Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning
Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary. To study whether ventricular overdrive pacing (VOP) induces preconditioning, rabbits were equipped with right ventricular electrode...
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Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1994-05, Vol.266 (5), p.H2033-H2041 |
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container_title | American journal of physiology. Heart and circulatory physiology |
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creator | Szilvassy, Z Ferdinandy, P Bor, P Jakab, I Lonovics, J Koltai, M |
description | Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai
First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary.
To study whether ventricular overdrive pacing (VOP) induces
preconditioning, rabbits were equipped with right ventricular electrode
catheters for pacing and intracavital recording and polyethylene cannulas
in the left ventricle and right carotid artery to measure intraventricular
pressure and blood pressure. One week after surgery in conscious animals,
VOP at 500 beats/min over 2, 5, or 10 min resulted in an intracavital S-T
segment elevation, shortening of ventricular effective refractory period,
decrease in maximum rate of pressure development and blood pressure, and
increase in left ventricular end-diastolic pressure proportional to the
duration of stimulation. A 5-min preconditioning VOP applied 5 or 30 min
before a 10-min VOP markedly attenuated ischemic changes, whereas a 2-min
VOP had no effect. In anesthetized rabbits, a 5-min VOP slightly increased
guanosine 3',5'-cyclic monophosphate (cGMP) and profoundly elevated
adenosine 3',5'-cyclic monophosphate (cAMP) content in left ventricular
samples. When this VOP was preceded (5 or 30 min) by a preconditioning VOP,
the cAMP increase was significantly attenuated, whereas the cGMP increase
was amplified. We conclude that a single 5-min VOP induces preconditioning
in association with alterations in cardiac cyclic nucleotide contents. |
doi_str_mv | 10.1152/ajpheart.1994.266.5.h2033 |
format | Article |
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First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary.
To study whether ventricular overdrive pacing (VOP) induces
preconditioning, rabbits were equipped with right ventricular electrode
catheters for pacing and intracavital recording and polyethylene cannulas
in the left ventricle and right carotid artery to measure intraventricular
pressure and blood pressure. One week after surgery in conscious animals,
VOP at 500 beats/min over 2, 5, or 10 min resulted in an intracavital S-T
segment elevation, shortening of ventricular effective refractory period,
decrease in maximum rate of pressure development and blood pressure, and
increase in left ventricular end-diastolic pressure proportional to the
duration of stimulation. A 5-min preconditioning VOP applied 5 or 30 min
before a 10-min VOP markedly attenuated ischemic changes, whereas a 2-min
VOP had no effect. In anesthetized rabbits, a 5-min VOP slightly increased
guanosine 3',5'-cyclic monophosphate (cGMP) and profoundly elevated
adenosine 3',5'-cyclic monophosphate (cAMP) content in left ventricular
samples. When this VOP was preceded (5 or 30 min) by a preconditioning VOP,
the cAMP increase was significantly attenuated, whereas the cGMP increase
was amplified. We conclude that a single 5-min VOP induces preconditioning
in association with alterations in cardiac cyclic nucleotide contents.</description><identifier>ISSN: 0363-6135</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.1994.266.5.h2033</identifier><identifier>PMID: 8203601</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Blood Pressure ; Cardiac Pacing, Artificial ; Cyclic AMP - metabolism ; Cyclic GMP - metabolism ; Diastole ; Electric Stimulation ; Electrocardiography ; Hemodynamics ; Male ; Myocardial Contraction ; Myocardial Ischemia - metabolism ; Myocardial Ischemia - physiopathology ; Myocardium - metabolism ; Rabbits ; Systole ; Time Factors ; Ventricular Function, Left - physiology</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1994-05, Vol.266 (5), p.H2033-H2041</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c267t-5078295a4416ebfba09630f40ce023bd1beb60eb1bcd1ba3b95ab09c3f0cfc83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8203601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szilvassy, Z</creatorcontrib><creatorcontrib>Ferdinandy, P</creatorcontrib><creatorcontrib>Bor, P</creatorcontrib><creatorcontrib>Jakab, I</creatorcontrib><creatorcontrib>Lonovics, J</creatorcontrib><creatorcontrib>Koltai, M</creatorcontrib><title>Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol</addtitle><description>Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai
First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary.
To study whether ventricular overdrive pacing (VOP) induces
preconditioning, rabbits were equipped with right ventricular electrode
catheters for pacing and intracavital recording and polyethylene cannulas
in the left ventricle and right carotid artery to measure intraventricular
pressure and blood pressure. One week after surgery in conscious animals,
VOP at 500 beats/min over 2, 5, or 10 min resulted in an intracavital S-T
segment elevation, shortening of ventricular effective refractory period,
decrease in maximum rate of pressure development and blood pressure, and
increase in left ventricular end-diastolic pressure proportional to the
duration of stimulation. A 5-min preconditioning VOP applied 5 or 30 min
before a 10-min VOP markedly attenuated ischemic changes, whereas a 2-min
VOP had no effect. In anesthetized rabbits, a 5-min VOP slightly increased
guanosine 3',5'-cyclic monophosphate (cGMP) and profoundly elevated
adenosine 3',5'-cyclic monophosphate (cAMP) content in left ventricular
samples. When this VOP was preceded (5 or 30 min) by a preconditioning VOP,
the cAMP increase was significantly attenuated, whereas the cGMP increase
was amplified. We conclude that a single 5-min VOP induces preconditioning
in association with alterations in cardiac cyclic nucleotide contents.</description><subject>Animals</subject><subject>Blood Pressure</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cyclic AMP - metabolism</subject><subject>Cyclic GMP - metabolism</subject><subject>Diastole</subject><subject>Electric Stimulation</subject><subject>Electrocardiography</subject><subject>Hemodynamics</subject><subject>Male</subject><subject>Myocardial Contraction</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Myocardium - metabolism</subject><subject>Rabbits</subject><subject>Systole</subject><subject>Time Factors</subject><subject>Ventricular Function, Left - physiology</subject><issn>0363-6135</issn><issn>0002-9513</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtPwzAQhC0EgvL4CUjmwi3Bjmun4YYQUCQkLoirZTvrxlUSBzsB9d_jquVx2pVmdnb0IXRFSU4pL27UemhAhTGnVTXPCyFynjcFYewAzZJeZJSz6hDNCBMsE5TxE3Qa45oQwkvBjtHxIpkFoTNk36EfgzNTqwL2nxDq4D4BD8q4fpW5vp4M1Fj1o8tcNA10zmCwFsx4ixU2vo_G-SnioLR2I-58DS32Fg8Bkli70fk-JZ2jI6vaCBf7eYbeHh_e7pfZy-vT8_3dS2YKUY4ZJ-WiqLiaz6kAbbUilWDEzokBUjBdUw1aENBUm7QrppNXk8owS4w1C3aGrnexQ_AfE8RRdqk1tK3qIbWUpeBFyUuWjNXOaIKPMYCVQ3CdChtJidwilj-I5RaxTIgll8st4nR7uX8y6Q7q38s906Tf7PTGrZovF0AOzSY63_rV5i_2f-I3UG2OMw</recordid><startdate>199405</startdate><enddate>199405</enddate><creator>Szilvassy, Z</creator><creator>Ferdinandy, P</creator><creator>Bor, P</creator><creator>Jakab, I</creator><creator>Lonovics, J</creator><creator>Koltai, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199405</creationdate><title>Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning</title><author>Szilvassy, Z ; Ferdinandy, P ; Bor, P ; Jakab, I ; Lonovics, J ; Koltai, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-5078295a4416ebfba09630f40ce023bd1beb60eb1bcd1ba3b95ab09c3f0cfc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Blood Pressure</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cyclic AMP - metabolism</topic><topic>Cyclic GMP - metabolism</topic><topic>Diastole</topic><topic>Electric Stimulation</topic><topic>Electrocardiography</topic><topic>Hemodynamics</topic><topic>Male</topic><topic>Myocardial Contraction</topic><topic>Myocardial Ischemia - metabolism</topic><topic>Myocardial Ischemia - physiopathology</topic><topic>Myocardium - metabolism</topic><topic>Rabbits</topic><topic>Systole</topic><topic>Time Factors</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szilvassy, Z</creatorcontrib><creatorcontrib>Ferdinandy, P</creatorcontrib><creatorcontrib>Bor, P</creatorcontrib><creatorcontrib>Jakab, I</creatorcontrib><creatorcontrib>Lonovics, J</creatorcontrib><creatorcontrib>Koltai, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szilvassy, Z</au><au>Ferdinandy, P</au><au>Bor, P</au><au>Jakab, I</au><au>Lonovics, J</au><au>Koltai, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1994-05</date><risdate>1994</risdate><volume>266</volume><issue>5</issue><spage>H2033</spage><epage>H2041</epage><pages>H2033-H2041</pages><issn>0363-6135</issn><issn>0002-9513</issn><eissn>1522-1539</eissn><abstract>Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai
First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary.
To study whether ventricular overdrive pacing (VOP) induces
preconditioning, rabbits were equipped with right ventricular electrode
catheters for pacing and intracavital recording and polyethylene cannulas
in the left ventricle and right carotid artery to measure intraventricular
pressure and blood pressure. One week after surgery in conscious animals,
VOP at 500 beats/min over 2, 5, or 10 min resulted in an intracavital S-T
segment elevation, shortening of ventricular effective refractory period,
decrease in maximum rate of pressure development and blood pressure, and
increase in left ventricular end-diastolic pressure proportional to the
duration of stimulation. A 5-min preconditioning VOP applied 5 or 30 min
before a 10-min VOP markedly attenuated ischemic changes, whereas a 2-min
VOP had no effect. In anesthetized rabbits, a 5-min VOP slightly increased
guanosine 3',5'-cyclic monophosphate (cGMP) and profoundly elevated
adenosine 3',5'-cyclic monophosphate (cAMP) content in left ventricular
samples. When this VOP was preceded (5 or 30 min) by a preconditioning VOP,
the cAMP increase was significantly attenuated, whereas the cGMP increase
was amplified. We conclude that a single 5-min VOP induces preconditioning
in association with alterations in cardiac cyclic nucleotide contents.</abstract><cop>United States</cop><pmid>8203601</pmid><doi>10.1152/ajpheart.1994.266.5.h2033</doi></addata></record> |
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source | MEDLINE; Alma/SFX Local Collection |
subjects | Animals Blood Pressure Cardiac Pacing, Artificial Cyclic AMP - metabolism Cyclic GMP - metabolism Diastole Electric Stimulation Electrocardiography Hemodynamics Male Myocardial Contraction Myocardial Ischemia - metabolism Myocardial Ischemia - physiopathology Myocardium - metabolism Rabbits Systole Time Factors Ventricular Function, Left - physiology |
title | Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning |
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