Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats
B. J. Holycross, B. M. Summers, R. B. Dunn and S. A. McCune College of Pharmacy, Division of Pharmacology, Ohio State University, Columbus 43210, USA. Plasma renin activity (PRA) increases during heart failure; however, PRA is altered by drug therapy, and it is difficult to study the natural progres...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1997-07, Vol.273 (1), p.H228-H233 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 273 |
| creator | Holycross, B. J Summers, B. M Dunn, R. B McCune, S. A |
| description | B. J. Holycross, B. M. Summers, R. B. Dunn and S. A. McCune
College of Pharmacy, Division of Pharmacology, Ohio State University, Columbus 43210, USA.
Plasma renin activity (PRA) increases during heart failure; however, PRA is
altered by drug therapy, and it is difficult to study the natural
progression of elevated PRA in humans and the possible factors that
contribute to its rise. This study evaluated PRA in a drug-naive
hypertensive rat model (SHHF/Mcc-facp) that has a genetic program resulting
in heart failure (HF). Mean arterial blood pressure and PRA were determined
and correlated to heart weight index in conscious normotensive,
spontaneously hypertensive rats and HF rats of various ages. PRA, atrial
natriuretic peptide, and aldosterone levels progressively increase with age
in male HF rats. PRA and blood pressure are independently correlated to
cardiac hypertrophy in male HF rats. Atrial natriuretic peptide was
elevated in spontaneously hypertensive compared with normotensive rats.
Female HF rats have elevated PRA, but the increase is temporally delayed
compared with that in male HF rats. Hypertension, PRA, and male gender are
independent factors contributing to cardiac hypertrophy and heart failure
in the HF model. The HF rat model may prove useful in determining the
contribution of these factors in the progression from cardiac hypertrophy
to heart failure. |
| doi_str_mv | 10.1152/ajpheart.1997.273.1.H228 |
| format | Article |
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College of Pharmacy, Division of Pharmacology, Ohio State University, Columbus 43210, USA.
Plasma renin activity (PRA) increases during heart failure; however, PRA is
altered by drug therapy, and it is difficult to study the natural
progression of elevated PRA in humans and the possible factors that
contribute to its rise. This study evaluated PRA in a drug-naive
hypertensive rat model (SHHF/Mcc-facp) that has a genetic program resulting
in heart failure (HF). Mean arterial blood pressure and PRA were determined
and correlated to heart weight index in conscious normotensive,
spontaneously hypertensive rats and HF rats of various ages. PRA, atrial
natriuretic peptide, and aldosterone levels progressively increase with age
in male HF rats. PRA and blood pressure are independently correlated to
cardiac hypertrophy in male HF rats. Atrial natriuretic peptide was
elevated in spontaneously hypertensive compared with normotensive rats.
Female HF rats have elevated PRA, but the increase is temporally delayed
compared with that in male HF rats. Hypertension, PRA, and male gender are
independent factors contributing to cardiac hypertrophy and heart failure
in the HF model. The HF rat model may prove useful in determining the
contribution of these factors in the progression from cardiac hypertrophy
to heart failure.</description><identifier>ISSN: 0363-6135</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.1997.273.1.H228</identifier><identifier>PMID: 9249494</identifier><language>eng</language><publisher>United States</publisher><subject>Aging ; Aldosterone - blood ; Animals ; Atrial Natriuretic Factor - metabolism ; Blood Pressure ; Blood Volume ; Disease Susceptibility ; Female ; Heart Failure - genetics ; Heart Failure - physiopathology ; Hypertension - blood ; Hypertension - enzymology ; Hypertension - physiopathology ; Male ; Organ Size ; Rats ; Rats, Inbred SHR ; Rats, Inbred Strains ; Rats, Inbred WF ; Rats, Sprague-Dawley ; Regression Analysis ; Renin - blood ; Species Specificity</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1997-07, Vol.273 (1), p.H228-H233</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1964-58e27cf8c98d6adba850a1dd25308bf7dc8a29b9007d22947127a299c39f8033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9249494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holycross, B. J</creatorcontrib><creatorcontrib>Summers, B. M</creatorcontrib><creatorcontrib>Dunn, R. B</creatorcontrib><creatorcontrib>McCune, S. A</creatorcontrib><title>Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol</addtitle><description>B. J. Holycross, B. M. Summers, R. B. Dunn and S. A. McCune
College of Pharmacy, Division of Pharmacology, Ohio State University, Columbus 43210, USA.
Plasma renin activity (PRA) increases during heart failure; however, PRA is
altered by drug therapy, and it is difficult to study the natural
progression of elevated PRA in humans and the possible factors that
contribute to its rise. This study evaluated PRA in a drug-naive
hypertensive rat model (SHHF/Mcc-facp) that has a genetic program resulting
in heart failure (HF). Mean arterial blood pressure and PRA were determined
and correlated to heart weight index in conscious normotensive,
spontaneously hypertensive rats and HF rats of various ages. PRA, atrial
natriuretic peptide, and aldosterone levels progressively increase with age
in male HF rats. PRA and blood pressure are independently correlated to
cardiac hypertrophy in male HF rats. Atrial natriuretic peptide was
elevated in spontaneously hypertensive compared with normotensive rats.
Female HF rats have elevated PRA, but the increase is temporally delayed
compared with that in male HF rats. Hypertension, PRA, and male gender are
independent factors contributing to cardiac hypertrophy and heart failure
in the HF model. The HF rat model may prove useful in determining the
contribution of these factors in the progression from cardiac hypertrophy
to heart failure.</description><subject>Aging</subject><subject>Aldosterone - blood</subject><subject>Animals</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Blood Pressure</subject><subject>Blood Volume</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Heart Failure - genetics</subject><subject>Heart Failure - physiopathology</subject><subject>Hypertension - blood</subject><subject>Hypertension - enzymology</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Organ Size</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Inbred WF</subject><subject>Rats, Sprague-Dawley</subject><subject>Regression Analysis</subject><subject>Renin - blood</subject><subject>Species Specificity</subject><issn>0363-6135</issn><issn>0002-9513</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS0EKqXwCUhZsUvqRxLbK4QQJUhFING95ThO4yov7ASUv8el5aFZzGjuzJ3RASBAMEIowUu56yst7RAhzmmEKYlQlGHMTsDcyzhECeGnYA5JSsIUkeQcXDi3gxAmNCUzMOM45j7m4Pa1lq6RgdWtaQOpBvNhhinw9bd_UEpTj1aHve1aHbxl2Wr5rFRYStUHVg7uEpyVsnb66pgXYLN62Nxn4frl8en-bh0qxNM4TJjGVJVMcVakssglS6BERYETAlle0kIxiXnOIaQFxjymCFPf4IrwkkFCFuDmYOv_eB-1G0RjnNJ1LVvdjU5QjiiL08QPssOgsp1zVpeit6aRdhIIij068YNO7NEJj04gsUfnV6-PN8a80cXv4pGV16ODXplt9WmsFn01OdPV3Xb6c_1n-AWRjHxJ</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Holycross, B. J</creator><creator>Summers, B. M</creator><creator>Dunn, R. B</creator><creator>McCune, S. A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats</title><author>Holycross, B. J ; Summers, B. M ; Dunn, R. B ; McCune, S. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1964-58e27cf8c98d6adba850a1dd25308bf7dc8a29b9007d22947127a299c39f8033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aging</topic><topic>Aldosterone - blood</topic><topic>Animals</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>Blood Pressure</topic><topic>Blood Volume</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Heart Failure - genetics</topic><topic>Heart Failure - physiopathology</topic><topic>Hypertension - blood</topic><topic>Hypertension - enzymology</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Organ Size</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Inbred WF</topic><topic>Rats, Sprague-Dawley</topic><topic>Regression Analysis</topic><topic>Renin - blood</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holycross, B. J</creatorcontrib><creatorcontrib>Summers, B. M</creatorcontrib><creatorcontrib>Dunn, R. B</creatorcontrib><creatorcontrib>McCune, S. A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holycross, B. J</au><au>Summers, B. M</au><au>Dunn, R. B</au><au>McCune, S. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>273</volume><issue>1</issue><spage>H228</spage><epage>H233</epage><pages>H228-H233</pages><issn>0363-6135</issn><issn>0002-9513</issn><eissn>1522-1539</eissn><abstract>B. J. Holycross, B. M. Summers, R. B. Dunn and S. A. McCune
College of Pharmacy, Division of Pharmacology, Ohio State University, Columbus 43210, USA.
Plasma renin activity (PRA) increases during heart failure; however, PRA is
altered by drug therapy, and it is difficult to study the natural
progression of elevated PRA in humans and the possible factors that
contribute to its rise. This study evaluated PRA in a drug-naive
hypertensive rat model (SHHF/Mcc-facp) that has a genetic program resulting
in heart failure (HF). Mean arterial blood pressure and PRA were determined
and correlated to heart weight index in conscious normotensive,
spontaneously hypertensive rats and HF rats of various ages. PRA, atrial
natriuretic peptide, and aldosterone levels progressively increase with age
in male HF rats. PRA and blood pressure are independently correlated to
cardiac hypertrophy in male HF rats. Atrial natriuretic peptide was
elevated in spontaneously hypertensive compared with normotensive rats.
Female HF rats have elevated PRA, but the increase is temporally delayed
compared with that in male HF rats. Hypertension, PRA, and male gender are
independent factors contributing to cardiac hypertrophy and heart failure
in the HF model. The HF rat model may prove useful in determining the
contribution of these factors in the progression from cardiac hypertrophy
to heart failure.</abstract><cop>United States</cop><pmid>9249494</pmid><doi>10.1152/ajpheart.1997.273.1.H228</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 1997-07, Vol.273 (1), p.H228-H233 |
| issn | 0363-6135 0002-9513 1522-1539 |
| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aging Aldosterone - blood Animals Atrial Natriuretic Factor - metabolism Blood Pressure Blood Volume Disease Susceptibility Female Heart Failure - genetics Heart Failure - physiopathology Hypertension - blood Hypertension - enzymology Hypertension - physiopathology Male Organ Size Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WF Rats, Sprague-Dawley Regression Analysis Renin - blood Species Specificity |
| title | Plasma renin activity in heart failure-prone SHHF/Mcc-facp rats |
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