Arginine-Glycine-Aspartic Acid Mimics Can Identify a Transitional Activation State of Recombinant αIIbβ3 in Human Embryonic Kidney 293 Cells

The platelet-specific integrin αIIbβ3 achieves a high affinity binding state in response to extracellular agonists such as thrombin, ADP, or collagen. During this activation, the receptor undergoes a number of conformational changes. To characterize the different conformations of αIIbβ3, we expr...

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Veröffentlicht in:	Molecular pharmacology 1997-08, Vol.52 (2), p.227
Hauptverfasser:	Dicky G. Abraham, Elka M. Nutt, Rodney A. Bednar, Bohumil Bednar, Robert J. Gould, Le T. Duong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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