Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor Pathway
Nuclear receptors play important roles in the maintenance of the endocrine system, regulation of organ differentiation, and fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms. To assess the effects of endocrine disruptors on...
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| Veröffentlicht in: | Molecular pharmacology 2005-03, Vol.67 (3), p.766 |
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| container_title | Molecular pharmacology |
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| creator | Tomohiko Kanayama Naoki Kobayashi Satoru Mamiya Tsuyoshi Nakanishi Jun-ichi Nishikawa |
| description | Nuclear receptors play important roles in the maintenance of the endocrine system, regulation of organ differentiation, and
fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms.
To assess the effects of endocrine disruptors on nuclear receptors, we developed a high-throughput method for identifying
activators of nuclear receptors. Using this system, we found that triphenyltin and tributyltin were activators of peroxisome
proliferator-activated receptor (PPAR) γ and retinoid X receptor. Because PPARγ is a master regulator of adipocyte differentiation,
we assessed the effect of organotin compounds on preadipocyte 3T3-L1 cells. We found that organotin compounds stimulated differentiation
of 3T3-L1 cells as well as expression of adipocyte marker genes. |
| doi_str_mv | 10.1124/mol.104.008409 |
| format | Article |
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fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms.
To assess the effects of endocrine disruptors on nuclear receptors, we developed a high-throughput method for identifying
activators of nuclear receptors. Using this system, we found that triphenyltin and tributyltin were activators of peroxisome
proliferator-activated receptor (PPAR) γ and retinoid X receptor. Because PPARγ is a master regulator of adipocyte differentiation,
we assessed the effect of organotin compounds on preadipocyte 3T3-L1 cells. We found that organotin compounds stimulated differentiation
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fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms.
To assess the effects of endocrine disruptors on nuclear receptors, we developed a high-throughput method for identifying
activators of nuclear receptors. Using this system, we found that triphenyltin and tributyltin were activators of peroxisome
proliferator-activated receptor (PPAR) γ and retinoid X receptor. Because PPARγ is a master regulator of adipocyte differentiation,
we assessed the effect of organotin compounds on preadipocyte 3T3-L1 cells. We found that organotin compounds stimulated differentiation
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fetal development. Endocrine disruptors exert their adverse effects by disrupting the endocrine system via various mechanisms.
To assess the effects of endocrine disruptors on nuclear receptors, we developed a high-throughput method for identifying
activators of nuclear receptors. Using this system, we found that triphenyltin and tributyltin were activators of peroxisome
proliferator-activated receptor (PPAR) γ and retinoid X receptor. Because PPARγ is a master regulator of adipocyte differentiation,
we assessed the effect of organotin compounds on preadipocyte 3T3-L1 cells. We found that organotin compounds stimulated differentiation
of 3T3-L1 cells as well as expression of adipocyte marker genes.</abstract><pub>American Society for Pharmacology and Experimental Therapeutics</pub><pmid>15611480</pmid><doi>10.1124/mol.104.008409</doi></addata></record> |
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| ispartof | Molecular pharmacology, 2005-03, Vol.67 (3), p.766 |
| issn | 0026-895X 1521-0111 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| title | Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor Pathway |
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