Effects of dynamic exercise on mean blood velocity and muscle interstitial metabolite responses in humans

1 Department of Medicine, Division of Cardiology, and 2 Department of Health Evaluation Sciences, Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey 17033; and 3 Lebanon Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042 We examined the effects of dynamic one-legged knee extension exercise on mean blood velocity (MBV) and muscle interstitial metabolite concentrations in healthy young subjects ( n = 7). Femoral MBV (Doppler), mean arterial pressure (MAP) and muscle interstitial metabolite (adenosine, lactate, phosphate, K + , pH, and H + ; by microdialysis) concentrations were measured during 5 min of exercise at 30 and 60% of maximal work capacity (W max ). MAP increased ( P