Effect of arterial stretch on transmural albumin and Evan's blue dye transport
D. L. Fry, R. W. Mahley and S. Y. Oh The influence of arterial wall circumferential stretch (lambda) on the 32-min diffusive mural uptake of 125I-albumin and of Evan's blue dye (EBD) across the injured endothelial surface was studied in the intimal-medial preparation of the canine descending th...
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| Veröffentlicht in: | American journal of physiology. Heart and circulatory physiology 1981-04, Vol.240 (4), p.H645-H649 |
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| container_end_page | H649 |
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| container_issue | 4 |
| container_start_page | H645 |
| container_title | American journal of physiology. Heart and circulatory physiology |
| container_volume | 240 |
| creator | Fry, D. L Mahley, R. W Oh, S. Y |
| description | D. L. Fry, R. W. Mahley and S. Y. Oh
The influence of arterial wall circumferential stretch (lambda) on the
32-min diffusive mural uptake of 125I-albumin and of Evan's blue dye (EBD)
across the injured endothelial surface was studied in the intimal-medial
preparation of the canine descending thoracic aorta (DTA). Albumin uptake
(MA nmol/cm2) was measured by standard gamma counting techniques and the
corresponding EBD uptake (ME) by the reflectance method. MA and ME were
measured at a physiological stretch (lambda = 1.4) and at a hypertensive
stretch (lambda = 1.8) at four equispaced locations (z) along the DTA. When
lambda was changed from 1.4 to 1.8, the average percentage change of MA was
-2% and of ME was -4%. These decreases were not significant (P greater than
0.10), and we conclude that arterial wall stretch exerts only minor
influence on the parameters governing albumin and EBD-albumin accumulation
in the intimal surface of the deendothelialized arterial intimal-medial
tissue system. |
| doi_str_mv | 10.1152/ajpheart.1981.240.4.h645 |
| format | Article |
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The influence of arterial wall circumferential stretch (lambda) on the
32-min diffusive mural uptake of 125I-albumin and of Evan's blue dye (EBD)
across the injured endothelial surface was studied in the intimal-medial
preparation of the canine descending thoracic aorta (DTA). Albumin uptake
(MA nmol/cm2) was measured by standard gamma counting techniques and the
corresponding EBD uptake (ME) by the reflectance method. MA and ME were
measured at a physiological stretch (lambda = 1.4) and at a hypertensive
stretch (lambda = 1.8) at four equispaced locations (z) along the DTA. When
lambda was changed from 1.4 to 1.8, the average percentage change of MA was
-2% and of ME was -4%. These decreases were not significant (P greater than
0.10), and we conclude that arterial wall stretch exerts only minor
influence on the parameters governing albumin and EBD-albumin accumulation
in the intimal surface of the deendothelialized arterial intimal-medial
tissue system.</description><identifier>ISSN: 0363-6135</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1539</identifier><identifier>DOI: 10.1152/ajpheart.1981.240.4.h645</identifier><identifier>PMID: 7223913</identifier><language>eng</language><publisher>United States</publisher><subject>Absorption ; Animals ; Aorta, Thoracic - metabolism ; Azo Compounds - metabolism ; Biological Transport ; Dogs ; Evans Blue - metabolism ; In Vitro Techniques ; Mathematics ; Serum Albumin - metabolism ; Stress, Mechanical ; Time Factors</subject><ispartof>American journal of physiology. Heart and circulatory physiology, 1981-04, Vol.240 (4), p.H645-H649</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-c8745cc6269b9cb12d74f8b10ad5227a5e1dbf97f17d9a64e6f9ad11d8529a423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7223913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fry, D. L</creatorcontrib><creatorcontrib>Mahley, R. W</creatorcontrib><creatorcontrib>Oh, S. Y</creatorcontrib><title>Effect of arterial stretch on transmural albumin and Evan's blue dye transport</title><title>American journal of physiology. Heart and circulatory physiology</title><addtitle>Am J Physiol</addtitle><description>D. L. Fry, R. W. Mahley and S. Y. Oh
The influence of arterial wall circumferential stretch (lambda) on the
32-min diffusive mural uptake of 125I-albumin and of Evan's blue dye (EBD)
across the injured endothelial surface was studied in the intimal-medial
preparation of the canine descending thoracic aorta (DTA). Albumin uptake
(MA nmol/cm2) was measured by standard gamma counting techniques and the
corresponding EBD uptake (ME) by the reflectance method. MA and ME were
measured at a physiological stretch (lambda = 1.4) and at a hypertensive
stretch (lambda = 1.8) at four equispaced locations (z) along the DTA. When
lambda was changed from 1.4 to 1.8, the average percentage change of MA was
-2% and of ME was -4%. These decreases were not significant (P greater than
0.10), and we conclude that arterial wall stretch exerts only minor
influence on the parameters governing albumin and EBD-albumin accumulation
in the intimal surface of the deendothelialized arterial intimal-medial
tissue system.</description><subject>Absorption</subject><subject>Animals</subject><subject>Aorta, Thoracic - metabolism</subject><subject>Azo Compounds - metabolism</subject><subject>Biological Transport</subject><subject>Dogs</subject><subject>Evans Blue - metabolism</subject><subject>In Vitro Techniques</subject><subject>Mathematics</subject><subject>Serum Albumin - metabolism</subject><subject>Stress, Mechanical</subject><subject>Time Factors</subject><issn>0363-6135</issn><issn>0002-9513</issn><issn>1522-1539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkElLxDAUx4Mo47h8BCEnPbU2e3MUGRcQveg5pFmmlW4mrTLf3gwzLqcH77-8xw8AiIocIYav9ftYOx2mHMkS5ZgWOc1rTtkBWCYZZ4gReQiWBeEk44iwY3AS43tRFExwsgALgTGRiCzB88p7ZyY4eJjqXGh0C-MU3GRqOPRwCrqP3RzSVrfV3DU91L2Fq0_dX0VYtbODduN2tnEI0xk48rqN7nw_T8Hb3er19iF7erl_vL15ygwheMpMKSgzhmMuK2kqhK2gvqxQoW36XmjmkK28FB4JKzWnjnupLUK2ZFhqiskpuNz1jmH4mF2cVNdE49pW926YoxKMU0pFmYzlzmjCEGNwXo2h6XTYKFSoLUr1g1JtUaqEUlH1kFCm6MX-xlx1zv4G9-ySnu_0ulnXX01waqw3sRnaYb35a_1X-A0jKoN9</recordid><startdate>198104</startdate><enddate>198104</enddate><creator>Fry, D. L</creator><creator>Mahley, R. W</creator><creator>Oh, S. Y</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198104</creationdate><title>Effect of arterial stretch on transmural albumin and Evan's blue dye transport</title><author>Fry, D. L ; Mahley, R. W ; Oh, S. Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-c8745cc6269b9cb12d74f8b10ad5227a5e1dbf97f17d9a64e6f9ad11d8529a423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Aorta, Thoracic - metabolism</topic><topic>Azo Compounds - metabolism</topic><topic>Biological Transport</topic><topic>Dogs</topic><topic>Evans Blue - metabolism</topic><topic>In Vitro Techniques</topic><topic>Mathematics</topic><topic>Serum Albumin - metabolism</topic><topic>Stress, Mechanical</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fry, D. L</creatorcontrib><creatorcontrib>Mahley, R. W</creatorcontrib><creatorcontrib>Oh, S. Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fry, D. L</au><au>Mahley, R. W</au><au>Oh, S. Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of arterial stretch on transmural albumin and Evan's blue dye transport</atitle><jtitle>American journal of physiology. Heart and circulatory physiology</jtitle><addtitle>Am J Physiol</addtitle><date>1981-04</date><risdate>1981</risdate><volume>240</volume><issue>4</issue><spage>H645</spage><epage>H649</epage><pages>H645-H649</pages><issn>0363-6135</issn><issn>0002-9513</issn><eissn>1522-1539</eissn><abstract>D. L. Fry, R. W. Mahley and S. Y. Oh
The influence of arterial wall circumferential stretch (lambda) on the
32-min diffusive mural uptake of 125I-albumin and of Evan's blue dye (EBD)
across the injured endothelial surface was studied in the intimal-medial
preparation of the canine descending thoracic aorta (DTA). Albumin uptake
(MA nmol/cm2) was measured by standard gamma counting techniques and the
corresponding EBD uptake (ME) by the reflectance method. MA and ME were
measured at a physiological stretch (lambda = 1.4) and at a hypertensive
stretch (lambda = 1.8) at four equispaced locations (z) along the DTA. When
lambda was changed from 1.4 to 1.8, the average percentage change of MA was
-2% and of ME was -4%. These decreases were not significant (P greater than
0.10), and we conclude that arterial wall stretch exerts only minor
influence on the parameters governing albumin and EBD-albumin accumulation
in the intimal surface of the deendothelialized arterial intimal-medial
tissue system.</abstract><cop>United States</cop><pmid>7223913</pmid><doi>10.1152/ajpheart.1981.240.4.h645</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6135 |
| ispartof | American journal of physiology. Heart and circulatory physiology, 1981-04, Vol.240 (4), p.H645-H649 |
| issn | 0363-6135 0002-9513 1522-1539 |
| language | eng |
| recordid | cdi_highwire_physiology_ajpheart_240_4_H645 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Absorption Animals Aorta, Thoracic - metabolism Azo Compounds - metabolism Biological Transport Dogs Evans Blue - metabolism In Vitro Techniques Mathematics Serum Albumin - metabolism Stress, Mechanical Time Factors |
| title | Effect of arterial stretch on transmural albumin and Evan's blue dye transport |
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