Novel Tight-Binding Inhibitory Factor-κB Kinase (IKK-2) Inhibitors Demonstrate Target-Specific Anti-Inflammatory Activities in Cellular Assays and following Oral and Local Delivery in an in Vivo Model of Airway Inflammation

Nuclear factor-κB (NF-κB) is one of the major families of transcription factors activated during the inflammatory response in asthma and chronic obstructive pulmonary disease. Inhibitory factor-κB kinase 2 (IKK-2) has been shown to play a pivotal role in cytokine-induced NF-κB activation in airw...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-08, Vol.330 (2), p.377
Hauptverfasser:	Cynthia D. Sommers, Janice M. Thompson, Julia A. Guzova, Sheri L. Bonar, Randall K. Rader, Sumathy Mathialagan, Neetu Venkatraman, Vicky Walker Holway, Larry E. Kahn, George Hu, Debra S. Garner, Horng-Chih Huang, Po-Chang Chiang, John F. Schindler, Yiding Hu, Debra M. Meyer, Nandini N. Kishore
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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