Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb
T. S. Guyton, H. De Wilt, P. V. Fennessey, G. Meschia, R. B. Wilkening and F. C. Battaglia Department of Anesthesiology, University of Colorado Health Sciences Center, Denver 80262. Fetal plasma alanine disposal rate (DR) and decarboxylation rate were measured at 132 +/- 1 days gestation in nine fet...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 1993-09, Vol.265 (3), p.E497-E503 |
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| container_title | American journal of physiology: endocrinology and metabolism |
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| creator | Guyton, T. S De Wilt, H Fennessey, P. V Meschia, G Wilkening, R. B Battaglia, F. C |
| description | T. S. Guyton, H. De Wilt, P. V. Fennessey, G. Meschia, R. B. Wilkening and F. C. Battaglia
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver 80262.
Fetal plasma alanine disposal rate (DR) and decarboxylation rate were
measured at 132 +/- 1 days gestation in nine fetal lambs infused with
L-[1-14C]alanine via a brachial vein. In five experiments, L-[1-13C]alanine
was added to the infusate. Using L-[1-14C]alanine, we found mean DR to be
15.5 +/- 1.8 mumol.min-1 . kg-1. DR was significantly correlated to both
arterial plasma alanine and whole blood lactate concentrations. Placental
uptake of fetal plasma alanine accounted for 19 +/- 4% of DR. Fetal and
placental production of CO2 from the first carbon of alanine were 61 +/- 2
and 16 +/- 2% of DR, respectively, for a total uterine excretion of 77 +/-
3%. Net alanine flux from placenta to fetus was 5.2 +/- 0.5 mumol.min-1 x
kg-1, which was less than fetal plasma alanine decarboxylation (9.4 +/- 1.2
mumol.min-1 x kg-1) plus fetal alanine accretion (2.4 mumol.min-1 x kg-1).
Utilizing L-[1-13C]alanine, we found DR to be 14.2 +/- 0.8 mumol.min-1 x
kg-1, not significantly different from the 14C data. We conclude that both
the umbilical uptake of alanine from the placenta and fetal alanine
synthesis contribute to fetal alanine supply and that oxidation is the main
route of fetal plasma alanine disposal. |
| doi_str_mv | 10.1152/ajpendo.1993.265.3.e497 |
| format | Article |
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Department of Anesthesiology, University of Colorado Health Sciences Center, Denver 80262.
Fetal plasma alanine disposal rate (DR) and decarboxylation rate were
measured at 132 +/- 1 days gestation in nine fetal lambs infused with
L-[1-14C]alanine via a brachial vein. In five experiments, L-[1-13C]alanine
was added to the infusate. Using L-[1-14C]alanine, we found mean DR to be
15.5 +/- 1.8 mumol.min-1 . kg-1. DR was significantly correlated to both
arterial plasma alanine and whole blood lactate concentrations. Placental
uptake of fetal plasma alanine accounted for 19 +/- 4% of DR. Fetal and
placental production of CO2 from the first carbon of alanine were 61 +/- 2
and 16 +/- 2% of DR, respectively, for a total uterine excretion of 77 +/-
3%. Net alanine flux from placenta to fetus was 5.2 +/- 0.5 mumol.min-1 x
kg-1, which was less than fetal plasma alanine decarboxylation (9.4 +/- 1.2
mumol.min-1 x kg-1) plus fetal alanine accretion (2.4 mumol.min-1 x kg-1).
Utilizing L-[1-13C]alanine, we found DR to be 14.2 +/- 0.8 mumol.min-1 x
kg-1, not significantly different from the 14C data. We conclude that both
the umbilical uptake of alanine from the placenta and fetal alanine
synthesis contribute to fetal alanine supply and that oxidation is the main
route of fetal plasma alanine disposal.</description><identifier>ISSN: 0193-1849</identifier><identifier>ISSN: 0002-9513</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.1993.265.3.e497</identifier><identifier>PMID: 8214057</identifier><language>eng</language><publisher>United States</publisher><subject>Alanine - blood ; Alanine - metabolism ; Animals ; Decarboxylation ; Fetal Blood ; Fetus - metabolism ; Glucose - metabolism ; Lactates - metabolism ; Lactic Acid ; Placenta - metabolism ; Sheep</subject><ispartof>American journal of physiology: endocrinology and metabolism, 1993-09, Vol.265 (3), p.E497-E503</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-3dff59f94f07aa7907b75145e6357d7d03eaf993f84170fa7766ba6e890fd8bf3</citedby><cites>FETCH-LOGICAL-c346t-3dff59f94f07aa7907b75145e6357d7d03eaf993f84170fa7766ba6e890fd8bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8214057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guyton, T. S</creatorcontrib><creatorcontrib>De Wilt, H</creatorcontrib><creatorcontrib>Fennessey, P. V</creatorcontrib><creatorcontrib>Meschia, G</creatorcontrib><creatorcontrib>Wilkening, R. B</creatorcontrib><creatorcontrib>Battaglia, F. C</creatorcontrib><title>Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol</addtitle><description>T. S. Guyton, H. De Wilt, P. V. Fennessey, G. Meschia, R. B. Wilkening and F. C. Battaglia
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver 80262.
Fetal plasma alanine disposal rate (DR) and decarboxylation rate were
measured at 132 +/- 1 days gestation in nine fetal lambs infused with
L-[1-14C]alanine via a brachial vein. In five experiments, L-[1-13C]alanine
was added to the infusate. Using L-[1-14C]alanine, we found mean DR to be
15.5 +/- 1.8 mumol.min-1 . kg-1. DR was significantly correlated to both
arterial plasma alanine and whole blood lactate concentrations. Placental
uptake of fetal plasma alanine accounted for 19 +/- 4% of DR. Fetal and
placental production of CO2 from the first carbon of alanine were 61 +/- 2
and 16 +/- 2% of DR, respectively, for a total uterine excretion of 77 +/-
3%. Net alanine flux from placenta to fetus was 5.2 +/- 0.5 mumol.min-1 x
kg-1, which was less than fetal plasma alanine decarboxylation (9.4 +/- 1.2
mumol.min-1 x kg-1) plus fetal alanine accretion (2.4 mumol.min-1 x kg-1).
Utilizing L-[1-13C]alanine, we found DR to be 14.2 +/- 0.8 mumol.min-1 x
kg-1, not significantly different from the 14C data. We conclude that both
the umbilical uptake of alanine from the placenta and fetal alanine
synthesis contribute to fetal alanine supply and that oxidation is the main
route of fetal plasma alanine disposal.</description><subject>Alanine - blood</subject><subject>Alanine - metabolism</subject><subject>Animals</subject><subject>Decarboxylation</subject><subject>Fetal Blood</subject><subject>Fetus - metabolism</subject><subject>Glucose - metabolism</subject><subject>Lactates - metabolism</subject><subject>Lactic Acid</subject><subject>Placenta - metabolism</subject><subject>Sheep</subject><issn>0193-1849</issn><issn>0002-9513</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1OwzAQhC0EKqXwCIicOJFgx3EcHytUfqRKHICz5cTr1iWJQ5wI-va4tKo4rbwzO9Z8CN0QnBDC0nu16aDVLiFC0CTNWUITyAQ_QdOgpjFhjJ2iKSaCxqTIxDm68H6DMeYsSydoUqQkw4xP0du8Vq1tIRqb0ta2UnU0doP6hLtIW985Hxa9GsJTtTrSUKm-dD_bWg3WtX9KZNtoWENkYAjeWjXlJTozqvZwdZgz9PG4eH94jpevTy8P82Vc0SwfYqqNYcKIzGCuFBeYl5yRjEFOGddcYwrKhHqmyAjHRnGe56XKoRDY6KI0dIZu97ld775G8INsrK-gDo3AjV7yPPTnhAQj3xur3nnfg5FdbxvVbyXBcodTHnDKHU4ZcEoqFwFnuLw-fDGWDejj3YFf0OO9vrar9bftQXbrrbeudqvtMfRf3i_79IPO</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Guyton, T. S</creator><creator>De Wilt, H</creator><creator>Fennessey, P. V</creator><creator>Meschia, G</creator><creator>Wilkening, R. B</creator><creator>Battaglia, F. C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930901</creationdate><title>Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb</title><author>Guyton, T. S ; De Wilt, H ; Fennessey, P. V ; Meschia, G ; Wilkening, R. B ; Battaglia, F. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-3dff59f94f07aa7907b75145e6357d7d03eaf993f84170fa7766ba6e890fd8bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Alanine - blood</topic><topic>Alanine - metabolism</topic><topic>Animals</topic><topic>Decarboxylation</topic><topic>Fetal Blood</topic><topic>Fetus - metabolism</topic><topic>Glucose - metabolism</topic><topic>Lactates - metabolism</topic><topic>Lactic Acid</topic><topic>Placenta - metabolism</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guyton, T. S</creatorcontrib><creatorcontrib>De Wilt, H</creatorcontrib><creatorcontrib>Fennessey, P. V</creatorcontrib><creatorcontrib>Meschia, G</creatorcontrib><creatorcontrib>Wilkening, R. B</creatorcontrib><creatorcontrib>Battaglia, F. C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guyton, T. S</au><au>De Wilt, H</au><au>Fennessey, P. V</au><au>Meschia, G</au><au>Wilkening, R. B</au><au>Battaglia, F. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>265</volume><issue>3</issue><spage>E497</spage><epage>E503</epage><pages>E497-E503</pages><issn>0193-1849</issn><issn>0002-9513</issn><eissn>1522-1555</eissn><abstract>T. S. Guyton, H. De Wilt, P. V. Fennessey, G. Meschia, R. B. Wilkening and F. C. Battaglia
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver 80262.
Fetal plasma alanine disposal rate (DR) and decarboxylation rate were
measured at 132 +/- 1 days gestation in nine fetal lambs infused with
L-[1-14C]alanine via a brachial vein. In five experiments, L-[1-13C]alanine
was added to the infusate. Using L-[1-14C]alanine, we found mean DR to be
15.5 +/- 1.8 mumol.min-1 . kg-1. DR was significantly correlated to both
arterial plasma alanine and whole blood lactate concentrations. Placental
uptake of fetal plasma alanine accounted for 19 +/- 4% of DR. Fetal and
placental production of CO2 from the first carbon of alanine were 61 +/- 2
and 16 +/- 2% of DR, respectively, for a total uterine excretion of 77 +/-
3%. Net alanine flux from placenta to fetus was 5.2 +/- 0.5 mumol.min-1 x
kg-1, which was less than fetal plasma alanine decarboxylation (9.4 +/- 1.2
mumol.min-1 x kg-1) plus fetal alanine accretion (2.4 mumol.min-1 x kg-1).
Utilizing L-[1-13C]alanine, we found DR to be 14.2 +/- 0.8 mumol.min-1 x
kg-1, not significantly different from the 14C data. We conclude that both
the umbilical uptake of alanine from the placenta and fetal alanine
synthesis contribute to fetal alanine supply and that oxidation is the main
route of fetal plasma alanine disposal.</abstract><cop>United States</cop><pmid>8214057</pmid><doi>10.1152/ajpendo.1993.265.3.e497</doi></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alanine - blood Alanine - metabolism Animals Decarboxylation Fetal Blood Fetus - metabolism Glucose - metabolism Lactates - metabolism Lactic Acid Placenta - metabolism Sheep |
| title | Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb |
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