Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning

Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary. To study whether ventricular overdrive pacing (VOP) induces preconditioning, rabbits were equipped with right ventricular electrode...

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Veröffentlicht in:American journal of physiology. Heart and circulatory physiology 1994-05, Vol.266 (5), p.H2033-H2041
Hauptverfasser: Szilvassy, Z, Ferdinandy, P, Bor, P, Jakab, I, Lonovics, J, Koltai, M
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container_end_page H2041
container_issue 5
container_start_page H2033
container_title American journal of physiology. Heart and circulatory physiology
container_volume 266
creator Szilvassy, Z
Ferdinandy, P
Bor, P
Jakab, I
Lonovics, J
Koltai, M
description Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary. To study whether ventricular overdrive pacing (VOP) induces preconditioning, rabbits were equipped with right ventricular electrode catheters for pacing and intracavital recording and polyethylene cannulas in the left ventricle and right carotid artery to measure intraventricular pressure and blood pressure. One week after surgery in conscious animals, VOP at 500 beats/min over 2, 5, or 10 min resulted in an intracavital S-T segment elevation, shortening of ventricular effective refractory period, decrease in maximum rate of pressure development and blood pressure, and increase in left ventricular end-diastolic pressure proportional to the duration of stimulation. A 5-min preconditioning VOP applied 5 or 30 min before a 10-min VOP markedly attenuated ischemic changes, whereas a 2-min VOP had no effect. In anesthetized rabbits, a 5-min VOP slightly increased guanosine 3',5'-cyclic monophosphate (cGMP) and profoundly elevated adenosine 3',5'-cyclic monophosphate (cAMP) content in left ventricular samples. When this VOP was preceded (5 or 30 min) by a preconditioning VOP, the cAMP increase was significantly attenuated, whereas the cGMP increase was amplified. We conclude that a single 5-min VOP induces preconditioning in association with alterations in cardiac cyclic nucleotide contents.
doi_str_mv 10.1152/ajpheart.1994.266.5.h2033
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Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary. To study whether ventricular overdrive pacing (VOP) induces preconditioning, rabbits were equipped with right ventricular electrode catheters for pacing and intracavital recording and polyethylene cannulas in the left ventricle and right carotid artery to measure intraventricular pressure and blood pressure. One week after surgery in conscious animals, VOP at 500 beats/min over 2, 5, or 10 min resulted in an intracavital S-T segment elevation, shortening of ventricular effective refractory period, decrease in maximum rate of pressure development and blood pressure, and increase in left ventricular end-diastolic pressure proportional to the duration of stimulation. A 5-min preconditioning VOP applied 5 or 30 min before a 10-min VOP markedly attenuated ischemic changes, whereas a 2-min VOP had no effect. In anesthetized rabbits, a 5-min VOP slightly increased guanosine 3',5'-cyclic monophosphate (cGMP) and profoundly elevated adenosine 3',5'-cyclic monophosphate (cAMP) content in left ventricular samples. When this VOP was preceded (5 or 30 min) by a preconditioning VOP, the cAMP increase was significantly attenuated, whereas the cGMP increase was amplified. 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Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szilvassy, Z</au><au>Ferdinandy, P</au><au>Bor, P</au><au>Jakab, I</au><au>Lonovics, J</au><au>Koltai, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1994-05</date><risdate>1994</risdate><volume>266</volume><issue>5</issue><spage>H2033</spage><epage>H2041</epage><pages>H2033-H2041</pages><issn>0363-6135</issn><issn>0002-9513</issn><eissn>1522-1539</eissn><abstract>Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Lonovics and M. Koltai First Department of Medicine, Albert Szent-Gyorgyi University Medical School, Szeged, Hungary. To study whether ventricular overdrive pacing (VOP) induces preconditioning, rabbits were equipped with right ventricular electrode catheters for pacing and intracavital recording and polyethylene cannulas in the left ventricle and right carotid artery to measure intraventricular pressure and blood pressure. One week after surgery in conscious animals, VOP at 500 beats/min over 2, 5, or 10 min resulted in an intracavital S-T segment elevation, shortening of ventricular effective refractory period, decrease in maximum rate of pressure development and blood pressure, and increase in left ventricular end-diastolic pressure proportional to the duration of stimulation. A 5-min preconditioning VOP applied 5 or 30 min before a 10-min VOP markedly attenuated ischemic changes, whereas a 2-min VOP had no effect. In anesthetized rabbits, a 5-min VOP slightly increased guanosine 3',5'-cyclic monophosphate (cGMP) and profoundly elevated adenosine 3',5'-cyclic monophosphate (cAMP) content in left ventricular samples. When this VOP was preceded (5 or 30 min) by a preconditioning VOP, the cAMP increase was significantly attenuated, whereas the cGMP increase was amplified. We conclude that a single 5-min VOP induces preconditioning in association with alterations in cardiac cyclic nucleotide contents.</abstract><cop>United States</cop><pmid>8203601</pmid><doi>10.1152/ajpheart.1994.266.5.h2033</doi></addata></record>
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source MEDLINE; Alma/SFX Local Collection
subjects Animals
Blood Pressure
Cardiac Pacing, Artificial
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Diastole
Electric Stimulation
Electrocardiography
Hemodynamics
Male
Myocardial Contraction
Myocardial Ischemia - metabolism
Myocardial Ischemia - physiopathology
Myocardium - metabolism
Rabbits
Systole
Time Factors
Ventricular Function, Left - physiology
title Ventricular overdrive pacing-induced anti-ischemic effect: a conscious rabbit model of preconditioning
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