Hemodynamic alterations in chronically conscious unrestrained diabetic rats
L. F. Carbonell, M. G. Salom, J. Garcia-Estan, F. J. Salazar, M. Ubeda and T. Quesada Important cardiovascular dysfunctions have been described in streptozotocin (STZ)-diabetic rats. To determine the influence of these changes on the hemodynamic state and whether insulin treatment can avoid them, di...
Gespeichert in:
| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1987-05, Vol.252 (5), p.H900-H905 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | H905 |
|---|---|
| container_issue | 5 |
| container_start_page | H900 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 252 |
| creator | Carbonell, L.F Salom, M.G Garcia-Estan, J Salazar, F.J Ubeda, M Quesada, T |
| description | L. F. Carbonell, M. G. Salom, J. Garcia-Estan, F. J. Salazar, M. Ubeda and T. Quesada
Important cardiovascular dysfunctions have been described in streptozotocin
(STZ)-diabetic rats. To determine the influence of these changes on the
hemodynamic state and whether insulin treatment can avoid them, different
hemodynamic parameters, obtained by the thermodilution method, were studied
in STZ-induced (65 mg/kg) diabetic male Wistar rats, as well as in
age-control, weight-control, and insulin-treated diabetic ones. All rats
were examined in the conscious, unrestrained state 12 wk after induction of
diabetes or acidified saline (pH 4.5) injection. At 12 wk of diabetic state
most important findings were normotension, high blood volume, bradycardia,
increase in stroke volume, cardiac output, and cardiosomatic ratio, and
decrease in total peripheral resistance and cardiac contractility and
relaxation (dP/dtmax and dP/dtmin of left ventricular pressure curves). The
insulin-treated diabetic rats did not show any hemodynamic differences when
compared with the control animals. These results suggest that important
hemodynamic alterations are present in the chronic diabetic state, possibly
conditioning congestive heart failure. These alterations can be prevented
by insulin treatment. |
| doi_str_mv | 10.1152/ajpheart.1987.252.5.h900 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_fao_a</sourceid><recordid>TN_cdi_highwire_physiology_ajpheart_252_5_H900</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77523369</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-36c4fd1b1e09fa0f6fd6a740bf333684a9de09aba50f03d05a8dd571f2ace02b3</originalsourceid><addsrcrecordid>eNpVkFtLwzAUx4Moc06_gCD0ybfWXJZeHkXUiQMfdM_hNJc1o21m0iH99mZsKj4dcv6XHH4IJQRnhHB6B5tto8EPGanKIqOcZjxrKoxP0JSSnKW8KNgpmmKMaVpxws7RRQib-CSczSdoQivOKGdT9LrQnVNjD52VCbSD9jBY14fE9olsvOuthLYdExl30rpdSHa912HwYHutEmWh1kOMxli4RGcG2qCvjnOGVk-PHw-LdPn2_PJwv0wly8shZbmcG0VqonFlAJvcqByKOa4NY9Ewh0pFBWrg2GCmMIdSKV4QQ0FqTGs2Q7eH3q13n7t4jOhskLptodfxQlEUnMamKhrLg1F6F4LXRmy97cCPgmCx5yh-OIo9RxE5Ci4WkWOM3hz_2NWdVr_BI7ioZwe9sevmy3otts0YrGvdevxr_Vd4fQgYcALW3gaxei8LVtEofgP0CIxS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77523369</pqid></control><display><type>article</type><title>Hemodynamic alterations in chronically conscious unrestrained diabetic rats</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Carbonell, L.F ; Salom, M.G ; Garcia-Estan, J ; Salazar, F.J ; Ubeda, M ; Quesada, T</creator><creatorcontrib>Carbonell, L.F ; Salom, M.G ; Garcia-Estan, J ; Salazar, F.J ; Ubeda, M ; Quesada, T</creatorcontrib><description>L. F. Carbonell, M. G. Salom, J. Garcia-Estan, F. J. Salazar, M. Ubeda and T. Quesada
Important cardiovascular dysfunctions have been described in streptozotocin
(STZ)-diabetic rats. To determine the influence of these changes on the
hemodynamic state and whether insulin treatment can avoid them, different
hemodynamic parameters, obtained by the thermodilution method, were studied
in STZ-induced (65 mg/kg) diabetic male Wistar rats, as well as in
age-control, weight-control, and insulin-treated diabetic ones. All rats
were examined in the conscious, unrestrained state 12 wk after induction of
diabetes or acidified saline (pH 4.5) injection. At 12 wk of diabetic state
most important findings were normotension, high blood volume, bradycardia,
increase in stroke volume, cardiac output, and cardiosomatic ratio, and
decrease in total peripheral resistance and cardiac contractility and
relaxation (dP/dtmax and dP/dtmin of left ventricular pressure curves). The
insulin-treated diabetic rats did not show any hemodynamic differences when
compared with the control animals. These results suggest that important
hemodynamic alterations are present in the chronic diabetic state, possibly
conditioning congestive heart failure. These alterations can be prevented
by insulin treatment.</description><identifier>ISSN: 0002-9513</identifier><identifier>ISSN: 0363-6135</identifier><identifier>EISSN: 2163-5773</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.1987.252.5.h900</identifier><identifier>PMID: 2953253</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; BLOOD ; Blood Glucose - analysis ; Body Weight ; Chronic Disease ; COEUR ; Consciousness ; CORAZON ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - physiopathology ; ENFERMEDADES METABOLICAS ; EXPERIMENTATION ; EXPERIMENTOS ; EXPERIMENTS ; FREQUENCE DU POULS ; HEART ; Hemodynamics - drug effects ; Insulin - therapeutic use ; MALADIE METABOLIQUE ; Male ; METABOLIC DISEASES ; Motor Activity ; PULSACIONES ; PULSE RATE ; RAT ; RATA ; RATS ; Rats, Inbred Strains ; SANG ; SANGRE ; Streptozocin</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1987-05, Vol.252 (5), p.H900-H905</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-36c4fd1b1e09fa0f6fd6a740bf333684a9de09aba50f03d05a8dd571f2ace02b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2953253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carbonell, L.F</creatorcontrib><creatorcontrib>Salom, M.G</creatorcontrib><creatorcontrib>Garcia-Estan, J</creatorcontrib><creatorcontrib>Salazar, F.J</creatorcontrib><creatorcontrib>Ubeda, M</creatorcontrib><creatorcontrib>Quesada, T</creatorcontrib><title>Hemodynamic alterations in chronically conscious unrestrained diabetic rats</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol</addtitle><description>L. F. Carbonell, M. G. Salom, J. Garcia-Estan, F. J. Salazar, M. Ubeda and T. Quesada
Important cardiovascular dysfunctions have been described in streptozotocin
(STZ)-diabetic rats. To determine the influence of these changes on the
hemodynamic state and whether insulin treatment can avoid them, different
hemodynamic parameters, obtained by the thermodilution method, were studied
in STZ-induced (65 mg/kg) diabetic male Wistar rats, as well as in
age-control, weight-control, and insulin-treated diabetic ones. All rats
were examined in the conscious, unrestrained state 12 wk after induction of
diabetes or acidified saline (pH 4.5) injection. At 12 wk of diabetic state
most important findings were normotension, high blood volume, bradycardia,
increase in stroke volume, cardiac output, and cardiosomatic ratio, and
decrease in total peripheral resistance and cardiac contractility and
relaxation (dP/dtmax and dP/dtmin of left ventricular pressure curves). The
insulin-treated diabetic rats did not show any hemodynamic differences when
compared with the control animals. These results suggest that important
hemodynamic alterations are present in the chronic diabetic state, possibly
conditioning congestive heart failure. These alterations can be prevented
by insulin treatment.</description><subject>Animals</subject><subject>BLOOD</subject><subject>Blood Glucose - analysis</subject><subject>Body Weight</subject><subject>Chronic Disease</subject><subject>COEUR</subject><subject>Consciousness</subject><subject>CORAZON</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>ENFERMEDADES METABOLICAS</subject><subject>EXPERIMENTATION</subject><subject>EXPERIMENTOS</subject><subject>EXPERIMENTS</subject><subject>FREQUENCE DU POULS</subject><subject>HEART</subject><subject>Hemodynamics - drug effects</subject><subject>Insulin - therapeutic use</subject><subject>MALADIE METABOLIQUE</subject><subject>Male</subject><subject>METABOLIC DISEASES</subject><subject>Motor Activity</subject><subject>PULSACIONES</subject><subject>PULSE RATE</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Inbred Strains</subject><subject>SANG</subject><subject>SANGRE</subject><subject>Streptozocin</subject><issn>0002-9513</issn><issn>0363-6135</issn><issn>2163-5773</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkFtLwzAUx4Moc06_gCD0ybfWXJZeHkXUiQMfdM_hNJc1o21m0iH99mZsKj4dcv6XHH4IJQRnhHB6B5tto8EPGanKIqOcZjxrKoxP0JSSnKW8KNgpmmKMaVpxws7RRQib-CSczSdoQivOKGdT9LrQnVNjD52VCbSD9jBY14fE9olsvOuthLYdExl30rpdSHa912HwYHutEmWh1kOMxli4RGcG2qCvjnOGVk-PHw-LdPn2_PJwv0wly8shZbmcG0VqonFlAJvcqByKOa4NY9Ewh0pFBWrg2GCmMIdSKV4QQ0FqTGs2Q7eH3q13n7t4jOhskLptodfxQlEUnMamKhrLg1F6F4LXRmy97cCPgmCx5yh-OIo9RxE5Ci4WkWOM3hz_2NWdVr_BI7ioZwe9sevmy3otts0YrGvdevxr_Vd4fQgYcALW3gaxei8LVtEofgP0CIxS</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Carbonell, L.F</creator><creator>Salom, M.G</creator><creator>Garcia-Estan, J</creator><creator>Salazar, F.J</creator><creator>Ubeda, M</creator><creator>Quesada, T</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19870501</creationdate><title>Hemodynamic alterations in chronically conscious unrestrained diabetic rats</title><author>Carbonell, L.F ; Salom, M.G ; Garcia-Estan, J ; Salazar, F.J ; Ubeda, M ; Quesada, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-36c4fd1b1e09fa0f6fd6a740bf333684a9de09aba50f03d05a8dd571f2ace02b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>BLOOD</topic><topic>Blood Glucose - analysis</topic><topic>Body Weight</topic><topic>Chronic Disease</topic><topic>COEUR</topic><topic>Consciousness</topic><topic>CORAZON</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>ENFERMEDADES METABOLICAS</topic><topic>EXPERIMENTATION</topic><topic>EXPERIMENTOS</topic><topic>EXPERIMENTS</topic><topic>FREQUENCE DU POULS</topic><topic>HEART</topic><topic>Hemodynamics - drug effects</topic><topic>Insulin - therapeutic use</topic><topic>MALADIE METABOLIQUE</topic><topic>Male</topic><topic>METABOLIC DISEASES</topic><topic>Motor Activity</topic><topic>PULSACIONES</topic><topic>PULSE RATE</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Inbred Strains</topic><topic>SANG</topic><topic>SANGRE</topic><topic>Streptozocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carbonell, L.F</creatorcontrib><creatorcontrib>Salom, M.G</creatorcontrib><creatorcontrib>Garcia-Estan, J</creatorcontrib><creatorcontrib>Salazar, F.J</creatorcontrib><creatorcontrib>Ubeda, M</creatorcontrib><creatorcontrib>Quesada, T</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carbonell, L.F</au><au>Salom, M.G</au><au>Garcia-Estan, J</au><au>Salazar, F.J</au><au>Ubeda, M</au><au>Quesada, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemodynamic alterations in chronically conscious unrestrained diabetic rats</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>252</volume><issue>5</issue><spage>H900</spage><epage>H905</epage><pages>H900-H905</pages><issn>0002-9513</issn><issn>0363-6135</issn><eissn>2163-5773</eissn><eissn>1522-1539</eissn><abstract>L. F. Carbonell, M. G. Salom, J. Garcia-Estan, F. J. Salazar, M. Ubeda and T. Quesada
Important cardiovascular dysfunctions have been described in streptozotocin
(STZ)-diabetic rats. To determine the influence of these changes on the
hemodynamic state and whether insulin treatment can avoid them, different
hemodynamic parameters, obtained by the thermodilution method, were studied
in STZ-induced (65 mg/kg) diabetic male Wistar rats, as well as in
age-control, weight-control, and insulin-treated diabetic ones. All rats
were examined in the conscious, unrestrained state 12 wk after induction of
diabetes or acidified saline (pH 4.5) injection. At 12 wk of diabetic state
most important findings were normotension, high blood volume, bradycardia,
increase in stroke volume, cardiac output, and cardiosomatic ratio, and
decrease in total peripheral resistance and cardiac contractility and
relaxation (dP/dtmax and dP/dtmin of left ventricular pressure curves). The
insulin-treated diabetic rats did not show any hemodynamic differences when
compared with the control animals. These results suggest that important
hemodynamic alterations are present in the chronic diabetic state, possibly
conditioning congestive heart failure. These alterations can be prevented
by insulin treatment.</abstract><cop>United States</cop><pmid>2953253</pmid><doi>10.1152/ajpheart.1987.252.5.h900</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9513 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 1987-05, Vol.252 (5), p.H900-H905 |
| issn | 0002-9513 0363-6135 2163-5773 1522-1539 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpheart_252_5_H900 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals BLOOD Blood Glucose - analysis Body Weight Chronic Disease COEUR Consciousness CORAZON Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - physiopathology ENFERMEDADES METABOLICAS EXPERIMENTATION EXPERIMENTOS EXPERIMENTS FREQUENCE DU POULS HEART Hemodynamics - drug effects Insulin - therapeutic use MALADIE METABOLIQUE Male METABOLIC DISEASES Motor Activity PULSACIONES PULSE RATE RAT RATA RATS Rats, Inbred Strains SANG SANGRE Streptozocin |
| title | Hemodynamic alterations in chronically conscious unrestrained diabetic rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T10%3A01%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_fao_a&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hemodynamic%20alterations%20in%20chronically%20conscious%20unrestrained%20diabetic%20rats&rft.jtitle=American%20journal%20of%20physiology.%20Heart%20and%20circulatory%20physiology&rft.au=Carbonell,%20L.F&rft.date=1987-05-01&rft.volume=252&rft.issue=5&rft.spage=H900&rft.epage=H905&rft.pages=H900-H905&rft.issn=0002-9513&rft.eissn=2163-5773&rft_id=info:doi/10.1152/ajpheart.1987.252.5.h900&rft_dat=%3Cproquest_fao_a%3E77523369%3C/proquest_fao_a%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77523369&rft_id=info:pmid/2953253&rfr_iscdi=true |