Effect of short-term propionate infusion on feed intake and blood parameters in sheep
The hypothesis that propionate is a short-term feed intake-regulating agent was studied. Mature wether sheep were infused over 20 min with Na propionate into the mesenteric vein, while feed intake and feeding pattern were monitored over 1.5 h. Feed intake was reduced by infusions at 2 mmol/min, whic...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 1997-06, Vol.272 (6), p.E997-E1001 |
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| container_title | American journal of physiology: endocrinology and metabolism |
| container_volume | 272 |
| creator | Leuvenink, H.G.D. (Agricultural University, Wageningen, The Netherlands.) Bleumer, E.J.B Bongers, L.J.G.M Bruchem, J. van Heide, D. van der |
| description | The hypothesis that propionate is a short-term feed intake-regulating agent was studied. Mature wether sheep were infused over 20 min with Na propionate into the mesenteric vein, while feed intake and feeding pattern were monitored over 1.5 h. Feed intake was reduced by infusions at 2 mmol/min, which were associated with marked increases in jugular as well as portal concentrations of insulin, glucose, and propionate. In a second experiment, animals were infused with 2 mmol/min Na propionate into the portal vein. No decrease in feed intake was observed, although there were similar increases in insulin, glucose, and propionate as found in mesenteric vein-infused animals. It is concluded that mesenteric propionate in high doses acts as a satiety factor. Possible explanations for the difference between site of infusion may be a different distribution of the infusate over the liver and/or the presence of propionate-sensitive receptors in the mesenteric/portal vein region. It seems unlikely that insulin concentrations are involved in inducing satiety in propionate-infused animals |
| doi_str_mv | 10.1152/ajpendo.1997.272.6.E997 |
| format | Article |
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(Agricultural University, Wageningen, The Netherlands.) ; Bleumer, E.J.B ; Bongers, L.J.G.M ; Bruchem, J. van ; Heide, D. van der</creator><creatorcontrib>Leuvenink, H.G.D. (Agricultural University, Wageningen, The Netherlands.) ; Bleumer, E.J.B ; Bongers, L.J.G.M ; Bruchem, J. van ; Heide, D. van der</creatorcontrib><description>The hypothesis that propionate is a short-term feed intake-regulating agent was studied. Mature wether sheep were infused over 20 min with Na propionate into the mesenteric vein, while feed intake and feeding pattern were monitored over 1.5 h. Feed intake was reduced by infusions at 2 mmol/min, which were associated with marked increases in jugular as well as portal concentrations of insulin, glucose, and propionate. In a second experiment, animals were infused with 2 mmol/min Na propionate into the portal vein. No decrease in feed intake was observed, although there were similar increases in insulin, glucose, and propionate as found in mesenteric vein-infused animals. It is concluded that mesenteric propionate in high doses acts as a satiety factor. Possible explanations for the difference between site of infusion may be a different distribution of the infusate over the liver and/or the presence of propionate-sensitive receptors in the mesenteric/portal vein region. It seems unlikely that insulin concentrations are involved in inducing satiety in propionate-infused animals</description><identifier>ISSN: 0002-9513</identifier><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 2163-5773</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.1997.272.6.E997</identifier><identifier>PMID: 9227443</identifier><identifier>CODEN: AJPHAP</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; Blood Glucose - metabolism ; Feeding Behavior - drug effects ; Female ; Fysiologie van Mens en Dier ; Human and Animal Physiology ; Infusions, Intravenous ; INGESTION DE PIENSOS ; Insulin - blood ; Insulin - metabolism ; Insulin Secretion ; Jugular Veins ; Leerstoelgroep Fysiologie van mens en dier ; Male ; Mesenteric Veins ; Orchiectomy ; OVIN ; OVINOS ; Portal Vein ; PRISE ALIMENTAIRE (ANIMAUX) ; PROPIONATE (SEL) ; Propionates - administration & dosage ; Propionates - pharmacokinetics ; Propionates - pharmacology ; PROPIONATOS (SALES) ; SANG ; SANGRE ; Sheep ; Time Factors ; WIAS</subject><ispartof>American journal of physiology: endocrinology and metabolism, 1997-06, Vol.272 (6), p.E997-E1001</ispartof><rights>Copyright American Physiological Society Jun 1997</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-15fcb0f9d0f04fcd7a3741d0aae3a4e4d2fd87683d2164225da07ab2fefa916f3</citedby><cites>FETCH-LOGICAL-c442t-15fcb0f9d0f04fcd7a3741d0aae3a4e4d2fd87683d2164225da07ab2fefa916f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9227443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leuvenink, H.G.D. (Agricultural University, Wageningen, The Netherlands.)</creatorcontrib><creatorcontrib>Bleumer, E.J.B</creatorcontrib><creatorcontrib>Bongers, L.J.G.M</creatorcontrib><creatorcontrib>Bruchem, J. van</creatorcontrib><creatorcontrib>Heide, D. van der</creatorcontrib><title>Effect of short-term propionate infusion on feed intake and blood parameters in sheep</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol</addtitle><description>The hypothesis that propionate is a short-term feed intake-regulating agent was studied. Mature wether sheep were infused over 20 min with Na propionate into the mesenteric vein, while feed intake and feeding pattern were monitored over 1.5 h. Feed intake was reduced by infusions at 2 mmol/min, which were associated with marked increases in jugular as well as portal concentrations of insulin, glucose, and propionate. In a second experiment, animals were infused with 2 mmol/min Na propionate into the portal vein. No decrease in feed intake was observed, although there were similar increases in insulin, glucose, and propionate as found in mesenteric vein-infused animals. It is concluded that mesenteric propionate in high doses acts as a satiety factor. Possible explanations for the difference between site of infusion may be a different distribution of the infusate over the liver and/or the presence of propionate-sensitive receptors in the mesenteric/portal vein region. It seems unlikely that insulin concentrations are involved in inducing satiety in propionate-infused animals</description><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Feeding Behavior - drug effects</subject><subject>Female</subject><subject>Fysiologie van Mens en Dier</subject><subject>Human and Animal Physiology</subject><subject>Infusions, Intravenous</subject><subject>INGESTION DE PIENSOS</subject><subject>Insulin - blood</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Jugular Veins</subject><subject>Leerstoelgroep Fysiologie van mens en dier</subject><subject>Male</subject><subject>Mesenteric Veins</subject><subject>Orchiectomy</subject><subject>OVIN</subject><subject>OVINOS</subject><subject>Portal Vein</subject><subject>PRISE ALIMENTAIRE (ANIMAUX)</subject><subject>PROPIONATE (SEL)</subject><subject>Propionates - administration & dosage</subject><subject>Propionates - pharmacokinetics</subject><subject>Propionates - pharmacology</subject><subject>PROPIONATOS (SALES)</subject><subject>SANG</subject><subject>SANGRE</subject><subject>Sheep</subject><subject>Time Factors</subject><subject>WIAS</subject><issn>0002-9513</issn><issn>0193-1849</issn><issn>2163-5773</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUV2r1DAQLaJc16t_QBCLD7615qvN5lEu6wdc8EH3OUybyW7WblKTlmX_vSldLiiEzGTmnJNMTlG8p6SmtGGf4DSiN6GmSsmaSVa39S6nz4oNoy2vGin582JDCGGVaih_WbxK6ZSPtOHirrhTjEkh-KbY76zFfiqDLdMxxKmaMJ7LMYbRBQ8Tls7bOeW8zMsimlyY4DeW4E3ZDSGYcoQIZ8y8lHtZBXF8XbywMCR8c4v3xf7L7tfDt-rxx9fvD58fq14INlW0sX1HrDLEEmF7I4FLQQ0BQA4ChWHWbGW75SYPJRhrDBAJHbNoQdHW8vtCrboXOKB3Pm_aQ-xd0gGcHlwXIV71ZY7aD0sY5y5pLpmSmftx5eZh_8yYJn12qcdhAI9hTloqKiSV2wz88B_wFObo81x6eVbDFFlAcgX1MaQU0eoxuvNyOSV6cUzfHNOLYzo7plu9OJaZ727yc3dG88S7WZT71do_usPx4iLq8XjNjgzhcH0S_Ufv7Yq3EDQcYv6L_c9cVw2j_C9D4q72</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Leuvenink, H.G.D. (Agricultural University, Wageningen, The Netherlands.)</creator><creator>Bleumer, E.J.B</creator><creator>Bongers, L.J.G.M</creator><creator>Bruchem, J. van</creator><creator>Heide, D. van der</creator><general>American Physiological Society</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>QVL</scope></search><sort><creationdate>19970601</creationdate><title>Effect of short-term propionate infusion on feed intake and blood parameters in sheep</title><author>Leuvenink, H.G.D. (Agricultural University, Wageningen, The Netherlands.) ; Bleumer, E.J.B ; Bongers, L.J.G.M ; Bruchem, J. van ; Heide, D. van der</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-15fcb0f9d0f04fcd7a3741d0aae3a4e4d2fd87683d2164225da07ab2fefa916f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Feeding Behavior - drug effects</topic><topic>Female</topic><topic>Fysiologie van Mens en Dier</topic><topic>Human and Animal Physiology</topic><topic>Infusions, Intravenous</topic><topic>INGESTION DE PIENSOS</topic><topic>Insulin - blood</topic><topic>Insulin - metabolism</topic><topic>Insulin Secretion</topic><topic>Jugular Veins</topic><topic>Leerstoelgroep Fysiologie van mens en dier</topic><topic>Male</topic><topic>Mesenteric Veins</topic><topic>Orchiectomy</topic><topic>OVIN</topic><topic>OVINOS</topic><topic>Portal Vein</topic><topic>PRISE ALIMENTAIRE (ANIMAUX)</topic><topic>PROPIONATE (SEL)</topic><topic>Propionates - administration & dosage</topic><topic>Propionates - pharmacokinetics</topic><topic>Propionates - pharmacology</topic><topic>PROPIONATOS (SALES)</topic><topic>SANG</topic><topic>SANGRE</topic><topic>Sheep</topic><topic>Time Factors</topic><topic>WIAS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leuvenink, H.G.D. (Agricultural University, Wageningen, The Netherlands.)</creatorcontrib><creatorcontrib>Bleumer, E.J.B</creatorcontrib><creatorcontrib>Bongers, L.J.G.M</creatorcontrib><creatorcontrib>Bruchem, J. van</creatorcontrib><creatorcontrib>Heide, D. van der</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NARCIS:Publications</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leuvenink, H.G.D. (Agricultural University, Wageningen, The Netherlands.)</au><au>Bleumer, E.J.B</au><au>Bongers, L.J.G.M</au><au>Bruchem, J. van</au><au>Heide, D. van der</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of short-term propionate infusion on feed intake and blood parameters in sheep</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>272</volume><issue>6</issue><spage>E997</spage><epage>E1001</epage><pages>E997-E1001</pages><issn>0002-9513</issn><issn>0193-1849</issn><eissn>2163-5773</eissn><eissn>1522-1555</eissn><coden>AJPHAP</coden><abstract>The hypothesis that propionate is a short-term feed intake-regulating agent was studied. Mature wether sheep were infused over 20 min with Na propionate into the mesenteric vein, while feed intake and feeding pattern were monitored over 1.5 h. Feed intake was reduced by infusions at 2 mmol/min, which were associated with marked increases in jugular as well as portal concentrations of insulin, glucose, and propionate. In a second experiment, animals were infused with 2 mmol/min Na propionate into the portal vein. No decrease in feed intake was observed, although there were similar increases in insulin, glucose, and propionate as found in mesenteric vein-infused animals. It is concluded that mesenteric propionate in high doses acts as a satiety factor. Possible explanations for the difference between site of infusion may be a different distribution of the infusate over the liver and/or the presence of propionate-sensitive receptors in the mesenteric/portal vein region. It seems unlikely that insulin concentrations are involved in inducing satiety in propionate-infused animals</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>9227443</pmid><doi>10.1152/ajpendo.1997.272.6.E997</doi></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Blood Glucose - metabolism Feeding Behavior - drug effects Female Fysiologie van Mens en Dier Human and Animal Physiology Infusions, Intravenous INGESTION DE PIENSOS Insulin - blood Insulin - metabolism Insulin Secretion Jugular Veins Leerstoelgroep Fysiologie van mens en dier Male Mesenteric Veins Orchiectomy OVIN OVINOS Portal Vein PRISE ALIMENTAIRE (ANIMAUX) PROPIONATE (SEL) Propionates - administration & dosage Propionates - pharmacokinetics Propionates - pharmacology PROPIONATOS (SALES) SANG SANGRE Sheep Time Factors WIAS |
| title | Effect of short-term propionate infusion on feed intake and blood parameters in sheep |
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