Partial Agonism through a Zinc-Ion Switch Constructed between Transmembrane Domains III and VII in the Tachykinin NK1 Receptor

Partly due to lack of detailed knowledge of the molecular recognition of ligands the structural basis for partial versus full agonism is not known. In the β 2 -adrenergic receptor the agonist binding site has previously been structurally and functionally exchanged with an activating metal-ion site...

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Veröffentlicht in:	Molecular pharmacology 2000-08, Vol.58 (2), p.263
Hauptverfasser:	Birgitte Holst, Christian E. Elling, Thue W. Schwartz
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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