Increased MAPK Activation and Impaired Insulin Signaling in Subcutaneous Microvascular Endothelial Cells in Type 2 Diabetes: The Role of Endothelin-1

Increased MAPK Activation and Impaired Insulin Signaling in Subcutaneous Microvascular Endothelial Cells in Type 2 Diabetes: The Role of Endothelin-1 Silvia Gogg , Ulf Smith and Per-Anders Jansson From the Lundberg Laboratory for Diabetes Research, Center of Excellence for Cardiovascular and Metabol...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2009-10, Vol.58 (10), p.2238-2245
Hauptverfasser:	GOGG, Silvia, SMITH, Ulf, JANSSON, Per-Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - enzymology Adipose Tissue - metabolism Adipose Tissue - pathology Adipose Tissue/enzymology/metabolism/pathology Biological and medical sciences Biopsy Biopsy, Needle Body fat Cell growth Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelin Endothelin-1 - physiology Endothelium Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzyme Activation Epithelial cells Etiopathogenesis. Screening. Investigations. Target tissue resistance Fibroblasts Gene Expression Regulation Genetic aspects Humans Insulin - physiology Insulin Receptor Substrate Proteins - genetics Insulin resistance Insulin/genetics Kinases Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Microcirculation Mitogen-Activated Protein Kinase Kinases - metabolism Needle Original Phosphorylation Phosphoserine - metabolism Physiological aspects Protein expression Protein kinases Proteins Proto-Oncogene Proteins c-akt - metabolism Receptor Receptor, Insulin - genetics Reference Values Research design Type 2 diabetes Type 2/enzymology/genetics/pathology/physiopathology Vascular/metabolism/pathology
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