Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance
OBJECTIVE:--We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism. RESEARCH DE...
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| Veröffentlicht in: | Diabetes care 2008-03, Vol.31 (3), p.576-582 |
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| creator | Caballero, A. Enrique Bousquet-Santos, Kelb Robles-Osorio, Ludivina Montagnani, Valeria Soodini, Geetha Porramatikul, Sriurai Hamdy, Osama Nobrega, Antonio C.L Horton, Edward S |
| description | OBJECTIVE:--We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism. RESEARCH DESIGN AND METHODS--A total of 38 lean or obese Hispanic children and adolescents (10-18 years of age) were selected. The overweight group (n = 21) had a BMI >85th percentile for their age and sex, and the lean group (n = 17) had a BMI between the 25th and 50th percentiles. Studies included an oral glucose tolerance test, measurements of plasma glucose and lipids, several markers of endothelial function and inflammation, and determination of body composition by dual X-ray absorptiometry. RESULTS:--The obese group had higher systolic blood pressure and plasma triglycerides and was more insulin resistant than the lean group. The obese group also had higher plasma soluble intercellular adhesion molecule (259.5 ± 60.0 vs. 223.2 ± 47.5 ng/ml, P = 0.047), tumor necrosis factor-α (2.57 ± 1.1 vs. 1.74 ± 0.6 pg/ml, P = 0.008), high-sensitivity C-reactive protein (2.0 vs. 0.13 mg/l, P < 0.0001), plasminogen-activated inhibitor-1 (47.0 ± 35.7 vs. 12.0 ± 5.2 ng/ml, P < 0.0001), tissue plasminogen activator (6.1 ± 1.9 vs. 4.1 ± 0.8 ng/ml, P = 0.001), and white blood cell count (6.9 vs. 5.3 x 10³, P = 0.031) and lower levels of adiponectin (8.7 ± 3.3 vs. 12.6 ± 5.2 μg/ml, P = 0.022). No significant differences were observed for soluble vascular cell adhesion molecule or interleukin-6. CONCLUSIONS:--Overweight Hispanic children and adolescents with normal glucose tolerance exhibit increased plasma markers of endothelial dysfunction and subclinical inflammation in association with obesity and insulin resistance. These abnormalities may predispose them to the development of type 2 diabetes and cardiovascular disease. |
| doi_str_mv | 10.2337/dc07-1540 |
| format | Article |
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Enrique ; Bousquet-Santos, Kelb ; Robles-Osorio, Ludivina ; Montagnani, Valeria ; Soodini, Geetha ; Porramatikul, Sriurai ; Hamdy, Osama ; Nobrega, Antonio C.L ; Horton, Edward S</creator><creatorcontrib>Caballero, A. Enrique ; Bousquet-Santos, Kelb ; Robles-Osorio, Ludivina ; Montagnani, Valeria ; Soodini, Geetha ; Porramatikul, Sriurai ; Hamdy, Osama ; Nobrega, Antonio C.L ; Horton, Edward S</creatorcontrib><description>OBJECTIVE:--We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism. RESEARCH DESIGN AND METHODS--A total of 38 lean or obese Hispanic children and adolescents (10-18 years of age) were selected. The overweight group (n = 21) had a BMI >85th percentile for their age and sex, and the lean group (n = 17) had a BMI between the 25th and 50th percentiles. Studies included an oral glucose tolerance test, measurements of plasma glucose and lipids, several markers of endothelial function and inflammation, and determination of body composition by dual X-ray absorptiometry. RESULTS:--The obese group had higher systolic blood pressure and plasma triglycerides and was more insulin resistant than the lean group. The obese group also had higher plasma soluble intercellular adhesion molecule (259.5 ± 60.0 vs. 223.2 ± 47.5 ng/ml, P = 0.047), tumor necrosis factor-α (2.57 ± 1.1 vs. 1.74 ± 0.6 pg/ml, P = 0.008), high-sensitivity C-reactive protein (2.0 vs. 0.13 mg/l, P < 0.0001), plasminogen-activated inhibitor-1 (47.0 ± 35.7 vs. 12.0 ± 5.2 ng/ml, P < 0.0001), tissue plasminogen activator (6.1 ± 1.9 vs. 4.1 ± 0.8 ng/ml, P = 0.001), and white blood cell count (6.9 vs. 5.3 x 10³, P = 0.031) and lower levels of adiponectin (8.7 ± 3.3 vs. 12.6 ± 5.2 μg/ml, P = 0.022). No significant differences were observed for soluble vascular cell adhesion molecule or interleukin-6. CONCLUSIONS:--Overweight Hispanic children and adolescents with normal glucose tolerance exhibit increased plasma markers of endothelial dysfunction and subclinical inflammation in association with obesity and insulin resistance. These abnormalities may predispose them to the development of type 2 diabetes and cardiovascular disease.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc07-1540</identifier><identifier>PMID: 18083792</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Absorptiometry, Photon ; Adiponectin - blood ; Adipose Tissue - physiopathology ; Adolescent ; Biological and medical sciences ; Blood ; Blood Pressure ; Body fat ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Cell adhesion & migration ; Child ; Children & youth ; Chronic illnesses ; Complications and side effects ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diagnosis ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Families & family life ; Female ; Gene expression ; Glucose Tolerance Test ; Hispanic Americans ; Hispanic Americans - statistics & numerical data ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Intercellular Adhesion Molecule-1 - blood ; Leukocyte Count ; Male ; Medical sciences ; Metabolic diseases ; Metabolic syndrome ; Miscellaneous ; Obesity ; Obesity - blood ; Obesity - ethnology ; Obesity - physiopathology ; Overweight - blood ; Overweight - ethnology ; Overweight - physiopathology ; Physical examinations ; Plasma ; Plasminogen Activator Inhibitor 1 - blood ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk factors ; Studies ; Tissue Plasminogen Activator - blood ; Triglycerides - blood ; Tumor Necrosis Factor-alpha - blood ; Type 2 diabetes ; Vasculitis - blood ; Vasculitis - physiopathology</subject><ispartof>Diabetes care, 2008-03, Vol.31 (3), p.576-582</ispartof><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 American Diabetes Association</rights><rights>Copyright American Diabetes Association Mar 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-2992c64082b3d69a6d7d390cc2fb7859501451f0fb76e16c6da2e6f1f4d201013</citedby><cites>FETCH-LOGICAL-c510t-2992c64082b3d69a6d7d390cc2fb7859501451f0fb76e16c6da2e6f1f4d201013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20162720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18083792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caballero, A. Enrique</creatorcontrib><creatorcontrib>Bousquet-Santos, Kelb</creatorcontrib><creatorcontrib>Robles-Osorio, Ludivina</creatorcontrib><creatorcontrib>Montagnani, Valeria</creatorcontrib><creatorcontrib>Soodini, Geetha</creatorcontrib><creatorcontrib>Porramatikul, Sriurai</creatorcontrib><creatorcontrib>Hamdy, Osama</creatorcontrib><creatorcontrib>Nobrega, Antonio C.L</creatorcontrib><creatorcontrib>Horton, Edward S</creatorcontrib><title>Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE:--We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism. RESEARCH DESIGN AND METHODS--A total of 38 lean or obese Hispanic children and adolescents (10-18 years of age) were selected. The overweight group (n = 21) had a BMI >85th percentile for their age and sex, and the lean group (n = 17) had a BMI between the 25th and 50th percentiles. Studies included an oral glucose tolerance test, measurements of plasma glucose and lipids, several markers of endothelial function and inflammation, and determination of body composition by dual X-ray absorptiometry. RESULTS:--The obese group had higher systolic blood pressure and plasma triglycerides and was more insulin resistant than the lean group. The obese group also had higher plasma soluble intercellular adhesion molecule (259.5 ± 60.0 vs. 223.2 ± 47.5 ng/ml, P = 0.047), tumor necrosis factor-α (2.57 ± 1.1 vs. 1.74 ± 0.6 pg/ml, P = 0.008), high-sensitivity C-reactive protein (2.0 vs. 0.13 mg/l, P < 0.0001), plasminogen-activated inhibitor-1 (47.0 ± 35.7 vs. 12.0 ± 5.2 ng/ml, P < 0.0001), tissue plasminogen activator (6.1 ± 1.9 vs. 4.1 ± 0.8 ng/ml, P = 0.001), and white blood cell count (6.9 vs. 5.3 x 10³, P = 0.031) and lower levels of adiponectin (8.7 ± 3.3 vs. 12.6 ± 5.2 μg/ml, P = 0.022). No significant differences were observed for soluble vascular cell adhesion molecule or interleukin-6. CONCLUSIONS:--Overweight Hispanic children and adolescents with normal glucose tolerance exhibit increased plasma markers of endothelial dysfunction and subclinical inflammation in association with obesity and insulin resistance. These abnormalities may predispose them to the development of type 2 diabetes and cardiovascular disease.</description><subject>Absorptiometry, Photon</subject><subject>Adiponectin - blood</subject><subject>Adipose Tissue - physiopathology</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Pressure</subject><subject>Body fat</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cell adhesion & migration</subject><subject>Child</subject><subject>Children & youth</subject><subject>Chronic illnesses</subject><subject>Complications and side effects</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diagnosis</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Families & family life</subject><subject>Female</subject><subject>Gene expression</subject><subject>Glucose Tolerance Test</subject><subject>Hispanic Americans</subject><subject>Hispanic Americans - statistics & numerical data</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic syndrome</subject><subject>Miscellaneous</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - ethnology</subject><subject>Obesity - physiopathology</subject><subject>Overweight - blood</subject><subject>Overweight - ethnology</subject><subject>Overweight - physiopathology</subject><subject>Physical examinations</subject><subject>Plasma</subject><subject>Plasminogen Activator Inhibitor 1 - blood</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Tissue Plasminogen Activator - blood</subject><subject>Triglycerides - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Type 2 diabetes</subject><subject>Vasculitis - blood</subject><subject>Vasculitis - physiopathology</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks9uEzEQxlcIREPhwAuAhQQShy3-s_buHkNIaaSgSpTC0XLs2cTFaxd7tyVPxSviNBGVUOWDPePffLbHX1G8JPiEMlZ_MBrXJeEVflRMSMt4yXnVPC4mmFRtyduWHhXPUrrCGFdV0zwtjkiDG1a3dFL8Ob-BeAt2vRnQUg3WBzTbWGcieKS8QVMTHCQNfkjoTN0A-qLiTzBo7k0YNuCscujTNnWj14MN-5qLcaWd9Vbnve8q6dGpiBa-c6rv1R1lPZqmFLTdhz_ssEHz3xpSQh-D2aJTNdwpLXwasxL6CsmmQXkNz4snnXIJXhzm4-LydP5tdlYuzz8vZtNlqTnBQ0nzo7WocENXzIhWCVMb1mKtabeqG97y3BpOOpwjAURoYRQF0ZGuMhQTTNhx8W6vex3DrxHSIHub2-Cc8hDGJGvMOMNtncE3_4FXYYw-301SyjDFmDcZKvfQWjmQ1ndhiEqvwUNULnjobE5PSS0a0grCMn_yAJ-Hgd7qBwve7wt0DClF6OR1tL2KW0mw3HlE7jwidx7J7KvDjcdVD-aePJgiA28PQP485bqYG2_TPy43SNCa4vtDN9k-tzaCNFatYIC0W2iVE4xIJnktMvt6z3YqSLWOWe_yIisxjBvB60qwv8en3BY</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Caballero, A. Enrique</creator><creator>Bousquet-Santos, Kelb</creator><creator>Robles-Osorio, Ludivina</creator><creator>Montagnani, Valeria</creator><creator>Soodini, Geetha</creator><creator>Porramatikul, Sriurai</creator><creator>Hamdy, Osama</creator><creator>Nobrega, Antonio C.L</creator><creator>Horton, Edward S</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance</title><author>Caballero, A. Enrique ; Bousquet-Santos, Kelb ; Robles-Osorio, Ludivina ; Montagnani, Valeria ; Soodini, Geetha ; Porramatikul, Sriurai ; Hamdy, Osama ; Nobrega, Antonio C.L ; Horton, Edward S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-2992c64082b3d69a6d7d390cc2fb7859501451f0fb76e16c6da2e6f1f4d201013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Absorptiometry, Photon</topic><topic>Adiponectin - blood</topic><topic>Adipose Tissue - physiopathology</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood Pressure</topic><topic>Body fat</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cell adhesion & migration</topic><topic>Child</topic><topic>Children & youth</topic><topic>Chronic illnesses</topic><topic>Complications and side effects</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diagnosis</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Families & family life</topic><topic>Female</topic><topic>Gene expression</topic><topic>Glucose Tolerance Test</topic><topic>Hispanic Americans</topic><topic>Hispanic Americans - statistics & numerical data</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic syndrome</topic><topic>Miscellaneous</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - ethnology</topic><topic>Obesity - physiopathology</topic><topic>Overweight - blood</topic><topic>Overweight - ethnology</topic><topic>Overweight - physiopathology</topic><topic>Physical examinations</topic><topic>Plasma</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Tissue Plasminogen Activator - blood</topic><topic>Triglycerides - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Type 2 diabetes</topic><topic>Vasculitis - blood</topic><topic>Vasculitis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caballero, A. Enrique</creatorcontrib><creatorcontrib>Bousquet-Santos, Kelb</creatorcontrib><creatorcontrib>Robles-Osorio, Ludivina</creatorcontrib><creatorcontrib>Montagnani, Valeria</creatorcontrib><creatorcontrib>Soodini, Geetha</creatorcontrib><creatorcontrib>Porramatikul, Sriurai</creatorcontrib><creatorcontrib>Hamdy, Osama</creatorcontrib><creatorcontrib>Nobrega, Antonio C.L</creatorcontrib><creatorcontrib>Horton, Edward S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caballero, A. Enrique</au><au>Bousquet-Santos, Kelb</au><au>Robles-Osorio, Ludivina</au><au>Montagnani, Valeria</au><au>Soodini, Geetha</au><au>Porramatikul, Sriurai</au><au>Hamdy, Osama</au><au>Nobrega, Antonio C.L</au><au>Horton, Edward S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>31</volume><issue>3</issue><spage>576</spage><epage>582</epage><pages>576-582</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE:--We measured plasma markers of endothelial dysfunction, vascular inflammation, and pro-coagulation in obese Hispanic/Latino children and adolescents with normal glucose tolerance and determined their relationship to body composition and indexes of glucose and lipid metabolism. RESEARCH DESIGN AND METHODS--A total of 38 lean or obese Hispanic children and adolescents (10-18 years of age) were selected. The overweight group (n = 21) had a BMI >85th percentile for their age and sex, and the lean group (n = 17) had a BMI between the 25th and 50th percentiles. Studies included an oral glucose tolerance test, measurements of plasma glucose and lipids, several markers of endothelial function and inflammation, and determination of body composition by dual X-ray absorptiometry. RESULTS:--The obese group had higher systolic blood pressure and plasma triglycerides and was more insulin resistant than the lean group. The obese group also had higher plasma soluble intercellular adhesion molecule (259.5 ± 60.0 vs. 223.2 ± 47.5 ng/ml, P = 0.047), tumor necrosis factor-α (2.57 ± 1.1 vs. 1.74 ± 0.6 pg/ml, P = 0.008), high-sensitivity C-reactive protein (2.0 vs. 0.13 mg/l, P < 0.0001), plasminogen-activated inhibitor-1 (47.0 ± 35.7 vs. 12.0 ± 5.2 ng/ml, P < 0.0001), tissue plasminogen activator (6.1 ± 1.9 vs. 4.1 ± 0.8 ng/ml, P = 0.001), and white blood cell count (6.9 vs. 5.3 x 10³, P = 0.031) and lower levels of adiponectin (8.7 ± 3.3 vs. 12.6 ± 5.2 μg/ml, P = 0.022). No significant differences were observed for soluble vascular cell adhesion molecule or interleukin-6. CONCLUSIONS:--Overweight Hispanic children and adolescents with normal glucose tolerance exhibit increased plasma markers of endothelial dysfunction and subclinical inflammation in association with obesity and insulin resistance. These abnormalities may predispose them to the development of type 2 diabetes and cardiovascular disease.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>18083792</pmid><doi>10.2337/dc07-1540</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2008-03, Vol.31 (3), p.576-582 |
| issn | 0149-5992 1935-5548 |
| language | eng |
| recordid | cdi_highwire_diabetes_diacare_31_3_576 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Absorptiometry, Photon Adiponectin - blood Adipose Tissue - physiopathology Adolescent Biological and medical sciences Blood Blood Pressure Body fat C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular diseases Cell adhesion & migration Child Children & youth Chronic illnesses Complications and side effects Diabetes Diabetes. Impaired glucose tolerance Diagnosis Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Families & family life Female Gene expression Glucose Tolerance Test Hispanic Americans Hispanic Americans - statistics & numerical data Humans Insulin resistance Insulin Resistance - physiology Intercellular Adhesion Molecule-1 - blood Leukocyte Count Male Medical sciences Metabolic diseases Metabolic syndrome Miscellaneous Obesity Obesity - blood Obesity - ethnology Obesity - physiopathology Overweight - blood Overweight - ethnology Overweight - physiopathology Physical examinations Plasma Plasminogen Activator Inhibitor 1 - blood Public health. Hygiene Public health. Hygiene-occupational medicine Risk factors Studies Tissue Plasminogen Activator - blood Triglycerides - blood Tumor Necrosis Factor-alpha - blood Type 2 diabetes Vasculitis - blood Vasculitis - physiopathology |
| title | Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T01%3A00%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_highw&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Overweight%20Latino%20Children%20and%20Adolescents%20Have%20Marked%20Endothelial%20Dysfunction%20and%20Subclinical%20Vascular%20Inflammation%20in%20Association%20With%20Excess%20Body%20Fat%20and%20Insulin%20Resistance&rft.jtitle=Diabetes%20care&rft.au=Caballero,%20A.%20Enrique&rft.date=2008-03-01&rft.volume=31&rft.issue=3&rft.spage=576&rft.epage=582&rft.pages=576-582&rft.issn=0149-5992&rft.eissn=1935-5548&rft.coden=DICAD2&rft_id=info:doi/10.2337/dc07-1540&rft_dat=%3Cgale_highw%3EA176819613%3C/gale_highw%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=223020058&rft_id=info:pmid/18083792&rft_galeid=A176819613&rfr_iscdi=true |