Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect

1 Dipartimento di Scienze Cliniche e Biologiche and 2 Dipartimento di Neuroscienze, Sezione di Fisiologia, dell'Università di Torino, 10043 Orbassano (TO), Italy; and 3 Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-6568 This study focused on the mechan...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2001-06, Vol.280 (6), p.H2823-H2832
Hauptverfasser:	Rastaldo, R, Paolocci, N, Chiribiri, A, Penna, C, Gattullo, D, Pagliaro, P
Format:	Artikel
Sprache:	eng
Schlagworte:	8,11,14-Eicosatrienoic Acid - analogs & derivatives 8,11,14-Eicosatrienoic Acid - metabolism 8,11,14-Eicosatrienoic Acid - pharmacology Animals Arachidonic Acid - metabolism Blood Pressure - drug effects Bradykinin - metabolism Bradykinin - pharmacology Coronary Vessels - drug effects Coronary Vessels - physiology Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Enzyme Inhibitors - pharmacology Heart - drug effects Heart - physiology Heart Rate - drug effects Heart Rate - physiology In Vitro Techniques Indomethacin - pharmacology Male Myocardium - metabolism NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Octoxynol - pharmacology Proadifen - pharmacology Rats Rats, Wistar Tachyphylaxis - physiology Triazoles - pharmacology Ventricular Function, Left - drug effects
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