Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep

We measured leucine flux rates during infusions of L-[1-14C]- and L-[1-13C] in fetal sheep exposed to maternal insulin-induced hypoglycemia over the last 8 wk (40%) of gestation to determine effects of chronic glucose deficiency and hypoglycemia on fetal leucine metabolism. Compared with control fet...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1997-01, Vol.272 (1), p.E107-E117
Hauptverfasser:	Carver, T.D. (University of Colorado, Denver, CO.), Quick, A.A, Teng, C.C, Pike, A.W, Fennessey, P.V, Hay, W.W. Jr
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - analysis Body Weight Carbon Isotopes Chronic Disease Female Fetal Blood - metabolism Fetal Growth Retardation - blood Fetus - anatomy & histology HIPOGLICEMIA Hypoglycemia - blood Hypoglycemia - metabolism Hypoglycemia - pathology HYPOGLYCEMIE Insulin - blood Keto Acids - blood LEUCINA LEUCINE Leucine - blood Leucine - metabolism METABOLISME METABOLISMO Organ Size Oxygen - blood Placenta - anatomy & histology Pregnancy Sheep
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