage>H1642</spage><epage>H1647</epage><pages>H1642-H1647</pages><issn>0363-6135</issn><eissn>1522-1539</eissn><abstract>1 Departments of Medicine and
2 Anesthesiology, College of Physicians and
Surgeons, Columbia University, New York, New York 10032;
3 IMPULSE Dynamics, Tirat Hacarmel, 39120; and
4 Department of Physiology And Biophysics,
Technion-Israel Institute of Technology, Haifa 31096, Israel
Inotropic effects of electric currents
applied during the refractory period have been reported in cardiac
muscle in vitro using voltage-clamp techniques. We investigated how
electric currents modulate cardiac contractility in normal canine
hearts in vivo. Six dogs were instrumented to measure regional segment
length, ventricular volume (sonomicrometry), and ventricular pressure. Cardiac contractility modulating (CCM) electric currents (biphasic square pulses, amplitude ±20 mA, total duration 30 ms) were
delivered during the refractory period between pairs of electrodes
placed on anterior and posterior walls. CCM significantly increased
index of global contractility ( E es ) from
5.9 ± 2.9 to 8.3 ± 4.6 mmHg/ml with anterior CCM, from
5.3 ± 1.8 to 8.9 ± 4.0 mmHg/ml with posterior CCM, and from
6.1 ± 2.6 to 11.0 ± 7.0 mmHg/ml with combined CCM ( P < 0.01, no significant change in volume axis
intercept). End-systolic pressure-segment length relations showed
contractility enhancement near CCM delivery sites, but not remotely.
Relaxation was not influenced. CCM increased mean aortic pressure, but
did not change peripheral resistance. Locally applied
electrical currents enhanced global cardiac contractility via regional
changes in myocardial contractility without impairing relaxation in situ.
canine heart; calcium; in situ heart failure; voltage
clamping</abstract><cop>United States</cop><pmid>11959626</pmid><doi>10.1152/ajpheart.00959.2001</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 2002-05, Vol.282 (5), p.H1642-H1647 |
| issn | 0363-6135 1522-1539 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpheart_282_5_H1642 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Aorta - physiology Blood Pressure Dogs Electric Conductivity Electric Stimulation Electrodes Female Heart Ventricles - anatomy & histology Male Myocardial Contraction Patch-Clamp Techniques Pressure Systole Vascular Resistance Ventricular Function Ventricular Function, Left |
| title | Cardiac contractility modulation by electric currents applied during the refractory period |
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