Proinsulin stimulates growth of small intestinal crypt-like cells acting via specific receptors

Division of Nephrology, Departments of Internal Medicine I and II, University of Ulm, 89070 Ulm, Germany The mechanisms that regulate cell turnover in the intestinal epithelium are incompletely understood. Here we tested the hypothesis that proinsulin, present in serum and pancreatic juice in picomo...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1999-02, Vol.276 (2), p.E262-E268
Hauptverfasser:	Jehle, Peter M, Fussgaenger, Rolf D, Angelus, Niklas K. O, Jungwirth, Robert J, Saile, Bernhard, Lutz, Manfred P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive - physiology C-Peptide - metabolism Cell Division - drug effects Cell Division - physiology Cell Line Cell Membrane - metabolism Humans Insulin - metabolism Insulin - pharmacology Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor I - pharmacology Insulin-Like Growth Factor II - metabolism Intestine, Small - cytology Intestine, Small - drug effects Proinsulin - metabolism Proinsulin - pharmacology Rats Receptors, Cell Surface - physiology
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