Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction
Department of Pharmacological and Physiological Science, Saint Louis University Health Sciences Center, St. Louis, Missouri 63104 Neuropeptide Y (NPY) is a vasoconstrictor peptide and a cotransmitter with norepinephrine (NE) in sympathetic nerve terminals and is thought to be involved in sympathetic...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1998-01, Vol.274 (1), p.H290-H294 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
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| creator | Han, Songping Yang, Chun-Lian Chen, Xiaoli Naes, Linda Cox, Bryan F Westfall, Thomas |
| description | Department of Pharmacological and Physiological Science, Saint Louis
University Health Sciences Center, St. Louis, Missouri 63104
Neuropeptide Y (NPY) is a vasoconstrictor
peptide and a cotransmitter with norepinephrine (NE) in sympathetic
nerve terminals and is thought to be involved in sympathetic nerve
stimulation (SNS)-induced vasoconstriction. Using BIBP-3226, a
Y 1 receptor selective antagonist,
we examined this hypothesis in the isolated and perfused mesenteric
vascular bed. SNS produced a frequency-dependent increase in perfusion
pressure and concomitant overflow of NPY immunoreactivity in the
perfusate.
[Leu 31 ,Pro 34 ]NPY
potentiated NE-induced and ATP-induced vasoconstriction, indicating the
presence and biological action of
Y 1 receptors in this vascular bed.
The potentiation effect of
[Leu 31 ,Pro 34 ]NPY
of the increase in perfusion pressure by NE, ATP, or SNS was prevented
by BIBP-3226. In addition, SNS-induced vasoconstriction at both high
and low frequencies was significantly attenuated by BIBP-3226 at a
concentration that completely blocked the
[Leu 31 ,Pro 34 ]NPY-induced
potentiation of the NE- or ATP-induced vasoconstrictor effect. These
results suggest that ~30% of vasoconstriction produced by SNS
depends on NPY in the mesenteric vascular bed.
BIBP-3226; neuropeptide Y release; adenosine 5'-triphosphate; mesenteric vascular bed; rat |
| doi_str_mv | 10.1152/ajpheart.1998.274.1.H290 |
| format | Article |
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University Health Sciences Center, St. Louis, Missouri 63104
Neuropeptide Y (NPY) is a vasoconstrictor
peptide and a cotransmitter with norepinephrine (NE) in sympathetic
nerve terminals and is thought to be involved in sympathetic nerve
stimulation (SNS)-induced vasoconstriction. Using BIBP-3226, a
Y 1 receptor selective antagonist,
we examined this hypothesis in the isolated and perfused mesenteric
vascular bed. SNS produced a frequency-dependent increase in perfusion
pressure and concomitant overflow of NPY immunoreactivity in the
perfusate.
[Leu 31 ,Pro 34 ]NPY
potentiated NE-induced and ATP-induced vasoconstriction, indicating the
presence and biological action of
Y 1 receptors in this vascular bed.
The potentiation effect of
[Leu 31 ,Pro 34 ]NPY
of the increase in perfusion pressure by NE, ATP, or SNS was prevented
by BIBP-3226. In addition, SNS-induced vasoconstriction at both high
and low frequencies was significantly attenuated by BIBP-3226 at a
concentration that completely blocked the
[Leu 31 ,Pro 34 ]NPY-induced
potentiation of the NE- or ATP-induced vasoconstrictor effect. These
results suggest that ~30% of vasoconstriction produced by SNS
depends on NPY in the mesenteric vascular bed.
BIBP-3226; neuropeptide Y release; adenosine 5'-triphosphate; mesenteric vascular bed; rat</description><identifier>ISSN: 0363-6135</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.1998.274.1.H290</identifier><identifier>PMID: 9458879</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Arginine - analogs & derivatives ; Arginine - pharmacology ; Electric Stimulation ; Intestines - blood supply ; Male ; Muscle, Smooth, Vascular - innervation ; Muscle, Smooth, Vascular - physiology ; Neuropeptide Y - analogs & derivatives ; Neuropeptide Y - metabolism ; Neuropeptide Y - pharmacology ; Neuropeptide Y - physiology ; Norepinephrine - pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Neuropeptide Y - antagonists & inhibitors ; Splanchnic Circulation - drug effects ; Splanchnic Circulation - physiology ; Sympathetic Nervous System - physiology ; Vasoconstriction - drug effects ; Vasoconstriction - physiology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1998-01, Vol.274 (1), p.H290-H294</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-f54117f3fff60a163de976d3522ba8acb83c6fa28e8f04052cd0fe0c1a37335f3</citedby><cites>FETCH-LOGICAL-c400t-f54117f3fff60a163de976d3522ba8acb83c6fa28e8f04052cd0fe0c1a37335f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3038,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9458879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Songping</creatorcontrib><creatorcontrib>Yang, Chun-Lian</creatorcontrib><creatorcontrib>Chen, Xiaoli</creatorcontrib><creatorcontrib>Naes, Linda</creatorcontrib><creatorcontrib>Cox, Bryan F</creatorcontrib><creatorcontrib>Westfall, Thomas</creatorcontrib><title>Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol</addtitle><description>Department of Pharmacological and Physiological Science, Saint Louis
University Health Sciences Center, St. Louis, Missouri 63104
Neuropeptide Y (NPY) is a vasoconstrictor
peptide and a cotransmitter with norepinephrine (NE) in sympathetic
nerve terminals and is thought to be involved in sympathetic nerve
stimulation (SNS)-induced vasoconstriction. Using BIBP-3226, a
Y 1 receptor selective antagonist,
we examined this hypothesis in the isolated and perfused mesenteric
vascular bed. SNS produced a frequency-dependent increase in perfusion
pressure and concomitant overflow of NPY immunoreactivity in the
perfusate.
[Leu 31 ,Pro 34 ]NPY
potentiated NE-induced and ATP-induced vasoconstriction, indicating the
presence and biological action of
Y 1 receptors in this vascular bed.
The potentiation effect of
[Leu 31 ,Pro 34 ]NPY
of the increase in perfusion pressure by NE, ATP, or SNS was prevented
by BIBP-3226. In addition, SNS-induced vasoconstriction at both high
and low frequencies was significantly attenuated by BIBP-3226 at a
concentration that completely blocked the
[Leu 31 ,Pro 34 ]NPY-induced
potentiation of the NE- or ATP-induced vasoconstrictor effect. These
results suggest that ~30% of vasoconstriction produced by SNS
depends on NPY in the mesenteric vascular bed.
BIBP-3226; neuropeptide Y release; adenosine 5'-triphosphate; mesenteric vascular bed; rat</description><subject>Animals</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - pharmacology</subject><subject>Electric Stimulation</subject><subject>Intestines - blood supply</subject><subject>Male</subject><subject>Muscle, Smooth, Vascular - innervation</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>Neuropeptide Y - analogs & derivatives</subject><subject>Neuropeptide Y - metabolism</subject><subject>Neuropeptide Y - pharmacology</subject><subject>Neuropeptide Y - physiology</subject><subject>Norepinephrine - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Neuropeptide Y - antagonists & inhibitors</subject><subject>Splanchnic Circulation - drug effects</subject><subject>Splanchnic Circulation - physiology</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstriction - physiology</subject><issn>0363-6135</issn><issn>0002-9513</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1u2zAURokigeO4fYQAnLJJIUX9UN2CpGkKGMjiDp0Imrq0aEiiSlJO_falYNft0onDud_Hew9CmJKU0iJ7kPuxBelCSuuap1mVpzR9zWryAS0jzhJasPoKLQkrWVJSVtygW-_3hJCiKtkCLeq84Lyql6h9Ng5UwHAwDQwKsLYOhxawsx1gq_EAk7MjjCFy_AObAftjP8o4EoyK1B0A-2D6qZPB2CExQzMpaPBBeqvs4IMzagYf0bWWnYdP53eFvr982Ty9Juu3r9-eHteJygkJiS5ySivNtNYlkbRkDdRV2bB41FZyqbacqVLLjAPXJCdFphqigSgqWcVYodkK3Z96R2d_TuCD6I1X0HVyADt5UdVlxTLO4yA_DSpnvXegxehML91RUCJmyeKPZDFLFlGyoGKWHKN35z-mbQ_NJXi2GvnnE2_Nrn2PgsXYHr2xnd0dxcvUdRv4FS71f4vF2MwHpP8PX1b6Z5vfRUGj_Q</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Han, Songping</creator><creator>Yang, Chun-Lian</creator><creator>Chen, Xiaoli</creator><creator>Naes, Linda</creator><creator>Cox, Bryan F</creator><creator>Westfall, Thomas</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980101</creationdate><title>Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction</title><author>Han, Songping ; Yang, Chun-Lian ; Chen, Xiaoli ; Naes, Linda ; Cox, Bryan F ; Westfall, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-f54117f3fff60a163de976d3522ba8acb83c6fa28e8f04052cd0fe0c1a37335f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - pharmacology</topic><topic>Electric Stimulation</topic><topic>Intestines - blood supply</topic><topic>Male</topic><topic>Muscle, Smooth, Vascular - innervation</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>Neuropeptide Y - analogs & derivatives</topic><topic>Neuropeptide Y - metabolism</topic><topic>Neuropeptide Y - pharmacology</topic><topic>Neuropeptide Y - physiology</topic><topic>Norepinephrine - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Neuropeptide Y - antagonists & inhibitors</topic><topic>Splanchnic Circulation - drug effects</topic><topic>Splanchnic Circulation - physiology</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstriction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Songping</creatorcontrib><creatorcontrib>Yang, Chun-Lian</creatorcontrib><creatorcontrib>Chen, Xiaoli</creatorcontrib><creatorcontrib>Naes, Linda</creatorcontrib><creatorcontrib>Cox, Bryan F</creatorcontrib><creatorcontrib>Westfall, Thomas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Songping</au><au>Yang, Chun-Lian</au><au>Chen, Xiaoli</au><au>Naes, Linda</au><au>Cox, Bryan F</au><au>Westfall, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>274</volume><issue>1</issue><spage>H290</spage><epage>H294</epage><pages>H290-H294</pages><issn>0363-6135</issn><issn>0002-9513</issn><eissn>1522-1539</eissn><abstract>Department of Pharmacological and Physiological Science, Saint Louis
University Health Sciences Center, St. Louis, Missouri 63104
Neuropeptide Y (NPY) is a vasoconstrictor
peptide and a cotransmitter with norepinephrine (NE) in sympathetic
nerve terminals and is thought to be involved in sympathetic nerve
stimulation (SNS)-induced vasoconstriction. Using BIBP-3226, a
Y 1 receptor selective antagonist,
we examined this hypothesis in the isolated and perfused mesenteric
vascular bed. SNS produced a frequency-dependent increase in perfusion
pressure and concomitant overflow of NPY immunoreactivity in the
perfusate.
[Leu 31 ,Pro 34 ]NPY
potentiated NE-induced and ATP-induced vasoconstriction, indicating the
presence and biological action of
Y 1 receptors in this vascular bed.
The potentiation effect of
[Leu 31 ,Pro 34 ]NPY
of the increase in perfusion pressure by NE, ATP, or SNS was prevented
by BIBP-3226. In addition, SNS-induced vasoconstriction at both high
and low frequencies was significantly attenuated by BIBP-3226 at a
concentration that completely blocked the
[Leu 31 ,Pro 34 ]NPY-induced
potentiation of the NE- or ATP-induced vasoconstrictor effect. These
results suggest that ~30% of vasoconstriction produced by SNS
depends on NPY in the mesenteric vascular bed.
BIBP-3226; neuropeptide Y release; adenosine 5'-triphosphate; mesenteric vascular bed; rat</abstract><cop>United States</cop><pmid>9458879</pmid><doi>10.1152/ajpheart.1998.274.1.H290</doi></addata></record> |
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| ispartof | American journal of physiology. Heart and circulatory physiology, 1998-01, Vol.274 (1), p.H290-H294 |
| issn | 0363-6135 0002-9513 1522-1539 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpheart_274_1_H290 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Arginine - analogs & derivatives Arginine - pharmacology Electric Stimulation Intestines - blood supply Male Muscle, Smooth, Vascular - innervation Muscle, Smooth, Vascular - physiology Neuropeptide Y - analogs & derivatives Neuropeptide Y - metabolism Neuropeptide Y - pharmacology Neuropeptide Y - physiology Norepinephrine - pharmacology Rats Rats, Sprague-Dawley Receptors, Neuropeptide Y - antagonists & inhibitors Splanchnic Circulation - drug effects Splanchnic Circulation - physiology Sympathetic Nervous System - physiology Vasoconstriction - drug effects Vasoconstriction - physiology |
| title | Direct evidence for the role of neuropeptide Y in sympathetic nerve stimulation-induced vasoconstriction |
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