Regulation of G Protein Activation and Effector Modulation by Fusion Proteins between the Human 5-Hydroxytryptamine1AReceptor and the α Subunit of Gi1α: Differences in Receptor-Constitutive Activity Imparted by Single Amino Acid Substitutions in Gi1Î

Fusion proteins were generated between the human 5-hydroxytryptamine (5-HT) 1A receptor and both wild-type (Cys 351 ) and pertussis toxin-resistant (Gly 351 and Ile 351 ) forms of G i1 . These were expressed stably. Pertussis toxin treatment substantially reduced basal high-affinity GTPase activity...

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Veröffentlicht in:	Molecular pharmacology 1999-10, Vol.56 (4), p.684
Hauptverfasser:	Elaine Kellett, I. Craig Carr, Graeme Milligan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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