Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males
Center for Surgical Research and Department of Surgery, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island 02903 Although studies have shown that testosterone receptor blockade with flutamide after hemorrhage restores the depressed immune function, it remains unk...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1997-12, Vol.273 (6), p.H2919-H2925 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 273 |
| creator | Remmers, Dierk E Wang, Ping Cioffi, William G Bland, Kirby I Chaudry, Irshad H |
| description | Center for Surgical Research and Department of Surgery, Brown
University School of Medicine and Rhode Island Hospital,
Providence, Rhode Island 02903
Although studies have shown that testosterone
receptor blockade with flutamide after hemorrhage restores the
depressed immune function, it remains unknown whether administration of
flutamide following trauma and hemorrhage and resuscitation has any
salutary effects on the depressed cardiovascular and hepatocellular
functions. To study this, male rats underwent a laparotomy
(representing trauma) and were then bled and maintained at a mean
arterial pressure (MAP) of 40 mmHg until the animals could not maintain
this pressure. Ringer lactate was given to maintain a MAP of 40 mmHg
until 40% of the maximal shed blood volume was returned in the form of
Ringer lactate. The rats were then resuscitated with four times the
shed blood volume in the form of Ringer lactate over 60 min. Flutamide (25 mg/kg) or an equal volume of the vehicle propanediol was injected subcutaneously 15 min before the end of resuscitation. Various in vivo
heart performance parameters (e.g., maximal rate of the pressure
increase or decrease), cardiac output, and hepatocellular function
(i.e., the maximum velocity and the overall efficiency of indocyanine
green clearance) were determined at 20 h after resuscitation.
Additionally, hepatic microvascular blood flow (HMBF) was determined
using a laser Doppler flowmeter. The results indicate that left
ventricular performance, cardiac output, HMBF, and hepatocellular
function decreased significantly at 20 h after the completion of
trauma, hemorrhage, and resuscitation. Administration of the
testosterone receptor blocker flutamide, however, significantly improved cardiac performance, HMBF, and hepatocellular function. Thus
flutamide appears to be a novel and useful adjunct for improving cardiovascular and hepatocellular functions in males following trauma
and hemorrhagic shock.
cardiac performance; liver function; shock |
| doi_str_mv | 10.1152/ajpheart.1997.273.6.h2919 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_highwire_physiology_ajpheart_273_6_H2919</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79521075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-99003d915b13b63554789fc2b1c36f9ed47ad3006b8b5a64404a51961d3a697e3</originalsourceid><addsrcrecordid>eNp1kEFv1DAQhS0EKtvCT0AyF25J7Th2anFCFaWVKnFZztbEnmxckjjYCWX_PV7tsuqF0xzevDdvPkI-clZyLqtreJp7hLiUXOumrBpRqrKvNNevyCbrVcGl0K_JhgklCsWFfEsuU3pijMlGiQtyoWshlag2pNtiWkJaMIYJaUSL8xIibYdgf4JDCl2W6BJhHaHocQwx9rBD6sc5ht-YqIXoPFgKk6M9zrB4S7t1sosPU6J-oiMMmN6RNx0MCd-f5hX5cfd1e3tfPH7_9nD75bGwdVMvhdaMCae5bLlolZCybm50Z6uWW6E6ja5uwAnGVHvTSlB1zWqQXCvuBCjdoLgin465ud2vNb9mRp8sDgNMGNZkGi0rzhqZF_Vx0caQUsTOzNGPEPeGM3NgbP4xNgfGJjM2ytwfGGfvh9ORtR3RnZ0nqFn_fNR7v-uffUQz9_vkwxB2e3O3DsMW_yzn_BfJZnZddl__330u9bLPXwgpotk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79521075</pqid></control><display><type>article</type><title>Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Remmers, Dierk E ; Wang, Ping ; Cioffi, William G ; Bland, Kirby I ; Chaudry, Irshad H</creator><creatorcontrib>Remmers, Dierk E ; Wang, Ping ; Cioffi, William G ; Bland, Kirby I ; Chaudry, Irshad H</creatorcontrib><description>Center for Surgical Research and Department of Surgery, Brown
University School of Medicine and Rhode Island Hospital,
Providence, Rhode Island 02903
Although studies have shown that testosterone
receptor blockade with flutamide after hemorrhage restores the
depressed immune function, it remains unknown whether administration of
flutamide following trauma and hemorrhage and resuscitation has any
salutary effects on the depressed cardiovascular and hepatocellular
functions. To study this, male rats underwent a laparotomy
(representing trauma) and were then bled and maintained at a mean
arterial pressure (MAP) of 40 mmHg until the animals could not maintain
this pressure. Ringer lactate was given to maintain a MAP of 40 mmHg
until 40% of the maximal shed blood volume was returned in the form of
Ringer lactate. The rats were then resuscitated with four times the
shed blood volume in the form of Ringer lactate over 60 min. Flutamide (25 mg/kg) or an equal volume of the vehicle propanediol was injected subcutaneously 15 min before the end of resuscitation. Various in vivo
heart performance parameters (e.g., maximal rate of the pressure
increase or decrease), cardiac output, and hepatocellular function
(i.e., the maximum velocity and the overall efficiency of indocyanine
green clearance) were determined at 20 h after resuscitation.
Additionally, hepatic microvascular blood flow (HMBF) was determined
using a laser Doppler flowmeter. The results indicate that left
ventricular performance, cardiac output, HMBF, and hepatocellular
function decreased significantly at 20 h after the completion of
trauma, hemorrhage, and resuscitation. Administration of the
testosterone receptor blocker flutamide, however, significantly improved cardiac performance, HMBF, and hepatocellular function. Thus
flutamide appears to be a novel and useful adjunct for improving cardiovascular and hepatocellular functions in males following trauma
and hemorrhagic shock.
cardiac performance; liver function; shock</description><identifier>ISSN: 0363-6135</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.1997.273.6.h2919</identifier><identifier>PMID: 9435632</identifier><language>eng</language><publisher>United States</publisher><subject>Androgen Antagonists - pharmacology ; Androgen Receptor Antagonists ; Animals ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; Flutamide - pharmacology ; Heart - drug effects ; Heart - physiology ; Heart - physiopathology ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Hemodynamics - physiology ; Indocyanine Green - pharmacokinetics ; Liver - blood supply ; Liver - drug effects ; Liver - physiopathology ; Liver Circulation - drug effects ; Male ; Microcirculation - physiology ; Rats ; Rats, Sprague-Dawley ; Regional Blood Flow - drug effects ; Resuscitation ; Shock, Hemorrhagic - physiopathology ; Stroke Volume - drug effects ; Wounds and Injuries - physiopathology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1997-12, Vol.273 (6), p.H2919-H2925</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-99003d915b13b63554789fc2b1c36f9ed47ad3006b8b5a64404a51961d3a697e3</citedby><cites>FETCH-LOGICAL-c474t-99003d915b13b63554789fc2b1c36f9ed47ad3006b8b5a64404a51961d3a697e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9435632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Remmers, Dierk E</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Cioffi, William G</creatorcontrib><creatorcontrib>Bland, Kirby I</creatorcontrib><creatorcontrib>Chaudry, Irshad H</creatorcontrib><title>Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol</addtitle><description>Center for Surgical Research and Department of Surgery, Brown
University School of Medicine and Rhode Island Hospital,
Providence, Rhode Island 02903
Although studies have shown that testosterone
receptor blockade with flutamide after hemorrhage restores the
depressed immune function, it remains unknown whether administration of
flutamide following trauma and hemorrhage and resuscitation has any
salutary effects on the depressed cardiovascular and hepatocellular
functions. To study this, male rats underwent a laparotomy
(representing trauma) and were then bled and maintained at a mean
arterial pressure (MAP) of 40 mmHg until the animals could not maintain
this pressure. Ringer lactate was given to maintain a MAP of 40 mmHg
until 40% of the maximal shed blood volume was returned in the form of
Ringer lactate. The rats were then resuscitated with four times the
shed blood volume in the form of Ringer lactate over 60 min. Flutamide (25 mg/kg) or an equal volume of the vehicle propanediol was injected subcutaneously 15 min before the end of resuscitation. Various in vivo
heart performance parameters (e.g., maximal rate of the pressure
increase or decrease), cardiac output, and hepatocellular function
(i.e., the maximum velocity and the overall efficiency of indocyanine
green clearance) were determined at 20 h after resuscitation.
Additionally, hepatic microvascular blood flow (HMBF) was determined
using a laser Doppler flowmeter. The results indicate that left
ventricular performance, cardiac output, HMBF, and hepatocellular
function decreased significantly at 20 h after the completion of
trauma, hemorrhage, and resuscitation. Administration of the
testosterone receptor blocker flutamide, however, significantly improved cardiac performance, HMBF, and hepatocellular function. Thus
flutamide appears to be a novel and useful adjunct for improving cardiovascular and hepatocellular functions in males following trauma
and hemorrhagic shock.
cardiac performance; liver function; shock</description><subject>Androgen Antagonists - pharmacology</subject><subject>Androgen Receptor Antagonists</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Flutamide - pharmacology</subject><subject>Heart - drug effects</subject><subject>Heart - physiology</subject><subject>Heart - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Hemodynamics - physiology</subject><subject>Indocyanine Green - pharmacokinetics</subject><subject>Liver - blood supply</subject><subject>Liver - drug effects</subject><subject>Liver - physiopathology</subject><subject>Liver Circulation - drug effects</subject><subject>Male</subject><subject>Microcirculation - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regional Blood Flow - drug effects</subject><subject>Resuscitation</subject><subject>Shock, Hemorrhagic - physiopathology</subject><subject>Stroke Volume - drug effects</subject><subject>Wounds and Injuries - physiopathology</subject><issn>0363-6135</issn><issn>0002-9513</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFv1DAQhS0EKtvCT0AyF25J7Th2anFCFaWVKnFZztbEnmxckjjYCWX_PV7tsuqF0xzevDdvPkI-clZyLqtreJp7hLiUXOumrBpRqrKvNNevyCbrVcGl0K_JhgklCsWFfEsuU3pijMlGiQtyoWshlag2pNtiWkJaMIYJaUSL8xIibYdgf4JDCl2W6BJhHaHocQwx9rBD6sc5ht-YqIXoPFgKk6M9zrB4S7t1sosPU6J-oiMMmN6RNx0MCd-f5hX5cfd1e3tfPH7_9nD75bGwdVMvhdaMCae5bLlolZCybm50Z6uWW6E6ja5uwAnGVHvTSlB1zWqQXCvuBCjdoLgin465ud2vNb9mRp8sDgNMGNZkGi0rzhqZF_Vx0caQUsTOzNGPEPeGM3NgbP4xNgfGJjM2ytwfGGfvh9ORtR3RnZ0nqFn_fNR7v-uffUQz9_vkwxB2e3O3DsMW_yzn_BfJZnZddl__330u9bLPXwgpotk</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Remmers, Dierk E</creator><creator>Wang, Ping</creator><creator>Cioffi, William G</creator><creator>Bland, Kirby I</creator><creator>Chaudry, Irshad H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971201</creationdate><title>Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males</title><author>Remmers, Dierk E ; Wang, Ping ; Cioffi, William G ; Bland, Kirby I ; Chaudry, Irshad H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-99003d915b13b63554789fc2b1c36f9ed47ad3006b8b5a64404a51961d3a697e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Androgen Antagonists - pharmacology</topic><topic>Androgen Receptor Antagonists</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Flutamide - pharmacology</topic><topic>Heart - drug effects</topic><topic>Heart - physiology</topic><topic>Heart - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Hemodynamics - physiology</topic><topic>Indocyanine Green - pharmacokinetics</topic><topic>Liver - blood supply</topic><topic>Liver - drug effects</topic><topic>Liver - physiopathology</topic><topic>Liver Circulation - drug effects</topic><topic>Male</topic><topic>Microcirculation - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regional Blood Flow - drug effects</topic><topic>Resuscitation</topic><topic>Shock, Hemorrhagic - physiopathology</topic><topic>Stroke Volume - drug effects</topic><topic>Wounds and Injuries - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Remmers, Dierk E</creatorcontrib><creatorcontrib>Wang, Ping</creatorcontrib><creatorcontrib>Cioffi, William G</creatorcontrib><creatorcontrib>Bland, Kirby I</creatorcontrib><creatorcontrib>Chaudry, Irshad H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Remmers, Dierk E</au><au>Wang, Ping</au><au>Cioffi, William G</au><au>Bland, Kirby I</au><au>Chaudry, Irshad H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>273</volume><issue>6</issue><spage>H2919</spage><epage>H2925</epage><pages>H2919-H2925</pages><issn>0363-6135</issn><issn>0002-9513</issn><eissn>1522-1539</eissn><abstract>Center for Surgical Research and Department of Surgery, Brown
University School of Medicine and Rhode Island Hospital,
Providence, Rhode Island 02903
Although studies have shown that testosterone
receptor blockade with flutamide after hemorrhage restores the
depressed immune function, it remains unknown whether administration of
flutamide following trauma and hemorrhage and resuscitation has any
salutary effects on the depressed cardiovascular and hepatocellular
functions. To study this, male rats underwent a laparotomy
(representing trauma) and were then bled and maintained at a mean
arterial pressure (MAP) of 40 mmHg until the animals could not maintain
this pressure. Ringer lactate was given to maintain a MAP of 40 mmHg
until 40% of the maximal shed blood volume was returned in the form of
Ringer lactate. The rats were then resuscitated with four times the
shed blood volume in the form of Ringer lactate over 60 min. Flutamide (25 mg/kg) or an equal volume of the vehicle propanediol was injected subcutaneously 15 min before the end of resuscitation. Various in vivo
heart performance parameters (e.g., maximal rate of the pressure
increase or decrease), cardiac output, and hepatocellular function
(i.e., the maximum velocity and the overall efficiency of indocyanine
green clearance) were determined at 20 h after resuscitation.
Additionally, hepatic microvascular blood flow (HMBF) was determined
using a laser Doppler flowmeter. The results indicate that left
ventricular performance, cardiac output, HMBF, and hepatocellular
function decreased significantly at 20 h after the completion of
trauma, hemorrhage, and resuscitation. Administration of the
testosterone receptor blocker flutamide, however, significantly improved cardiac performance, HMBF, and hepatocellular function. Thus
flutamide appears to be a novel and useful adjunct for improving cardiovascular and hepatocellular functions in males following trauma
and hemorrhagic shock.
cardiac performance; liver function; shock</abstract><cop>United States</cop><pmid>9435632</pmid><doi>10.1152/ajpheart.1997.273.6.h2919</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 1997-12, Vol.273 (6), p.H2919-H2925 |
| issn | 0363-6135 0002-9513 1522-1539 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpheart_273_6_H2919 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Androgen Antagonists - pharmacology Androgen Receptor Antagonists Animals Blood Pressure - drug effects Cardiac Output - drug effects Flutamide - pharmacology Heart - drug effects Heart - physiology Heart - physiopathology Heart Rate - drug effects Hemodynamics - drug effects Hemodynamics - physiology Indocyanine Green - pharmacokinetics Liver - blood supply Liver - drug effects Liver - physiopathology Liver Circulation - drug effects Male Microcirculation - physiology Rats Rats, Sprague-Dawley Regional Blood Flow - drug effects Resuscitation Shock, Hemorrhagic - physiopathology Stroke Volume - drug effects Wounds and Injuries - physiopathology |
| title | Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males |
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