Development of pulmonary vascular response to oxygen
F. C. Morin 3rd, E. A. Egan, W. Ferguson and C. E. Lundgren Department of Pediatrics, University at Buffalo, New York. The ability of the pulmonary circulation of the fetal lamb to respond to a rise in oxygen tension was studied from 94 to 146 days of gestation. The unanesthetized ewe breathed room...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1988-03, Vol.254 (3), p.H542-H546 |
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| container_title | American journal of physiology. Heart and circulatory physiology |
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| creator | Morin, F. C., 3rd Egan, E. A Ferguson, W Lundgren, C. E |
| description | F. C. Morin 3rd, E. A. Egan, W. Ferguson and C. E. Lundgren
Department of Pediatrics, University at Buffalo, New York.
The ability of the pulmonary circulation of the fetal lamb to respond to a
rise in oxygen tension was studied from 94 to 146 days of gestation. The
unanesthetized ewe breathed room air at normal atmospheric pressure,
followed by 100% oxygen at three atmospheres absolute pressure in a
hyperbaric chamber. In eleven near-term lambs (132 to 146 days of
gestation), fetal arterial oxygen tension (PaO2) increased from 25 +/- 1 to
55 +/- 6 Torr (mean +/- SE), which increased the proportion of right
ventricular output distributed to the fetal lungs from 8 +/- 1 to 59 +/-
5%. In five very immature lambs (94 to 101 days of gestation), fetal PaO2
increased from 27 +/- 1 to 174 +/- 70 Torr, but the proportion of right
ventricular output distributed to the lung did not change, 8 +/- 1 to 9 +/-
1%. In five of the near-term lambs, pulmonary blood flow was measured. It
increased from 34 +/- 3 to 298 +/- 35 ml.kg fetal wt-1.min-1, an 8.8-fold
increase. We conclude that the pulmonary circulation of the fetal lamb does
not respond to an increase in oxygen tension before 101 days of gestation;
however, near term an increase in oxygen tension alone can induce the
entire increase in pulmonary blood flow that normally occurs after the
onset of breathing at birth. |
| doi_str_mv | 10.1152/ajpheart.1988.254.3.H542 |
| format | Article |
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Department of Pediatrics, University at Buffalo, New York.
The ability of the pulmonary circulation of the fetal lamb to respond to a
rise in oxygen tension was studied from 94 to 146 days of gestation. The
unanesthetized ewe breathed room air at normal atmospheric pressure,
followed by 100% oxygen at three atmospheres absolute pressure in a
hyperbaric chamber. In eleven near-term lambs (132 to 146 days of
gestation), fetal arterial oxygen tension (PaO2) increased from 25 +/- 1 to
55 +/- 6 Torr (mean +/- SE), which increased the proportion of right
ventricular output distributed to the fetal lungs from 8 +/- 1 to 59 +/-
5%. In five very immature lambs (94 to 101 days of gestation), fetal PaO2
increased from 27 +/- 1 to 174 +/- 70 Torr, but the proportion of right
ventricular output distributed to the lung did not change, 8 +/- 1 to 9 +/-
1%. In five of the near-term lambs, pulmonary blood flow was measured. It
increased from 34 +/- 3 to 298 +/- 35 ml.kg fetal wt-1.min-1, an 8.8-fold
increase. We conclude that the pulmonary circulation of the fetal lamb does
not respond to an increase in oxygen tension before 101 days of gestation;
however, near term an increase in oxygen tension alone can induce the
entire increase in pulmonary blood flow that normally occurs after the
onset of breathing at birth.</description><identifier>ISSN: 0363-6135</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1539</identifier><identifier>EISSN: 2163-5773</identifier><identifier>DOI: 10.1152/ajpheart.1988.254.3.H542</identifier><identifier>PMID: 3348432</identifier><language>eng</language><publisher>United States</publisher><subject>ANIMALS ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BLOOD CIRCULATION ; BLOOD FLOW ; BLOOD PRESSURE ; BODY ; DAYS LIVING RADIOISOTOPES ; DOMESTIC ANIMALS ; ELECTRON CAPTURE RADIOISOTOPES ; ELEMENTS ; EVEN-ODD NUCLEI ; Female ; Fetus - physiology ; GADOLINIUM 153 ; GADOLINIUM ISOTOPES ; Hyperbaric Oxygenation ; INTERMEDIATE MASS NUCLEI ; INTERNAL CONVERSION RADIOISOTOPES ; ISOMERIC TRANSITION ISOTOPES ; ISOTOPES ; Lung - embryology ; LUNGS ; MAMMALS ; MICROSPHERES ; MINUTES LIVING RADIOISOTOPES ; NIOBIUM 95 ; NIOBIUM ISOTOPES ; NONMETALS ; NUCLEI ; ODD-EVEN NUCLEI ; ODD-ODD NUCLEI ; ORGANS ; OXYGEN ; Oxygen - blood ; Oxygen - pharmacology ; Partial Pressure ; PHYSIOLOGY ; Pregnancy ; Pulmonary Circulation - drug effects ; RADIOASSAY ; RADIOISOTOPES ; RARE EARTH ISOTOPES ; RARE EARTH NUCLEI ; RESPIRATORY SYSTEM ; RUMINANTS ; RUTHENIUM 103 ; RUTHENIUM ISOTOPES ; SCANDIUM 46 ; SCANDIUM ISOTOPES ; SECONDS LIVING RADIOISO ; SHEEP ; Sheep - embryology ; TIN 113 ; TIN ISOTOPES ; VASOCONSTRICTION ; VERTEBRATES 551001 -- Physiological Systems-- Tracer Techniques</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1988-03, Vol.254 (3), p.H542-H546</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c308t-67c9168c011a8791bc3d355063399184b5863612720c864ca80fefda6dfbf8b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3348432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6808837$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Morin, F. C., 3rd</creatorcontrib><creatorcontrib>Egan, E. A</creatorcontrib><creatorcontrib>Ferguson, W</creatorcontrib><creatorcontrib>Lundgren, C. E</creatorcontrib><title>Development of pulmonary vascular response to oxygen</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol</addtitle><description>F. C. Morin 3rd, E. A. Egan, W. Ferguson and C. E. Lundgren
Department of Pediatrics, University at Buffalo, New York.
The ability of the pulmonary circulation of the fetal lamb to respond to a
rise in oxygen tension was studied from 94 to 146 days of gestation. The
unanesthetized ewe breathed room air at normal atmospheric pressure,
followed by 100% oxygen at three atmospheres absolute pressure in a
hyperbaric chamber. In eleven near-term lambs (132 to 146 days of
gestation), fetal arterial oxygen tension (PaO2) increased from 25 +/- 1 to
55 +/- 6 Torr (mean +/- SE), which increased the proportion of right
ventricular output distributed to the fetal lungs from 8 +/- 1 to 59 +/-
5%. In five very immature lambs (94 to 101 days of gestation), fetal PaO2
increased from 27 +/- 1 to 174 +/- 70 Torr, but the proportion of right
ventricular output distributed to the lung did not change, 8 +/- 1 to 9 +/-
1%. In five of the near-term lambs, pulmonary blood flow was measured. It
increased from 34 +/- 3 to 298 +/- 35 ml.kg fetal wt-1.min-1, an 8.8-fold
increase. We conclude that the pulmonary circulation of the fetal lamb does
not respond to an increase in oxygen tension before 101 days of gestation;
however, near term an increase in oxygen tension alone can induce the
entire increase in pulmonary blood flow that normally occurs after the
onset of breathing at birth.</description><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BLOOD CIRCULATION</subject><subject>BLOOD FLOW</subject><subject>BLOOD PRESSURE</subject><subject>BODY</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DOMESTIC ANIMALS</subject><subject>ELECTRON CAPTURE RADIOISOTOPES</subject><subject>ELEMENTS</subject><subject>EVEN-ODD NUCLEI</subject><subject>Female</subject><subject>Fetus - physiology</subject><subject>GADOLINIUM 153</subject><subject>GADOLINIUM ISOTOPES</subject><subject>Hyperbaric Oxygenation</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>INTERNAL CONVERSION RADIOISOTOPES</subject><subject>ISOMERIC TRANSITION ISOTOPES</subject><subject>ISOTOPES</subject><subject>Lung - embryology</subject><subject>LUNGS</subject><subject>MAMMALS</subject><subject>MICROSPHERES</subject><subject>MINUTES LIVING RADIOISOTOPES</subject><subject>NIOBIUM 95</subject><subject>NIOBIUM ISOTOPES</subject><subject>NONMETALS</subject><subject>NUCLEI</subject><subject>ODD-EVEN NUCLEI</subject><subject>ODD-ODD NUCLEI</subject><subject>ORGANS</subject><subject>OXYGEN</subject><subject>Oxygen - blood</subject><subject>Oxygen - pharmacology</subject><subject>Partial Pressure</subject><subject>PHYSIOLOGY</subject><subject>Pregnancy</subject><subject>Pulmonary Circulation - drug effects</subject><subject>RADIOASSAY</subject><subject>RADIOISOTOPES</subject><subject>RARE EARTH ISOTOPES</subject><subject>RARE EARTH NUCLEI</subject><subject>RESPIRATORY SYSTEM</subject><subject>RUMINANTS</subject><subject>RUTHENIUM 103</subject><subject>RUTHENIUM ISOTOPES</subject><subject>SCANDIUM 46</subject><subject>SCANDIUM ISOTOPES</subject><subject>SECONDS LIVING RADIOISO</subject><subject>SHEEP</subject><subject>Sheep - embryology</subject><subject>TIN 113</subject><subject>TIN ISOTOPES</subject><subject>VASOCONSTRICTION</subject><subject>VERTEBRATES 551001 -- Physiological Systems-- Tracer Techniques</subject><issn>0363-6135</issn><issn>0002-9513</issn><issn>1522-1539</issn><issn>2163-5773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMlOwzAQhi0EgrI8AlLEgVuC7Ykd54jKUiQkLnC2HHfSpEriYCdA355ULctpDv8y-j9CIkYTxgS_Meu-QuOHhOVKJVykCSQLkfIDMptkHjMB-SGZUZAQSwbihJyGsKaUikzCMTkGSFUKfEbSO_zAxvUtdkPkyqgfm9Z1xm-iDxPs2BgfeQy96wJGg4vc12aF3Tk5Kk0T8GJ_z8jbw_3rfBE_vzw-zW-fYwtUDbHMbM6kspQxo7KcFRaWIASVAHnOVFoIJUEynnFqlUytUbTEcmnksixKVTA4I1e7XheGWgdbD2gr67oO7aClokpBNpmud6beu_cRw6DbOlhsGtOhG4PO1LSfCz4Z1c5ovQvBY6l7X7fTVM2o3lLVP1T1lqqeqGrQW6pT9HL_YyxaXP4G9xgnPdnpVb2qPmuPuq82oXaNW23-Wv8VfgN2zoVL</recordid><startdate>19880301</startdate><enddate>19880301</enddate><creator>Morin, F. C., 3rd</creator><creator>Egan, E. A</creator><creator>Ferguson, W</creator><creator>Lundgren, C. E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19880301</creationdate><title>Development of pulmonary vascular response to oxygen</title><author>Morin, F. C., 3rd ; Egan, E. A ; Ferguson, W ; Lundgren, C. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c308t-67c9168c011a8791bc3d355063399184b5863612720c864ca80fefda6dfbf8b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BLOOD CIRCULATION</topic><topic>BLOOD FLOW</topic><topic>BLOOD PRESSURE</topic><topic>BODY</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DOMESTIC ANIMALS</topic><topic>ELECTRON CAPTURE RADIOISOTOPES</topic><topic>ELEMENTS</topic><topic>EVEN-ODD NUCLEI</topic><topic>Female</topic><topic>Fetus - physiology</topic><topic>GADOLINIUM 153</topic><topic>GADOLINIUM ISOTOPES</topic><topic>Hyperbaric Oxygenation</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>INTERNAL CONVERSION RADIOISOTOPES</topic><topic>ISOMERIC TRANSITION ISOTOPES</topic><topic>ISOTOPES</topic><topic>Lung - embryology</topic><topic>LUNGS</topic><topic>MAMMALS</topic><topic>MICROSPHERES</topic><topic>MINUTES LIVING RADIOISOTOPES</topic><topic>NIOBIUM 95</topic><topic>NIOBIUM ISOTOPES</topic><topic>NONMETALS</topic><topic>NUCLEI</topic><topic>ODD-EVEN NUCLEI</topic><topic>ODD-ODD NUCLEI</topic><topic>ORGANS</topic><topic>OXYGEN</topic><topic>Oxygen - blood</topic><topic>Oxygen - pharmacology</topic><topic>Partial Pressure</topic><topic>PHYSIOLOGY</topic><topic>Pregnancy</topic><topic>Pulmonary Circulation - drug effects</topic><topic>RADIOASSAY</topic><topic>RADIOISOTOPES</topic><topic>RARE EARTH ISOTOPES</topic><topic>RARE EARTH NUCLEI</topic><topic>RESPIRATORY SYSTEM</topic><topic>RUMINANTS</topic><topic>RUTHENIUM 103</topic><topic>RUTHENIUM ISOTOPES</topic><topic>SCANDIUM 46</topic><topic>SCANDIUM ISOTOPES</topic><topic>SECONDS LIVING RADIOISO</topic><topic>SHEEP</topic><topic>Sheep - embryology</topic><topic>TIN 113</topic><topic>TIN ISOTOPES</topic><topic>VASOCONSTRICTION</topic><topic>VERTEBRATES 551001 -- Physiological Systems-- Tracer Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morin, F. C., 3rd</creatorcontrib><creatorcontrib>Egan, E. A</creatorcontrib><creatorcontrib>Ferguson, W</creatorcontrib><creatorcontrib>Lundgren, C. E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morin, F. C., 3rd</au><au>Egan, E. A</au><au>Ferguson, W</au><au>Lundgren, C. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of pulmonary vascular response to oxygen</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1988-03-01</date><risdate>1988</risdate><volume>254</volume><issue>3</issue><spage>H542</spage><epage>H546</epage><pages>H542-H546</pages><issn>0363-6135</issn><issn>0002-9513</issn><eissn>1522-1539</eissn><eissn>2163-5773</eissn><abstract>F. C. Morin 3rd, E. A. Egan, W. Ferguson and C. E. Lundgren
Department of Pediatrics, University at Buffalo, New York.
The ability of the pulmonary circulation of the fetal lamb to respond to a
rise in oxygen tension was studied from 94 to 146 days of gestation. The
unanesthetized ewe breathed room air at normal atmospheric pressure,
followed by 100% oxygen at three atmospheres absolute pressure in a
hyperbaric chamber. In eleven near-term lambs (132 to 146 days of
gestation), fetal arterial oxygen tension (PaO2) increased from 25 +/- 1 to
55 +/- 6 Torr (mean +/- SE), which increased the proportion of right
ventricular output distributed to the fetal lungs from 8 +/- 1 to 59 +/-
5%. In five very immature lambs (94 to 101 days of gestation), fetal PaO2
increased from 27 +/- 1 to 174 +/- 70 Torr, but the proportion of right
ventricular output distributed to the lung did not change, 8 +/- 1 to 9 +/-
1%. In five of the near-term lambs, pulmonary blood flow was measured. It
increased from 34 +/- 3 to 298 +/- 35 ml.kg fetal wt-1.min-1, an 8.8-fold
increase. We conclude that the pulmonary circulation of the fetal lamb does
not respond to an increase in oxygen tension before 101 days of gestation;
however, near term an increase in oxygen tension alone can induce the
entire increase in pulmonary blood flow that normally occurs after the
onset of breathing at birth.</abstract><cop>United States</cop><pmid>3348432</pmid><doi>10.1152/ajpheart.1988.254.3.H542</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 1988-03, Vol.254 (3), p.H542-H546 |
| issn | 0363-6135 0002-9513 1522-1539 2163-5773 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpheart_254_3_H542 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | ANIMALS BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BLOOD CIRCULATION BLOOD FLOW BLOOD PRESSURE BODY DAYS LIVING RADIOISOTOPES DOMESTIC ANIMALS ELECTRON CAPTURE RADIOISOTOPES ELEMENTS EVEN-ODD NUCLEI Female Fetus - physiology GADOLINIUM 153 GADOLINIUM ISOTOPES Hyperbaric Oxygenation INTERMEDIATE MASS NUCLEI INTERNAL CONVERSION RADIOISOTOPES ISOMERIC TRANSITION ISOTOPES ISOTOPES Lung - embryology LUNGS MAMMALS MICROSPHERES MINUTES LIVING RADIOISOTOPES NIOBIUM 95 NIOBIUM ISOTOPES NONMETALS NUCLEI ODD-EVEN NUCLEI ODD-ODD NUCLEI ORGANS OXYGEN Oxygen - blood Oxygen - pharmacology Partial Pressure PHYSIOLOGY Pregnancy Pulmonary Circulation - drug effects RADIOASSAY RADIOISOTOPES RARE EARTH ISOTOPES RARE EARTH NUCLEI RESPIRATORY SYSTEM RUMINANTS RUTHENIUM 103 RUTHENIUM ISOTOPES SCANDIUM 46 SCANDIUM ISOTOPES SECONDS LIVING RADIOISO SHEEP Sheep - embryology TIN 113 TIN ISOTOPES VASOCONSTRICTION VERTEBRATES 551001 -- Physiological Systems-- Tracer Techniques |
| title | Development of pulmonary vascular response to oxygen |
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